hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06475
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ETF1 | Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Protein Cl1) (TB3-1) | UniProt NCBI |
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| GSPT1 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3A (Eukaryotic peptide chain release factor subunit 3a) (eRF3a) (G1 to S phase transition protein 1 homolog) | UniProt NCBI |
| GSPT2 | Eukaryotic peptide chain release factor GTP-binding subunit ERF3B (Eukaryotic peptide chain release factor subunit 3b) (eRF3b) (G1 to S phase transition protein 2 homolog) | UniProt NCBI |
| KLC2 | Kinesin light chain 2 (KLC 2) | UniProt NCBI |
| AMPD2 | AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0018444 | 1.81637152046e-06 | 0.5 | GSPT2 GSPT1 ETF1 | translation release factor complex |
| GO:0002184 | 1.81637152046e-06 | 0.5 | GSPT2 GSPT1 ETF1 | cytoplasmic translational termination |
| CORUM:809 | 8.39001385941e-06 | 0.333333333333 | GSPT1 ETF1 | eRF1-eRF3-GTP-Mg(2+) complex |
| GO:0003747 | 3.63109651748e-05 | 0.5 | GSPT2 GSPT1 ETF1 | translation release factor activity |
| GO:0008079 | 3.63109651748e-05 | 0.5 | GSPT2 GSPT1 ETF1 | translation termination factor activity |
| CORUM:784 | 5.0322056017e-05 | 0.333333333333 | GSPT1 ETF1 | SMG-1-UPF-ERF1-ERF3 complex (SURF) |
| KEGG:03015 | 0.000182197158451 | 0.5 | GSPT2 GSPT1 ETF1 | mRNA surveillance pathway |
| REAC:R-HSA-72764 | 0.000737858985933 | 0.5 | GSPT2 GSPT1 ETF1 | Eukaryotic Translation Termination |
| REAC:R-HSA-975956 | 0.000787351219981 | 0.5 | GSPT2 GSPT1 ETF1 | Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) |
| REAC:R-HSA-927802 | 0.00137131417468 | 0.5 | GSPT2 GSPT1 ETF1 | Nonsense-Mediated Decay (NMD) |
| REAC:R-HSA-975957 | 0.00137131417468 | 0.5 | GSPT2 GSPT1 ETF1 | Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) |
| REAC:R-HSA-9010553 | 0.00450837720112 | 0.5 | GSPT2 GSPT1 ETF1 | Regulation of expression of SLITs and ROBOs |
| WP:WP107 | 0.0067875461385 | 0.333333333333 | GSPT2 ETF1 | Translation Factors |
| REAC:R-HSA-8953854 | 0.00833913786065 | 0.666666666667 | ETF1 LSM2 GSPT1 GSPT2 | Metabolism of RNA |
| REAC:R-HSA-376176 | 0.0091602408755 | 0.5 | GSPT2 GSPT1 ETF1 | Signaling by ROBO receptors |
| GO:0000956 | 0.0218120988519 | 0.666666666667 | ETF1 LSM2 GSPT1 GSPT2 | nuclear-transcribed mRNA catabolic process |
| REAC:R-HSA-72766 | 0.0229344817985 | 0.5 | GSPT2 GSPT1 ETF1 | Translation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GSPT2 | ETF1 | 0.783 | 0.756 | youn (ETF1) bioplex (GSPT2) bioplex_WMM youn_WMM gupta_WMM |
| GSPT2 | GSPT1 | 0.546 | 0.643 | bioplex (GSPT2) bioplex_WMM youn_WMM gupta_WMM |
| LSM2 | GSPT1 | 0.373 | 0.546 | youn (LSM2) youn_WMM gupta_WMM fraction |
| LSM2 | KLC2 | 0.302 | 0.497 | youn (LSM2) youn_WMM gupta_WMM fraction |
| GSPT1 | ETF1 | 0.188 | 0.438 | hein_WMM youn (ETF1) bioplex_WMM youn_WMM hein (GSPT1) gupta_WMM |
| AMPD2 | KLC2 | 0.054 | 0.301 | boldt fraction boldt_WMM |
| LSM2 | ETF1 | 0.007 | 0.005 | youn (LSM2) bioplex_WMM youn_WMM gupta_WMM |
| KLC2 | GSPT1 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| GSPT2 | KLC2 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| LSM2 | GSPT2 | 0.007 | 0.001 | youn_WMM WMM_only |
| AMPD2 | ETF1 | 0.0 | 0.015 | bioplex_WMM fraction |
| KLC2 | ETF1 | 0.0 | 0.013 | youn (ETF1) youn_WMM gupta_WMM fraction |
| LSM2 | AMPD2 | 0.0 | 0.003 | fraction |
| AMPD2 | GSPT1 | 0.0 | 0.0 | fraction |
| AMPD2 | GSPT2 | 0.0 | 0.0 | fraction |
Images
Click to enlarge
Complex HuMAP2_06475 has an average edge precision of 0.215 which is ranked 5950 out of all 6965 complexes.
Related Complexes