hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06600
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NUP188 | Nucleoporin NUP188 homolog (hNup188) | UniProt NCBI |
| NDC1 | Nucleoporin NDC1 (hNDC1) (Transmembrane protein 48) | UniProt NCBI |
| HOXB5 | Homeobox protein Hox-B5 (Homeobox protein HHO.C10) (Homeobox protein Hox-2A) (Homeobox protein Hu-1) | UniProt NCBI |
| LYN | Tyrosine-protein kinase Lyn (EC 2.7.10.2) (Lck/Yes-related novel protein tyrosine kinase) (V-yes-1 Yamaguchi sarcoma viral related oncogene homolog) (p53Lyn) (p56Lyn) | UniProt NCBI |
| NUP155 | Nuclear pore complex protein Nup155 (155 kDa nucleoporin) (Nucleoporin Nup155) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-170822 | 8.88541585136e-06 | 0.6 | NUP155 NUP188 NDC1 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| REAC:R-HSA-5619107 | 8.88541585136e-06 | 0.6 | NUP155 NUP188 NDC1 | Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) |
| REAC:R-HSA-168271 | 8.88541585136e-06 | 0.6 | NUP155 NUP188 NDC1 | Transport of Ribonucleoproteins into the Host Nucleus |
| REAC:R-HSA-168333 | 8.88541585136e-06 | 0.6 | NUP155 NUP188 NDC1 | NEP/NS2 Interacts with the Cellular Export Machinery |
| REAC:R-HSA-168274 | 8.88541585136e-06 | 0.6 | NUP155 NUP188 NDC1 | Export of Viral Ribonucleoproteins from Nucleus |
| REAC:R-HSA-180910 | 1.10096191184e-05 | 0.6 | NUP155 NUP188 NDC1 | Vpr-mediated nuclear import of PICs |
| REAC:R-HSA-159227 | 1.10096191184e-05 | 0.6 | NUP155 NUP188 NDC1 | Transport of the SLBP independent Mature mRNA |
| REAC:R-HSA-180746 | 1.10096191184e-05 | 0.6 | NUP155 NUP188 NDC1 | Nuclear import of Rev protein |
| REAC:R-HSA-159230 | 1.21879917622e-05 | 0.6 | NUP155 NUP188 NDC1 | Transport of the SLBP Dependant Mature mRNA |
| REAC:R-HSA-165054 | 1.21879917622e-05 | 0.6 | NUP155 NUP188 NDC1 | Rev-mediated nuclear export of HIV RNA |
| REAC:R-HSA-4085377 | 1.21879917622e-05 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of SUMOylation proteins |
| REAC:R-HSA-3301854 | 1.34474619847e-05 | 0.6 | NUP155 NUP188 NDC1 | Nuclear Pore Complex (NPC) Disassembly |
| REAC:R-HSA-176033 | 1.47907161009e-05 | 0.6 | NUP155 NUP188 NDC1 | Interactions of Vpr with host cellular proteins |
| REAC:R-HSA-177243 | 1.47907161009e-05 | 0.6 | NUP155 NUP188 NDC1 | Interactions of Rev with host cellular proteins |
| REAC:R-HSA-3232142 | 1.62204393343e-05 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of ubiquitinylation proteins |
| REAC:R-HSA-168276 | 2.10552596086e-05 | 0.6 | NUP155 NUP188 NDC1 | NS1 Mediated Effects on Host Pathways |
| REAC:R-HSA-159231 | 2.10552596086e-05 | 0.6 | NUP155 NUP188 NDC1 | Transport of Mature mRNA Derived from an Intronless Transcript |
| REAC:R-HSA-168253 | 2.28576897279e-05 | 0.6 | NUP155 NUP188 NDC1 | Host Interactions with Influenza Factors |
| REAC:R-HSA-159234 | 2.28576897279e-05 | 0.6 | NUP155 NUP188 NDC1 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| REAC:R-HSA-168325 | 2.67648652633e-05 | 0.6 | NUP155 NUP188 NDC1 | Viral Messenger RNA Synthesis |
| REAC:R-HSA-4570464 | 3.10929802736e-05 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4615885 | 3.10929802736e-05 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of DNA replication proteins |
| REAC:R-HSA-2980766 | 3.84212387398e-05 | 0.6 | NUP155 NUP188 NDC1 | Nuclear Envelope Breakdown |
| REAC:R-HSA-194441 | 5.30427262701e-05 | 0.6 | NUP155 NUP188 NDC1 | Metabolism of non-coding RNA |
| REAC:R-HSA-191859 | 5.30427262701e-05 | 0.6 | NUP155 NUP188 NDC1 | snRNP Assembly |
| REAC:R-HSA-6784531 | 6.70990066737e-05 | 0.6 | NUP155 NUP188 NDC1 | tRNA processing in the nucleus |
| REAC:R-HSA-4551638 | 0.000118030564163 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3371453 | 0.000118030564163 | 0.6 | NUP155 NUP188 NDC1 | Regulation of HSF1-mediated heat shock response |
| REAC:R-HSA-70171 | 0.000123638575202 | 0.6 | NUP155 NUP188 NDC1 | Glycolysis |
| REAC:R-HSA-1169408 | 0.00012942105654 | 0.6 | NUP155 NUP188 NDC1 | ISG15 antiviral mechanism |
| REAC:R-HSA-159236 | 0.000135380656388 | 0.6 | NUP155 NUP188 NDC1 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| REAC:R-HSA-3108214 | 0.000154348632803 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation of DNA damage response and repair proteins |
| REAC:R-HSA-1169410 | 0.000175005907139 | 0.6 | NUP155 NUP188 NDC1 | Antiviral mechanism by IFN-stimulated genes |
| REAC:R-HSA-72202 | 0.000197423805207 | 0.6 | NUP155 NUP188 NDC1 | Transport of Mature Transcript to Cytoplasm |
| REAC:R-HSA-5619102 | 0.000221673564929 | 0.6 | NUP155 NUP188 NDC1 | SLC transporter disorders |
| REAC:R-HSA-70326 | 0.000238892911782 | 0.6 | NUP155 NUP188 NDC1 | Glucose metabolism |
| REAC:R-HSA-3371556 | 0.000266353842167 | 0.6 | NUP155 NUP188 NDC1 | Cellular response to heat stress |
| REAC:R-HSA-72306 | 0.000462229124052 | 0.6 | NUP155 NUP188 NDC1 | tRNA processing |
| REAC:R-HSA-5578749 | 0.000462229124052 | 0.6 | NUP155 NUP188 NDC1 | Transcriptional regulation by small RNAs |
| KEGG:03013 | 0.000498609547209 | 0.6 | NUP155 NUP188 NDC1 | RNA transport |
| REAC:R-HSA-162909 | 0.000793200049211 | 0.6 | NUP155 NUP188 NDC1 | Host Interactions of HIV factors |
| REAC:R-HSA-168273 | 0.000960389260783 | 0.6 | NUP155 NUP188 NDC1 | Influenza Viral RNA Transcription and Replication |
| REAC:R-HSA-68875 | 0.00100555265154 | 0.6 | NUP155 NUP188 NDC1 | Mitotic Prophase |
| REAC:R-HSA-211000 | 0.00100555265154 | 0.6 | NUP155 NUP188 NDC1 | Gene Silencing by RNA |
| REAC:R-HSA-162599 | 0.00102865345201 | 0.6 | NUP155 NUP188 NDC1 | Late Phase of HIV Life Cycle |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | LYN NUP155 NUP188 NDC1 | Cell Cycle, Mitotic |
| REAC:R-HSA-168255 | 0.00114945154681 | 0.6 | NUP155 NUP188 NDC1 | Influenza Life Cycle |
| REAC:R-HSA-162587 | 0.00136170542712 | 0.6 | NUP155 NUP188 NDC1 | HIV Life Cycle |
| GO:0017056 | 0.00139593056214 | 0.6 | NUP155 NUP188 NDC1 | structural constituent of nuclear pore |
| REAC:R-HSA-168254 | 0.00141854667829 | 0.6 | NUP155 NUP188 NDC1 | Influenza Infection |
| REAC:R-HSA-5619115 | 0.00166163750872 | 0.6 | NUP155 NUP188 NDC1 | Disorders of transmembrane transporters |
| REAC:R-HSA-3108232 | 0.00200241639833 | 0.6 | NUP155 NUP188 NDC1 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | LYN NUP155 NUP188 NDC1 | Cell Cycle |
| REAC:R-HSA-2990846 | 0.00222754987811 | 0.6 | NUP155 NUP188 NDC1 | SUMOylation |
| REAC:R-HSA-913531 | 0.00230616063943 | 0.6 | NUP155 NUP188 NDC1 | Interferon Signaling |
| REAC:R-HSA-1280215 | 0.00329327042719 | 0.8 | LYN NUP155 NUP188 NDC1 | Cytokine Signaling in Immune system |
| GO:0044611 | 0.00450823411379 | 0.4 | NUP188 NUP155 | nuclear pore inner ring |
| REAC:R-HSA-162906 | 0.00484900153486 | 0.6 | NUP155 NUP188 NDC1 | HIV Infection |
| GO:0006409 | 0.0049400991777 | 0.6 | NUP155 NUP188 NDC1 | tRNA export from nucleus |
| GO:0071431 | 0.0049400991777 | 0.6 | NUP155 NUP188 NDC1 | tRNA-containing ribonucleoprotein complex export from nucleus |
| REAC:R-HSA-72203 | 0.00567167369058 | 0.6 | NUP155 NUP188 NDC1 | Processing of Capped Intron-Containing Pre-mRNA |
| GO:0051031 | 0.005924931483 | 0.6 | NUP155 NUP188 NDC1 | tRNA transport |
| GO:0097064 | 0.00703245670927 | 0.6 | NUP155 NUP188 NDC1 | ncRNA export from nucleus |
| REAC:R-HSA-71387 | 0.00784859202005 | 0.6 | NUP155 NUP188 NDC1 | Metabolism of carbohydrates |
| REAC:R-HSA-5663205 | 0.0198891654246 | 0.6 | NUP155 NUP188 NDC1 | Infectious disease |
| GO:0075733 | 0.022411068229 | 0.6 | NUP155 NUP188 NDC1 | intracellular transport of virus |
| REAC:R-HSA-68886 | 0.0231915667986 | 0.6 | NUP155 NUP188 NDC1 | M Phase |
| GO:0046794 | 0.0264291737868 | 0.6 | NUP155 NUP188 NDC1 | transport of virus |
| REAC:R-HSA-2262752 | 0.0291077226575 | 0.6 | NUP155 NUP188 NDC1 | Cellular responses to stress |
| GO:0006110 | 0.0376065209581 | 0.6 | NUP155 NUP188 NDC1 | regulation of glycolytic process |
| GO:1902579 | 0.0472676873043 | 0.6 | NUP155 NUP188 NDC1 | multi-organism localization |
| GO:0044766 | 0.0472676873043 | 0.6 | NUP155 NUP188 NDC1 | multi-organism transport |
| GO:0043470 | 0.0472676873043 | 0.6 | NUP155 NUP188 NDC1 | regulation of carbohydrate catabolic process |
| GO:0016925 | 0.0472676873043 | 0.6 | NUP155 NUP188 NDC1 | protein sumoylation |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | NUP155 NUP188 NDC1 | Cellular responses to external stimuli |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HOXB5 | NUP155 | 0.093 | 0.355 | bioplex (HOXB5) bioplex_WMM |
| HOXB5 | LYN | 0.049 | 0.295 | bioplex (HOXB5) bioplex_WMM |
| NDC1 | NUP155 | 0.042 | 0.27 | hein_WMM bioplex_WMM youn_WMM hein (NUP155) gupta_WMM |
| NUP188 | NUP155 | 0.041 | 0.267 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction treiber_WMM |
| NUP188 | LYN | 0.007 | 0.005 | bioplex_WMM WMM_only |
| LYN | NDC1 | 0.007 | 0.004 | bioplex_WMM gupta_WMM WMM_only |
| NUP188 | NDC1 | 0.006 | 0.01 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| LYN | NUP155 | 0.006 | 0.005 | bioplex_WMM gupta_WMM WMM_only |
| NUP188 | HOXB5 | 0.005 | 0.007 | bioplex (HOXB5) |
Images
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Complex HuMAP2_06600 has an average edge precision of 0.135 which is ranked 6800 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| NUP188 | HuMAP2_01007 HuMAP2_02294 HuMAP2_05690 HuMAP2_06600 |
| NDC1 | HuMAP2_02320 HuMAP2_04845 HuMAP2_06600 |
| HOXB5 | HuMAP2_01704 HuMAP2_04194 HuMAP2_05449 HuMAP2_05741 HuMAP2_06600 |
| LYN | HuMAP2_01704 HuMAP2_04194 HuMAP2_06600 |
| NUP155 | HuMAP2_04845 HuMAP2_06600 |