hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06518

Confidence: Medium High

Genename	Protein Name	Links
PEBP1	Phosphatidylethanolamine-binding protein 1 (PEBP-1) (HCNPpp) (Neuropolypeptide h3) (Prostatic-binding protein) (Raf kinase inhibitor protein) (RKIP) [Cleaved into: Hippocampal cholinergic neurostimulating peptide (HCNP)]	UniProt NCBI
ALDH2	Aldehyde dehydrogenase, mitochondrial (EC 1.2.1.3) (ALDH class 2) (ALDH-E2) (ALDHI)	UniProt NCBI
LYPLA2	Acyl-protein thioesterase 2 (APT-2) (EC 3.1.2.-) (Lysophospholipase II) (LPL-II) (LysoPLA II)	UniProt NCBI
HIBADH	3-hydroxyisobutyrate dehydrogenase, mitochondrial (HIBADH) (EC 1.1.1.31)	UniProt NCBI
OAT	Ornithine aminotransferase, mitochondrial (EC 2.6.1.13) (Ornithine delta-aminotransferase) (Ornithine--oxo-acid aminotransferase) [Cleaved into: Ornithine aminotransferase, hepatic form; Ornithine aminotransferase, renal form]	UniProt NCBI
SHMT1	Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	UniProt NCBI
GAA	Lysosomal alpha-glucosidase (EC 3.2.1.20) (Acid maltase) (Aglucosidase alfa) [Cleaved into: 76 kDa lysosomal alpha-glucosidase; 70 kDa lysosomal alpha-glucosidase]	UniProt NCBI
GOT2	Aspartate aminotransferase, mitochondrial (mAspAT) (EC 2.6.1.1) (EC 2.6.1.7) (Fatty acid-binding protein) (FABP-1) (Glutamate oxaloacetate transaminase 2) (Kynurenine aminotransferase 4) (Kynurenine aminotransferase IV) (Kynurenine--oxoglutarate transaminase 4) (Kynurenine--oxoglutarate transaminase IV) (Plasma membrane-associated fatty acid-binding protein) (FABPpm) (Transaminase A)	UniProt NCBI
SHMT2	Serine hydroxymethyltransferase, mitochondrial (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)	UniProt NCBI
ME1	NADP-dependent malic enzyme (NADP-ME) (EC 1.1.1.40) (Malic enzyme 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
KEGG:01100	5.52207777973e-06	0.8	ALDH2 HIBADH GOT2 ME1 GAA OAT SHMT1 SHMT2	Metabolic pathways
KEGG:01200	3.17227981278e-05	0.4	GOT2 ME1 SHMT1 SHMT2	Carbon metabolism
GO:0043648	3.26172626962e-05	0.5	GOT2 SHMT2 ME1 OAT SHMT1	dicarboxylic acid metabolic process
WP:WP1495	7.59542622695e-05	0.2	SHMT1 SHMT2	Glycine Metabolism
GO:1901606	7.90122616319e-05	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	alpha-amino acid catabolic process
KEGG:00330	0.000178390726274	0.3	ALDH2 OAT GOT2	Arginine and proline metabolism
GO:0009063	0.000223557723283	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	cellular amino acid catabolic process
REAC:R-HSA-1430728	0.000466695107701	0.8	ALDH2 HIBADH GOT2 ME1 GAA OAT SHMT1 SHMT2	Metabolism
KEGG:01230	0.000584726257012	0.3	GOT2 SHMT1 SHMT2	Biosynthesis of amino acids
MIRNA:hsa-miR-4765	0.00103653750585	0.3	ALDH2 LYPLA2 PEBP1	hsa-miR-4765
WP:WP4018	0.00108787337025	0.3	ME1 SHMT1 SHMT2	Pathways in clear cell renal cell carcinoma
GO:0050662	0.00113377160405	0.5	ALDH2 SHMT2 ME1 OAT SHMT1	coenzyme binding
WP:WP3925	0.00144890172029	0.3	HIBADH OAT GOT2	Amino Acid metabolism
GO:1901605	0.00213350763495	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	alpha-amino acid metabolic process
KEGG:00670	0.00296748099663	0.2	SHMT1 SHMT2	One carbon pool by folate
GO:0008652	0.00459827964391	0.4	GOT2 SHMT2 OAT SHMT1	cellular amino acid biosynthetic process
WP:WP4595	0.0052826264231	0.2	GOT2 OAT	Urea cycle and associated pathways
REAC:R-HSA-8964539	0.00558225067866	0.2	GOT2 OAT	Glutamate and glutamine metabolism
KEGG:01523	0.00628543348768	0.2	SHMT1 SHMT2	Antifolate resistance
MIRNA:hsa-miR-3174	0.00789503590445	0.3	PEBP1 SHMT1 LYPLA2	hsa-miR-3174
KEGG:00630	0.00840076411116	0.2	SHMT1 SHMT2	Glyoxylate and dicarboxylate metabolism
REAC:R-HSA-196757	0.00887131457927	0.2	SHMT1 SHMT2	Metabolism of folate and pterines
WP:WP241	0.00948491249007	0.2	SHMT1 SHMT2	One Carbon Metabolism
GO:0046395	0.00973448831007	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	carboxylic acid catabolic process
GO:0016054	0.00973448831007	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	organic acid catabolic process
GO:0070279	0.0105009568253	0.3	SHMT2 OAT SHMT1	vitamin B6 binding
GO:0030170	0.0105009568253	0.3	SHMT2 OAT SHMT1	pyridoxal phosphate binding
WP:WP2525	0.0109073591456	0.2	SHMT1 SHMT2	Trans-sulfuration and one carbon metabolism
REAC:R-HSA-71291	0.0116430874577	0.4	HIBADH GOT2 OAT SHMT1	Metabolism of amino acids and derivatives
KEGG:00620	0.0142642002018	0.2	ALDH2 ME1	Pyruvate metabolism
KEGG:00260	0.0142642002018	0.2	SHMT1 SHMT2	Glycine, serine and threonine metabolism
GO:0044281	0.0168575058864	0.8	ALDH2 HIBADH GOT2 ME1 GAA OAT SHMT1 SHMT2	small molecule metabolic process
GO:0048037	0.0169449399558	0.5	ALDH2 SHMT2 ME1 OAT SHMT1	cofactor binding
GO:1904482	0.020287053512	0.2	SHMT1 SHMT2	cellular response to tetrahydrofolate
GO:1904481	0.020287053512	0.2	SHMT1 SHMT2	response to tetrahydrofolate
GO:0019264	0.020287053512	0.2	SHMT1 SHMT2	glycine biosynthetic process from serine
GO:0004372	0.020287053512	0.2	SHMT1 SHMT2	glycine hydroxymethyltransferase activity
KEGG:00280	0.0207496192065	0.2	ALDH2 HIBADH	Valine, leucine and isoleucine degradation
WP:WP4290	0.0214964332109	0.2	GOT2 SHMT2	Metabolic reprogramming in colon cancer
WP:WP3940	0.0281020989545	0.2	SHMT1 SHMT2	One carbon metabolism and related pathways
GO:0006520	0.0336598738398	0.5	HIBADH SHMT2 GOT2 OAT SHMT1	cellular amino acid metabolic process
WP:WP176	0.0342689547801	0.2	SHMT1 SHMT2	Folate Metabolism

Edges

Protein 1	Protein 2	Score	Precision	Evidence
OAT	GAA	0.988	0.901	bioplex (GAA) bioplex_WMM fraction
ALDH2	GAA	0.983	0.899	bioplex_WMM fraction
OAT	SHMT2	0.696	0.718	bioplex_WMM Guru youn_WMM gupta_WMM fraction treiber_WMM
GAA	ME1	0.59	0.664	bioplex_WMM fraction
SHMT1	OAT	0.581	0.663	Guru fraction
GOT2	SHMT2	0.364	0.544	bioplex (GOT2) bioplex_WMM Guru fraction boldt_WMM treiber_WMM
ALDH2	HIBADH	0.357	0.539	bioplex_WMM fraction
ALDH2	SHMT2	0.351	0.538	bioplex_WMM gupta_WMM fraction treiber_WMM
SHMT2	HIBADH	0.203	0.454	bioplex_WMM fraction
ALDH2	OAT	0.194	0.447	bioplex_WMM gupta_WMM fraction treiber_WMM
OAT	ME1	0.154	0.415	bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM
ALDH2	ME1	0.146	0.409	bioplex_WMM fraction
GOT2	HIBADH	0.146	0.409	bioplex_WMM fraction
ALDH2	GOT2	0.128	0.399	bioplex (GOT2) bioplex_WMM fraction treiber_WMM
SHMT2	PEBP1	0.108	0.373	bioplex_WMM gupta_WMM fraction boldt_WMM
ALDH2	PEBP1	0.105	0.37	bioplex_WMM fraction
SHMT1	GOT2	0.082	0.35	bioplex (SHMT1) Guru fraction
SHMT1	GAA	0.072	0.353	bioplex_WMM fraction
SHMT2	LYPLA2	0.064	0.348	youn_WMM gupta_WMM fraction
SHMT1	HIBADH	0.059	0.328	fraction
SHMT1	PEBP1	0.056	0.313	bioplex (SHMT1) fraction
SHMT2	ME1	0.052	0.3	bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
SHMT1	LYPLA2	0.048	0.293	youn_WMM fraction
HIBADH	PEBP1	0.048	0.293	bioplex_WMM fraction
GAA	PEBP1	0.042	0.27	bioplex_WMM fraction
OAT	HIBADH	0.033	0.252	bioplex_WMM fraction treiber_WMM
GAA	SHMT2	0.031	0.242	bioplex_WMM fraction
LYPLA2	ME1	0.029	0.233	bioplex_WMM youn_WMM gupta_WMM fraction
OAT	LYPLA2	0.025	0.217	youn_WMM gupta_WMM fraction
GOT2	ME1	0.019	0.184	bioplex_WMM Guru fraction boldt_WMM treiber_WMM
ALDH2	SHMT1	0.011	0.144	fraction
OAT	PEBP1	0.011	0.145	bioplex_WMM gupta_WMM fraction treiber_WMM
SHMT1	ME1	0.008	0.032	bioplex_WMM Guru youn_WMM fraction
GOT2	GAA	0.007	0.004	bioplex_WMM WMM_only
ALDH2	LYPLA2	0.007	0.002	gupta_WMM WMM_only
GAA	HIBADH	0.004	0.012	bioplex_WMM fraction
OAT	GOT2	0.0	0.018	bioplex (GOT2) bioplex_WMM Guru fraction treiber_WMM
ME1	PEBP1	0.0	0.009	fraction boldt_WMM
SHMT1	SHMT2	0.0	0.009	bioplex (SHMT1,SHMT2) bioplex_WMM youn_WMM fraction
ME1	HIBADH	0.0	0.001	bioplex_WMM fraction
LYPLA2	PEBP1	0.0	0.0	youn_WMM gupta_WMM fraction
GOT2	LYPLA2	0.0	0.0	fraction
GOT2	PEBP1	0.0	0.001	bioplex (GOT2) bioplex_WMM fraction boldt_WMM treiber_WMM

Images

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Complex HuMAP2_06518 has an average edge precision of 0.305 which is ranked 4509 out of all 6965 complexes.

Related Complexes

Genename	Complexes
PEBP1	HuMAP2_02876 HuMAP2_04645 HuMAP2_05441 HuMAP2_06518
ALDH2	HuMAP2_00148 HuMAP2_00185 HuMAP2_00305 HuMAP2_01176 HuMAP2_02517 HuMAP2_04645 HuMAP2_06263 HuMAP2_06518 HuMAP2_06788
LYPLA2	HuMAP2_01176 HuMAP2_03524 HuMAP2_03847 HuMAP2_04782 HuMAP2_06518
HIBADH	HuMAP2_01197 HuMAP2_02298 HuMAP2_03189 HuMAP2_04645 HuMAP2_06518 HuMAP2_06949
OAT	HuMAP2_00285 HuMAP2_01176 HuMAP2_01672 HuMAP2_02517 HuMAP2_03524 HuMAP2_04782 HuMAP2_06263 HuMAP2_06518 HuMAP2_06907
SHMT1	HuMAP2_00285 HuMAP2_03524 HuMAP2_04782 HuMAP2_06518 HuMAP2_06907
GAA	HuMAP2_01176 HuMAP2_01672 HuMAP2_02517 HuMAP2_03982 HuMAP2_04227 HuMAP2_06251 HuMAP2_06263 HuMAP2_06518 HuMAP2_06684
GOT2	HuMAP2_00787 HuMAP2_02401 HuMAP2_03357 HuMAP2_04579 HuMAP2_04645 HuMAP2_06518
SHMT2	HuMAP2_01176 HuMAP2_03524 HuMAP2_04645 HuMAP2_06263 HuMAP2_06518 HuMAP2_06907
ME1	HuMAP2_01176 HuMAP2_02517 HuMAP2_06251 HuMAP2_06263 HuMAP2_06518 HuMAP2_06788

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06518