hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06522
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| IRF9 | Interferon regulatory factor 9 (IRF-9) (IFN-alpha-responsive transcription factor subunit) (ISGF3 p48 subunit) (Interferon-stimulated gene factor 3 gamma) (ISGF-3 gamma) (Transcriptional regulator ISGF3 subunit gamma) | UniProt NCBI |
| WARS2 | Tryptophan--tRNA ligase, mitochondrial (EC 6.1.1.2) ((Mt)TrpRS) (Tryptophanyl-tRNA synthetase) (TrpRS) | UniProt NCBI |
| ZNF692 | Zinc finger protein 692 | UniProt NCBI |
| STAT1 | Signal transducer and activator of transcription 1-alpha/beta (Transcription factor ISGF-3 components p91/p84) | UniProt NCBI |
| STAT2 | Signal transducer and activator of transcription 2 (p113) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:60 | 1.35146690511e-09 | 0.6 | IRF9 STAT1 STAT2 | Interferon-stimulated gene factor 3 transcription complex ISGF3 |
| WP:WP2113 | 3.76539185082e-08 | 0.6 | IRF9 STAT1 STAT2 | Type III interferon signaling |
| WP:WP4197 | 7.65599689843e-07 | 0.6 | IRF9 STAT1 STAT2 | The human immune response to tuberculosis |
| WP:WP619 | 1.74504852234e-06 | 0.6 | IRF9 STAT1 STAT2 | Type II interferon signaling (IFNG) |
| WP:WP585 | 1.66007912807e-05 | 0.6 | IRF9 STAT1 STAT2 | Interferon type I signaling pathways |
| KEGG:04625 | 9.41040777628e-05 | 0.6 | IRF9 STAT1 STAT2 | C-type lectin receptor signaling pathway |
| WP:WP4495 | 0.00015011307213 | 0.4 | STAT1 STAT2 | IL-10 Anti-inflammatory Signaling Pathway |
| KEGG:04380 | 0.000151428543228 | 0.6 | IRF9 STAT1 STAT2 | Osteoclast differentiation |
| KEGG:04630 | 0.000246133668344 | 0.6 | IRF9 STAT1 STAT2 | JAK-STAT signaling pathway |
| KEGG:05162 | 0.000291563855438 | 0.6 | IRF9 STAT1 STAT2 | Measles |
| KEGG:05160 | 0.000349924863199 | 0.6 | IRF9 STAT1 STAT2 | Hepatitis C |
| KEGG:05164 | 0.000451232943381 | 0.6 | IRF9 STAT1 STAT2 | Influenza A |
| KEGG:04217 | 0.00048888248268 | 0.6 | IRF9 STAT1 STAT2 | Necroptosis |
| KEGG:04621 | 0.000549173586032 | 0.6 | IRF9 STAT1 STAT2 | NOD-like receptor signaling pathway |
| KEGG:05167 | 0.000625511303776 | 0.6 | IRF9 STAT1 STAT2 | Kaposi sarcoma-associated herpesvirus infection |
| KEGG:05169 | 0.000853349557663 | 0.6 | IRF9 STAT1 STAT2 | Epstein-Barr virus infection |
| REAC:R-HSA-8854691 | 0.00206071490935 | 0.4 | STAT1 STAT2 | Interleukin-20 family signaling |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | IRF9 STAT1 STAT2 | Interferon Signaling |
| KEGG:05165 | 0.00420236199627 | 0.6 | IRF9 STAT1 STAT2 | Human papillomavirus infection |
| WP:WP4341 | 0.00646864373199 | 0.4 | STAT1 STAT2 | Non-genomic actions of 1,25 dihydroxyvitamin D3 |
| KEGG:05168 | 0.00749393790538 | 0.6 | IRF9 STAT1 STAT2 | Herpes simplex virus 1 infection |
| WP:WP236 | 0.0197310835566 | 0.4 | STAT1 STAT2 | Adipogenesis |
| REAC:R-HSA-909733 | 0.0221443716613 | 0.4 | IRF9 STAT2 | Interferon alpha/beta signaling |
| WP:WP3929 | 0.0250517914711 | 0.4 | STAT1 STAT2 | Chemokine signaling pathway |
| WP:WP4666 | 0.0341988987854 | 0.4 | STAT1 STAT2 | Hepatitis B infection |
| KEGG:04062 | 0.0353865382697 | 0.4 | STAT1 STAT2 | Chemokine signaling pathway |
| CORUM:5573 | 0.0499494897235 | 0.2 | STAT1 | Stat1-alpha-dimer-CBP DNA-protein complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| IRF9 | STAT2 | 0.213 | 0.464 | bioplex (IRF9,STAT2) bioplex_WMM |
| STAT2 | ZNF692 | 0.133 | 0.405 | bioplex (STAT2) bioplex_WMM |
| STAT1 | STAT2 | 0.056 | 0.316 | bioplex (STAT1,STAT2) bioplex_WMM youn_WMM gupta_WMM |
| WARS2 | IRF9 | 0.051 | 0.3 | bioplex (IRF9) bioplex_WMM |
| IRF9 | STAT1 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| STAT1 | ZNF692 | 0.008 | 0.084 | bioplex_WMM WMM_only |
| IRF9 | ZNF692 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| WARS2 | STAT2 | 0.008 | 0.012 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06522 has an average edge precision of 0.219 which is ranked 5878 out of all 6965 complexes.
Related Complexes