hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06451
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ERO1A | ERO1-like protein alpha (ERO1-L) (ERO1-L-alpha) (EC 1.8.4.-) (Endoplasmic oxidoreductin-1-like protein) (Endoplasmic reticulum oxidoreductase alpha) (Oxidoreductin-1-L-alpha) | UniProt NCBI |
| PLEKHO2 | Pleckstrin homology domain-containing family O member 2 (PH domain-containing family O member 2) (Pleckstrin homology domain-containing family Q member 1) (PH domain-containing family Q member 1) | UniProt NCBI |
| RCSD1 | CapZ-interacting protein (Protein kinase substrate CapZIP) (RCSD domain-containing protein 1) | UniProt NCBI |
| FLAD1 | FAD synthase (EC 2.7.7.2) (FAD pyrophosphorylase) (FMN adenylyltransferase) (Flavin adenine dinucleotide synthase) [Includes: Molybdenum cofactor biosynthesis protein-like region; FAD synthase region] | UniProt NCBI |
| TSN | Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO) | UniProt NCBI |
| CAPZB | F-actin-capping protein subunit beta (CapZ beta) | UniProt NCBI |
| CAPZA1 | F-actin-capping protein subunit alpha-1 (CapZ alpha-1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6483 | 1.007158685e-05 | 0.285714285714 | CAPZB CAPZA1 | CAPZalpha-CAPZbeta complex |
| CORUM:846 | 0.000211266711219 | 0.285714285714 | CAPZB CAPZA1 | RICH1/AMOT polarity complex, Flag-Rich1 precipitated |
| CORUM:6484 | 0.000211266711219 | 0.285714285714 | CAPZB CAPZA1 | WASH-CAPZalpa/beta complex |
| CORUM:6671 | 0.000914055366538 | 0.285714285714 | CAPZB CAPZA1 | PI4K2A-WASH complex |
| MIRNA:hsa-miR-582-5p | 0.007463646458 | 0.428571428571 | ERO1A TSN CAPZB | hsa-miR-582-5p |
| REAC:R-HSA-6811436 | 0.038372634236 | 0.285714285714 | CAPZB CAPZA1 | COPI-independent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-3371497 | 0.0415178062253 | 0.285714285714 | CAPZB CAPZA1 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| CORUM:7002 | 0.0499886427319 | 0.142857142857 | CAPZB | CAPZA3-CAPZB complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CAPZB | CAPZA1 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt Malo gupta_WMM fraction boldt_WMM treiber_WMM |
| PLEKHO2 | CAPZA1 | 0.812 | 0.771 | bioplex (PLEKHO2) bioplex_WMM |
| PLEKHO2 | CAPZB | 0.753 | 0.747 | bioplex (PLEKHO2) bioplex_WMM youn_WMM |
| FLAD1 | PLEKHO2 | 0.077 | 0.353 | bioplex (PLEKHO2) bioplex_WMM |
| CAPZA1 | TSN | 0.06 | 0.337 | gupta_WMM fraction boldt_WMM treiber_WMM |
| ERO1A | CAPZA1 | 0.054 | 0.3 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| CAPZA1 | RCSD1 | 0.046 | 0.292 | bioplex (RCSD1) bioplex_WMM |
| CAPZB | RCSD1 | 0.042 | 0.27 | bioplex (RCSD1) bioplex_WMM |
| ERO1A | CAPZB | 0.042 | 0.27 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| FLAD1 | CAPZA1 | 0.008 | 0.024 | bioplex_WMM gupta_WMM WMM_only treiber_WMM |
| FLAD1 | CAPZB | 0.007 | 0.008 | bioplex_WMM youn_WMM gupta_WMM WMM_only treiber_WMM |
| PLEKHO2 | TSN | 0.007 | 0.0 | youn_WMM WMM_only |
| ERO1A | FLAD1 | 0.007 | 0.0 | bioplex_WMM WMM_only treiber_WMM |
| FLAD1 | TSN | 0.007 | 0.001 | youn_WMM WMM_only |
| ERO1A | TSN | 0.007 | 0.001 | bioplex_WMM gupta_WMM WMM_only |
| CAPZB | TSN | 0.0 | 0.013 | youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_06451 has an average edge precision of 0.271 which is ranked 5006 out of all 6965 complexes.
Related Complexes