hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06587
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| ROCK2 | Rho-associated protein kinase 2 (EC 2.7.11.1) (Rho kinase 2) (Rho-associated, coiled-coil-containing protein kinase 2) (Rho-associated, coiled-coil-containing protein kinase II) (ROCK-II) (p164 ROCK-2) | UniProt NCBI |
| ROCK1 | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| WP:WP524 | 0.000261924676198 | 1.0 | ROCK1 ROCK2 | G13 Signaling Pathway |
| REAC:R-HSA-416572 | 0.000286582912066 | 1.0 | ROCK1 ROCK2 | Sema4D induced cell migration and growth-cone collapse |
| REAC:R-HSA-5627117 | 0.000286582912066 | 1.0 | ROCK1 ROCK2 | RHO GTPases Activate ROCKs |
| KEGG:05131 | 0.000294129448977 | 1.0 | ROCK1 ROCK2 | Shigellosis |
| KEGG:05132 | 0.000322579470084 | 1.0 | ROCK1 ROCK2 | Salmonella infection |
| REAC:R-HSA-400685 | 0.000424008635981 | 1.0 | ROCK1 ROCK2 | Sema4D in semaphorin signaling |
| GO:1905203 | 0.000450823411379 | 1.0 | ROCK1 ROCK2 | regulation of connective tissue replacement |
| GO:0072518 | 0.000450823411379 | 1.0 | ROCK1 ROCK2 | Rho-dependent protein serine/threonine kinase activity |
| GO:1905205 | 0.000450823411379 | 1.0 | ROCK1 ROCK2 | positive regulation of connective tissue replacement |
| GO:0110061 | 0.000450823411379 | 1.0 | ROCK1 ROCK2 | regulation of angiotensin-activated signaling pathway |
| WP:WP2272 | 0.000494042845858 | 1.0 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| REAC:R-HSA-3928663 | 0.000544675125272 | 1.0 | ROCK1 ROCK2 | EPHA-mediated growth cone collapse |
| KEGG:04670 | 0.000558495798951 | 1.0 | ROCK1 ROCK2 | Leukocyte transendothelial migration |
| KEGG:04270 | 0.000707748986601 | 1.0 | ROCK1 ROCK2 | Vascular smooth muscle contraction |
| KEGG:04071 | 0.000858752944782 | 1.0 | ROCK1 ROCK2 | Sphingolipid signaling pathway |
| KEGG:04611 | 0.000890704506947 | 1.0 | ROCK1 ROCK2 | Platelet activation |
| KEGG:05135 | 0.000906899134346 | 1.0 | ROCK1 ROCK2 | Yersinia infection |
| WP:WP2034 | 0.00100634217697 | 1.0 | ROCK1 ROCK2 | Leptin signaling pathway |
| WP:WP1544 | 0.0010618567954 | 1.0 | ROCK1 ROCK2 | MicroRNAs in cardiomyocyte hypertrophy |
| KEGG:04062 | 0.00122335090758 | 1.0 | ROCK1 ROCK2 | Chemokine signaling pathway |
| REAC:R-HSA-3928662 | 0.00124185928562 | 1.0 | ROCK1 ROCK2 | EPHB-mediated forward signaling |
| KEGG:04921 | 0.00131964328671 | 1.0 | ROCK1 ROCK2 | Oxytocin signaling pathway |
| MIRNA:hsa-miR-144-5p | 0.00134703862677 | 1.0 | ROCK1 ROCK2 | hsa-miR-144-5p |
| WP:WP138 | 0.00142624133782 | 1.0 | ROCK1 ROCK2 | Androgen receptor signaling pathway |
| KEGG:04022 | 0.00144000876062 | 1.0 | ROCK1 ROCK2 | cGMP-PKG signaling pathway |
| KEGG:04530 | 0.00152317036077 | 1.0 | ROCK1 ROCK2 | Tight junction |
| WP:WP185 | 0.00159390293709 | 1.0 | ROCK1 ROCK2 | Integrin-mediated Cell Adhesion |
| KEGG:04360 | 0.00197399377215 | 1.0 | ROCK1 ROCK2 | Axon guidance |
| KEGG:04024 | 0.00209581822151 | 1.0 | ROCK1 ROCK2 | cAMP signaling pathway |
| KEGG:05130 | 0.00227250014745 | 1.0 | ROCK1 ROCK2 | Pathogenic Escherichia coli infection |
| KEGG:04810 | 0.00253730419006 | 1.0 | ROCK1 ROCK2 | Regulation of actin cytoskeleton |
| KEGG:05205 | 0.00256458703081 | 1.0 | ROCK1 ROCK2 | Proteoglycans in cancer |
| KEGG:04510 | 0.00259201576911 | 1.0 | ROCK1 ROCK2 | Focal adhesion |
| GO:1903347 | 0.00270494046827 | 1.0 | ROCK1 ROCK2 | negative regulation of bicellular tight junction assembly |
| GO:0097709 | 0.00270494046827 | 1.0 | ROCK1 ROCK2 | connective tissue replacement |
| WP:WP3929 | 0.00284130523568 | 1.0 | ROCK1 ROCK2 | Chemokine signaling pathway |
| REAC:R-HSA-373755 | 0.00286750504412 | 1.0 | ROCK1 ROCK2 | Semaphorin interactions |
| KEGG:05163 | 0.0029618660435 | 1.0 | ROCK1 ROCK2 | Human cytomegalovirus infection |
| WP:WP51 | 0.00322133819403 | 1.0 | ROCK1 ROCK2 | Regulation of Actin Cytoskeleton |
| REAC:R-HSA-416482 | 0.00440432685912 | 1.0 | ROCK1 ROCK2 | G alpha (12/13) signalling events |
| GO:0035509 | 0.00450823411379 | 1.0 | ROCK1 ROCK2 | negative regulation of myosin-light-chain-phosphatase activity |
| REAC:R-HSA-2682334 | 0.00612550025498 | 1.0 | ROCK1 ROCK2 | EPH-Ephrin signaling |
| WP:WP306 | 0.00654923464894 | 1.0 | ROCK1 ROCK2 | Focal Adhesion |
| REAC:R-HSA-4420097 | 0.00686290657842 | 1.0 | ROCK1 ROCK2 | VEGFA-VEGFR2 Pathway |
| REAC:R-HSA-194138 | 0.00812990471598 | 1.0 | ROCK1 ROCK2 | Signaling by VEGF |
| WP:WP3888 | 0.00889388896944 | 1.0 | ROCK1 ROCK2 | VEGFA-VEGFR2 Signaling Pathway |
| MIRNA:hsa-miR-135a-5p | 0.00946729163895 | 1.0 | ROCK1 ROCK2 | hsa-miR-135a-5p |
| GO:0035507 | 0.00946729163895 | 1.0 | ROCK1 ROCK2 | regulation of myosin-light-chain-phosphatase activity |
| KEGG:05200 | 0.0157394270613 | 1.0 | ROCK1 ROCK2 | Pathways in cancer |
| GO:0038166 | 0.0162296428096 | 1.0 | ROCK1 ROCK2 | angiotensin-activated signaling pathway |
| CORUM:7424 | 0.0249595281251 | 0.5 | ROCK1 | ISLR2-ROCK1 complex |
| GO:1990776 | 0.029754345151 | 1.0 | ROCK1 ROCK2 | response to angiotensin |
| GO:1904385 | 0.029754345151 | 1.0 | ROCK1 ROCK2 | cellular response to angiotensin |
| GO:1903140 | 0.029754345151 | 1.0 | ROCK1 ROCK2 | regulation of establishment of endothelial barrier |
| GO:1901550 | 0.029754345151 | 1.0 | ROCK1 ROCK2 | regulation of endothelial cell development |
| GO:0034105 | 0.0351642260875 | 1.0 | ROCK1 ROCK2 | positive regulation of tissue remodeling |
| MIRNA:hsa-miR-1280 | 0.0404464642509 | 0.5 | ROCK1 | hsa-miR-1280 |
| GO:2000810 | 0.0473364581948 | 1.0 | ROCK1 ROCK2 | regulation of bicellular tight junction assembly |
| GO:0014742 | 0.0473364581948 | 1.0 | ROCK1 ROCK2 | positive regulation of muscle hypertrophy |
| GO:0010613 | 0.0473364581948 | 1.0 | ROCK1 ROCK2 | positive regulation of cardiac muscle hypertrophy |
| GO:0017049 | 0.0473364581948 | 1.0 | ROCK1 ROCK2 | GTP-Rho binding |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ROCK1 | ROCK2 | 0.809 | 0.77 | hein_WMM bioplex (ROCK2) bioplex_WMM hein (ROCK1) |
Images
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Complex HuMAP2_06587 has an average edge precision of 0.77 which is ranked 1052 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| ROCK2 | HuMAP2_06587 |
| ROCK1 | HuMAP2_06587 HuMAP2_06627 |