hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06589

Confidence: Medium

Genename	Protein Name	Links
BCL2L1	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	UniProt NCBI
TRMO	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	UniProt NCBI
BCL2L11	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	UniProt NCBI
BCL2L15	Bcl-2-like protein 15 (Bcl2-L-15)	UniProt NCBI
BCL2	Apoptosis regulator Bcl-2	UniProt NCBI
RHPN2	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-111453	4.99793187022e-07	0.5	BCL2L1 BCL2 BCL2L11	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
WP:WP3872	1.70690021658e-06	0.5	BCL2L1 BCL2 BCL2L15	Regulation of Apoptosis by Parathyroid Hormone-related Protein
KEGG:04215	6.80039367008e-06	0.5	BCL2L1 BCL2 BCL2L11	Apoptosis - multiple species
WP:WP3611	2.41794273383e-05	0.5	BCL2L1 BCL2 BCL2L11	Photodynamic therapy-induced AP-1 survival signaling.
REAC:R-HSA-844455	6.65030189148e-05	0.333333333333	BCL2L1 BCL2	The NLRP1 inflammasome
WP:WP254	9.23806515429e-05	0.5	BCL2L1 BCL2 BCL2L11	Apoptosis
KEGG:01521	0.000107857457806	0.5	BCL2L1 BCL2 BCL2L11	EGFR tyrosine kinase inhibitor resistance
REAC:R-HSA-109606	0.000115897320389	0.5	BCL2L1 BCL2 BCL2L11	Intrinsic Pathway for Apoptosis
WP:WP1772	0.000126573478724	0.5	BCL2L1 BCL2 BCL2L11	Apoptosis Modulation and Signaling
KEGG:04210	0.000524612840052	0.5	BCL2L1 BCL2 BCL2L11	Apoptosis
WP:WP3657	0.000852627081304	0.333333333333	BCL2L1 BCL2	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex
MIRNA:hsa-miR-16-1-3p	0.00127334227449	0.5	BCL2L11 BCL2 TRMO	hsa-miR-16-1-3p
MIRNA:hsa-miR-3120-3p	0.00238133708387	0.5	BCL2L1 RHPN2 BCL2L11	hsa-miR-3120-3p
REAC:R-HSA-622312	0.00377982352449	0.333333333333	BCL2L1 BCL2	Inflammasomes
WP:WP2447	0.00390360990759	0.333333333333	BCL2L1 BCL2	Amyotrophic lateral sclerosis (ALS)
REAC:R-HSA-109581	0.00458915535708	0.5	BCL2L1 BCL2 BCL2L11	Apoptosis
WP:WP286	0.00477752328717	0.333333333333	BCL2L1 BCL2	IL-3 Signaling Pathway
REAC:R-HSA-5357801	0.0048372157697	0.5	BCL2L1 BCL2 BCL2L11	Programmed Cell Death
WP:WP4172	0.00560540779735	0.5	BCL2L1 BCL2 BCL2L11	PI3K-Akt Signaling Pathway
KEGG:04151	0.00716177546378	0.5	BCL2L1 BCL2 BCL2L11	PI3K-Akt signaling pathway
KEGG:05014	0.00791353680327	0.333333333333	BCL2L1 BCL2	Amyotrophic lateral sclerosis (ALS)
REAC:R-HSA-114452	0.00959640616298	0.333333333333	BCL2L11 BCL2	Activation of BH3-only proteins
KEGG:04115	0.0124835568261	0.333333333333	BCL2L1 BCL2	p53 signaling pathway
WP:WP4216	0.0137172539953	0.333333333333	BCL2L11 BCL2	Chromosomal and microsatellite instability in colorectal cancer
WP:WP4298	0.0153070697985	0.333333333333	BCL2L1 BCL2	Viral Acute Myocarditis
KEGG:01524	0.015804666162	0.333333333333	BCL2L1 BCL2	Platinum drug resistance
GO:2001244	0.0165096938447	0.5	BCL2L1 BCL2 BCL2L11	positive regulation of intrinsic apoptotic signaling pathway
WP:WP1438	0.0166465613198	0.166666666667	BCL2	Influenza A virus infection
KEGG:04064	0.0190270141569	0.333333333333	BCL2L1 BCL2	NF-kappa B signaling pathway
KEGG:05210	0.0204981178463	0.333333333333	BCL2L11 BCL2	Colorectal cancer
GO:0070059	0.0222806450818	0.5	BCL2L1 BCL2 BCL2L11	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0001836	0.0222806450818	0.5	BCL2L1 BCL2 BCL2L11	release of cytochrome c from mitochondria
WP:WP4658	0.02454095485	0.333333333333	BCL2L1 BCL2	Small cell lung cancer
KEGG:05222	0.0257907962007	0.333333333333	BCL2L1 BCL2	Small cell lung cancer
KEGG:05200	0.0260948095216	0.5	BCL2L1 BCL2 BCL2L11	Pathways in cancer
KEGG:05145	0.0269209504846	0.333333333333	BCL2L1 BCL2	Toxoplasmosis
WP:WP710	0.0293906161984	0.333333333333	BCL2L11 BCL2	DNA Damage Response (only ATM dependent)
REAC:R-HSA-168643	0.0302745579484	0.333333333333	BCL2L1 BCL2	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
MIRNA:hsa-miR-184	0.0388499553328	0.333333333333	BCL2L1 BCL2	hsa-miR-184
GO:0051434	0.0405595771497	0.333333333333	BCL2L1 BCL2	BH3 domain binding
GO:0051400	0.0405595771497	0.333333333333	BCL2L1 BCL2	BH domain binding
KEGG:04630	0.0444979624084	0.333333333333	BCL2L1 BCL2	JAK-STAT signaling pathway
KEGG:05162	0.0497554800317	0.333333333333	BCL2L1 BCL2	Measles
CORUM:5812	0.0499726005494	0.166666666667	BCL2L1	p53-BCL2 complex
CORUM:7275	0.0499726005494	0.166666666667	BCL2	BCL2-CISD2 complex
CORUM:5526	0.0499726005494	0.166666666667	BCL2	CALM1-FKBP38-BCL2 complex
CORUM:1062	0.0499726005494	0.166666666667	BCL2	BAR-BCL2-CASP8 complex
CORUM:5811	0.0499726005494	0.166666666667	BCL2	p53-BCL2 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BCL2	BCL2L1	0.831	0.778	bioplex (BCL2L1) bioplex_WMM
BCL2L11	BCL2L1	0.773	0.752	bioplex (BCL2L1,BCL2L11) bioplex_WMM
BCL2L11	RHPN2	0.731	0.736	bioplex (BCL2L11) bioplex_WMM
RHPN2	TRMO	0.149	0.41	bioplex (TRMO) bioplex_WMM
BCL2	BCL2L11	0.066	0.35	bioplex (BCL2L11) bioplex_WMM
BCL2L1	BCL2L15	0.024	0.213	bioplex (BCL2L15) bioplex_WMM
BCL2	RHPN2	0.009	0.096	bioplex_WMM WMM_only
BCL2L1	RHPN2	0.009	0.098	bioplex_WMM WMM_only

Images

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Complex HuMAP2_06589 has an average edge precision of 0.429 which is ranked 3033 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BCL2L1	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
TRMO	HuMAP2_01477 HuMAP2_02295 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2L11	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2L15	HuMAP2_01477 HuMAP2_02045 HuMAP2_06589 HuMAP2_06641
BCL2	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
RHPN2	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06589