hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06543
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| GPT | Alanine aminotransferase 1 (ALT1) (EC 2.6.1.2) (Glutamate pyruvate transaminase 1) (GPT 1) (Glutamic--alanine transaminase 1) (Glutamic--pyruvic transaminase 1) | UniProt NCBI |
| ALDH4A1 | Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (P5C dehydrogenase) (EC 1.2.1.88) (Aldehyde dehydrogenase family 4 member A1) (L-glutamate gamma-semialdehyde dehydrogenase) | UniProt NCBI |
| LONRF1 | LON peptidase N-terminal domain and RING finger protein 1 (RING finger protein 191) | UniProt NCBI |
| ISCU | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial (NifU-like N-terminal domain-containing protein) (NifU-like protein) | UniProt NCBI |
| IBA57 | Putative transferase CAF17, mitochondrial (EC 2.1.-.-) (Iron-sulfur cluster assembly factor homolog) | UniProt NCBI |
| TMEM184A | Transmembrane protein 184A | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0008314 | 0.00045066196833 | 0.333333333333 | ISCU IBA57 | Decreased activity of mitochondrial complex II |
| WP:WP4595 | 0.00116964360656 | 0.333333333333 | GPT ALDH4A1 | Urea cycle and associated pathways |
| KEGG:00250 | 0.0032877278217 | 0.333333333333 | GPT ALDH4A1 | Alanine, aspartate and glutamate metabolism |
| HP:0011923 | 0.044443111782 | 0.333333333333 | ISCU IBA57 | Decreased activity of mitochondrial complex I |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ALDH4A1 | TMEM184A | 0.167 | 0.423 | bioplex (TMEM184A) |
| ALDH4A1 | GPT | 0.071 | 0.352 | fraction |
| ISCU | TMEM184A | 0.057 | 0.323 | bioplex (TMEM184A) |
| LONRF1 | ISCU | 0.03 | 0.239 | bioplex (LONRF1) bioplex_WMM |
| TMEM184A | IBA57 | 0.021 | 0.189 | bioplex (TMEM184A) |
| ISCU | ALDH4A1 | 0.008 | 0.067 | bioplex_WMM WMM_only |
| ALDH4A1 | IBA57 | 0.007 | 0.009 | bioplex_WMM WMM_only |
| ISCU | IBA57 | 0.007 | 0.005 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06543 has an average edge precision of 0.201 which is ranked 6165 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| GPT | HuMAP2_06543 |
| ALDH4A1 | HuMAP2_01072 HuMAP2_01176 HuMAP2_01792 HuMAP2_02582 HuMAP2_03357 HuMAP2_03864 HuMAP2_04246 HuMAP2_06021 HuMAP2_06543 |
| LONRF1 | HuMAP2_00363 HuMAP2_03941 HuMAP2_06543 |
| ISCU | HuMAP2_00363 HuMAP2_03941 HuMAP2_04952 HuMAP2_06543 |
| IBA57 | HuMAP2_02191 HuMAP2_06543 |
| TMEM184A | HuMAP2_02025 HuMAP2_06543 |