hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06480
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| POLE3 | DNA polymerase epsilon subunit 3 (EC 2.7.7.7) (Arsenic-transactivated protein) (AsTP) (Chromatin accessibility complex 17 kDa protein) (CHRAC-17) (HuCHRAC17) (DNA polymerase II subunit 3) (DNA polymerase epsilon subunit p17) | UniProt NCBI |
| POLE | DNA polymerase epsilon catalytic subunit A (EC 2.7.7.7) (DNA polymerase II subunit A) | UniProt NCBI |
| POLE2 | DNA polymerase epsilon subunit 2 (EC 2.7.7.7) (DNA polymerase II subunit 2) (DNA polymerase epsilon subunit B) | UniProt NCBI |
| NFYA | Nuclear transcription factor Y subunit alpha (CAAT box DNA-binding protein subunit A) (Nuclear transcription factor Y subunit A) (NF-YA) | UniProt NCBI |
| POLE4 | DNA polymerase epsilon subunit 4 (EC 2.7.7.7) (DNA polymerase II subunit 4) (DNA polymerase epsilon subunit p12) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-68952 | 2.555871701e-11 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA replication initiation |
| REAC:R-HSA-174430 | 2.555871701e-11 | 0.8 | POLE3 POLE4 POLE2 POLE | Telomere C-strand synthesis initiation |
| CORUM:1108 | 2.4762098927e-10 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA synthesome complex (15 subunits) |
| CORUM:1111 | 4.31702996263e-10 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA synthesome complex (17 subunits) |
| CORUM:1099 | 4.31702996263e-10 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA synthesome complex (17 subunits) |
| GO:0008622 | 6.09856266088e-10 | 0.8 | POLE3 POLE4 POLE2 POLE | epsilon DNA polymerase complex |
| REAC:R-HSA-5651801 | 2.18374366255e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | PCNA-Dependent Long Patch Base Excision Repair |
| REAC:R-HSA-174417 | 3.87647729286e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03410 | 4.17116504798e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Base excision repair |
| REAC:R-HSA-5696397 | 4.61460570955e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Gap-filling DNA repair synthesis and ligation in GG-NER |
| REAC:R-HSA-110373 | 4.61460570955e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Resolution of AP sites via the multiple-nucleotide patch replacement pathway |
| KEGG:03030 | 6.83119004003e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA replication |
| REAC:R-HSA-110314 | 9.99440778064e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Recognition of DNA damage by PCNA-containing replication complex |
| REAC:R-HSA-180786 | 9.99440778064e-09 | 0.8 | POLE3 POLE4 POLE2 POLE | Extension of Telomeres |
| REAC:R-HSA-5656169 | 1.14744433983e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Termination of translesion DNA synthesis |
| REAC:R-HSA-68962 | 1.49208230389e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Activation of the pre-replicative complex |
| KEGG:03420 | 1.57362126176e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Nucleotide excision repair |
| REAC:R-HSA-73933 | 1.90901811802e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Resolution of Abasic Sites (AP sites) |
| REAC:R-HSA-110313 | 2.69082165127e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template |
| REAC:R-HSA-5696400 | 3.69105881227e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | Dual Incision in GG-NER |
| REAC:R-HSA-73893 | 6.49889456043e-08 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA Damage Bypass |
| WP:WP4022 | 1.35209832475e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Pyrimidine metabolism |
| GO:0042575 | 2.21856478938e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA polymerase complex |
| REAC:R-HSA-6782210 | 2.31293212985e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Gap-filling DNA repair synthesis and ligation in TC-NER |
| REAC:R-HSA-5685942 | 2.46446696587e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | HDR through Homologous Recombination (HRR) |
| REAC:R-HSA-6782135 | 2.46446696587e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Dual incision in TC-NER |
| REAC:R-HSA-6781827 | 5.1886356556e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Transcription-Coupled Nucleotide Excision Repair (TC-NER) |
| REAC:R-HSA-157579 | 6.0508920703e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Telomere Maintenance |
| REAC:R-HSA-5696399 | 7.01630822759e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Global Genome Nucleotide Excision Repair (GG-NER) |
| REAC:R-HSA-69002 | 7.36239529367e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA Replication Pre-Initiation |
| REAC:R-HSA-73884 | 8.09278526697e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | Base Excision Repair |
| GO:0003887 | 8.91404751529e-07 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA-directed DNA polymerase activity |
| REAC:R-HSA-73886 | 1.94622174999e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | Chromosome Maintenance |
| REAC:R-HSA-5696398 | 2.09637710842e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | Nucleotide Excision Repair |
| GO:0032201 | 2.13806517127e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | telomere maintenance via semi-conservative replication |
| GO:0034061 | 2.49427518271e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA polymerase activity |
| REAC:R-HSA-69239 | 2.78534254864e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | Synthesis of DNA |
| GO:0006270 | 3.33813219873e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA replication initiation |
| REAC:R-HSA-69306 | 3.63140268773e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA Replication |
| REAC:R-HSA-69206 | 4.12021471894e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | G1/S Transition |
| REAC:R-HSA-5693567 | 4.12021471894e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 4.94380388233e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | Homology Directed Repair |
| REAC:R-HSA-453279 | 6.76665795869e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 9.2847398572e-06 | 0.8 | POLE3 POLE4 POLE2 POLE | S Phase |
| REAC:R-HSA-5693532 | 1.05183097957e-05 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA Double-Strand Break Repair |
| GO:0033260 | 3.29372797631e-05 | 0.8 | POLE3 POLE4 POLE2 POLE | nuclear DNA replication |
| GO:0044786 | 4.46760620155e-05 | 0.8 | POLE3 POLE4 POLE2 POLE | cell cycle DNA replication |
| REAC:R-HSA-73894 | 0.00015586029631 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA Repair |
| CORUM:6665 | 0.000609506713326 | 0.4 | POLE3 POLE4 | ATAC complex, YEATS2-linked |
| GO:0016779 | 0.000726326030407 | 0.8 | POLE3 POLE4 POLE2 POLE | nucleotidyltransferase activity |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | POLE3 POLE4 POLE2 POLE | Cell Cycle, Mitotic |
| GO:0006261 | 0.00125226429768 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA-dependent DNA replication |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | POLE3 POLE4 POLE2 POLE | Cell Cycle |
| GO:0000723 | 0.00245191852964 | 0.8 | POLE3 POLE4 POLE2 POLE | telomere maintenance |
| WP:WP466 | 0.00285983596887 | 0.4 | POLE POLE2 | DNA Replication |
| GO:0032200 | 0.00342761547193 | 0.8 | POLE3 POLE4 POLE2 POLE | telomere organization |
| GO:0140097 | 0.00456271095818 | 0.8 | POLE3 POLE4 POLE2 POLE | catalytic activity, acting on DNA |
| WP:WP45 | 0.00646864373199 | 0.4 | POLE POLE2 | G1 to S cell cycle control |
| GO:0000082 | 0.00796512695553 | 0.8 | POLE3 POLE4 POLE2 POLE | G1/S transition of mitotic cell cycle |
| GO:0006260 | 0.00913982817851 | 0.8 | POLE3 POLE4 POLE2 POLE | DNA replication |
| GO:0044843 | 0.0100550100183 | 0.8 | POLE3 POLE4 POLE2 POLE | cell cycle G1/S phase transition |
| GO:0061695 | 0.0120893245383 | 0.8 | POLE3 POLE4 POLE2 POLE | transferase complex, transferring phosphorus-containing groups |
| WP:WP2446 | 0.0123508080289 | 0.4 | POLE POLE2 | Retinoblastoma Gene in Cancer |
| GO:0060249 | 0.0309921425814 | 0.8 | POLE3 POLE4 POLE2 POLE | anatomical structure homeostasis |
| GO:0044454 | 0.046479053704 | 1.0 | NFYA POLE2 POLE POLE4 POLE3 | nuclear chromosome part |
| CORUM:0000000 | 0.0474603483533 | 1.0 | NFYA POLE2 POLE POLE4 POLE3 | CORUM root |
| CORUM:6091 | 0.0499494897235 | 0.2 | NFYA | NF-YA-LaminA complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| POLE3 | POLE4 | 0.951 | 0.858 | bioplex_WMM Guru Malo fraction |
| POLE | POLE4 | 0.311 | 0.504 | bioplex_WMM Malo fraction |
| POLE3 | POLE | 0.27 | 0.483 | bioplex_WMM Malo fraction |
| POLE | POLE2 | 0.216 | 0.464 | bioplex (POLE,POLE2) bioplex_WMM Malo fraction |
| POLE2 | POLE4 | 0.045 | 0.285 | bioplex (POLE2) bioplex_WMM |
| POLE4 | NFYA | 0.025 | 0.21 | fraction |
| POLE3 | POLE2 | 0.015 | 0.14 | bioplex (POLE2) bioplex_WMM |
| POLE3 | NFYA | 0.004 | 0.013 | fraction |
Images
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Complex HuMAP2_06480 has an average edge precision of 0.37 which is ranked 3644 out of all 6965 complexes.
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