hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06601
Confidence: Very High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CWC27 | Spliceosome-associated protein CWC27 homolog (Antigen NY-CO-10) (Probable inactive peptidyl-prolyl cis-trans isomerase CWC27 homolog) (PPIase CWC27) (Serologically defined colon cancer antigen 10) | UniProt NCBI |
| LSM2 | U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5) | UniProt NCBI |
| LSM3 | U6 snRNA-associated Sm-like protein LSm3 | UniProt NCBI |
| LSM6 | U6 snRNA-associated Sm-like protein LSm6 | UniProt NCBI |
| LSM7 | U6 snRNA-associated Sm-like protein LSm7 | UniProt NCBI |
| LSM8 | U6 snRNA-associated Sm-like protein LSm8 | UniProt NCBI |
| LSM4 | U6 snRNA-associated Sm-like protein LSm4 (Glycine-rich protein) (GRP) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:562 | 1.72073925015e-19 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | LSm2-8 complex |
| GO:0120115 | 1.61749489514e-16 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | Lsm2-8 complex |
| GO:0005688 | 6.46960706472e-16 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | U6 snRNP |
| CORUM:561 | 3.84237387544e-15 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | LSm1-7 complex |
| GO:0071005 | 1.55035512047e-13 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | U2-type precatalytic spliceosome |
| GO:0071011 | 1.797002526e-13 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | precatalytic spliceosome |
| REAC:R-HSA-430039 | 1.72585087844e-12 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | mRNA decay by 5' to 3' exoribonuclease |
| REAC:R-HSA-72163 | 5.17487163652e-12 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | mRNA Splicing - Major Pathway |
| KEGG:03018 | 5.27418682697e-12 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | RNA degradation |
| REAC:R-HSA-72172 | 7.07632631111e-12 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | mRNA Splicing |
| GO:0005684 | 1.2563082059e-11 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | U2-type spliceosomal complex |
| GO:0046540 | 1.37022312199e-11 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | U4/U6 x U5 tri-snRNP complex |
| GO:0097526 | 1.37022312199e-11 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | spliceosomal tri-snRNP complex |
| REAC:R-HSA-72203 | 3.72507243281e-11 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | Processing of Capped Intron-Containing Pre-mRNA |
| KEGG:03040 | 1.43418364817e-10 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | Spliceosome |
| GO:0005681 | 7.56587227283e-10 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | spliceosomal complex |
| GO:0097525 | 8.36101257106e-10 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | spliceosomal snRNP complex |
| GO:0030532 | 1.56495974842e-09 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | small nuclear ribonucleoprotein complex |
| REAC:R-HSA-429914 | 2.18521316311e-09 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | Deadenylation-dependent mRNA decay |
| GO:0120114 | 4.26409003356e-09 | 0.857142857143 | LSM2 LSM3 LSM6 LSM4 LSM8 LSM7 | Sm-like protein family complex |
| GO:0043928 | 4.07011563508e-08 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | exonucleolytic catabolism of deadenylated mRNA |
| REAC:R-HSA-8953854 | 4.99493959204e-08 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | Metabolism of RNA |
| GO:0000291 | 5.56592142557e-08 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | nuclear-transcribed mRNA catabolic process, exonucleolytic |
| CORUM:351 | 7.51606177576e-08 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | Spliceosome |
| GO:0000377 | 8.28225620865e-08 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile |
| GO:0000398 | 8.28225620865e-08 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | mRNA splicing, via spliceosome |
| GO:0000375 | 8.86181505403e-08 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | RNA splicing, via transesterification reactions |
| GO:0008380 | 2.76134260047e-07 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | RNA splicing |
| GO:0017070 | 2.81450928027e-07 | 0.571428571429 | LSM7 LSM4 LSM2 LSM8 | U6 snRNA binding |
| GO:0006397 | 4.62001819528e-07 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | mRNA processing |
| GO:0000288 | 2.06696589169e-06 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay |
| GO:0016071 | 2.80091136626e-05 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | mRNA metabolic process |
| GO:1990726 | 3.17736949706e-05 | 0.428571428571 | LSM7 LSM2 LSM3 | Lsm1-7-Pat1 complex |
| GO:1990904 | 4.11074957841e-05 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | ribonucleoprotein complex |
| GO:0006396 | 4.89752975606e-05 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | RNA processing |
| GO:0017069 | 5.60927563414e-05 | 0.571428571429 | LSM7 LSM4 LSM2 LSM8 | snRNA binding |
| CORUM:1181 | 0.000253390302973 | 0.428571428571 | CWC27 LSM2 LSM3 | C complex spliceosome |
| GO:0000956 | 0.000395509369864 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | nuclear-transcribed mRNA catabolic process |
| GO:0000932 | 0.00057242223549 | 0.571428571429 | LSM3 LSM4 LSM6 LSM2 | P-body |
| CORUM:5613 | 0.00120480805051 | 0.285714285714 | LSM2 LSM8 | Emerin complex 25 |
| GO:0071013 | 0.00154914988886 | 0.571428571429 | LSM3 CWC27 LSM2 LSM7 | catalytic step 2 spliceosome |
| CORUM:0000000 | 0.00178557880024 | 1.0 | LSM2 LSM4 LSM6 LSM3 CWC27 LSM8 LSM7 | CORUM root |
| GO:0006402 | 0.00582560339799 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | mRNA catabolic process |
| GO:0006401 | 0.00891451540705 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | RNA catabolic process |
| GO:0034655 | 0.0271422741221 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | nucleobase-containing compound catabolic process |
| GO:0036464 | 0.0375020380686 | 0.571428571429 | LSM3 LSM4 LSM6 LSM2 | cytoplasmic ribonucleoprotein granule |
| GO:0046700 | 0.0390972199184 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | heterocycle catabolic process |
| GO:0044270 | 0.0394916293115 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | cellular nitrogen compound catabolic process |
| GO:0019439 | 0.0444762556298 | 0.714285714286 | LSM3 LSM7 LSM4 LSM6 LSM2 | aromatic compound catabolic process |
| GO:0035770 | 0.0464002563396 | 0.571428571429 | LSM3 LSM4 LSM6 LSM2 | ribonucleoprotein granule |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| LSM8 | LSM6 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM3 | 1.0 | 0.949 | bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM6 | 1.0 | 0.949 | youn (LSM2) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM6 | LSM3 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM Malo fraction boldt_WMM |
| LSM8 | LSM2 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru boldt youn_WMM fraction boldt_WMM |
| LSM2 | LSM3 | 1.0 | 0.949 | youn (LSM2) bioplex_WMM Guru youn_WMM gupta_WMM fraction boldt_WMM |
| LSM8 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM2 | LSM4 | 1.0 | 0.949 | youn (LSM2,LSM4) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM |
| LSM6 | LSM7 | 1.0 | 0.949 | bioplex (LSM6) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | LSM4 | 1.0 | 0.949 | youn (LSM4) bioplex (LSM6) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| LSM3 | LSM7 | 0.999 | 0.949 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM3 | CWC27 | 0.988 | 0.901 | bioplex_WMM youn_WMM fraction |
| LSM4 | LSM3 | 0.959 | 0.863 | youn (LSM4) bioplex_WMM Guru youn_WMM Malo gupta_WMM fraction boldt_WMM |
| LSM2 | LSM7 | 0.952 | 0.858 | youn (LSM2) bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM8 | LSM7 | 0.945 | 0.856 | bioplex_WMM Guru youn_WMM fraction boldt_WMM |
| LSM6 | CWC27 | 0.88 | 0.813 | bioplex_WMM youn_WMM fraction |
| LSM2 | CWC27 | 0.849 | 0.79 | bioplex_WMM youn_WMM fraction |
| LSM4 | CWC27 | 0.035 | 0.261 | bioplex_WMM youn_WMM fraction |
| LSM8 | CWC27 | 0.008 | 0.031 | bioplex_WMM youn_WMM fraction |
| LSM4 | LSM7 | 0.005 | 0.007 | youn (LSM4) bioplex_WMM Guru youn_WMM fraction boldt_WMM treiber_WMM |
| LSM7 | CWC27 | 0.0 | 0.008 | youn_WMM fraction |
Images
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Complex HuMAP2_06601 has an average edge precision of 0.754 which is ranked 1126 out of all 6965 complexes.
Related Complexes