hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06484
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GBA | Lysosomal acid glucosylceramidase (Lysosomal acid GCase) (EC 3.2.1.45) (Acid beta-glucosidase) (Alglucerase) (Beta-glucocerebrosidase) (Beta-GC) (Cholesterol glucosyltransferase) (SGTase) (EC 2.4.1.-) (Cholesteryl-beta-glucosidase) (EC 3.2.1.104) (D-glucosyl-N-acylsphingosine glucohydrolase) (Imiglucerase) | UniProt NCBI |
| MAN2B1 | Lysosomal alpha-mannosidase (Laman) (EC 3.2.1.24) (Lysosomal acid alpha-mannosidase) (Mannosidase alpha class 2B member 1) (Mannosidase alpha-B) [Cleaved into: Lysosomal alpha-mannosidase A peptide; Lysosomal alpha-mannosidase B peptide; Lysosomal alpha-mannosidase C peptide; Lysosomal alpha-mannosidase D peptide; Lysosomal alpha-mannosidase E peptide] | UniProt NCBI |
| RNASET2 | Ribonuclease T2 (EC 3.1.27.-) (Ribonuclease 6) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:00511 | 6.84701092407e-05 | 0.666666666667 | GBA MAN2B1 | Other glycan degradation |
| KEGG:04142 | 0.00307537091529 | 0.666666666667 | GBA MAN2B1 | Lysosome |
| HP:0001257 | 0.0255710895815 | 1.0 | RNASET2 GBA MAN2B1 | Spasticity |
| HP:0002171 | 0.0278358341925 | 0.666666666667 | GBA MAN2B1 | Gliosis |
| HPA:048020_12 | 0.0348124052904 | 0.666666666667 | GBA MAN2B1 | soft tissue 2; chondrocytes[Supported,Medium] |
| HP:0001251 | 0.0351100068041 | 1.0 | RNASET2 GBA MAN2B1 | Ataxia |
| HP:0000639 | 0.04291596551 | 1.0 | RNASET2 GBA MAN2B1 | Nystagmus |
| HP:0012547 | 0.0446392984448 | 1.0 | RNASET2 GBA MAN2B1 | Abnormal involuntary eye movements |
| HP:0001276 | 0.0448141259844 | 1.0 | RNASET2 GBA MAN2B1 | Hypertonia |
| HP:0001999 | 0.0448141259844 | 1.0 | RNASET2 GBA MAN2B1 | Abnormal facial shape |
| HP:0011443 | 0.0493345167285 | 1.0 | RNASET2 GBA MAN2B1 | Abnormality of coordination |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RNASET2 | MAN2B1 | 0.054 | 0.301 | bioplex_WMM fraction |
| GBA | RNASET2 | 0.021 | 0.188 | bioplex (RNASET2) bioplex_WMM fraction |
| GBA | MAN2B1 | 0.005 | 0.013 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06484 has an average edge precision of 0.167 which is ranked 6553 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GBA | HuMAP2_02425 HuMAP2_02471 HuMAP2_03443 HuMAP2_04766 HuMAP2_06484 |
| MAN2B1 | HuMAP2_03211 HuMAP2_04449 HuMAP2_04766 HuMAP2_06484 |
| RNASET2 | HuMAP2_02471 HuMAP2_03211 HuMAP2_04449 HuMAP2_04766 HuMAP2_06484 |