hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06540
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CPSF4 | Cleavage and polyadenylation specificity factor subunit 4 (Cleavage and polyadenylation specificity factor 30 kDa subunit) (CPSF 30 kDa subunit) (NS1 effector domain-binding protein 1) (Neb-1) (No arches homolog) | UniProt NCBI |
| FIP1L1 | Pre-mRNA 3'-end-processing factor FIP1 (hFip1) (FIP1-like 1 protein) (Factor interacting with PAP) (Rearranged in hypereosinophilia) | UniProt NCBI |
| CPSF2 | Cleavage and polyadenylation specificity factor subunit 2 (Cleavage and polyadenylation specificity factor 100 kDa subunit) (CPSF 100 kDa subunit) | UniProt NCBI |
| WDR33 | pre-mRNA 3' end processing protein WDR33 (WD repeat-containing protein 33) (WD repeat-containing protein of 146 kDa) | UniProt NCBI |
| CPSF1 | Cleavage and polyadenylation specificity factor subunit 1 (Cleavage and polyadenylation specificity factor 160 kDa subunit) (CPSF 160 kDa subunit) | UniProt NCBI |
| SYMPK | Symplekin | UniProt NCBI |
| CPSF3 | Cleavage and polyadenylation specificity factor subunit 3 (EC 3.1.27.-) (Cleavage and polyadenylation specificity factor 73 kDa subunit) (CPSF 73 kDa subunit) (mRNA 3'-end-processing endonuclease CPSF-73) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-77595 | 2.61570917152e-19 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Processing of Intronless Pre-mRNAs |
| REAC:R-HSA-75067 | 6.14651164454e-18 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Processing of Capped Intronless Pre-mRNA |
| REAC:R-HSA-159231 | 5.34451864244e-17 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-159234 | 6.55134543267e-17 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| CORUM:1144 | 1.83011155706e-16 | 0.714285714286 | CPSF3 CPSF4 CPSF2 CPSF1 FIP1L1 | Cleavage and polyadenylation factor (CPSF) |
| REAC:R-HSA-72187 | 9.19352939338e-16 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA 3'-end processing |
| REAC:R-HSA-73856 | 2.87210281906e-15 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA Polymerase II Transcription Termination |
| KEGG:03015 | 1.0328687652e-14 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA surveillance pathway |
| GO:0006369 | 1.04374597182e-14 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | termination of RNA polymerase II transcription |
| REAC:R-HSA-72202 | 1.24836850653e-14 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Transport of Mature Transcript to Cytoplasm |
| GO:0005847 | 1.84945530423e-13 | 0.857142857143 | CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA cleavage and polyadenylation specificity factor complex |
| GO:0005849 | 6.26507859919e-13 | 0.857142857143 | CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA cleavage factor complex |
| GO:0006353 | 2.52899247896e-12 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | DNA-templated transcription, termination |
| REAC:R-HSA-72163 | 5.17487163652e-12 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 7.07632631111e-12 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA Splicing |
| GO:0031124 | 1.47044774414e-11 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA 3'-end processing |
| CORUM:1147 | 3.17767167158e-11 | 0.571428571429 | SYMPK CPSF2 CPSF1 CPSF3 | Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) |
| REAC:R-HSA-72203 | 3.72507243281e-11 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0006406 | 4.04738052769e-11 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA export from nucleus |
| GO:0071427 | 4.04738052769e-11 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA-containing ribonucleoprotein complex export from nucleus |
| GO:0051028 | 5.62310987093e-11 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA transport |
| GO:0071426 | 1.03968613668e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | ribonucleoprotein complex export from nucleus |
| GO:0071166 | 1.10242581734e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | ribonucleoprotein complex localization |
| GO:0006405 | 1.7322141956e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA export from nucleus |
| GO:0031123 | 2.03726575378e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA 3'-end processing |
| GO:0050657 | 4.56502241237e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nucleic acid transport |
| GO:0050658 | 4.56502241237e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA transport |
| GO:0051236 | 5.25861686629e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | establishment of RNA localization |
| GO:0006611 | 6.61563843774e-10 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | protein export from nucleus |
| GO:0051168 | 1.11506515729e-09 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nuclear export |
| GO:0015931 | 1.26309211976e-09 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nucleobase-containing compound transport |
| GO:0006403 | 2.11582156702e-09 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA localization |
| GO:0031503 | 9.27135075192e-09 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | protein-containing complex localization |
| GO:0006913 | 2.82577461251e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nucleocytoplasmic transport |
| GO:0051169 | 3.05746776784e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nuclear transport |
| REAC:R-HSA-8953854 | 4.99493959204e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Metabolism of RNA |
| GO:0000398 | 8.28225620865e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA splicing, via spliceosome |
| GO:0000377 | 8.28225620865e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000375 | 8.86181505403e-08 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA splicing, via transesterification reactions |
| GO:0006378 | 1.12754376227e-07 | 0.714285714286 | SYMPK FIP1L1 CPSF3 WDR33 CPSF1 | mRNA polyadenylation |
| GO:0043631 | 1.45735349275e-07 | 0.714285714286 | SYMPK FIP1L1 CPSF3 WDR33 CPSF1 | RNA polyadenylation |
| GO:0008380 | 2.76134260047e-07 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA splicing |
| GO:0006397 | 4.62001819528e-07 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA processing |
| GO:0006379 | 2.60687308082e-06 | 0.571428571429 | CPSF3 CPSF4 CPSF1 FIP1L1 | mRNA cleavage |
| REAC:R-HSA-73857 | 2.73975723867e-06 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA Polymerase II Transcription |
| REAC:R-HSA-74160 | 5.89406198727e-06 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | Gene expression (Transcription) |
| WP:WP411 | 8.63257872854e-06 | 0.571428571429 | CPSF3 CPSF2 CPSF1 CPSF4 | mRNA Processing |
| GO:0016071 | 2.80091136626e-05 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | mRNA metabolic process |
| GO:0006396 | 4.89752975606e-05 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | RNA processing |
| GO:0090501 | 0.00016496565098 | 0.571428571429 | CPSF3 CPSF4 CPSF1 FIP1L1 | RNA phosphodiester bond hydrolysis |
| GO:0006886 | 0.000166634167312 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | intracellular protein transport |
| GO:0098789 | 0.000698035893352 | 0.428571428571 | CPSF4 CPSF1 FIP1L1 | pre-mRNA cleavage required for polyadenylation |
| GO:0098787 | 0.000907263777246 | 0.428571428571 | CPSF4 CPSF1 FIP1L1 | mRNA cleavage involved in mRNA processing |
| GO:0015031 | 0.00215038892806 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | protein transport |
| GO:0015833 | 0.00237664126968 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | peptide transport |
| GO:0042886 | 0.00259607662238 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | amide transport |
| GO:0046907 | 0.00363859974134 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | intracellular transport |
| GO:0045184 | 0.0036745489957 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | establishment of protein localization |
| CORUM:1257 | 0.00378495968457 | 0.285714285714 | SYMPK CPSF2 | ALL-1 supercomplex |
| GO:0034613 | 0.00546147189892 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | cellular protein localization |
| GO:0070727 | 0.00569376331345 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | cellular macromolecule localization |
| GO:0071705 | 0.00632623715462 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nitrogen compound transport |
| GO:0006366 | 0.0065302926108 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | transcription by RNA polymerase II |
| GO:0090305 | 0.00892801112716 | 0.571428571429 | CPSF3 CPSF4 CPSF1 FIP1L1 | nucleic acid phosphodiester bond hydrolysis |
| GO:0051649 | 0.015479871164 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | establishment of localization in cell |
| GO:0044451 | 0.0180209467821 | 0.857142857143 | CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | nucleoplasm part |
| GO:0071702 | 0.0180623174395 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | organic substance transport |
| GO:0008104 | 0.0342210950981 | 1.0 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 WDR33 | protein localization |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | SYMPK CPSF2 FIP1L1 CPSF3 CPSF4 CPSF1 | CORUM root |
| REAC:R-HSA-6784531 | 0.0447853370322 | 0.285714285714 | CPSF4 CPSF1 | tRNA processing in the nucleus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CPSF1 | FIP1L1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF1 | 1.0 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) Malo gupta_WMM fraction treiber_WMM |
| CPSF3 | CPSF2 | 1.0 | 0.949 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF4 | 1.0 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| CPSF1 | SYMPK | 1.0 | 0.949 | hein_WMM youn (CPSF1,SYMPK) bioplex_WMM Guru youn_WMM hein (SYMPK) Malo fraction treiber_WMM |
| CPSF4 | SYMPK | 0.999 | 0.949 | hein_WMM youn (SYMPK) bioplex (CPSF4) bioplex_WMM youn_WMM hein (SYMPK) Malo fraction |
| CPSF2 | SYMPK | 0.999 | 0.949 | hein_WMM youn (SYMPK) bioplex_WMM youn_WMM hein (SYMPK) Malo fraction treiber_WMM |
| CPSF1 | CPSF3 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| FIP1L1 | CPSF4 | 0.999 | 0.949 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF1 | CPSF2 | 0.999 | 0.949 | hein_WMM youn (CPSF1) bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | CPSF3 | 0.999 | 0.947 | hein_WMM bioplex_WMM Guru youn_WMM hein (CPSF3) Malo gupta_WMM fraction treiber_WMM |
| CPSF4 | CPSF2 | 0.995 | 0.924 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM Malo gupta_WMM fraction |
| WDR33 | SYMPK | 0.992 | 0.911 | hein_WMM youn (SYMPK) bioplex_WMM Guru youn_WMM hein (SYMPK) Malo fraction treiber_WMM |
| CPSF1 | CPSF4 | 0.988 | 0.901 | hein_WMM youn (CPSF1) bioplex (CPSF4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction |
| WDR33 | CPSF2 | 0.974 | 0.886 | hein_WMM bioplex_WMM youn_WMM Malo gupta_WMM fraction treiber_WMM |
| WDR33 | FIP1L1 | 0.969 | 0.88 | hein_WMM bioplex_WMM youn_WMM hein (FIP1L1) gupta_WMM treiber_WMM |
| CPSF3 | SYMPK | 0.922 | 0.843 | hein_WMM youn (SYMPK) bioplex_WMM Guru youn_WMM hein (CPSF3,SYMPK) Malo fraction treiber_WMM |
| CPSF3 | CPSF4 | 0.469 | 0.605 | hein_WMM bioplex (CPSF4) bioplex_WMM youn_WMM hein (CPSF3) gupta_WMM |
| FIP1L1 | CPSF3 | 0.141 | 0.405 | hein_WMM bioplex_WMM youn_WMM hein (CPSF3,FIP1L1) gupta_WMM treiber_WMM |
| FIP1L1 | SYMPK | 0.091 | 0.355 | hein_WMM youn (SYMPK) bioplex_WMM youn_WMM hein (FIP1L1,SYMPK) gupta_WMM treiber_WMM |
Images
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Complex HuMAP2_06540 has an average edge precision of 0.862 which is ranked 716 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CPSF4 | HuMAP2_00220 HuMAP2_00374 HuMAP2_03166 HuMAP2_04008 HuMAP2_06540 |
| FIP1L1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| CPSF2 | HuMAP2_00220 HuMAP2_00374 HuMAP2_02763 HuMAP2_06540 |
| WDR33 | HuMAP2_00220 HuMAP2_00374 HuMAP2_05059 HuMAP2_06540 |
| CPSF1 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |
| SYMPK | HuMAP2_01680 HuMAP2_02937 HuMAP2_04894 HuMAP2_06540 |
| CPSF3 | HuMAP2_00220 HuMAP2_00374 HuMAP2_06540 |