hu.MAP 2.0: Complex View
Human Protein Complex Map
Search for a protein
Complex: HuMAP2_06523
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TERF2IP | Telomeric repeat-binding factor 2-interacting protein 1 (TERF2-interacting telomeric protein 1) (TRF2-interacting telomeric protein 1) (Dopamine receptor-interacting protein 5) (Repressor/activator protein 1 homolog) (RAP1 homolog) (hRap1) | UniProt NCBI |
| TERF2 | Telomeric repeat-binding factor 2 (TTAGGG repeat-binding factor 2) (Telomeric DNA-binding protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1205 | 1.67592346237e-06 | 1.0 | TERF2 TERF2IP | TRF2-Rap1 complex III |
| CORUM:1207 | 1.00555407742e-05 | 1.0 | TERF2 TERF2IP | TRF2-Rap1 complex II |
| CORUM:1206 | 2.51388519356e-05 | 1.0 | TERF2 TERF2IP | TRF-Rap1 complex I, 2MD |
| CORUM:1197 | 2.51388519356e-05 | 1.0 | TERF2 TERF2IP | Telomere-associated protein complex |
| CORUM:138 | 2.51388519356e-05 | 1.0 | TERF2 TERF2IP | Telomere-associated protein complex |
| CORUM:2766 | 3.51943927099e-05 | 1.0 | TERF2 TERF2IP | TERF2-RAP1 complex |
| CORUM:1204 | 3.51943927099e-05 | 1.0 | TERF2 TERF2IP | Rap1 complex |
| CORUM:1193 | 3.51943927099e-05 | 1.0 | TERF2 TERF2IP | Rap1 complex |
| GO:0048239 | 0.000450823411379 | 1.0 | TERF2 TERF2IP | negative regulation of DNA recombination at telomere |
| GO:0072695 | 0.000450823411379 | 1.0 | TERF2 TERF2IP | regulation of DNA recombination at telomere |
| REAC:R-HSA-171306 | 0.00213680241453 | 1.0 | TERF2 TERF2IP | Packaging Of Telomere Ends |
| REAC:R-HSA-110330 | 0.00239824647466 | 1.0 | TERF2 TERF2IP | Recognition and association of DNA glycosylase with site containing an affected purine |
| REAC:R-HSA-110331 | 0.00239824647466 | 1.0 | TERF2 TERF2IP | Cleavage of the damaged purine |
| REAC:R-HSA-73927 | 0.00239824647466 | 1.0 | TERF2 TERF2IP | Depurination |
| REAC:R-HSA-110329 | 0.00277030148331 | 1.0 | TERF2 TERF2IP | Cleavage of the damaged pyrimidine |
| REAC:R-HSA-73928 | 0.00277030148331 | 1.0 | TERF2 TERF2IP | Depyrimidination |
| REAC:R-HSA-110328 | 0.00277030148331 | 1.0 | TERF2 TERF2IP | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| REAC:R-HSA-73929 | 0.00286750504412 | 1.0 | TERF2 TERF2IP | Base-Excision Repair, AP Site Formation |
| REAC:R-HSA-1221632 | 0.00465068760809 | 1.0 | TERF2 TERF2IP | Meiotic synapsis |
| REAC:R-HSA-2559586 | 0.00516352018758 | 1.0 | TERF2 TERF2IP | DNA Damage/Telomere Stress Induced Senescence |
| REAC:R-HSA-157579 | 0.00542999201809 | 1.0 | TERF2 TERF2IP | Telomere Maintenance |
| REAC:R-HSA-73884 | 0.00626962967274 | 1.0 | TERF2 TERF2IP | Base Excision Repair |
| GO:0070187 | 0.00676235117068 | 1.0 | TERF2 TERF2IP | shelterin complex |
| GO:0030870 | 0.00946729163895 | 1.0 | TERF2 TERF2IP | Mre11 complex |
| REAC:R-HSA-73886 | 0.0096834857656 | 1.0 | TERF2 TERF2IP | Chromosome Maintenance |
| REAC:R-HSA-1500620 | 0.0107946230212 | 1.0 | TERF2 TERF2IP | Meiosis |
| REAC:R-HSA-1474165 | 0.0134090636225 | 1.0 | TERF2 TERF2IP | Reproduction |
| GO:0031848 | 0.0162296428096 | 1.0 | TERF2 TERF2IP | protection from non-homologous end joining at telomere |
| GO:0098505 | 0.020287053512 | 1.0 | TERF2 TERF2IP | G-rich strand telomeric DNA binding |
| REAC:R-HSA-2559583 | 0.0294593826216 | 1.0 | TERF2 TERF2IP | Cellular Senescence |
| GO:0043247 | 0.029754345151 | 1.0 | TERF2 TERF2IP | telomere maintenance in response to DNA damage |
| GO:0000783 | 0.029754345151 | 1.0 | TERF2 TERF2IP | nuclear telomere cap complex |
| GO:0000782 | 0.029754345151 | 1.0 | TERF2 TERF2IP | telomere cap complex |
| GO:0098847 | 0.029754345151 | 1.0 | TERF2 TERF2IP | sequence-specific single stranded DNA binding |
| GO:0043047 | 0.029754345151 | 1.0 | TERF2 TERF2IP | single-stranded telomeric DNA binding |
| CORUM:1218 | 0.0499173803268 | 0.5 | TERF2 | BLM-TRF2 complex |
| CORUM:1217 | 0.0499173803268 | 0.5 | TERF2 | WRN-TRF2 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| TERF2IP | TERF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM hein (TERF2,TERF2IP) Malo fraction |
Images
Click to enlarge
Complex HuMAP2_06523 has an average edge precision of 0.949 which is ranked 5 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TERF2IP | HuMAP2_01336 HuMAP2_03683 HuMAP2_04123 HuMAP2_06271 HuMAP2_06523 |
| TERF2 | HuMAP2_01336 HuMAP2_03683 HuMAP2_04123 HuMAP2_06271 HuMAP2_06523 |