hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06559
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SUPT20H | Transcription factor SPT20 homolog (p38-interacting protein) (p38IP) | UniProt NCBI |
| KAT2A | Histone acetyltransferase KAT2A (EC 2.3.1.48) (General control of amino acid synthesis protein 5-like 2) (Histone acetyltransferase GCN5) (hGCN5) (Histone succinyltransferase KAT2A) (EC 2.3.1.-) (Lysine acetyltransferase 2A) (STAF97) | UniProt NCBI |
| TADA3 | Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein) | UniProt NCBI |
| TADA2A | Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein) | UniProt NCBI |
| KAT14 | Cysteine-rich protein 2-binding protein (CSRP2-binding protein) (ADA2A-containing complex subunit 2) (ATAC2) (CRP2-binding partner) (CRP2BP) (Lysine acetyltransferase 14) | UniProt NCBI |
| SGF29 | SAGA-associated factor 29 (Coiled-coil domain-containing protein 101) (SAGA complex-associated factor 29) | UniProt NCBI |
| MBIP | MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein) | UniProt NCBI |
| KAT2B | Histone acetyltransferase KAT2B (EC 2.3.1.48) (Histone acetyltransferase PCAF) (Histone acetylase PCAF) (Lysine acetyltransferase 2B) (P300/CBP-associated factor) (P/CAF) (Spermidine acetyltransferase KAT2B) (EC 2.3.1.57) | UniProt NCBI |
| YEATS2 | YEATS domain-containing protein 2 | UniProt NCBI |
| ZZZ3 | ZZ-type zinc finger-containing protein 3 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6657 | 2.5128602383e-24 | 0.8 | YEATS2 TADA2A SGF29 KAT14 MBIP ZZZ3 KAT2A TADA3 | ATAC complex, GCN5-linked |
| CORUM:6665 | 1.67611430697e-22 | 0.8 | YEATS2 TADA2A SGF29 KAT14 MBIP ZZZ3 KAT2A TADA3 | ATAC complex, YEATS2-linked |
| GO:0005671 | 6.38448484234e-16 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | Ada2/Gcn5/Ada3 transcription activator complex |
| REAC:R-HSA-3214847 | 1.04529949481e-15 | 0.9 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP ZZZ3 KAT2A TADA3 | HATs acetylate histones |
| REAC:R-HSA-4839726 | 3.68693627847e-13 | 0.9 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP ZZZ3 KAT2A TADA3 | Chromatin organization |
| REAC:R-HSA-3247509 | 3.68693627847e-13 | 0.9 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP ZZZ3 KAT2A TADA3 | Chromatin modifying enzymes |
| GO:0000123 | 8.72721486011e-13 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | histone acetyltransferase complex |
| GO:0031248 | 2.38959681234e-12 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | protein acetyltransferase complex |
| GO:1902493 | 2.38959681234e-12 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | acetyltransferase complex |
| GO:1902562 | 4.16238462771e-12 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | H4 histone acetyltransferase complex |
| GO:0043966 | 1.84635552067e-11 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | histone H3 acetylation |
| GO:0016573 | 4.77172175627e-09 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | histone acetylation |
| GO:0018393 | 5.45066847942e-09 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | internal peptidyl-lysine acetylation |
| GO:0006475 | 7.52024584097e-09 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | internal protein amino acid acetylation |
| GO:0018394 | 8.00624855491e-09 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | peptidyl-lysine acetylation |
| CORUM:6664 | 2.32231642197e-08 | 0.4 | SUPT20H KAT2A TADA3 SGF29 | STAGA complex, SPT3-linked |
| CORUM:6643 | 2.94065197021e-08 | 0.4 | SUPT20H KAT2A TADA3 SGF29 | SAGA complex, GCN5-linked |
| GO:0006473 | 4.62555510194e-08 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | protein acetylation |
| GO:0070461 | 1.09067223824e-07 | 0.5 | SUPT20H KAT2A KAT2B TADA3 SGF29 | SAGA-type complex |
| GO:0043543 | 2.10861102893e-07 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | protein acylation |
| CORUM:471 | 1.94131410987e-06 | 0.3 | KAT2B TADA3 TADA2A | PCAF complex |
| CORUM:477 | 1.94131410987e-06 | 0.3 | KAT2B TADA3 TADA2A | PCAF complex |
| GO:0018205 | 5.11181727015e-06 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | peptidyl-lysine modification |
| GO:0016570 | 1.2532575542e-05 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | histone modification |
| GO:0016569 | 1.71906868138e-05 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | covalent chromatin modification |
| CORUM:0000000 | 3.01031808081e-05 | 1.0 | YEATS2 TADA2A SUPT20H SGF29 KAT14 KAT2B MBIP ZZZ3 KAT2A TADA3 | CORUM root |
| GO:1990234 | 4.68463310657e-05 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | transferase complex |
| GO:0044451 | 0.000410768266253 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | nucleoplasm part |
| GO:0006325 | 0.000727184854317 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | chromatin organization |
| CORUM:6641 | 0.000843479125085 | 0.2 | KAT2A TADA3 | USP22-SAGA complex |
| CORUM:438 | 0.00135462062278 | 0.2 | KAT2A TADA3 | GCN5-TRRAP histone acetyltransferase complex |
| GO:0000124 | 0.00179314168727 | 0.3 | SGF29 TADA3 SUPT20H | SAGA complex |
| GO:0004402 | 0.0018503338385 | 0.4 | KAT2A KAT2B TADA3 KAT14 | histone acetyltransferase activity |
| CORUM:476 | 0.00198535403601 | 0.2 | KAT2A TADA3 | STAGA complex |
| CORUM:475 | 0.00198535403601 | 0.2 | KAT2A TADA3 | STAGA complex |
| GO:0061733 | 0.00213600683488 | 0.4 | KAT2A KAT2B TADA3 KAT14 | peptide-lysine-N-acetyltransferase activity |
| CORUM:445 | 0.00315512527447 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:462 | 0.00315512527447 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:456 | 0.00315512527447 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:455 | 0.00315512527447 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| GO:1902494 | 0.00326458532783 | 0.8 | YEATS2 SUPT20H SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | catalytic complex |
| CORUM:470 | 0.00360456598324 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| CORUM:513 | 0.00360456598324 | 0.2 | KAT2A TADA3 | TFTC complex (TATA-binding protein-free TAF-II-containing complex) |
| GO:0034212 | 0.00384767000195 | 0.4 | KAT2A KAT2B TADA3 KAT14 | peptide N-acetyltransferase activity |
| REAC:R-HSA-8941856 | 0.00659484253239 | 0.2 | KAT2A KAT2B | RUNX3 regulates NOTCH signaling |
| GO:0008080 | 0.00677140498416 | 0.4 | KAT2A KAT2B TADA3 KAT14 | N-acetyltransferase activity |
| REAC:R-HSA-210744 | 0.00769122730898 | 0.2 | KAT2A KAT2B | Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells |
| GO:0018193 | 0.0121093775605 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | peptidyl-amino acid modification |
| GO:0016410 | 0.0127317909148 | 0.4 | KAT2A KAT2B TADA3 KAT14 | N-acyltransferase activity |
| REAC:R-HSA-9013695 | 0.0144268822495 | 0.2 | KAT2A KAT2B | NOTCH4 Intracellular Domain Regulates Transcription |
| GO:0016407 | 0.0165202794236 | 0.4 | KAT2A KAT2B TADA3 KAT14 | acetyltransferase activity |
| GO:0051276 | 0.0181227164942 | 0.7 | YEATS2 SGF29 KAT14 KAT2B MBIP KAT2A TADA3 | chromosome organization |
| WP:WP268 | 0.018520309875 | 0.2 | KAT2A KAT2B | Notch Signaling |
| KEGG:04330 | 0.0207496192065 | 0.2 | KAT2A KAT2B | Notch signaling pathway |
| REAC:R-HSA-9013508 | 0.0213144720828 | 0.2 | KAT2A KAT2B | NOTCH3 Intracellular Domain Regulates Transcription |
| REAC:R-HSA-350054 | 0.0295283272229 | 0.2 | KAT2A KAT2B | Notch-HLH transcription pathway |
| REAC:R-HSA-186712 | 0.0341308097173 | 0.2 | KAT2A KAT2B | Regulation of beta-cell development |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SGF29 | TADA3 | 1.0 | 0.949 | hein_WMM bioplex (SGF29,TADA3) bioplex_WMM Guru youn_WMM hein (SGF29) Malo fraction boldt_WMM |
| KAT14 | MBIP | 1.0 | 0.949 | bioplex (MBIP) bioplex_WMM |
| ZZZ3 | MBIP | 0.999 | 0.949 | hein_WMM bioplex (MBIP) bioplex_WMM youn_WMM |
| MBIP | YEATS2 | 0.999 | 0.949 | hein_WMM bioplex (MBIP) bioplex_WMM youn_WMM |
| SGF29 | SUPT20H | 0.994 | 0.919 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) boldt_WMM |
| MBIP | TADA2A | 0.987 | 0.901 | hein_WMM bioplex (MBIP) bioplex_WMM |
| TADA3 | KAT14 | 0.987 | 0.901 | bioplex (TADA3) bioplex_WMM youn_WMM |
| TADA3 | KAT2B | 0.986 | 0.901 | bioplex (TADA3) bioplex_WMM |
| KAT2A | SGF29 | 0.981 | 0.897 | hein_WMM bioplex (SGF29) bioplex_WMM hein (SGF29) boldt_WMM |
| SGF29 | TADA2A | 0.972 | 0.885 | hein_WMM bioplex (SGF29) bioplex_WMM hein (SGF29) |
| SGF29 | YEATS2 | 0.969 | 0.881 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) gupta_WMM |
| TADA3 | TADA2A | 0.963 | 0.871 | hein_WMM bioplex (TADA3) bioplex_WMM |
| KAT2A | TADA3 | 0.962 | 0.87 | hein_WMM bioplex (TADA3) bioplex_WMM boldt_WMM |
| TADA3 | MBIP | 0.946 | 0.857 | hein_WMM bioplex (MBIP,TADA3) bioplex_WMM youn_WMM |
| TADA3 | YEATS2 | 0.895 | 0.821 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM |
| SGF29 | MBIP | 0.872 | 0.804 | hein_WMM bioplex (MBIP,SGF29) bioplex_WMM youn_WMM hein (SGF29) |
| SGF29 | ZZZ3 | 0.871 | 0.804 | hein_WMM bioplex (SGF29) bioplex_WMM youn_WMM hein (SGF29) |
| TADA3 | ZZZ3 | 0.818 | 0.773 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM |
| SUPT20H | TADA3 | 0.742 | 0.74 | hein_WMM bioplex (TADA3) bioplex_WMM youn_WMM boldt_WMM |
| KAT2A | MBIP | 0.585 | 0.663 | hein_WMM bioplex (MBIP) bioplex_WMM |
| MBIP | KAT2B | 0.486 | 0.615 | bioplex (MBIP) bioplex_WMM |
| SGF29 | KAT2B | 0.137 | 0.407 | bioplex (SGF29) bioplex_WMM |
| ZZZ3 | YEATS2 | 0.086 | 0.351 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KAT14 | ZZZ3 | 0.06 | 0.336 | bioplex_WMM WMM_only |
| KAT14 | YEATS2 | 0.058 | 0.325 | bioplex_WMM youn_WMM WMM_only |
| KAT2A | KAT2B | 0.031 | 0.24 | bioplex_WMM WMM_only |
| ZZZ3 | TADA2A | 0.025 | 0.211 | hein_WMM bioplex_WMM WMM_only |
| YEATS2 | TADA2A | 0.021 | 0.194 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | TADA2A | 0.021 | 0.184 | hein_WMM bioplex_WMM WMM_only |
| KAT14 | TADA2A | 0.02 | 0.185 | bioplex_WMM WMM_only |
| KAT2A | KAT14 | 0.016 | 0.157 | bioplex_WMM WMM_only |
| KAT2A | YEATS2 | 0.016 | 0.161 | hein_WMM bioplex_WMM WMM_only |
| KAT2A | ZZZ3 | 0.016 | 0.154 | hein_WMM bioplex_WMM WMM_only |
| KAT2B | TADA2A | 0.015 | 0.143 | bioplex_WMM WMM_only |
| KAT14 | KAT2B | 0.014 | 0.144 | bioplex_WMM WMM_only |
| KAT2B | YEATS2 | 0.013 | 0.151 | bioplex_WMM WMM_only |
| SUPT20H | KAT2B | 0.013 | 0.151 | bioplex_WMM WMM_only |
| KAT2A | SUPT20H | 0.013 | 0.155 | hein_WMM bioplex_WMM WMM_only boldt_WMM |
| ZZZ3 | KAT2B | 0.012 | 0.146 | bioplex_WMM WMM_only |
| SUPT20H | TADA2A | 0.009 | 0.113 | hein_WMM bioplex_WMM WMM_only |
| SUPT20H | ZZZ3 | 0.009 | 0.101 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SUPT20H | MBIP | 0.009 | 0.099 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SUPT20H | YEATS2 | 0.008 | 0.089 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SUPT20H | KAT14 | 0.008 | 0.024 | bioplex_WMM youn_WMM WMM_only |
| SGF29 | KAT14 | 0.005 | 0.008 | bioplex (SGF29) bioplex_WMM youn_WMM |
Images
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Complex HuMAP2_06559 has an average edge precision of 0.492 which is ranked 2545 out of all 6965 complexes.
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