hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06536
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GMPPA | Mannose-1-phosphate guanyltransferase alpha (GDP-mannose pyrophosphorylase A) (GMPP-alpha) (GTP-mannose-1-phosphate guanylyltransferase alpha) | UniProt NCBI |
| GMPPB | Mannose-1-phosphate guanyltransferase beta (EC 2.7.7.13) (GDP-mannose pyrophosphorylase B) (GTP-mannose-1-phosphate guanylyltransferase beta) | UniProt NCBI |
| MMACHC | Methylmalonic aciduria and homocystinuria type C protein (EC 1.16.1.-) (CblC) (Cyanocobalamin reductase (cyanide-eliminating)) | UniProt NCBI |
| DHODH | Dihydroorotate dehydrogenase (quinone), mitochondrial (DHOdehase) (EC 1.3.5.2) (Dihydroorotate oxidase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446205 | 0.000100528399861 | 0.5 | GMPPA GMPPB | Synthesis of GDP-mannose |
| KEGG:00051 | 0.00105499815766 | 0.5 | GMPPA GMPPB | Fructose and mannose metabolism |
| KEGG:00520 | 0.00206562690353 | 0.5 | GMPPA GMPPB | Amino sugar and nucleotide sugar metabolism |
| REAC:R-HSA-446219 | 0.0165385846138 | 0.5 | GMPPA GMPPB | Synthesis of substrates in N-glycan biosythesis |
| HP:0000496 | 0.0174481816875 | 1.0 | MMACHC DHODH GMPPA GMPPB | Abnormality of eye movement |
| REAC:R-HSA-446193 | 0.0262582706021 | 0.5 | GMPPA GMPPB | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| HP:0031703 | 0.0361704819456 | 1.0 | MMACHC DHODH GMPPA GMPPB | Abnormal ear morphology |
| HP:0001430 | 0.0386938410225 | 0.5 | GMPPA GMPPB | Abnormality of the calf musculature |
| REAC:R-HSA-3359474 | 0.0499190562503 | 0.25 | MMACHC | Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| MMACHC | GMPPB | 0.369 | 0.544 | bioplex (GMPPB) bioplex_WMM |
| GMPPB | DHODH | 0.095 | 0.359 | bioplex (GMPPB) bioplex_WMM |
| GMPPA | GMPPB | 0.047 | 0.293 | bioplex (GMPPB) bioplex_WMM Guru fraction |
| MMACHC | DHODH | 0.008 | 0.067 | bioplex_WMM WMM_only |
| GMPPA | DHODH | 0.008 | 0.062 | bioplex_WMM WMM_only |
| MMACHC | GMPPA | 0.007 | 0.008 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06536 has an average edge precision of 0.222 which is ranked 5821 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GMPPA | HuMAP2_00295 HuMAP2_02171 HuMAP2_03394 HuMAP2_04215 HuMAP2_06536 |
| GMPPB | HuMAP2_00422 HuMAP2_03528 HuMAP2_06536 |
| MMACHC | HuMAP2_00210 HuMAP2_00422 HuMAP2_00669 HuMAP2_06536 |
| DHODH | HuMAP2_00422 HuMAP2_06536 |