hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06471
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DDAH2 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 2 (DDAH-2) (Dimethylarginine dimethylaminohydrolase 2) (EC 3.5.3.18) (DDAHII) (Dimethylargininase-2) (Protein G6a) (S-phase protein) | UniProt NCBI |
| EPB41L1 | Band 4.1-like protein 1 (Neuronal protein 4.1) (4.1N) | UniProt NCBI |
| PTPA | Serine/threonine-protein phosphatase 2A activator (EC 5.2.1.8) (PP2A, subunit B', PR53 isoform) (Phosphotyrosyl phosphatase activator) (PTPA) (Serine/threonine-protein phosphatase 2A regulatory subunit 4) (Serine/threonine-protein phosphatase 2A regulatory subunit B') | UniProt NCBI |
| DDAH1 | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 (DDAH-1) (Dimethylarginine dimethylaminohydrolase 1) (EC 3.5.3.18) (DDAHI) (Dimethylargininase-1) | UniProt NCBI |
| AACS | Acetoacetyl-CoA synthetase (EC 6.2.1.16) (Acyl-CoA synthetase family member 1) (Protein sur-5 homolog) | UniProt NCBI |
| GMDS | GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-203615 | 0.000996295422965 | 0.333333333333 | DDAH2 DDAH1 | eNOS activation |
| REAC:R-HSA-202131 | 0.00201328766088 | 0.333333333333 | DDAH2 DDAH1 | Metabolism of nitric oxide: eNOS activation and regulation |
| GO:0016403 | 0.00676235117068 | 0.333333333333 | DDAH2 DDAH1 | dimethylargininase activity |
| MIRNA:hsa-miR-1231 | 0.0291098991863 | 0.333333333333 | GMDS PTPA | hsa-miR-1231 |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DDAH1 | DDAH2 | 0.997 | 0.934 | bioplex (DDAH2) bioplex_WMM |
| DDAH2 | EPB41L1 | 0.597 | 0.667 | bioplex (DDAH2) bioplex_WMM |
| DDAH2 | GMDS | 0.198 | 0.45 | fraction |
| DDAH2 | PTPA | 0.178 | 0.438 | fraction |
| GMDS | AACS | 0.029 | 0.233 | fraction |
| GMDS | PTPA | 0.023 | 0.206 | fraction |
| GMDS | EPB41L1 | 0.007 | 0.004 | WMM_only bioplex_WMM |
| DDAH1 | EPB41L1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| DDAH1 | PTPA | 0.006 | 0.008 | bioplex_WMM fraction |
| DDAH1 | GMDS | 0.0 | 0.009 | fraction |
| AACS | PTPA | 0.0 | 0.009 | fraction |
Images
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Complex HuMAP2_06471 has an average edge precision of 0.269 which is ranked 5039 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DDAH2 | HuMAP2_00111 HuMAP2_02844 HuMAP2_06471 |
| EPB41L1 | HuMAP2_02844 HuMAP2_05297 HuMAP2_06471 |
| PTPA | HuMAP2_06063 HuMAP2_06471 |
| DDAH1 | HuMAP2_00111 HuMAP2_02844 HuMAP2_06471 HuMAP2_06892 |
| AACS | HuMAP2_01015 HuMAP2_01617 HuMAP2_03397 HuMAP2_04552 HuMAP2_06471 |
| GMDS | HuMAP2_01015 HuMAP2_01652 HuMAP2_04552 HuMAP2_06471 |