hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06461
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB11FIP5 | Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11) | UniProt NCBI |
| RAB11FIP1 | Rab11 family-interacting protein 1 (Rab11-FIP1) (Rab-coupling protein) | UniProt NCBI |
| RAB25 | Ras-related protein Rab-25 (CATX-8) | UniProt NCBI |
| RAB11FIP2 | Rab11 family-interacting protein 2 (Rab11-FIP2) (NRip11) | UniProt NCBI |
| RAB11A | Ras-related protein Rab-11A (Rab-11) (YL8) | UniProt NCBI |
| RAB11B | Ras-related protein Rab-11B (GTP-binding protein YPT3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:04144 | 2.35797867986e-07 | 0.833333333333 | RAB11B RAB11A RAB11FIP2 RAB11FIP1 RAB11FIP5 | Endocytosis |
| CORUM:3941 | 8.39001385941e-06 | 0.333333333333 | RAB11A RAB11FIP1 | RAB11FIP1-RAB11A complex |
| CORUM:6253 | 2.51655344529e-05 | 0.333333333333 | RAB11A RAB11FIP2 | myosin-Vb-Rab11-FIP2-Rab11a complex |
| REAC:R-HSA-8873719 | 0.000223228442122 | 0.5 | RAB11B RAB25 RAB11A | RAB geranylgeranylation |
| GO:0006887 | 0.000551073614899 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | exocytosis |
| GO:0031489 | 0.000660060925697 | 0.5 | RAB11B RAB25 RAB11A | myosin V binding |
| GO:0055037 | 0.0028699930952 | 0.666666666667 | RAB11B RAB25 RAB11FIP5 RAB11A | recycling endosome |
| KEGG:04962 | 0.00485078019495 | 0.333333333333 | RAB11A RAB11B | Vasopressin-regulated water reabsorption |
| GO:0032940 | 0.00591957567682 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | secretion by cell |
| GO:0035773 | 0.00592798461195 | 0.5 | RAB11B RAB11FIP5 RAB11FIP2 | insulin secretion involved in cellular response to glucose stimulus |
| GO:0140352 | 0.00709575398112 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | export from cell |
| GO:0046903 | 0.00754248597554 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | secretion |
| GO:0046879 | 0.00811327342942 | 0.666666666667 | RAB11B RAB11FIP2 RAB11FIP1 RAB11FIP5 | hormone secretion |
| GO:0009914 | 0.0089947338343 | 0.666666666667 | RAB11B RAB11FIP2 RAB11FIP1 RAB11FIP5 | hormone transport |
| REAC:R-HSA-432040 | 0.0146740061797 | 0.333333333333 | RAB11A RAB11FIP2 | Vasopressin regulates renal water homeostasis via Aquaporins |
| REAC:R-HSA-445717 | 0.0163206320028 | 0.333333333333 | RAB11A RAB11FIP2 | Aquaporin-mediated transport |
| REAC:R-HSA-8854214 | 0.019874448248 | 0.333333333333 | RAB11A RAB11B | TBC/RABGAPs |
| GO:0070164 | 0.020283420769 | 0.333333333333 | RAB11FIP1 RAB11FIP5 | negative regulation of adiponectin secretion |
| GO:0015031 | 0.0243090283682 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | protein transport |
| GO:0015833 | 0.0264846072029 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | peptide transport |
| GO:0042886 | 0.0285664366252 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | amide transport |
| GO:0005768 | 0.0326105521072 | 0.833333333333 | RAB11B RAB25 RAB11A RAB11FIP5 RAB11FIP2 | endosome |
| GO:0071333 | 0.0353486827187 | 0.5 | RAB11B RAB11FIP5 RAB11FIP2 | cellular response to glucose stimulus |
| GO:0045184 | 0.0384716494008 | 1.0 | RAB25 RAB11FIP5 RAB11A RAB11FIP1 RAB11B RAB11FIP2 | establishment of protein localization |
| GO:0071326 | 0.0398453744123 | 0.5 | RAB11B RAB11FIP5 RAB11FIP2 | cellular response to monosaccharide stimulus |
| GO:0071331 | 0.0398453744123 | 0.5 | RAB11B RAB11FIP5 RAB11FIP2 | cellular response to hexose stimulus |
| GO:0070162 | 0.0405595771497 | 0.333333333333 | RAB11FIP1 RAB11FIP5 | adiponectin secretion |
| GO:0070163 | 0.0405595771497 | 0.333333333333 | RAB11FIP1 RAB11FIP5 | regulation of adiponectin secretion |
| GO:0017022 | 0.0422297014162 | 0.5 | RAB11B RAB25 RAB11A | myosin binding |
| GO:0023061 | 0.0480888208923 | 0.666666666667 | RAB11B RAB11FIP2 RAB11FIP1 RAB11FIP5 | signal release |
| GO:0071322 | 0.0499477329172 | 0.5 | RAB11B RAB11FIP5 RAB11FIP2 | cellular response to carbohydrate stimulus |
| CORUM:6561 | 0.0499726005494 | 0.166666666667 | RAB11A | RAB11A-SPG33 complex |
| CORUM:6562 | 0.0499726005494 | 0.166666666667 | RAB11B | RAB11B-SPG33 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB11B | RAB11FIP2 | 1.0 | 0.949 | hein_WMM bioplex (RAB11B) bioplex_WMM gupta_WMM |
| RAB11FIP2 | RAB11A | 1.0 | 0.949 | hein_WMM bioplex (RAB11A) bioplex_WMM hein (RAB11A) |
| RAB11B | RAB11FIP5 | 0.998 | 0.936 | hein_WMM bioplex (RAB11B) bioplex_WMM gupta_WMM |
| RAB11FIP1 | RAB11A | 0.985 | 0.899 | hein_WMM bioplex (RAB11A) bioplex_WMM youn_WMM hein (RAB11A) |
| RAB11A | RAB11FIP5 | 0.958 | 0.863 | hein_WMM bioplex (RAB11A) bioplex_WMM youn_WMM hein (RAB11A) |
| RAB11FIP1 | RAB11B | 0.842 | 0.786 | hein_WMM bioplex (RAB11B,RAB11FIP1) bioplex_WMM hein (RAB11FIP1) gupta_WMM |
| RAB25 | RAB11A | 0.807 | 0.767 | bioplex (RAB11A) bioplex_WMM treiber_WMM |
| RAB11B | RAB25 | 0.703 | 0.723 | bioplex (RAB11B) bioplex_WMM |
| RAB11B | RAB11A | 0.106 | 0.373 | hein_WMM hein (RAB11A) |
| RAB25 | RAB11FIP2 | 0.011 | 0.14 | bioplex_WMM WMM_only |
| RAB11FIP1 | RAB11FIP2 | 0.011 | 0.142 | hein_WMM bioplex_WMM boldt gupta_WMM boldt_WMM |
| RAB11FIP2 | RAB11FIP5 | 0.01 | 0.139 | hein_WMM bioplex_WMM gupta_WMM WMM_only boldt_WMM |
| RAB11FIP1 | RAB25 | 0.01 | 0.118 | bioplex_WMM WMM_only |
| RAB11FIP1 | RAB11FIP5 | 0.01 | 0.116 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only boldt_WMM |
| RAB25 | RAB11FIP5 | 0.01 | 0.097 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06461 has an average edge precision of 0.533 which is ranked 2316 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RAB11FIP5 | HuMAP2_03348 HuMAP2_05097 HuMAP2_06358 HuMAP2_06461 |
| RAB11FIP1 | HuMAP2_03348 HuMAP2_06089 HuMAP2_06358 HuMAP2_06461 |
| RAB25 | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| RAB11FIP2 | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| RAB11A | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |
| RAB11B | HuMAP2_03348 HuMAP2_06358 HuMAP2_06461 |