hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06602
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| AKR1B10 | Aldo-keto reductase family 1 member B10 (EC 1.1.1.300) (EC 1.1.1.54) (ARL-1) (Aldose reductase-like) (Aldose reductase-related protein) (ARP) (hARP) (Small intestine reductase) (SI reductase) | UniProt NCBI |
| LDHA | L-lactate dehydrogenase A chain (LDH-A) (EC 1.1.1.27) (Cell proliferation-inducing gene 19 protein) (LDH muscle subunit) (LDH-M) (Renal carcinoma antigen NY-REN-59) | UniProt NCBI |
| PPIAL4D | Peptidyl-prolyl cis-trans isomerase A-like 4D (PPIase A-like 4D) (EC 5.2.1.8) | UniProt NCBI |
| AKR1B15 | Aldo-keto reductase family 1 member B15 (EC 1.1.1.-) (EC 1.1.1.300) (EC 1.1.1.54) (Estradiol 17-beta-dehydrogenase AKR1B15) (Farnesol dehydrogenase) (EC 1.1.1.216) (Testosterone 17beta-dehydrogenase) (EC 1.1.1.64) | UniProt NCBI |
| LDHB | L-lactate dehydrogenase B chain (LDH-B) (EC 1.1.1.27) (LDH heart subunit) (LDH-H) (Renal carcinoma antigen NY-REN-46) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0016616 | 0.000495430747346 | 0.8 | AKR1B15 AKR1B10 LDHB LDHA | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0016614 | 0.000650038064497 | 0.8 | AKR1B15 AKR1B10 LDHB LDHA | oxidoreductase activity, acting on CH-OH group of donors |
| KEGG:00640 | 0.00239834964959 | 0.4 | LDHB LDHA | Propanoate metabolism |
| WP:WP534 | 0.00314132080553 | 0.4 | LDHB LDHA | Glycolysis and Gluconeogenesis |
| KEGG:00620 | 0.00316574451287 | 0.4 | LDHB LDHA | Pyruvate metabolism |
| KEGG:00270 | 0.00441762805526 | 0.4 | LDHB LDHA | Cysteine and methionine metabolism |
| REAC:R-HSA-70268 | 0.00546022370076 | 0.4 | LDHB LDHA | Pyruvate metabolism |
| KEGG:00010 | 0.00831682765542 | 0.4 | LDHB LDHA | Glycolysis / Gluconeogenesis |
| KEGG:05230 | 0.00941045001151 | 0.4 | LDHB LDHA | Central carbon metabolism in cancer |
| WP:WP4018 | 0.0104424923561 | 0.4 | LDHB LDHA | Pathways in clear cell renal cell carcinoma |
| REAC:R-HSA-71406 | 0.017778070678 | 0.4 | LDHB LDHA | Pyruvate metabolism and Citric Acid (TCA) cycle |
| KEGG:04922 | 0.0193326076279 | 0.4 | LDHB LDHA | Glucagon signaling pathway |
| KEGG:04066 | 0.020974746694 | 0.4 | LDHB LDHA | HIF-1 signaling pathway |
| MIRNA:hsa-miR-5585-5p | 0.0435496282017 | 0.4 | AKR1B10 LDHA | hsa-miR-5585-5p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| AKR1B10 | AKR1B15 | 0.998 | 0.939 | bioplex (AKR1B10) bioplex_WMM |
| LDHB | AKR1B15 | 0.709 | 0.728 | fraction |
| LDHA | AKR1B15 | 0.709 | 0.729 | fraction treiber_WMM |
| AKR1B15 | PPIAL4D | 0.69 | 0.715 | fraction |
| LDHA | AKR1B10 | 0.246 | 0.469 | bioplex (AKR1B10) fraction treiber_WMM |
| AKR1B10 | LDHB | 0.241 | 0.468 | bioplex (AKR1B10) fraction treiber_WMM |
| LDHA | LDHB | 0.203 | 0.455 | hein_WMM bioplex (LDHA,LDHB) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_06602 has an average edge precision of 0.643 which is ranked 1685 out of all 6965 complexes.
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