hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06464
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TESPA1 | Protein TESPA1 (Thymocyte-expressed positive selection-associated protein 1) | UniProt NCBI |
| BOK | Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9) | UniProt NCBI |
| RAB29 | Ras-related protein Rab-7L1 (Rab-7-like protein 1) (Ras-related protein Rab-29) | UniProt NCBI |
| ITPR1 | Inositol 1,4,5-trisphosphate receptor type 1 (IP3 receptor isoform 1) (IP3R 1) (InsP3R1) (Type 1 inositol 1,4,5-trisphosphate receptor) (Type 1 InsP3 receptor) | UniProt NCBI |
| ITPR3 | Inositol 1,4,5-trisphosphate receptor type 3 (IP3 receptor isoform 3) (IP3R 3) (InsP3R3) (Type 3 inositol 1,4,5-trisphosphate receptor) (Type 3 InsP3 receptor) | UniProt NCBI |
| ITPR2 | Inositol 1,4,5-trisphosphate receptor type 2 (IP3 receptor isoform 2) (IP3R 2) (InsP3R2) (Type 2 inositol 1,4,5-trisphosphate receptor) (Type 2 InsP3 receptor) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5607763 | 4.99793187022e-07 | 0.5 | ITPR1 ITPR3 ITPR2 | CLEC7A (Dectin-1) induces NFAT activation |
| GO:0005220 | 1.81637152046e-06 | 0.5 | ITPR1 ITPR3 ITPR2 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| REAC:R-HSA-139853 | 2.16413418261e-06 | 0.5 | ITPR1 ITPR3 ITPR2 | Elevation of cytosolic Ca2+ levels |
| REAC:R-HSA-5218921 | 3.32843063241e-06 | 0.5 | ITPR1 ITPR3 ITPR2 | VEGFR2 mediated cell proliferation |
| REAC:R-HSA-2029485 | 7.89904848188e-06 | 0.5 | ITPR1 ITPR3 ITPR2 | Role of phospholipids in phagocytosis |
| REAC:R-HSA-2871809 | 1.05150257754e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | FCERI mediated Ca+2 mobilization |
| REAC:R-HSA-983695 | 1.20153549581e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Antigen activates B Cell Receptor (BCR) leading to generation of second messengers |
| REAC:R-HSA-114508 | 1.36517474966e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Effects of PIP2 hydrolysis |
| REAC:R-HSA-418360 | 1.36517474966e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Platelet calcium homeostasis |
| REAC:R-HSA-381676 | 3.878939824e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Glucagon-like Peptide-1 (GLP1) regulates insulin secretion |
| KEGG:04924 | 3.91015753854e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Renin secretion |
| KEGG:04730 | 3.91015753854e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Long-term depression |
| KEGG:04929 | 4.13953986709e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | GnRH secretion |
| KEGG:04927 | 4.88098353951e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Cortisol synthesis and secretion |
| REAC:R-HSA-1489509 | 5.41301437531e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | DAG and IP3 signaling |
| KEGG:04971 | 6.00000658266e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Gastric acid secretion |
| KEGG:04720 | 6.30413655994e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Long-term potentiation |
| KEGG:04918 | 8.34614014946e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Thyroid hormone synthesis |
| REAC:R-HSA-5578775 | 8.3970836606e-05 | 0.5 | ITPR1 ITPR3 ITPR2 | Ion homeostasis |
| KEGG:04970 | 0.000107857457806 | 0.5 | ITPR1 ITPR3 ITPR2 | Salivary secretion |
| WP:WP2059 | 0.000121904053629 | 0.5 | ITPR1 ITPR3 ITPR2 | Alzheimers Disease |
| REAC:R-HSA-112043 | 0.00012312225834 | 0.5 | ITPR1 ITPR3 ITPR2 | PLC beta mediated events |
| REAC:R-HSA-112040 | 0.000130640571844 | 0.5 | ITPR1 ITPR3 ITPR2 | G-protein mediated events |
| REAC:R-HSA-4086398 | 0.00013845803743 | 0.5 | ITPR1 ITPR3 ITPR2 | Ca2+ pathway |
| KEGG:04912 | 0.000141809175237 | 0.5 | ITPR1 ITPR3 ITPR2 | GnRH signaling pathway |
| KEGG:04750 | 0.000141809175237 | 0.5 | ITPR1 ITPR3 ITPR2 | Inflammatory mediator regulation of TRP channels |
| KEGG:04972 | 0.000141809175237 | 0.5 | ITPR1 ITPR3 ITPR2 | Pancreatic secretion |
| GO:0031095 | 0.000152436922042 | 0.5 | ITPR1 ITPR3 ITPR2 | platelet dense tubular network membrane |
| KEGG:04540 | 0.000158298174337 | 0.5 | ITPR1 ITPR3 ITPR2 | Gap junction |
| KEGG:04625 | 0.000182197158451 | 0.5 | ITPR1 ITPR3 ITPR2 | C-type lectin receptor signaling pathway |
| KEGG:04925 | 0.000182197158451 | 0.5 | ITPR1 ITPR3 ITPR2 | Aldosterone synthesis and secretion |
| KEGG:04070 | 0.00020837684325 | 0.5 | ITPR1 ITPR3 ITPR2 | Phosphatidylinositol signaling system |
| GO:0070679 | 0.000217734118711 | 0.5 | ITPR1 ITPR3 ITPR2 | inositol 1,4,5 trisphosphate binding |
| KEGG:04726 | 0.000229569653691 | 0.5 | ITPR1 ITPR3 ITPR2 | Serotonergic synapse |
| KEGG:04725 | 0.000236939175691 | 0.5 | ITPR1 ITPR3 ITPR2 | Cholinergic synapse |
| KEGG:04922 | 0.000236939175691 | 0.5 | ITPR1 ITPR3 ITPR2 | Glucagon signaling pathway |
| KEGG:04928 | 0.000244463970221 | 0.5 | ITPR1 ITPR3 ITPR2 | Parathyroid hormone synthesis, secretion and action |
| KEGG:04270 | 0.000259985721773 | 0.5 | ITPR1 ITPR3 ITPR2 | Vascular smooth muscle contraction |
| KEGG:04724 | 0.000267985848775 | 0.5 | ITPR1 ITPR3 ITPR2 | Glutamatergic synapse |
| GO:0031094 | 0.000299339163023 | 0.5 | ITPR1 ITPR3 ITPR2 | platelet dense tubular network |
| REAC:R-HSA-422356 | 0.000308922066904 | 0.5 | ITPR1 ITPR3 ITPR2 | Regulation of insulin secretion |
| KEGG:04114 | 0.000328600438861 | 0.5 | ITPR1 ITPR3 ITPR2 | Oocyte meiosis |
| KEGG:04611 | 0.000367001333139 | 0.5 | ITPR1 ITPR3 ITPR2 | Platelet activation |
| WP:WP536 | 0.00041417182098 | 0.5 | ITPR1 ITPR3 ITPR2 | Calcium Regulation in the Cardiac Cell |
| REAC:R-HSA-418346 | 0.000430779573811 | 0.5 | ITPR1 ITPR3 ITPR2 | Platelet homeostasis |
| KEGG:04728 | 0.000475750838962 | 0.5 | ITPR1 ITPR3 ITPR2 | Dopaminergic synapse |
| REAC:R-HSA-2029480 | 0.0004836193603 | 0.5 | ITPR1 ITPR3 ITPR2 | Fcgamma receptor (FCGR) dependent phagocytosis |
| KEGG:04915 | 0.00048767047927 | 0.5 | ITPR1 ITPR3 ITPR2 | Estrogen signaling pathway |
| KEGG:04371 | 0.000512099919502 | 0.5 | ITPR1 ITPR3 ITPR2 | Apelin signaling pathway |
| KEGG:04210 | 0.000524612840052 | 0.5 | ITPR1 ITPR3 ITPR2 | Apoptosis |
| WP:WP289 | 0.000539074693736 | 0.5 | ITPR1 ITPR3 ITPR2 | Myometrial Relaxation and Contraction Pathways |
| REAC:R-HSA-111885 | 0.000601857302474 | 0.5 | ITPR1 ITPR3 ITPR2 | Opioid Signalling |
| KEGG:04723 | 0.000617915068855 | 0.5 | ITPR1 ITPR3 ITPR2 | Retrograde endocannabinoid signaling |
| KEGG:04921 | 0.000661047116041 | 0.5 | ITPR1 ITPR3 ITPR2 | Oxytocin signaling pathway |
| REAC:R-HSA-4420097 | 0.000713906652255 | 0.5 | ITPR1 ITPR3 ITPR2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-5607764 | 0.000737858985933 | 0.5 | ITPR1 ITPR3 ITPR2 | CLEC7A (Dectin-1) signaling |
| KEGG:04022 | 0.000753196125616 | 0.5 | ITPR1 ITPR3 ITPR2 | cGMP-PKG signaling pathway |
| KEGG:04934 | 0.000753196125616 | 0.5 | ITPR1 ITPR3 ITPR2 | Cushing syndrome |
| KEGG:04218 | 0.000819121924932 | 0.5 | ITPR1 ITPR3 ITPR2 | Cellular senescence |
| REAC:R-HSA-163685 | 0.000865642910945 | 0.5 | ITPR1 ITPR3 ITPR2 | Integration of energy metabolism |
| REAC:R-HSA-194138 | 0.000920605178739 | 0.5 | ITPR1 ITPR3 ITPR2 | Signaling by VEGF |
| REAC:R-HSA-983705 | 0.000977834083021 | 0.5 | ITPR1 ITPR3 ITPR2 | Signaling by the B Cell Receptor (BCR) |
| KEGG:05010 | 0.000981167923329 | 0.5 | ITPR1 ITPR3 ITPR2 | Alzheimer disease |
| KEGG:04621 | 0.00105950907114 | 0.5 | ITPR1 ITPR3 ITPR2 | NOD-like receptor signaling pathway |
| KEGG:04020 | 0.00107971996751 | 0.5 | ITPR1 ITPR3 ITPR2 | Calcium signaling pathway |
| KEGG:05167 | 0.00120635789569 | 0.5 | ITPR1 ITPR3 ITPR2 | Kaposi sarcoma-associated herpesvirus infection |
| REAC:R-HSA-5576891 | 0.00123031208945 | 0.5 | ITPR1 ITPR3 ITPR2 | Cardiac conduction |
| REAC:R-HSA-2454202 | 0.00164310787995 | 0.5 | ITPR1 ITPR3 ITPR2 | Fc epsilon receptor (FCERI) signaling |
| KEGG:05205 | 0.0017821830589 | 0.5 | ITPR1 ITPR3 ITPR2 | Proteoglycans in cancer |
| REAC:R-HSA-5621481 | 0.00190266482243 | 0.5 | ITPR1 ITPR3 ITPR2 | C-type lectin receptors (CLRs) |
| GO:0015278 | 0.00206534926206 | 0.5 | ITPR1 ITPR3 ITPR2 | calcium-release channel activity |
| KEGG:05170 | 0.00211201253822 | 0.5 | ITPR1 ITPR3 ITPR2 | Human immunodeficiency virus 1 infection |
| KEGG:05163 | 0.00220846662002 | 0.5 | ITPR1 ITPR3 ITPR2 | Human cytomegalovirus infection |
| REAC:R-HSA-416476 | 0.0022381799141 | 0.5 | ITPR1 ITPR3 ITPR2 | G alpha (q) signalling events |
| REAC:R-HSA-3858494 | 0.00244639935002 | 0.5 | ITPR1 ITPR3 ITPR2 | Beta-catenin independent WNT signaling |
| GO:0099604 | 0.00470617323084 | 0.5 | ITPR1 ITPR3 ITPR2 | ligand-gated calcium channel activity |
| REAC:R-HSA-397014 | 0.0048372157697 | 0.5 | ITPR1 ITPR3 ITPR2 | Muscle contraction |
| GO:0005217 | 0.00661098268806 | 0.5 | ITPR1 ITPR3 ITPR2 | intracellular ligand-gated ion channel activity |
| REAC:R-HSA-76002 | 0.0105025954201 | 0.5 | ITPR1 ITPR3 ITPR2 | Platelet activation, signaling and aggregation |
| GO:0016529 | 0.0152420239566 | 0.5 | ITPR1 ITPR3 ITPR2 | sarcoplasmic reticulum |
| REAC:R-HSA-418594 | 0.0167741368829 | 0.5 | ITPR1 ITPR3 ITPR2 | G alpha (i) signalling events |
| REAC:R-HSA-9006925 | 0.0171589759047 | 0.5 | ITPR1 ITPR3 ITPR2 | Intracellular signaling by second messengers |
| GO:0016528 | 0.0192515670318 | 0.5 | ITPR1 ITPR3 ITPR2 | sarcoplasm |
| KEGG:04713 | 0.0236020276363 | 0.333333333333 | ITPR1 ITPR3 | Circadian entrainment |
| REAC:R-HSA-195721 | 0.0279474259382 | 0.5 | ITPR1 ITPR3 ITPR2 | Signaling by WNT |
| CORUM:74 | 0.0499726005494 | 0.166666666667 | ITPR3 | HOMER3-IP3R-TRPC1 complex |
| CORUM:553 | 0.0499726005494 | 0.166666666667 | ITPR1 | RHOA-IP3R-TRPC1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ITPR1 | TESPA1 | 1.0 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| TESPA1 | ITPR3 | 1.0 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| TESPA1 | ITPR2 | 0.999 | 0.949 | bioplex (TESPA1) bioplex_WMM |
| BOK | TESPA1 | 0.971 | 0.883 | bioplex (TESPA1) bioplex_WMM |
| ITPR1 | RAB29 | 0.052 | 0.301 | bioplex (RAB29) bioplex_WMM youn_WMM |
| ITPR2 | RAB29 | 0.047 | 0.293 | bioplex (RAB29) bioplex_WMM youn_WMM |
| ITPR3 | RAB29 | 0.036 | 0.265 | bioplex (RAB29) bioplex_WMM youn_WMM |
| ITPR1 | ITPR2 | 0.014 | 0.139 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| ITPR3 | ITPR2 | 0.011 | 0.139 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| ITPR1 | ITPR3 | 0.011 | 0.141 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| BOK | ITPR1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| BOK | ITPR3 | 0.009 | 0.093 | bioplex_WMM WMM_only |
| BOK | ITPR2 | 0.009 | 0.098 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06464 has an average edge precision of 0.408 which is ranked 3218 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TESPA1 | HuMAP2_01231 HuMAP2_06464 |
| BOK | HuMAP2_01231 HuMAP2_06464 |
| RAB29 | HuMAP2_06464 |
| ITPR1 | HuMAP2_01231 HuMAP2_06464 |
| ITPR3 | HuMAP2_01231 HuMAP2_06464 |
| ITPR2 | HuMAP2_01231 HuMAP2_06368 HuMAP2_06464 |