hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06470
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MAP2K5 | Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5) | UniProt NCBI |
| MAPK7 | Mitogen-activated protein kinase 7 (MAP kinase 7) (MAPK 7) (EC 2.7.11.24) (Big MAP kinase 1) (BMK-1) (Extracellular signal-regulated kinase 5) (ERK-5) | UniProt NCBI |
| MAP3K3 | Mitogen-activated protein kinase kinase kinase 3 (EC 2.7.11.25) (MAPK/ERK kinase kinase 3) (MEK kinase 3) (MEKK 3) | UniProt NCBI |
| MAP3K2 | Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP3915 | 1.42149617596e-07 | 1.0 | MAP2K5 MAP3K3 MAPK7 MAP3K2 | Angiopoietin Like Protein 8 Regulatory Pathway |
| WP:WP481 | 3.41433700488e-07 | 1.0 | MAP2K5 MAP3K3 MAPK7 MAP3K2 | Insulin Signaling |
| WP:WP437 | 3.98425883597e-07 | 1.0 | MAP2K5 MAP3K3 MAPK7 MAP3K2 | EGF/EGFR Signaling Pathway |
| KEGG:04010 | 3.15864042444e-06 | 1.0 | MAP2K5 MAP3K3 MAPK7 MAP3K2 | MAPK signaling pathway |
| REAC:R-HSA-198765 | 1.00555407742e-05 | 0.5 | MAP2K5 MAPK7 | Signalling to ERK5 |
| KEGG:04912 | 2.28687407492e-05 | 0.75 | MAP3K3 MAPK7 MAP3K2 | GnRH signaling pathway |
| KEGG:04540 | 2.55355666749e-05 | 0.75 | MAP3K2 MAPK7 MAP2K5 | Gap junction |
| KEGG:04722 | 5.31309720846e-05 | 0.75 | MAP3K3 MAPK7 MAP2K5 | Neurotrophin signaling pathway |
| WP:WP2380 | 9.19001123239e-05 | 0.75 | MAP3K2 MAPK7 MAP2K5 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| WP:WP382 | 0.000385360586168 | 0.75 | MAP3K2 MAPK7 MAP2K5 | MAPK Signaling Pathway |
| CORUM:5199 | 0.000602576435264 | 0.5 | MAP3K3 MAP2K5 | Kinase maturation complex 1 |
| WP:WP422 | 0.000884625784373 | 0.5 | MAP3K3 MAP3K2 | MAPK Cascade |
| WP:WP2795 | 0.00188734205227 | 0.5 | MAP2K5 MAPK7 | Cardiac Hypertrophic Response |
| WP:WP195 | 0.00213272485195 | 0.5 | MAP3K3 MAP3K2 | IL-1 signaling pathway |
| WP:WP1544 | 0.00475658252429 | 0.5 | MAP2K5 MAPK7 | MicroRNAs in cardiomyocyte hypertrophy |
| WP:WP185 | 0.0071289861505 | 0.5 | MAP2K5 MAPK7 | Integrin-mediated Cell Adhesion |
| WP:WP3931 | 0.00791698216111 | 0.5 | MAP2K5 MAPK7 | ESC Pluripotency Pathways |
| KEGG:05418 | 0.0153578793248 | 0.5 | MAP2K5 MAPK7 | Fluid shear stress and atherosclerosis |
| KEGG:04921 | 0.0179080093657 | 0.5 | MAP2K5 MAPK7 | Oxytocin signaling pathway |
| GO:0004674 | 0.0181401540934 | 1.0 | MAP2K5 MAP3K3 MAPK7 MAP3K2 | protein serine/threonine kinase activity |
| REAC:R-HSA-187037 | 0.0262582706021 | 0.5 | MAP2K5 MAPK7 | Signaling by NTRK1 (TRKA) |
| GO:0071499 | 0.0405595771497 | 0.5 | MAP2K5 MAPK7 | cellular response to laminar fluid shear stress |
| REAC:R-HSA-166520 | 0.0408500448467 | 0.5 | MAP2K5 MAPK7 | Signaling by NTRKs |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MAP3K2 | MAP2K5 | 0.999 | 0.949 | bioplex (MAP2K5) bioplex_WMM |
| MAP2K5 | MAPK7 | 0.993 | 0.918 | bioplex (MAP2K5) bioplex_WMM |
| MAP3K3 | MAP2K5 | 0.089 | 0.355 | bioplex (MAP2K5) bioplex_WMM |
| MAP3K3 | MAP3K2 | 0.02 | 0.187 | hein_WMM bioplex_WMM boldt hein (MAP3K2) boldt_WMM |
| MAP3K3 | MAPK7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| MAP3K2 | MAPK7 | 0.009 | 0.095 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06470 has an average edge precision of 0.433 which is ranked 2989 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MAP2K5 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |
| MAPK7 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |
| MAP3K3 | HuMAP2_01089 HuMAP2_05510 HuMAP2_06470 |
| MAP3K2 | HuMAP2_01089 HuMAP2_02532 HuMAP2_05510 HuMAP2_06470 |