hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06528
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RMI2 | RecQ-mediated genome instability protein 2 (hRMI2) (BLM-associated protein of 18 kDa) (BLAP18) | UniProt NCBI |
| TOP3A | DNA topoisomerase 3-alpha (EC 5.6.2.2) (DNA topoisomerase III alpha) | UniProt NCBI |
| RMI1 | RecQ-mediated genome instability protein 1 (BLM-associated protein of 75 kDa) (BLAP75) (FAAP75) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03460 | 5.54053458493e-07 | 1.0 | RMI1 RMI2 TOP3A | Fanconi anemia pathway |
| REAC:R-HSA-5693554 | 1.16895196861e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| REAC:R-HSA-5693568 | 2.23000067859e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-loop Structures through Holliday Junction Intermediates |
| REAC:R-HSA-5693537 | 2.45300074645e-06 | 1.0 | RMI1 RMI2 TOP3A | Resolution of D-Loop Structures |
| REAC:R-HSA-5685938 | 3.21012194458e-06 | 1.0 | RMI1 RMI2 TOP3A | HDR through Single Strand Annealing (SSA) |
| REAC:R-HSA-5693616 | 3.79279954124e-06 | 1.0 | RMI1 RMI2 TOP3A | Presynaptic phase of homologous DNA pairing and strand exchange |
| REAC:R-HSA-5693579 | 4.79270307132e-06 | 1.0 | RMI1 RMI2 TOP3A | Homologous DNA Pairing and Strand Exchange |
| REAC:R-HSA-5685942 | 1.96383930727e-05 | 1.0 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) |
| CORUM:246 | 2.01342304124e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex III |
| CORUM:2738 | 5.03310689057e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex II |
| CORUM:2222 | 5.03310689057e-05 | 0.666666666667 | TOP3A RMI1 | BLM complex II |
| REAC:R-HSA-6804756 | 5.46192807335e-05 | 1.0 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-69473 | 6.02657683388e-05 | 1.0 | RMI1 RMI2 TOP3A | G2/M DNA damage checkpoint |
| REAC:R-HSA-5693607 | 6.62885685587e-05 | 1.0 | RMI1 RMI2 TOP3A | Processing of DNA double-strand break ends |
| CORUM:2739 | 0.000120778339722 | 0.666666666667 | TOP3A RMI1 | FA complex (Fanconi anemia complex) |
| REAC:R-HSA-5693567 | 0.000160847790881 | 1.0 | RMI1 RMI2 TOP3A | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| REAC:R-HSA-5693538 | 0.000184352717389 | 1.0 | RMI1 RMI2 TOP3A | Homology Directed Repair |
| CORUM:244 | 0.000184505937338 | 0.666666666667 | TOP3A RMI1 | BRAFT complex |
| REAC:R-HSA-5633007 | 0.000284464461562 | 1.0 | RMI1 RMI2 TOP3A | Regulation of TP53 Activity |
| REAC:R-HSA-5693532 | 0.000324502864875 | 1.0 | RMI1 RMI2 TOP3A | DNA Double-Strand Break Repair |
| REAC:R-HSA-69481 | 0.00034275245309 | 1.0 | RMI1 RMI2 TOP3A | G2/M Checkpoints |
| REAC:R-HSA-69620 | 0.00175293114833 | 1.0 | RMI1 RMI2 TOP3A | Cell Cycle Checkpoints |
| REAC:R-HSA-73894 | 0.00245537461814 | 1.0 | RMI1 RMI2 TOP3A | DNA Repair |
| WP:WP4016 | 0.0028706736774 | 0.666666666667 | TOP3A RMI1 | DNA IR-damage and cellular response via ATR |
| REAC:R-HSA-3700989 | 0.00313081125109 | 1.0 | RMI1 RMI2 TOP3A | Transcriptional Regulation by TP53 |
| REAC:R-HSA-1640170 | 0.0176005573074 | 1.0 | RMI1 RMI2 TOP3A | Cell Cycle |
| CORUM:2223 | 0.0499776345577 | 0.333333333333 | TOP3A | BLM-TOP3A complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RMI2 | RMI1 | 1.0 | 0.949 | bioplex (RMI2) bioplex_WMM |
| RMI2 | TOP3A | 0.952 | 0.858 | bioplex (RMI2) bioplex_WMM |
| TOP3A | RMI1 | 0.032 | 0.244 | hein_WMM bioplex (RMI1) bioplex_WMM |
Images
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Complex HuMAP2_06528 has an average edge precision of 0.684 which is ranked 1441 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| RMI2 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |
| TOP3A | HuMAP2_00083 HuMAP2_04847 HuMAP2_06528 |
| RMI1 | HuMAP2_00083 HuMAP2_03260 HuMAP2_04847 HuMAP2_06528 |