hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06556
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| HEXIM1 | Protein HEXIM1 (Cardiac lineage protein 1) (Estrogen down-regulated gene 1 protein) (Hexamethylene bis-acetamide-inducible protein 1) (Menage a quatre protein 1) | UniProt NCBI |
| MEPCE | 7SK snRNA methylphosphate capping enzyme (MePCE) (EC 2.1.1.-) (Bicoid-interacting protein 3 homolog) (Bin3 homolog) | UniProt NCBI |
| HEXIM2 | Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2) | UniProt NCBI |
| CCNT1 | Cyclin-T1 (CycT1) (Cyclin-T) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0017069 | 1.61120484949e-06 | 1.0 | HEXIM1 CCNT1 MEPCE HEXIM2 | snRNA binding |
| GO:0097322 | 7.26438828159e-06 | 0.75 | HEXIM1 HEXIM2 CCNT1 | 7SK snRNA binding |
| CORUM:2878 | 1.50819606993e-05 | 0.5 | HEXIM1 CCNT1 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:2873 | 1.50819606993e-05 | 0.5 | HEXIM1 CCNT1 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:2602 | 1.50819606993e-05 | 0.5 | HEXIM1 CCNT1 | P-TEFb-7SKRNA-HEXIM1 complex |
| CORUM:7566 | 3.01612206104e-05 | 0.5 | HEXIM1 CCNT1 | 7SK RNP complex |
| WP:WP3414 | 0.000729007032317 | 0.5 | HEXIM1 CCNT1 | Initiation of transcription and translation elongation at the HIV-1 LTR |
| GO:0016538 | 0.00281780772825 | 0.75 | HEXIM1 HEXIM2 CCNT1 | cyclin-dependent protein serine/threonine kinase regulator activity |
| HPA:024010_13 | 0.0031703873793 | 0.75 | HEXIM1 MEPCE CCNT1 | kidney; cells in glomeruli[Supported,High] |
| HPA:056010_13 | 0.00674771511883 | 0.75 | HEXIM1 MEPCE CCNT1 | tonsil; germinal center cells[Supported,High] |
| HPA:024010_03 | 0.00940611765369 | 0.75 | HEXIM1 MEPCE CCNT1 | kidney; cells in glomeruli[Uncertain,High] |
| HPA:039010_13 | 0.0101046758484 | 0.75 | HEXIM1 MEPCE CCNT1 | salivary gland; glandular cells[Supported,High] |
| HPA:055010_13 | 0.0170761600268 | 0.75 | HEXIM1 MEPCE CCNT1 | thyroid gland; glandular cells[Supported,High] |
| HPA:014010_12 | 0.0185798771417 | 0.75 | HEXIM1 MEPCE CCNT1 | endometrium 2; cells in endometrial stroma[Supported,Medium] |
| HPA:057010_13 | 0.0188187097484 | 0.75 | HEXIM1 MEPCE CCNT1 | urinary bladder; urothelial cells[Supported,High] |
| HPA:001040_13 | 0.0188187097484 | 0.75 | HEXIM1 MEPCE CCNT1 | adrenal gland; glandular cells[Supported,High] |
| HPA:056010_03 | 0.019302446397 | 0.75 | HEXIM1 MEPCE CCNT1 | tonsil; germinal center cells[Uncertain,High] |
| HPA:032010_13 | 0.0201686361907 | 0.75 | HEXIM1 MEPCE CCNT1 | pancreas; exocrine glandular cells[Supported,High] |
| GO:0000079 | 0.0206918321066 | 0.75 | HEXIM1 HEXIM2 CCNT1 | regulation of cyclin-dependent protein serine/threonine kinase activity |
| HPA:018010_13 | 0.0209312173501 | 0.75 | HEXIM1 MEPCE CCNT1 | fallopian tube; glandular cells[Supported,High] |
| HPA:029010_13 | 0.0210601377494 | 0.75 | HEXIM1 MEPCE CCNT1 | nasopharynx; respiratory epithelial cells[Supported,High] |
| GO:1904029 | 0.023464682987 | 0.75 | HEXIM1 HEXIM2 CCNT1 | regulation of cyclin-dependent protein kinase activity |
| HPA:051010_13 | 0.0237498929607 | 0.75 | HEXIM1 MEPCE CCNT1 | stomach 1; glandular cells[Supported,High] |
| HPA:035020_13 | 0.025175887812 | 0.75 | HEXIM1 MEPCE CCNT1 | placenta; trophoblastic cells[Supported,High] |
| HPA:006010_12 | 0.0254677066879 | 0.75 | HEXIM1 MEPCE CCNT1 | caudate; glial cells[Supported,Medium] |
| HPA:013010_12 | 0.02561445023 | 0.75 | HEXIM1 MEPCE CCNT1 | endometrium 1; cells in endometrial stroma[Supported,Medium] |
| HPA:031020_12 | 0.0259096106078 | 0.75 | HEXIM1 MEPCE CCNT1 | ovary; ovarian stroma cells[Supported,Medium] |
| HPA:037010_13 | 0.0296284087039 | 0.75 | HEXIM1 MEPCE CCNT1 | rectum; glandular cells[Supported,High] |
| HPA:050020_12 | 0.0296284087039 | 0.75 | HEXIM1 MEPCE CCNT1 | spleen; cells in white pulp[Supported,Medium] |
| HPA:011030_12 | 0.0312763482879 | 0.75 | HEXIM1 MEPCE CCNT1 | colon; peripheral nerve/ganglion[Supported,Medium] |
| HPA:019010_13 | 0.0338599256539 | 0.75 | HEXIM1 MEPCE CCNT1 | gallbladder; glandular cells[Supported,High] |
| HPA:024010_12 | 0.038664676769 | 0.75 | HEXIM1 MEPCE CCNT1 | kidney; cells in glomeruli[Supported,Medium] |
| HPA:050010_12 | 0.0410259794916 | 0.75 | HEXIM1 MEPCE CCNT1 | spleen; cells in red pulp[Supported,Medium] |
| HPA:039010_03 | 0.0416307958449 | 0.75 | HEXIM1 MEPCE CCNT1 | salivary gland; glandular cells[Uncertain,High] |
| HPA:027020_12 | 0.0418336999884 | 0.75 | HEXIM1 MEPCE CCNT1 | lung; pneumocytes[Supported,Medium] |
| HPA:041010_12 | 0.0438987109299 | 0.75 | HEXIM1 MEPCE CCNT1 | skeletal muscle; myocytes[Supported,Medium] |
| MIRNA:hsa-miR-3975 | 0.044421033949 | 0.5 | HEXIM1 CCNT1 | hsa-miR-3975 |
| HPA:007030_12 | 0.0447431662559 | 0.75 | HEXIM1 MEPCE CCNT1 | cerebellum; cells in molecular layer[Supported,Medium] |
| HPA:032020_12 | 0.0460298167372 | 0.75 | HEXIM1 MEPCE CCNT1 | pancreas; islets of Langerhans[Supported,Medium] |
| HPA:043010_12 | 0.0462466007541 | 0.75 | HEXIM1 MEPCE CCNT1 | skin 1; Langerhans[Supported,Medium] |
| HPA:006020_12 | 0.0462466007541 | 0.75 | HEXIM1 MEPCE CCNT1 | caudate; neuronal cells[Supported,Medium] |
| HPA:028010_12 | 0.0466821853682 | 0.75 | HEXIM1 MEPCE CCNT1 | lymph node; germinal center cells[Supported,Medium] |
| HPA:002020_12 | 0.0469009879466 | 0.75 | HEXIM1 MEPCE CCNT1 | appendix; lymphoid tissue[Supported,Medium] |
| CORUM:1079 | 0.0499140284799 | 0.25 | CCNT1 | P-TEFb.1 complex |
| CORUM:1082 | 0.0499140284799 | 0.25 | CCNT1 | P-TEFb.1 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HEXIM2 | HEXIM1 | 1.0 | 0.949 | bioplex (HEXIM1,HEXIM2) bioplex_WMM |
| HEXIM1 | CCNT1 | 0.874 | 0.807 | hein_WMM bioplex (HEXIM1) bioplex_WMM boldt gupta_WMM boldt_WMM |
| HEXIM1 | MEPCE | 0.644 | 0.687 | hein_WMM bioplex (HEXIM1) bioplex_WMM boldt gupta_WMM boldt_WMM |
| HEXIM2 | CCNT1 | 0.095 | 0.359 | bioplex (HEXIM2) bioplex_WMM |
| HEXIM2 | MEPCE | 0.017 | 0.177 | bioplex (HEXIM2) bioplex_WMM |
| CCNT1 | MEPCE | 0.011 | 0.148 | hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_06556 has an average edge precision of 0.521 which is ranked 2391 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| HEXIM1 | HuMAP2_00506 HuMAP2_01724 HuMAP2_04903 HuMAP2_05053 HuMAP2_06556 |
| MEPCE | HuMAP2_04903 HuMAP2_05096 HuMAP2_06556 |
| HEXIM2 | HuMAP2_00506 HuMAP2_01724 HuMAP2_04903 HuMAP2_06556 |
| CCNT1 | HuMAP2_01724 HuMAP2_03417 HuMAP2_04903 HuMAP2_06556 |