hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06571
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDK5R1 | Cyclin-dependent kinase 5 activator 1 (CDK5 activator 1) (Cyclin-dependent kinase 5 regulatory subunit 1) (TPKII regulatory subunit) [Cleaved into: Cyclin-dependent kinase 5 activator 1, p35 (p35); Cyclin-dependent kinase 5 activator 1, p25 (p25) (Tau protein kinase II 23 kDa subunit) (p23)] | UniProt NCBI |
| CDK20 | Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42) | UniProt NCBI |
| CDK5 | Cyclin-dependent-like kinase 5 (EC 2.7.11.1) (Cell division protein kinase 5) (Serine/threonine-protein kinase PSSALRE) (Tau protein kinase II catalytic subunit) (TPKII catalytic subunit) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-9032845 | 6.69449800487e-05 | 0.666666666667 | CDK5 CDK5R1 | Activated NTRK2 signals through CDK5 |
| KEGG:05030 | 0.000462599152438 | 0.666666666667 | CDK5 CDK5R1 | Cocaine addiction |
| REAC:R-HSA-399956 | 0.000802944115303 | 0.666666666667 | CDK5 CDK5R1 | CRMPs in Sema3A signaling |
| WP:WP3878 | 0.000905695914221 | 0.666666666667 | CDK5 CDK5R1 | ATM Signaling Network in Development and Disease |
| REAC:R-HSA-9006115 | 0.00127110038679 | 0.666666666667 | CDK5 CDK5R1 | Signaling by NTRK2 (TRKB) |
| REAC:R-HSA-8862803 | 0.00140483748394 | 0.666666666667 | CDK5 CDK5R1 | Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models |
| REAC:R-HSA-8863678 | 0.00140483748394 | 0.666666666667 | CDK5 CDK5R1 | Neurodegenerative Diseases |
| WP:WP2059 | 0.00302048413579 | 0.666666666667 | CDK5 CDK5R1 | Alzheimers Disease |
| KEGG:05010 | 0.00524007678336 | 0.666666666667 | CDK5 CDK5R1 | Alzheimer disease |
| WP:WP2380 | 0.00875262287344 | 0.666666666667 | CDK5 CDK5R1 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| REAC:R-HSA-373755 | 0.011426592715 | 0.666666666667 | CDK5 CDK5R1 | Semaphorin interactions |
| REAC:R-HSA-6804756 | 0.0273084129672 | 0.666666666667 | CDK5 CDK5R1 | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-166520 | 0.0273084129672 | 0.666666666667 | CDK5 CDK5R1 | Signaling by NTRKs |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDK20 | CDK5 | 0.994 | 0.921 | bioplex (CDK5) bioplex_WMM |
| CDK5R1 | CDK5 | 0.661 | 0.698 | bioplex (CDK5R1) bioplex_WMM |
Images
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Complex HuMAP2_06571 has an average edge precision of 0.809 which is ranked 911 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDK5R1 | HuMAP2_05673 HuMAP2_05950 HuMAP2_06571 |
| CDK20 | HuMAP2_04781 HuMAP2_05950 HuMAP2_06068 HuMAP2_06571 |
| CDK5 | HuMAP2_05673 HuMAP2_05950 HuMAP2_06068 HuMAP2_06571 |