hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06453
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TRMT6 | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6) | UniProt NCBI |
| TRMT61A | tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (EC 2.1.1.220) (mRNA methyladenosine-N(1)-methyltransferase catalytic subunit TRMT61A) (EC 2.1.1.-) (tRNA(m1A58)-methyltransferase subunit TRMT61A) (tRNA(m1A58)MTase subunit TRMT61A) | UniProt NCBI |
| ARHGEF12 | Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0031515 | 0.00405722906526 | 0.666666666667 | TRMT61A TRMT6 | tRNA (m1A) methyltransferase complex |
| REAC:R-HSA-6782315 | 0.00548064029679 | 0.666666666667 | TRMT61A TRMT6 | tRNA modification in the nucleus and cytosol |
| GO:0016429 | 0.00811409485621 | 0.666666666667 | TRMT61A TRMT6 | tRNA (adenine-N1-)-methyltransferase activity |
| GO:0043527 | 0.00811409485621 | 0.666666666667 | TRMT61A TRMT6 | tRNA methyltransferase complex |
| GO:0016426 | 0.0135228859698 | 0.666666666667 | TRMT61A TRMT6 | tRNA (adenine) methyltransferase activity |
| REAC:R-HSA-72306 | 0.0343335993912 | 0.666666666667 | TRMT61A TRMT6 | tRNA processing |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TRMT61A | TRMT6 | 1.0 | 0.949 | bioplex (TRMT61A) bioplex_WMM Guru youn_WMM Malo fraction |
| TRMT61A | ARHGEF12 | 0.591 | 0.664 | bioplex (TRMT61A) bioplex_WMM |
| TRMT6 | ARHGEF12 | 0.008 | 0.024 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06453 has an average edge precision of 0.546 which is ranked 2226 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TRMT6 | HuMAP2_00423 HuMAP2_04884 HuMAP2_06453 |
| TRMT61A | HuMAP2_00423 HuMAP2_04884 HuMAP2_06453 |
| ARHGEF12 | HuMAP2_00871 HuMAP2_04884 HuMAP2_06453 |