hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06595
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| TENM3 | Teneurin-3 (Ten-3) (Protein Odd Oz/ten-m homolog 3) (Tenascin-M3) (Ten-m3) (Teneurin transmembrane protein 3) | UniProt NCBI |
| ILK | Integrin-linked protein kinase (EC 2.7.11.1) (59 kDa serine/threonine-protein kinase) (ILK-1) (ILK-2) (p59ILK) | UniProt NCBI |
| LIMS1 | LIM and senescent cell antigen-like-containing domain protein 1 (Particularly interesting new Cys-His protein 1) (PINCH-1) (Renal carcinoma antigen NY-REN-48) | UniProt NCBI |
| RSU1 | Ras suppressor protein 1 (RSP-1) (Rsu-1) | UniProt NCBI |
| PARVB | Beta-parvin (Affixin) | UniProt NCBI |
| PARVA | Alpha-parvin (Actopaxin) (CH-ILKBP) (Calponin-like integrin-linked kinase-binding protein) (Matrix-remodeling-associated protein 2) | UniProt NCBI |
| PARVG | Gamma-parvin | UniProt NCBI |
| CMAS | N-acylneuraminate cytidylyltransferase (EC 2.7.7.43) (CMP-N-acetylneuraminic acid synthase) (CMP-NeuNAc synthase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-446353 | 1.39077262119e-11 | 0.625 | PARVB LIMS1 ILK PARVA RSU1 | Cell-extracellular matrix interactions |
| REAC:R-HSA-446388 | 4.23530201987e-10 | 0.5 | PARVB LIMS1 RSU1 PARVA | Regulation of cytoskeletal remodeling and cell spreading by IPP complex components |
| CORUM:6919 | 4.70911134935e-09 | 0.375 | PARVA ILK LIMS1 | ILK-LIMS1-PARVA complex |
| REAC:R-HSA-446728 | 2.09464996215e-08 | 0.625 | PARVB LIMS1 ILK PARVA RSU1 | Cell junction organization |
| REAC:R-HSA-1500931 | 1.40078811705e-07 | 0.625 | PARVB LIMS1 ILK PARVA RSU1 | Cell-Cell communication |
| GO:0034446 | 1.08900176497e-05 | 0.625 | PARVG LIMS1 ILK PARVA PARVB | substrate adhesion-dependent cell spreading |
| GO:0031589 | 1.73396024303e-05 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | cell-substrate adhesion |
| CORUM:6920 | 3.50546248845e-05 | 0.25 | PARVA ILK | ILK-LIMS2-PARVA complex |
| CORUM:5498 | 3.50546248845e-05 | 0.25 | PARVB ILK | ILK-PARVB-ARHGEF6 complex |
| KEGG:04510 | 8.12446581323e-05 | 0.5 | PARVG ILK PARVA PARVB | Focal adhesion |
| WP:WP306 | 8.37288818332e-05 | 0.5 | PARVG ILK PARVA PARVB | Focal Adhesion |
| WP:WP2572 | 0.000201347625851 | 0.375 | PARVA ILK LIMS1 | Primary Focal Segmental Glomerulosclerosis FSGS |
| GO:0005925 | 0.000232510576091 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | focal adhesion |
| GO:0005924 | 0.000240505807924 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | cell-substrate adherens junction |
| GO:0030055 | 0.000261498831336 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | cell-substrate junction |
| REAC:R-HSA-446343 | 0.000268431388343 | 0.25 | PARVA ILK | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| GO:0007155 | 0.000868137842232 | 0.875 | PARVG ILK PARVB LIMS1 TENM3 PARVA RSU1 | cell adhesion |
| GO:0022610 | 0.000910687487507 | 0.875 | PARVG ILK PARVB LIMS1 TENM3 PARVA RSU1 | biological adhesion |
| GO:0005912 | 0.00105961614518 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | adherens junction |
| GO:0070161 | 0.00122189928453 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | anchoring junction |
| GO:0030054 | 0.012189998323 | 0.75 | PARVG LIMS1 PARVB RSU1 PARVA ILK | cell junction |
| CORUM:764 | 0.0497224828424 | 0.125 | PARVB | Dysferlin-affixin complex |
| CORUM:4025 | 0.0497224828424 | 0.125 | PARVB | ACTN1-PARVB complex |
| CORUM:5499 | 0.0497224828424 | 0.125 | PARVB | PARVB-ARHGEF6 complex |
| CORUM:6510 | 0.0497224828424 | 0.125 | ILK | ILK-SERCA2A-PLN complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| ILK | PARVA | 1.0 | 0.949 | hein_WMM bioplex (ILK,PARVA) bioplex_WMM Guru hein (ILK) Malo fraction treiber_WMM |
| ILK | LIMS1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,LIMS1) bioplex_WMM hein (ILK) fraction |
| ILK | PARVB | 1.0 | 0.949 | hein_WMM bioplex (ILK) bioplex_WMM Guru hein (ILK) fraction |
| ILK | RSU1 | 1.0 | 0.949 | hein_WMM bioplex (ILK,RSU1) bioplex_WMM hein (ILK) Malo fraction |
| PARVB | PARVA | 1.0 | 0.949 | hein_WMM bioplex (PARVA) bioplex_WMM |
| RSU1 | PARVB | 0.996 | 0.928 | hein_WMM bioplex (RSU1) bioplex_WMM Guru fraction |
| PARVB | LIMS1 | 0.99 | 0.909 | hein_WMM bioplex (LIMS1) bioplex_WMM fraction |
| ILK | PARVG | 0.986 | 0.9 | bioplex (PARVG) bioplex_WMM |
| RSU1 | LIMS1 | 0.985 | 0.899 | hein_WMM bioplex (LIMS1,RSU1) bioplex_WMM fraction |
| RSU1 | PARVA | 0.979 | 0.895 | hein_WMM bioplex (PARVA,RSU1) bioplex_WMM Guru Malo fraction |
| PARVG | RSU1 | 0.894 | 0.82 | bioplex (PARVG) bioplex_WMM |
| PARVA | LIMS1 | 0.867 | 0.801 | hein_WMM bioplex (LIMS1,PARVA) bioplex_WMM fraction |
| PARVG | LIMS1 | 0.683 | 0.711 | bioplex (PARVG) bioplex_WMM |
| LIMS1 | CMAS | 0.233 | 0.471 | bioplex (LIMS1) bioplex_WMM |
| PARVA | TENM3 | 0.02 | 0.184 | fraction |
| PARVA | CMAS | 0.007 | 0.01 | bioplex_WMM WMM_only |
| PARVB | CMAS | 0.007 | 0.009 | bioplex_WMM WMM_only |
| RSU1 | CMAS | 0.007 | 0.005 | bioplex_WMM WMM_only |
| ILK | CMAS | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06595 has an average edge precision of 0.647 which is ranked 1662 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| TENM3 | HuMAP2_06579 HuMAP2_06595 |
| ILK | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| LIMS1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| RSU1 | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVB | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| PARVA | HuMAP2_01374 HuMAP2_02505 HuMAP2_06435 HuMAP2_06595 |
| PARVG | HuMAP2_01374 HuMAP2_06435 HuMAP2_06595 |
| CMAS | HuMAP2_01374 HuMAP2_06595 |