hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06562

Confidence: Medium

Genename	Protein Name	Links
VSIG2	V-set and immunoglobulin domain-containing protein 2 (Cortical thymocyte-like protein) (CT-like protein)	UniProt NCBI
TNPO1	Transportin-1 (Importin beta-2) (Karyopherin beta-2) (M9 region interaction protein) (MIP)	UniProt NCBI
XPO6	Exportin-6 (Exp6) (Ran-binding protein 20)	UniProt NCBI
THADA	Thyroid adenoma-associated protein (Gene inducing thyroid adenomas protein)	UniProt NCBI
XPO7	Exportin-7 (Exp7) (Ran-binding protein 16)	UniProt NCBI
XPO5	Exportin-5 (Exp5) (Ran-binding protein 21)	UniProt NCBI
TNPO3	Transportin-3 (Importin-12) (Imp12) (Transportin-SR) (TRN-SR)	UniProt NCBI
CIP2A	Protein CIP2A (Cancerous inhibitor of PP2A) (p90 autoantigen)	UniProt NCBI
IPO11	Importin-11 (Imp11) (Ran-binding protein 11) (RanBP11)	UniProt NCBI
ATXN10	Ataxin-10 (Brain protein E46 homolog) (Spinocerebellar ataxia type 10 protein)	UniProt NCBI
TRIP13	Pachytene checkpoint protein 2 homolog (Human papillomavirus type 16 E1 protein-binding protein) (16E1-BP) (HPV16 E1 protein-binding protein) (Thyroid hormone receptor interactor 13) (Thyroid receptor-interacting protein 13) (TR-interacting protein 13) (TRIP-13)	UniProt NCBI
ARFIP2	Arfaptin-2 (ADP-ribosylation factor-interacting protein 2) (Partner of RAC1) (Protein POR1)	UniProt NCBI
TFB2M	Dimethyladenosine transferase 2, mitochondrial (EC 2.1.1.-) (Hepatitis C virus NS5A-transactivated protein 5) (HCV NS5A-transactivated protein 5) (Mitochondrial 12S rRNA dimethylase 2) (Mitochondrial transcription factor B2) (h-mtTFB) (h-mtTFB2) (hTFB2M) (mtTFB2) (S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2)	UniProt NCBI
MTG1	Mitochondrial ribosome-associated GTPase 1 (GTP-binding protein 7) (Mitochondrial GTPase 1)	UniProt NCBI
XPO4	Exportin-4 (Exp4)	UniProt NCBI
FANCD2	Fanconi anemia group D2 protein (Protein FACD2)	UniProt NCBI
SAAL1	Protein SAAL1 (Synoviocyte proliferation-associated in collagen-induced arthritis protein 1) (SPACIA1)	UniProt NCBI
TNPO2	Transportin-2 (Karyopherin beta-2b)	UniProt NCBI
HEATR3	HEAT repeat-containing protein 3	UniProt NCBI
PUSL1	tRNA pseudouridine synthase-like 1 (EC 5.4.99.-) (tRNA pseudouridylate synthase-like 1) (tRNA-uridine isomerase-like 1)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
GO:0140142	9.23515633398e-12	0.35	TNPO3 TNPO1 XPO4 XPO6 XPO5 XPO7 TNPO2	nucleocytoplasmic carrier activity
GO:0006913	1.22181822421e-06	0.45	TNPO3 TNPO1 XPO4 HEATR3 XPO6 XPO5 XPO7 IPO11 TNPO2	nucleocytoplasmic transport
GO:0051169	1.3498874629e-06	0.45	TNPO3 TNPO1 XPO4 HEATR3 XPO6 XPO5 XPO7 IPO11 TNPO2	nuclear transport
GO:0005049	3.87707234858e-05	0.2	XPO4 XPO6 XPO5 XPO7	nuclear export signal receptor activity
GO:0006886	0.00399038550948	0.5	TNPO3 TNPO1 XPO4 HEATR3 XPO6 ARFIP2 XPO7 IPO11 TNPO2 XPO5	intracellular protein transport
GO:0006606	0.00839335184691	0.25	IPO11 TNPO1 TNPO3 HEATR3 TNPO2	protein import into nucleus
GO:0061608	0.00865220447533	0.15	TNPO1 TNPO3 TNPO2	nuclear import signal receptor activity
MIRNA:hsa-miR-711	0.00884820006159	0.15	TNPO3 VSIG2 TRIP13	hsa-miR-711
GO:0051170	0.0210745258899	0.25	IPO11 TNPO1 TNPO3 HEATR3 TNPO2	import into nucleus

Edges

Protein 1	Protein 2	Score	Precision	Evidence
TNPO1	FANCD2	0.586	0.662	bioplex_WMM boldt youn_WMM fraction boldt_WMM treiber_WMM
TNPO1	ATXN10	0.174	0.433	hein_WMM bioplex_WMM boldt youn_WMM hein (TNPO1) gupta_WMM boldt_WMM
TNPO1	TNPO2	0.105	0.369	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
ATXN10	TRIP13	0.08	0.35	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
VSIG2	TNPO2	0.071	0.352	bioplex (VSIG2) bioplex_WMM
SAAL1	XPO4	0.068	0.349	bioplex_WMM boldt boldt_WMM
ARFIP2	CIP2A	0.054	0.302	bioplex_WMM fraction
TNPO3	VSIG2	0.05	0.297	bioplex (VSIG2) bioplex_WMM
XPO4	VSIG2	0.045	0.279	bioplex (VSIG2) bioplex_WMM
XPO6	VSIG2	0.043	0.269	bioplex (VSIG2) bioplex_WMM
TNPO1	VSIG2	0.042	0.27	bioplex (VSIG2) bioplex_WMM
TFB2M	TNPO1	0.042	0.27	hein_WMM bioplex_WMM boldt hein (TNPO1) fraction boldt_WMM
XPO5	XPO7	0.039	0.264	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
XPO4	CIP2A	0.039	0.264	bioplex_WMM boldt boldt_WMM
XPO6	THADA	0.036	0.264	bioplex_WMM boldt boldt_WMM
MTG1	TRIP13	0.034	0.258	bioplex (TRIP13) bioplex_WMM
XPO4	TNPO2	0.033	0.248	bioplex_WMM boldt boldt_WMM
PUSL1	TRIP13	0.031	0.24	bioplex (TRIP13) bioplex_WMM
SAAL1	CIP2A	0.03	0.231	bioplex_WMM boldt boldt_WMM
SAAL1	TNPO3	0.029	0.233	bioplex_WMM boldt boldt_WMM
XPO4	TNPO3	0.029	0.232	bioplex_WMM boldt boldt_WMM
TNPO3	XPO7	0.027	0.228	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
TNPO2	XPO7	0.027	0.224	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
XPO6	CIP2A	0.027	0.223	bioplex_WMM boldt boldt_WMM
TNPO1	HEATR3	0.026	0.222	bioplex_WMM boldt youn_WMM fraction boldt_WMM
TNPO1	CIP2A	0.026	0.22	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SAAL1	TNPO2	0.024	0.216	bioplex_WMM boldt boldt_WMM
FANCD2	XPO4	0.023	0.206	bioplex_WMM boldt boldt_WMM
TNPO2	CIP2A	0.023	0.209	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
CIP2A	THADA	0.023	0.211	bioplex_WMM boldt youn_WMM boldt_WMM
FANCD2	IPO11	0.023	0.21	bioplex_WMM boldt youn_WMM boldt_WMM
XPO4	IPO11	0.022	0.206	bioplex_WMM boldt boldt_WMM
XPO4	THADA	0.022	0.209	bioplex_WMM boldt boldt_WMM
XPO5	THADA	0.022	0.207	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
CIP2A	XPO7	0.022	0.199	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TNPO1	SAAL1	0.022	0.195	bioplex_WMM boldt boldt_WMM
TNPO3	XPO5	0.022	0.195	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
TNPO1	XPO4	0.021	0.194	bioplex_WMM boldt boldt_WMM
XPO6	TNPO2	0.021	0.188	bioplex_WMM boldt boldt_WMM
ATXN10	IPO11	0.02	0.187	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
SAAL1	HEATR3	0.02	0.185	bioplex_WMM boldt boldt_WMM
TNPO3	THADA	0.02	0.184	bioplex_WMM boldt youn_WMM boldt_WMM
TNPO1	XPO5	0.02	0.185	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
XPO6	XPO5	0.02	0.187	bioplex_WMM boldt boldt_WMM
XPO6	TNPO3	0.019	0.183	bioplex_WMM boldt boldt_WMM
XPO4	XPO6	0.019	0.188	bioplex_WMM boldt boldt_WMM
FANCD2	CIP2A	0.018	0.18	bioplex_WMM boldt youn_WMM boldt_WMM
TNPO2	IPO11	0.018	0.177	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TNPO3	CIP2A	0.018	0.178	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
XPO7	THADA	0.018	0.177	bioplex_WMM boldt youn_WMM boldt_WMM
XPO4	XPO7	0.017	0.174	bioplex_WMM boldt boldt_WMM
TNPO1	XPO6	0.017	0.173	bioplex_WMM boldt boldt_WMM
TNPO2	THADA	0.017	0.176	bioplex_WMM boldt youn_WMM boldt_WMM
SAAL1	IPO11	0.017	0.17	bioplex_WMM boldt boldt_WMM
XPO5	CIP2A	0.017	0.167	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TNPO2	XPO5	0.016	0.165	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
TNPO1	IPO11	0.016	0.165	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
XPO4	HEATR3	0.016	0.159	bioplex_WMM boldt boldt_WMM
CIP2A	IPO11	0.016	0.156	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
IPO11	XPO7	0.016	0.154	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
ATXN10	XPO4	0.015	0.14	bioplex_WMM boldt boldt_WMM
CIP2A	HEATR3	0.014	0.14	bioplex_WMM boldt boldt_WMM
ATXN10	CIP2A	0.014	0.137	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TNPO3	HEATR3	0.014	0.139	bioplex_WMM boldt youn_WMM boldt_WMM
TNPO1	TNPO3	0.013	0.151	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
SAAL1	XPO7	0.013	0.151	bioplex_WMM boldt boldt_WMM
IPO11	HEATR3	0.013	0.153	bioplex_WMM boldt youn_WMM boldt_WMM
XPO6	IPO11	0.013	0.154	bioplex_WMM boldt boldt_WMM
IPO11	THADA	0.013	0.15	bioplex_WMM boldt youn_WMM boldt_WMM
VSIG2	XPO5	0.012	0.147	bioplex (VSIG2) bioplex_WMM
ATXN10	SAAL1	0.012	0.151	bioplex_WMM boldt boldt_WMM
XPO5	IPO11	0.012	0.151	youn (IPO11) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
FANCD2	SAAL1	0.011	0.15	bioplex_WMM boldt boldt_WMM
ATXN10	HEATR3	0.011	0.148	bioplex_WMM boldt youn_WMM boldt_WMM
XPO4	XPO5	0.011	0.143	bioplex_WMM boldt boldt_WMM
TNPO1	XPO7	0.011	0.143	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM treiber_WMM
TNPO1	THADA	0.011	0.142	bioplex_WMM boldt youn_WMM boldt_WMM
FANCD2	XPO7	0.011	0.141	bioplex_WMM boldt youn_WMM boldt_WMM
SAAL1	THADA	0.011	0.141	bioplex_WMM boldt boldt_WMM
SAAL1	XPO6	0.011	0.142	bioplex_WMM boldt boldt_WMM
FANCD2	XPO5	0.01	0.139	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
FANCD2	XPO6	0.01	0.132	bioplex_WMM boldt boldt_WMM
TNPO2	HEATR3	0.01	0.134	bioplex_WMM boldt boldt_WMM
SAAL1	XPO5	0.01	0.134	bioplex_WMM boldt gupta_WMM boldt_WMM
TNPO3	TNPO2	0.01	0.13	bioplex_WMM boldt youn_WMM fraction boldt_WMM
FANCD2	THADA	0.01	0.127	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
SAAL1	VSIG2	0.01	0.12	bioplex (VSIG2) bioplex_WMM
TNPO3	IPO11	0.01	0.106	youn (IPO11) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
ATXN10	TNPO2	0.01	0.1	bioplex_WMM boldt youn_WMM boldt_WMM
FANCD2	HEATR3	0.009	0.113	hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM
XPO7	HEATR3	0.009	0.107	bioplex_WMM boldt youn_WMM boldt_WMM
ATXN10	XPO6	0.009	0.109	bioplex_WMM boldt boldt_WMM
ATXN10	FANCD2	0.009	0.108	bioplex_WMM boldt youn_WMM boldt_WMM
ATXN10	XPO5	0.009	0.107	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
PUSL1	MTG1	0.009	0.104	bioplex_WMM WMM_only
XPO6	HEATR3	0.009	0.1	bioplex_WMM boldt boldt_WMM
ATXN10	TNPO3	0.009	0.099	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
ATXN10	THADA	0.009	0.097	bioplex_WMM boldt youn_WMM boldt_WMM
HEATR3	THADA	0.008	0.087	bioplex_WMM boldt boldt_WMM
ATXN10	XPO7	0.008	0.088	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
XPO5	HEATR3	0.008	0.065	bioplex_WMM boldt youn_WMM boldt_WMM
FANCD2	TNPO2	0.008	0.037	bioplex_WMM boldt youn_WMM fraction boldt_WMM
TFB2M	XPO7	0.007	0.007	bioplex_WMM boldt boldt_WMM
ARFIP2	XPO5	0.007	0.005	bioplex_WMM gupta_WMM WMM_only
ARFIP2	XPO7	0.007	0.002	bioplex_WMM gupta_WMM WMM_only
ARFIP2	THADA	0.007	0.003	bioplex_WMM WMM_only
TNPO1	ARFIP2	0.007	0.004	bioplex_WMM WMM_only
ARFIP2	HEATR3	0.007	0.001	bioplex_WMM WMM_only
ARFIP2	TRIP13	0.007	0.0	bioplex_WMM gupta_WMM WMM_only
ARFIP2	TNPO2	0.007	0.004	bioplex_WMM WMM_only
ARFIP2	IPO11	0.007	0.005	bioplex_WMM WMM_only
ARFIP2	TNPO3	0.007	0.001	bioplex_WMM WMM_only
TNPO1	MTG1	0.007	0.001	bioplex_WMM WMM_only
MTG1	XPO5	0.007	0.0	bioplex_WMM WMM_only
MTG1	TNPO3	0.007	0.002	bioplex_WMM WMM_only
ATXN10	ARFIP2	0.007	0.002	bioplex_WMM WMM_only
MTG1	XPO7	0.007	0.006	bioplex_WMM WMM_only
FANCD2	ARFIP2	0.007	0.001	bioplex_WMM WMM_only
TFB2M	ARFIP2	0.007	0.001	bioplex_WMM WMM_only
ARFIP2	SAAL1	0.007	0.007	bioplex_WMM WMM_only
MTG1	TNPO2	0.007	0.007	bioplex_WMM WMM_only
XPO6	XPO7	0.007	0.004	bioplex_WMM boldt fraction boldt_WMM
FANCD2	MTG1	0.007	0.006	bioplex_WMM WMM_only
ATXN10	MTG1	0.007	0.006	bioplex_WMM WMM_only treiber_WMM
TFB2M	MTG1	0.006	0.005	bioplex_WMM WMM_only
FANCD2	TNPO3	0.006	0.008	bioplex_WMM boldt youn_WMM fraction boldt_WMM
THADA	TRIP13	0.006	0.005	bioplex_WMM youn_WMM WMM_only boldt_WMM
XPO4	TRIP13	0.006	0.008	bioplex_WMM boldt boldt_WMM
XPO5	TRIP13	0.006	0.005	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM
IPO11	TRIP13	0.005	0.006	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TFB2M	IPO11	0.005	0.012	bioplex_WMM boldt boldt_WMM
SAAL1	TRIP13	0.005	0.008	bioplex_WMM boldt gupta_WMM boldt_WMM
TFB2M	XPO6	0.005	0.009	bioplex_WMM WMM_only
CIP2A	TRIP13	0.005	0.009	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
TNPO3	TRIP13	0.005	0.009	bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
HEATR3	TRIP13	0.005	0.01	bioplex_WMM boldt youn_WMM boldt_WMM
TFB2M	THADA	0.005	0.01	bioplex_WMM WMM_only
FANCD2	TRIP13	0.005	0.009	bioplex_WMM boldt youn_WMM boldt_WMM treiber_WMM
TFB2M	XPO4	0.005	0.011	bioplex_WMM WMM_only
ATXN10	VSIG2	0.005	0.011	bioplex (VSIG2) bioplex_WMM
TFB2M	XPO5	0.005	0.011	bioplex_WMM boldt boldt_WMM
TFB2M	CIP2A	0.005	0.01	bioplex_WMM boldt boldt_WMM
XPO7	TRIP13	0.004	0.012	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
TFB2M	SAAL1	0.004	0.009	bioplex_WMM boldt boldt_WMM
VSIG2	THADA	0.004	0.014	bioplex (VSIG2) bioplex_WMM
TFB2M	HEATR3	0.004	0.008	hein_WMM bioplex_WMM WMM_only
TFB2M	TNPO3	0.003	0.014	bioplex_WMM WMM_only boldt_WMM
TFB2M	TNPO2	0.003	0.015	bioplex_WMM WMM_only boldt_WMM
FANCD2	VSIG2	0.003	0.014	bioplex (VSIG2) bioplex_WMM
TFB2M	TRIP13	0.003	0.016	bioplex_WMM boldt boldt_WMM
TFB2M	ATXN10	0.003	0.007	hein_WMM bioplex_WMM boldt boldt_WMM
XPO6	TRIP13	0.003	0.015	bioplex_WMM boldt fraction boldt_WMM
TFB2M	FANCD2	0.003	0.019	bioplex_WMM boldt boldt_WMM
VSIG2	CIP2A	0.0	0.011	bioplex (VSIG2) bioplex_WMM
TNPO2	TRIP13	0.0	0.01	bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
VSIG2	XPO7	0.0	0.011	bioplex (VSIG2) bioplex_WMM
TNPO1	TRIP13	0.0	0.001	hein_WMM bioplex_WMM boldt youn_WMM gupta_WMM fraction boldt_WMM
ARFIP2	XPO6	0.0	0.002	bioplex_WMM fraction

Images

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Complex HuMAP2_06562 has an average edge precision of 0.124 which is ranked 6856 out of all 6965 complexes.

Related Complexes

Genename	Complexes
VSIG2	HuMAP2_01794 HuMAP2_03084 HuMAP2_06562 HuMAP2_06809
TNPO1	HuMAP2_00442 HuMAP2_03084 HuMAP2_03089 HuMAP2_06562
XPO6	HuMAP2_01794 HuMAP2_03084 HuMAP2_06562 HuMAP2_06809
THADA	HuMAP2_03084 HuMAP2_06562
XPO7	HuMAP2_03084 HuMAP2_05243 HuMAP2_06562
XPO5	HuMAP2_02331 HuMAP2_03084 HuMAP2_06562
TNPO3	HuMAP2_01794 HuMAP2_03084 HuMAP2_03408 HuMAP2_06562
CIP2A	HuMAP2_03084 HuMAP2_03525 HuMAP2_05972 HuMAP2_06562
IPO11	HuMAP2_03084 HuMAP2_06562
ATXN10	HuMAP2_00442 HuMAP2_03084 HuMAP2_03966 HuMAP2_06390 HuMAP2_06562
TRIP13	HuMAP2_03966 HuMAP2_04835 HuMAP2_06390 HuMAP2_06562
ARFIP2	HuMAP2_00763 HuMAP2_05972 HuMAP2_06562 HuMAP2_06715
TFB2M	HuMAP2_00442 HuMAP2_04255 HuMAP2_06562 HuMAP2_06671
MTG1	HuMAP2_01662 HuMAP2_06390 HuMAP2_06562
XPO4	HuMAP2_00813 HuMAP2_03084 HuMAP2_06562 HuMAP2_06809
FANCD2	HuMAP2_00442 HuMAP2_03084 HuMAP2_03089 HuMAP2_03715 HuMAP2_03950 HuMAP2_06562
SAAL1	HuMAP2_00813 HuMAP2_03084 HuMAP2_06562
TNPO2	HuMAP2_01904 HuMAP2_03084 HuMAP2_06562
HEATR3	HuMAP2_03084 HuMAP2_06562
PUSL1	HuMAP2_00728 HuMAP2_06390 HuMAP2_06562

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06562