hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06560
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRPF3 | U4/U6 small nuclear ribonucleoprotein Prp3 (Pre-mRNA-splicing factor 3) (hPrp3) (U4/U6 snRNP 90 kDa protein) | UniProt NCBI |
| TUT1 | Speckle targeted PIP5K1A-regulated poly(A) polymerase (Star-PAP) (EC 2.7.7.19) (RNA-binding motif protein 21) (RNA-binding protein 21) (U6 snRNA-specific terminal uridylyltransferase 1) (U6-TUTase) (EC 2.7.7.52) | UniProt NCBI |
| SNU13 | NHP2-like protein 1 (High mobility group-like nuclear protein 2 homolog 1) (OTK27) (SNU13 homolog) (hSNU13) (U4/U6.U5 small nuclear ribonucleoprotein SNU13) (U4/U6.U5 tri-snRNP 15.5 kDa protein) [Cleaved into: NHP2-like protein 1, N-terminally processed] | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| KEGG:03040 | 9.56545898299e-05 | 0.75 | LSM4 SNU13 PRPF3 | Spliceosome |
| CORUM:351 | 0.000300134552669 | 0.75 | LSM4 SNU13 PRPF3 | Spliceosome |
| REAC:R-HSA-72163 | 0.0012370641562 | 0.75 | LSM4 SNU13 PRPF3 | mRNA Splicing - Major Pathway |
| REAC:R-HSA-72172 | 0.00141192686346 | 0.75 | LSM4 SNU13 PRPF3 | mRNA Splicing |
| GO:0046540 | 0.00147288799354 | 0.75 | LSM4 SNU13 PRPF3 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 0.00147288799354 | 0.75 | LSM4 SNU13 PRPF3 | spliceosomal tri-snRNP complex |
| REAC:R-HSA-72203 | 0.00285014014969 | 0.75 | LSM4 SNU13 PRPF3 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0071005 | 0.00710332146687 | 0.75 | LSM4 SNU13 PRPF3 | U2-type precatalytic spliceosome |
| GO:0071011 | 0.00754689803038 | 0.75 | LSM4 SNU13 PRPF3 | precatalytic spliceosome |
| GO:0097525 | 0.0106004966657 | 0.75 | LSM4 SNU13 PRPF3 | spliceosomal snRNP complex |
| WP:WP411 | 0.0128777248997 | 0.5 | PRPF3 SNU13 | mRNA Processing |
| GO:0030532 | 0.0143823911437 | 0.75 | LSM4 SNU13 PRPF3 | small nuclear ribonucleoprotein complex |
| GO:0120114 | 0.023464682987 | 0.75 | LSM4 SNU13 PRPF3 | Sm-like protein family complex |
| GO:0006397 | 0.0251226492241 | 1.0 | SNU13 LSM4 TUT1 PRPF3 | mRNA processing |
| GO:0005684 | 0.0439367749778 | 0.75 | LSM4 SNU13 PRPF3 | U2-type spliceosomal complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRPF3 | TUT1 | 0.994 | 0.921 | hein_WMM bioplex (PRPF3) bioplex_WMM hein (PRPF3) |
| PRPF3 | SNU13 | 0.929 | 0.845 | hein_WMM bioplex (PRPF3) bioplex_WMM youn_WMM hein (PRPF3) gupta_WMM fraction boldt_WMM |
| PRPF3 | LSM4 | 0.912 | 0.835 | youn (LSM4) bioplex (PRPF3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM |
| LSM4 | TUT1 | 0.026 | 0.216 | bioplex_WMM gupta_WMM WMM_only |
| TUT1 | SNU13 | 0.018 | 0.177 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| LSM4 | SNU13 | 0.01 | 0.106 | youn (LSM4) bioplex_WMM youn_WMM gupta_WMM boldt_WMM |
Images
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Complex HuMAP2_06560 has an average edge precision of 0.517 which is ranked 2409 out of all 6965 complexes.
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