hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06564
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| BCL2L2 | Bcl-2-like protein 2 (Bcl2-L-2) (Apoptosis regulator Bcl-W) | UniProt NCBI |
| TNIP3 | TNFAIP3-interacting protein 3 (A20-binding inhibitor of NF-kappa-B activation 3) (ABIN-3) (Listeria-induced gene protein) | UniProt NCBI |
| BBC3 | Bcl-2-binding component 3 (JFY-1) (p53 up-regulated modulator of apoptosis) | UniProt NCBI |
| BMF | Bcl-2-modifying factor | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-111453 | 0.000240958766872 | 0.666666666667 | BMF BBC3 | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members |
| REAC:R-HSA-114452 | 0.00290884705451 | 0.666666666667 | BMF BBC3 | Activation of BH3-only proteins |
| WP:WP1772 | 0.00309681296226 | 0.666666666667 | BMF BBC3 | Apoptosis Modulation and Signaling |
| REAC:R-HSA-109606 | 0.00818423736949 | 0.666666666667 | BMF BBC3 | Intrinsic Pathway for Apoptosis |
| MIRNA:hsa-miR-876-3p | 0.0178183335155 | 0.666666666667 | TNIP3 BBC3 | hsa-miR-876-3p |
| MIRNA:hsa-miR-323a-5p | 0.0264402587388 | 0.666666666667 | TNIP3 BBC3 | hsa-miR-323a-5p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| BCL2L2 | TNIP3 | 0.971 | 0.881 | bioplex (BCL2L2) bioplex_WMM |
| BCL2L2 | BBC3 | 0.193 | 0.446 | bioplex (BCL2L2) bioplex_WMM |
| BCL2L2 | BMF | 0.14 | 0.407 | bioplex (BCL2L2) bioplex_WMM |
| TNIP3 | BMF | 0.009 | 0.095 | bioplex_WMM WMM_only |
| TNIP3 | BBC3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
| BMF | BBC3 | 0.008 | 0.091 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06564 has an average edge precision of 0.335 which is ranked 4173 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| BCL2L2 | HuMAP2_00267 HuMAP2_00612 HuMAP2_03119 HuMAP2_06564 |
| TNIP3 | HuMAP2_00267 HuMAP2_03119 HuMAP2_06564 |
| BBC3 | HuMAP2_00283 HuMAP2_00612 HuMAP2_03955 HuMAP2_04371 HuMAP2_06133 HuMAP2_06564 |
| BMF | HuMAP2_00267 HuMAP2_06564 |