hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06590
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| OSBPL3 | Oxysterol-binding protein-related protein 3 (ORP-3) (OSBP-related protein 3) | UniProt NCBI |
| NOP53 | Ribosome biogenesis protein NOP53 (Glioma tumor suppressor candidate region gene 2 protein) (Protein interacting with carboxyl terminus 1) (PICT-1) (p60) | UniProt NCBI |
| IMP3 | U3 small nucleolar ribonucleoprotein protein IMP3 (U3 snoRNP protein IMP3) (BRMS2) | UniProt NCBI |
| OSBPL6 | Oxysterol-binding protein-related protein 6 (ORP-6) (OSBP-related protein 6) | UniProt NCBI |
| MPHOSPH10 | U3 small nucleolar ribonucleoprotein protein MPP10 (M phase phosphoprotein 10) | UniProt NCBI |
| IMP4 | U3 small nucleolar ribonucleoprotein protein IMP4 (U3 snoRNP protein IMP4) (Brix domain-containing protein 4) | UniProt NCBI |
| KRI1 | Protein KRI1 homolog | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:533 | 3.38154272427e-09 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | IMP3-IMP4-MPP10 complex |
| GO:0034457 | 3.17865016081e-06 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | Mpp10 complex |
| GO:0030686 | 2.01980560179e-05 | 0.571428571429 | KRI1 IMP4 MPHOSPH10 IMP3 | 90S preribosome |
| GO:0006364 | 0.000205648445059 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | rRNA processing |
| KEGG:03008 | 0.000240117545455 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | Ribosome biogenesis in eukaryotes |
| GO:0016072 | 0.000265505155617 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | rRNA metabolic process |
| REAC:R-HSA-6790901 | 0.000359631908423 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | rRNA modification in the nucleus and cytosol |
| GO:0030684 | 0.000919053594983 | 0.571428571429 | KRI1 IMP4 MPHOSPH10 IMP3 | preribosome |
| GO:0042254 | 0.000959205344393 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | ribosome biogenesis |
| GO:0034470 | 0.00415838115463 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | ncRNA processing |
| GO:0022613 | 0.00928376179311 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | ribonucleoprotein complex biogenesis |
| REAC:R-HSA-6791226 | 0.00996765717623 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | Major pathway of rRNA processing in the nucleolus and cytosol |
| REAC:R-HSA-8868773 | 0.0116992025039 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | rRNA processing in the nucleus and cytosol |
| REAC:R-HSA-72312 | 0.0136177314146 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | rRNA processing |
| REAC:R-HSA-192105 | 0.0136873957341 | 0.285714285714 | OSBPL6 OSBPL3 | Synthesis of bile acids and bile salts |
| GO:0034660 | 0.0138615837302 | 0.714285714286 | KRI1 NOP53 IMP4 MPHOSPH10 IMP3 | ncRNA metabolic process |
| REAC:R-HSA-194068 | 0.0197964991178 | 0.285714285714 | OSBPL6 OSBPL3 | Bile acid and bile salt metabolism |
| GO:0032040 | 0.0225450636661 | 0.428571428571 | IMP3 IMP4 MPHOSPH10 | small-subunit processome |
| GO:0044452 | 0.0253749350715 | 0.571428571429 | IMP3 IMP4 NOP53 MPHOSPH10 | nucleolar part |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| NOP53 | MPHOSPH10 | 0.3 | 0.497 | bioplex (NOP53) bioplex_WMM fraction treiber_WMM |
| MPHOSPH10 | IMP3 | 0.232 | 0.47 | bioplex_WMM Guru youn_WMM fraction |
| NOP53 | OSBPL6 | 0.158 | 0.415 | bioplex (NOP53) bioplex_WMM |
| NOP53 | KRI1 | 0.106 | 0.371 | bioplex (NOP53) bioplex_WMM gupta_WMM treiber_WMM |
| NOP53 | OSBPL3 | 0.106 | 0.371 | hein_WMM bioplex (NOP53) bioplex_WMM |
| IMP4 | MPHOSPH10 | 0.068 | 0.349 | bioplex_WMM Guru youn_WMM fraction treiber_WMM |
| NOP53 | IMP4 | 0.066 | 0.349 | hein_WMM bioplex (NOP53) bioplex_WMM treiber_WMM |
| KRI1 | MPHOSPH10 | 0.049 | 0.295 | bioplex_WMM youn_WMM fraction treiber_WMM |
| NOP53 | IMP3 | 0.042 | 0.27 | bioplex (NOP53) bioplex_WMM |
| IMP4 | IMP3 | 0.028 | 0.233 | bioplex_WMM youn_WMM WMM_only treiber_WMM |
| OSBPL6 | OSBPL3 | 0.016 | 0.161 | bioplex_WMM boldt youn_WMM boldt_WMM |
| KRI1 | IMP3 | 0.013 | 0.149 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| KRI1 | IMP4 | 0.012 | 0.146 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OSBPL6 | IMP4 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| OSBPL3 | IMP4 | 0.007 | 0.006 | bioplex_WMM WMM_only |
| OSBPL6 | MPHOSPH10 | 0.007 | 0.007 | bioplex_WMM WMM_only |
| OSBPL3 | MPHOSPH10 | 0.007 | 0.006 | bioplex_WMM WMM_only treiber_WMM |
| OSBPL6 | IMP3 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| OSBPL3 | IMP3 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| OSBPL6 | KRI1 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
| OSBPL3 | KRI1 | 0.007 | 0.002 | bioplex_WMM youn_WMM WMM_only |
Images
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Complex HuMAP2_06590 has an average edge precision of 0.196 which is ranked 6230 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| OSBPL3 | HuMAP2_00871 HuMAP2_06590 |
| NOP53 | HuMAP2_00446 HuMAP2_01863 HuMAP2_06147 HuMAP2_06590 |
| IMP3 | HuMAP2_02537 HuMAP2_06590 HuMAP2_06780 |
| OSBPL6 | HuMAP2_00871 HuMAP2_06590 |
| MPHOSPH10 | HuMAP2_02537 HuMAP2_06590 HuMAP2_06780 |
| IMP4 | HuMAP2_02537 HuMAP2_06590 HuMAP2_06780 |
| KRI1 | HuMAP2_02349 HuMAP2_02949 HuMAP2_06590 HuMAP2_06780 |