hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06584
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| APAF1 | Apoptotic protease-activating factor 1 (APAF-1) | UniProt NCBI |
| PKN3 | Serine/threonine-protein kinase N3 (EC 2.7.11.13) (Protein kinase PKN-beta) (Protein-kinase C-related kinase 3) | UniProt NCBI |
| PLCB1 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (EC 3.1.4.11) (PLC-154) (Phosphoinositide phospholipase C-beta-1) (Phospholipase C-I) (PLC-I) (Phospholipase C-beta-1) (PLC-beta-1) | UniProt NCBI |
| DEF8 | Differentially expressed in FDCP 8 homolog (DEF-8) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP2059 | 0.00527207105384 | 0.5 | APAF1 PLCB1 | Alzheimers Disease |
| KEGG:05010 | 0.0232850911193 | 0.5 | APAF1 PLCB1 | Alzheimer disease |
| KEGG:05016 | 0.03037774612 | 0.5 | APAF1 PLCB1 | Huntington disease |
| CORUM:1248 | 0.0499140284799 | 0.25 | APAF1 | Apoptosome |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| DEF8 | PKN3 | 0.029 | 0.231 | bioplex (DEF8) bioplex_WMM |
| DEF8 | APAF1 | 0.024 | 0.213 | bioplex (DEF8) bioplex_WMM |
| DEF8 | PLCB1 | 0.022 | 0.204 | bioplex (DEF8) bioplex_WMM |
| PKN3 | PLCB1 | 0.009 | 0.095 | bioplex_WMM WMM_only |
| APAF1 | PLCB1 | 0.007 | 0.01 | bioplex_WMM WMM_only |
| APAF1 | PKN3 | 0.007 | 0.006 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06584 has an average edge precision of 0.127 which is ranked 6847 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| APAF1 | HuMAP2_06584 |
| PKN3 | HuMAP2_06584 HuMAP2_06878 |
| PLCB1 | HuMAP2_06584 |
| DEF8 | HuMAP2_01014 HuMAP2_06584 |