hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06530
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MYCL | Protein L-Myc (Class E basic helix-loop-helix protein 38) (bHLHe38) (Protein L-Myc-1) (V-myc myelocytomatosis viral oncogene homolog) | UniProt NCBI |
| KIF5B | Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC) | UniProt NCBI |
| KLC1 | Kinesin light chain 1 (KLC 1) | UniProt NCBI |
| KIF5C | Kinesin heavy chain isoform 5C (Kinesin heavy chain neuron-specific 2) | UniProt NCBI |
| KLC3 | Kinesin light chain 3 (KLC2-like) (kinesin light chain 2) | UniProt NCBI |
| SYNE4 | Nesprin-4 (KASH domain-containing protein 4) (KASH4) (Nuclear envelope spectrin repeat protein 4) | UniProt NCBI |
| KLC4 | Kinesin light chain 4 (KLC 4) (Kinesin-like protein 8) | UniProt NCBI |
| KIF5A | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC) | UniProt NCBI |
| KLC2 | Kinesin light chain 2 (KLC 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-5625970 | 5.09969562986e-16 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | RHO GTPases activate KTN1 |
| REAC:R-HSA-983189 | 3.97385759943e-11 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Kinesins |
| REAC:R-HSA-6811434 | 1.008350709e-09 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | COPI-dependent Golgi-to-ER retrograde traffic |
| REAC:R-HSA-2132295 | 3.21623854592e-09 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | MHC class II antigen presentation |
| REAC:R-HSA-8856688 | 6.44819862896e-09 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Golgi-to-ER retrograde transport |
| REAC:R-HSA-983231 | 2.19457181036e-08 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Factors involved in megakaryocyte development and platelet production |
| REAC:R-HSA-6811442 | 8.03448831815e-08 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Intra-Golgi and retrograde Golgi-to-ER traffic |
| REAC:R-HSA-195258 | 1.2066067896e-06 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | RHO GTPase Effectors |
| GO:0005871 | 1.75045805272e-06 | 0.555555555556 | KLC1 KIF5A KIF5B KIF5C KLC2 | kinesin complex |
| KEGG:05132 | 2.37097171947e-06 | 0.444444444444 | KLC1 KLC2 KLC3 KLC4 | Salmonella infection |
| REAC:R-HSA-194315 | 8.69674718396e-06 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Signaling by Rho GTPases |
| GO:0098935 | 3.05058200216e-05 | 0.333333333333 | KIF5C KIF5B KIF5A | dendritic transport |
| GO:0098937 | 3.05058200216e-05 | 0.333333333333 | KIF5C KIF5B KIF5A | anterograde dendritic transport |
| GO:0098971 | 3.05058200216e-05 | 0.333333333333 | KIF5C KIF5B KIF5A | anterograde dendritic transport of neurotransmitter receptor complex |
| REAC:R-HSA-109582 | 3.2239468963e-05 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Hemostasis |
| REAC:R-HSA-199991 | 5.19902461402e-05 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Membrane Trafficking |
| REAC:R-HSA-264876 | 6.11270357961e-05 | 0.333333333333 | KIF5C KIF5B KIF5A | Insulin processing |
| REAC:R-HSA-5653656 | 7.14061492029e-05 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Vesicle-mediated transport |
| REAC:R-HSA-1280218 | 9.914735111e-05 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Adaptive Immune System |
| GO:0005875 | 0.000334761267862 | 0.555555555556 | KLC1 KIF5A KIF5B KIF5C KLC2 | microtubule associated complex |
| GO:0099641 | 0.000426565421795 | 0.333333333333 | KIF5C KIF5B KIF5A | anterograde axonal protein transport |
| GO:0099640 | 0.00063965474072 | 0.333333333333 | KIF5C KIF5B KIF5A | axo-dendritic protein transport |
| GO:1905383 | 0.000913516286731 | 0.333333333333 | KIF5C KIF5B KIF5A | protein localization to presynapse |
| REAC:R-HSA-2980736 | 0.00156095030356 | 0.333333333333 | KIF5C KIF5B KIF5A | Peptide hormone metabolism |
| KEGG:04728 | 0.00216971375766 | 0.333333333333 | KIF5C KIF5B KIF5A | Dopaminergic synapse |
| GO:0007018 | 0.0052598275062 | 0.555555555556 | KLC1 KIF5A KIF5B KIF5C KLC2 | microtubule-based movement |
| GO:0003774 | 0.01174566688 | 0.444444444444 | KLC1 KIF5A KIF5B KIF5C | motor activity |
| KEGG:04144 | 0.0147754907738 | 0.333333333333 | KIF5C KIF5B KIF5A | Endocytosis |
| WP:WP4535 | 0.0181466094007 | 0.222222222222 | SYNE4 KIF5B | Envelope proteins and their potential roles in EDMD physiopathology |
| GO:0099637 | 0.0196973219908 | 0.333333333333 | KIF5C KIF5B KIF5A | neurotransmitter receptor transport |
| GO:0008574 | 0.027657204222 | 0.333333333333 | KIF5C KIF5B KIF5A | ATP-dependent microtubule motor activity, plus-end-directed |
| REAC:R-HSA-168256 | 0.0324601785032 | 0.666666666667 | KLC4 KLC2 KIF5B KLC3 KLC1 KIF5A | Immune System |
| GO:0097120 | 0.0375082902074 | 0.333333333333 | KIF5C KIF5B KIF5A | receptor localization to synapse |
| GO:0048489 | 0.045224564378 | 0.333333333333 | KIF5C KIF5B KIF5A | synaptic vesicle transport |
| CORUM:6554 | 0.0499262710315 | 0.111111111111 | KIF5C | KIF5C-SPG33 complex |
| CORUM:5401 | 0.0499262710315 | 0.111111111111 | KIF5B | PLEKHM2-KIF5B complex |
| CORUM:6526 | 0.0499262710315 | 0.111111111111 | KIF5A | SPG10-SPG33 complex |
| CORUM:6552 | 0.0499262710315 | 0.111111111111 | KIF5B | KIF5B-SPG33 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYNE4 | KLC1 | 1.0 | 0.949 | bioplex (SYNE4) bioplex_WMM |
| SYNE4 | KLC3 | 1.0 | 0.949 | bioplex (SYNE4) bioplex_WMM |
| KIF5B | KLC2 | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC2) gupta_WMM fraction boldt_WMM treiber_WMM |
| KLC1 | KLC2 | 1.0 | 0.949 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM hein (KLC1,KLC2) gupta_WMM boldt_WMM |
| KLC1 | KLC4 | 0.998 | 0.939 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM hein (KLC1,KLC4) gupta_WMM boldt_WMM |
| SYNE4 | KLC2 | 0.918 | 0.841 | bioplex (SYNE4) bioplex_WMM |
| KIF5B | KLC4 | 0.916 | 0.839 | hein_WMM bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC4) gupta_WMM fraction boldt_WMM treiber_WMM |
| KLC1 | KLC3 | 0.84 | 0.784 | hein_WMM bioplex (KLC1) bioplex_WMM boldt youn_WMM boldt_WMM |
| KLC3 | MYCL | 0.75 | 0.743 | bioplex (MYCL) bioplex_WMM youn_WMM |
| SYNE4 | KLC4 | 0.71 | 0.729 | bioplex (SYNE4) bioplex_WMM |
| KLC2 | KLC4 | 0.636 | 0.684 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC2,KLC4) gupta_WMM boldt_WMM treiber_WMM |
| KLC4 | MYCL | 0.545 | 0.642 | bioplex (MYCL) bioplex_WMM youn_WMM |
| SYNE4 | KIF5A | 0.474 | 0.609 | bioplex (SYNE4) bioplex_WMM |
| KLC2 | KLC3 | 0.288 | 0.489 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC3) boldt_WMM |
| SYNE4 | KIF5C | 0.283 | 0.488 | bioplex (SYNE4) bioplex_WMM |
| SYNE4 | KIF5B | 0.192 | 0.446 | bioplex (SYNE4) bioplex_WMM |
| KLC4 | KLC3 | 0.062 | 0.34 | hein_WMM bioplex_WMM boldt youn_WMM hein (KLC3,KLC4) boldt_WMM |
| KIF5B | MYCL | 0.047 | 0.291 | bioplex (MYCL) bioplex_WMM youn_WMM |
| KIF5B | KIF5A | 0.038 | 0.264 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| KIF5C | KIF5A | 0.037 | 0.266 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| KIF5C | KIF5B | 0.03 | 0.233 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| MYCL | KIF5A | 0.027 | 0.232 | bioplex (MYCL) bioplex_WMM |
| KLC2 | MYCL | 0.024 | 0.213 | bioplex (MYCL) bioplex_WMM youn_WMM |
| KLC2 | KIF5A | 0.022 | 0.207 | bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| KIF5B | KLC3 | 0.022 | 0.195 | hein_WMM bioplex_WMM boldt youn_WMM hein (KIF5B,KLC3) boldt_WMM |
| KIF5C | MYCL | 0.018 | 0.178 | bioplex (MYCL) bioplex_WMM |
| KIF5C | KLC3 | 0.012 | 0.15 | bioplex_WMM boldt youn_WMM boldt_WMM |
| KLC3 | KIF5A | 0.012 | 0.144 | bioplex_WMM boldt youn_WMM boldt_WMM |
| KLC1 | MYCL | 0.011 | 0.146 | bioplex (MYCL) bioplex_WMM youn_WMM |
| KIF5B | KLC1 | 0.008 | 0.028 | hein_WMM bioplex (KLC1) bioplex_WMM Guru boldt youn_WMM hein (KIF5B,KLC1) gupta_WMM fraction boldt_WMM |
| KLC1 | KIF5A | 0.0 | 0.0 | bioplex (KLC1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5C | KLC2 | 0.0 | 0.0 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5C | KLC1 | 0.0 | 0.0 | bioplex (KLC1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KIF5C | KLC4 | 0.0 | 0.001 | bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| KLC4 | KIF5A | 0.0 | 0.001 | bioplex_WMM Guru boldt gupta_WMM fraction boldt_WMM |
Images
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Complex HuMAP2_06530 has an average edge precision of 0.426 which is ranked 3058 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MYCL | HuMAP2_01817 HuMAP2_03860 HuMAP2_06530 HuMAP2_06981 |
| KIF5B | HuMAP2_01759 HuMAP2_03083 HuMAP2_06530 |
| KLC1 | HuMAP2_01759 HuMAP2_04729 HuMAP2_06530 |
| KIF5C | HuMAP2_01187 HuMAP2_01759 HuMAP2_06530 |
| KLC3 | HuMAP2_01759 HuMAP2_06530 HuMAP2_06981 |
| SYNE4 | HuMAP2_01187 HuMAP2_01759 HuMAP2_04729 HuMAP2_06530 HuMAP2_06720 |
| KLC4 | HuMAP2_01759 HuMAP2_03083 HuMAP2_06530 |
| KIF5A | HuMAP2_03618 HuMAP2_06530 |
| KLC2 | HuMAP2_01759 HuMAP2_03083 HuMAP2_06475 HuMAP2_06530 |