hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06605
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| FGFR1 | Fibroblast growth factor receptor 1 (FGFR-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (BFGFR) (bFGF-R-1) (Fms-like tyrosine kinase 2) (FLT-2) (N-sam) (Proto-oncogene c-Fgr) (CD antigen CD331) | UniProt NCBI |
| FGFR2 | Fibroblast growth factor receptor 2 (FGFR-2) (EC 2.7.10.1) (K-sam) (KGFR) (Keratinocyte growth factor receptor) (CD antigen CD332) | UniProt NCBI |
| RPS6KA3 | Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (Insulin-stimulated protein kinase 1) (ISPK-1) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) | UniProt NCBI |
| FGFR3 | Fibroblast growth factor receptor 3 (FGFR-3) (EC 2.7.10.1) (CD antigen CD333) | UniProt NCBI |
| DNAJC30 | DnaJ homolog subfamily C member 30, mitochondrial (Williams-Beuren syndrome chromosomal region 18 protein) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0003795 | 9.36085359213e-08 | 0.6 | FGFR2 FGFR3 FGFR1 | Short middle phalanx of toe |
| HP:0002676 | 3.27563865676e-07 | 0.6 | FGFR2 FGFR3 FGFR1 | Cloverleaf skull |
| HP:0010183 | 7.85994870532e-07 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the middle phalanges of the toes |
| HP:0000678 | 1.08331624297e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Dental crowding |
| HP:0100538 | 1.69507317585e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the supraorbital ridges |
| HP:0100498 | 2.65861240424e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Deviation of toes |
| HP:0001500 | 2.78658791667e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Broad finger |
| HP:0000327 | 4.70955338699e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Hypoplasia of the maxilla |
| HP:0000326 | 7.48789722069e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the maxilla |
| HP:0004440 | 7.62845613622e-06 | 0.6 | FGFR2 FGFR3 FGFR1 | Coronal craniosynostosis |
| HP:0000506 | 8.04931916476e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Telecanthus |
| WP:WP382 | 8.32729603862e-06 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | MAPK Signaling Pathway |
| GO:0005007 | 9.08002798436e-06 | 0.6 | FGFR2 FGFR3 FGFR1 | fibroblast growth factor-activated receptor activity |
| HP:0008368 | 1.65480236581e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Tarsal synostosis |
| KEGG:04010 | 2.00306229537e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | MAPK signaling pathway |
| HP:0009138 | 2.42867577851e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the lower limbs |
| HP:0009140 | 2.42867577851e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the feet |
| WP:WP4155 | 2.52916810244e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Endometrial cancer |
| HP:0000606 | 3.2788105727e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the periorbital region |
| HP:0000262 | 3.41219105177e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Turricephaly |
| HP:0009803 | 3.8960999147e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short phalanx of finger |
| KEGG:05230 | 4.11682217947e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Central carbon metabolism in cancer |
| HP:0006482 | 4.49113443655e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of dental morphology |
| HP:0006292 | 4.5965589507e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of dental eruption |
| HP:0005347 | 4.64766403483e-05 | 0.4 | FGFR2 FGFR1 | Cartilaginous trachea |
| HP:0008122 | 4.64766403483e-05 | 0.4 | FGFR2 FGFR1 | Calcaneonavicular fusion |
| WP:WP2064 | 4.69458396902e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Neural Crest Differentiation |
| HP:0005819 | 6.1081767866e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Short middle phalanx of finger |
| REAC:R-HSA-1226099 | 6.33776832781e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Signaling by FGFR in disease |
| HP:0009767 | 6.41111781023e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the phalanges of the hand |
| WP:WP4540 | 7.07040269841e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Pathways Regulating Hippo Signaling |
| HP:0010055 | 7.87058594756e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad hallux |
| HP:0010051 | 9.21594329683e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Deviation of the hallux |
| HP:0011800 | 9.60583515574e-05 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Midface retrusion |
| HP:0100266 | 9.94251439245e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Synostosis of carpals/tarsals |
| HP:0009843 | 9.94251439245e-05 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the middle phalanges of the hand |
| WP:WP3931 | 0.000101342892843 | 0.6 | FGFR2 FGFR3 FGFR1 | ESC Pluripotency Pathways |
| HP:0000940 | 0.000107625221209 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal diaphysis morphology |
| HP:0009381 | 0.000109649926687 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short finger |
| HP:0009804 | 0.000111703009259 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Reduced number of teeth |
| WP:WP4541 | 0.00011435890921 | 0.6 | FGFR2 FGFR3 FGFR1 | Hippo-Merlin Signaling Dysregulation |
| HP:0009833 | 0.000115080494194 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal middle phalanx morphology of the hand |
| HP:0000692 | 0.000124632211735 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Misalignment of teeth |
| HP:0011329 | 0.000136235753783 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of cranial sutures |
| HP:0009637 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Absent proximal phalanx of thumb |
| HP:0008454 | 0.000139411195565 | 0.4 | RPS6KA3 FGFR3 | Lumbar kyphosis |
| HP:0032107 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Limbal stem cell deficiency |
| HP:0009899 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Prominent crus of helix |
| HP:0100583 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Corneal perforation |
| HP:0009741 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Nephrosclerosis |
| HP:0009462 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Radial deviation of the 3rd finger |
| HP:0009740 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Aplasia of the parotid gland |
| HP:0007892 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Hypoplasia of the lacrimal punctum |
| HP:0007656 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Lacrimal gland aplasia |
| HP:0005707 | 0.000139411195565 | 0.4 | FGFR2 FGFR3 | Bilateral triphalangeal thumbs |
| HP:0000614 | 0.00014151146773 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal nasolacrimal system morphology |
| HP:0001837 | 0.000151144719414 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad toe |
| HP:0100257 | 0.000161204760273 | 0.6 | FGFR2 FGFR3 FGFR1 | Ectrodactyly |
| HP:0006483 | 0.00016459429265 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal number of teeth |
| HP:0000629 | 0.000171700780036 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Periorbital fullness |
| HP:0000676 | 0.000194037496444 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the incisor |
| HP:0002308 | 0.000194037496444 | 0.6 | FGFR2 FGFR3 FGFR1 | Arnold-Chiari malformation |
| HP:0003312 | 0.000197154877826 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal form of the vertebral bodies |
| HP:0006265 | 0.000200336761049 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of fingers |
| HP:0007360 | 0.000227195240448 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the cerebellum |
| HP:0001156 | 0.000230732596549 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Brachydactyly |
| WP:WP51 | 0.00024878117453 | 0.6 | FGFR2 FGFR3 FGFR1 | Regulation of Actin Cytoskeleton |
| HP:0000270 | 0.000258151477707 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Delayed cranial suture closure |
| KEGG:04550 | 0.000258594789588 | 0.6 | FGFR2 FGFR3 FGFR1 | Signaling pathways regulating pluripotency of stem cells |
| HP:0100871 | 0.000268416035925 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the palm |
| HP:0011318 | 0.000278784943944 | 0.4 | FGFR2 FGFR1 | Bicoronal synostosis |
| HP:0007732 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Lacrimal gland hypoplasia |
| HP:0008743 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Coronal hypospadias |
| HP:0007900 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Hypoplastic lacrimal duct |
| HP:0008080 | 0.000278784943944 | 0.4 | FGFR2 FGFR1 | Hallux varus |
| HP:0005037 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Proximal radio-ulnar synostosis |
| HP:0000198 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Absence of Stensen duct |
| HP:0009317 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Deviation of the 3rd finger |
| HP:0009629 | 0.000278784943944 | 0.4 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the proximal phalanx of the thumb |
| HP:0011304 | 0.000302658877703 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad thumb |
| HP:0010535 | 0.000302658877703 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Sleep apnea |
| HP:0011218 | 0.000319506624551 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal shape of the frontal region |
| HP:0005922 | 0.000319506624551 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal hand morphology |
| HP:0002007 | 0.000319506624551 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Frontal bossing |
| HP:0002360 | 0.000372428600161 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Sleep disturbance |
| WP:WP4223 | 0.000403236542348 | 0.6 | FGFR2 FGFR3 FGFR1 | Ras Signaling |
| HP:0001159 | 0.00040391961752 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Syndactyly |
| HP:0000235 | 0.000420391650331 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the fontanelles or cranial sutures |
| HP:0004691 | 0.000445635390561 | 0.6 | FGFR2 RPS6KA3 FGFR1 | 2-3 toe syndactyly |
| HP:0011479 | 0.00046457916755 | 0.4 | FGFR2 FGFR3 | Abnormal lacrimal punctum morphology |
| HP:0008038 | 0.00046457916755 | 0.4 | FGFR2 FGFR3 | Aplastic/hypoplastic lacrimal glands |
| HP:0001092 | 0.00046457916755 | 0.4 | FGFR2 FGFR3 | Absent lacrimal punctum |
| HP:0009768 | 0.000509063514163 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad phalanges of the hand |
| HP:0000256 | 0.000516883468613 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Macrocephaly |
| HP:0040194 | 0.000516883468613 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Increased head circumference |
| HP:0001831 | 0.000531468488208 | 0.6 | FGFR2 FGFR3 FGFR1 | Short toe |
| HP:0040070 | 0.000577947900247 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal upper limb bone morphology |
| HP:0000973 | 0.000602597659635 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Cutis laxa |
| HP:0003468 | 0.000606752604166 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal vertebral morphology |
| HP:0001850 | 0.000627642453711 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the tarsal bones |
| HP:0006501 | 0.000653369933832 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the radius |
| HP:0000601 | 0.00067978918494 | 0.6 | FGFR2 FGFR3 FGFR1 | Hypotelorism |
| HP:0010239 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Aplasia of the middle phalanx of the hand |
| HP:0001245 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Small thenar eminence |
| HP:0009895 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Abnormality of the crus of the helix |
| HP:0011482 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Abnormal lacrimal gland morphology |
| HP:0000620 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Dacryocystitis |
| HP:0009618 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Abnormality of the proximal phalanx of the thumb |
| HP:0001227 | 0.000696775152219 | 0.4 | FGFR2 FGFR3 | Abnormality of the thenar eminence |
| KEGG:04015 | 0.000721004021602 | 0.6 | FGFR2 FGFR3 FGFR1 | Rap1 signaling pathway |
| GO:0017134 | 0.000739960245213 | 0.6 | FGFR2 FGFR3 FGFR1 | fibroblast growth factor binding |
| HP:0000494 | 0.000758491406495 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Downslanted palpebral fissures |
| HP:0030084 | 0.000775968644208 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Clinodactyly |
| HP:0000689 | 0.00079256546738 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Dental malocclusion |
| HP:0005280 | 0.000839518231679 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Depressed nasal bridge |
| HP:0005927 | 0.000848904522044 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia involving bones of the hand |
| KEGG:04014 | 0.000867405343471 | 0.6 | FGFR2 FGFR3 FGFR1 | Ras signaling pathway |
| KEGG:04810 | 0.000910491071115 | 0.6 | FGFR2 FGFR3 FGFR1 | Regulation of actin cytoskeleton |
| HP:0004279 | 0.000917135910141 | 0.6 | FGFR2 FGFR3 FGFR1 | Short palm |
| HP:0000286 | 0.000967765284185 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Epicanthus |
| HP:0009659 | 0.00097535418756 | 0.4 | FGFR2 FGFR3 | Partial absence of thumb |
| HP:0006110 | 0.00097535418756 | 0.4 | FGFR2 FGFR1 | Shortening of all middle phalanges of the fingers |
| HP:0003070 | 0.00097535418756 | 0.4 | FGFR2 FGFR1 | Elbow ankylosis |
| HP:0004150 | 0.00097535418756 | 0.4 | FGFR2 FGFR3 | Abnormal 3rd finger morphology |
| HP:0000244 | 0.00097535418756 | 0.4 | FGFR2 FGFR1 | Brachyturricephaly |
| HP:0000236 | 0.00098402511782 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of the anterior fontanelle |
| HP:0006503 | 0.0010540801576 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving forearm bones |
| HP:0009601 | 0.00109031746259 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of the thumb |
| HP:0100238 | 0.00112737333582 | 0.6 | FGFR2 FGFR3 FGFR1 | Synostosis involving bones of the upper limbs |
| HP:0003745 | 0.00112737333582 | 0.6 | FGFR1 FGFR3 RPS6KA3 | Sporadic |
| HP:0006496 | 0.00118085147505 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia involving bones of the upper limbs |
| HP:0006009 | 0.00120397689915 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad phalanx |
| HP:0000453 | 0.00120397689915 | 0.6 | FGFR2 FGFR3 FGFR1 | Choanal atresia |
| HP:0001792 | 0.00124354263601 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Small nail |
| HP:0000889 | 0.00128396303463 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the clavicle |
| HP:3000022 | 0.00130029756695 | 0.4 | FGFR2 FGFR3 | Abnormality of cartilage of external ear |
| HP:0000197 | 0.00130029756695 | 0.4 | FGFR2 FGFR3 | Abnormal parotid gland morphology |
| HP:0011927 | 0.00130615453284 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short digit |
| HP:0001991 | 0.00132524710908 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia of toe |
| HP:0001773 | 0.00136740386969 | 0.6 | FGFR2 FGFR3 FGFR1 | Short foot |
| HP:0000415 | 0.00141044232307 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the choanae |
| HP:0005622 | 0.00149920031601 | 0.6 | FGFR2 FGFR3 FGFR1 | Broad long bones |
| HP:0010161 | 0.00149920031601 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the phalanges of the toes |
| HP:0003764 | 0.00149920031601 | 0.6 | FGFR2 FGFR3 FGFR1 | Nevus |
| HP:0000309 | 0.00151240558538 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the midface |
| HP:0001783 | 0.00167158658755 | 0.4 | FGFR2 FGFR1 | Broad metatarsal |
| HP:0001233 | 0.00167158658755 | 0.4 | FGFR2 FGFR3 | 2-3 finger syndactyly |
| HP:0000008 | 0.00167844129266 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of female internal genitalia |
| WP:WP3932 | 0.00181204447901 | 0.6 | FGFR2 FGFR3 FGFR1 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| HP:0000463 | 0.0018747089112 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Anteverted nares |
| HP:0001844 | 0.00189129875245 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the hallux |
| HP:0008067 | 0.00194462919809 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormally lax or hyperextensible skin |
| HP:0005288 | 0.00208763178388 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the nares |
| HP:0002781 | 0.00208920255027 | 0.4 | FGFR2 FGFR3 | Upper airway obstruction |
| HP:0003938 | 0.00208920255027 | 0.4 | FGFR2 FGFR1 | Synostosis involving the elbow |
| HP:0003041 | 0.00208920255027 | 0.4 | FGFR2 FGFR1 | Humeroradial synostosis |
| HP:0000812 | 0.00223927995528 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal internal genitalia |
| HP:0045060 | 0.00225879835476 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia involving bones of the extremities |
| HP:0000218 | 0.00231811633149 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | High palate |
| HP:0000954 | 0.00234614920866 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Single transverse palmar crease |
| HP:0000104 | 0.00240764613107 | 0.6 | FGFR2 FGFR3 FGFR1 | Renal agenesis |
| WP:WP4172 | 0.00254843909372 | 0.6 | FGFR2 FGFR3 FGFR1 | PI3K-Akt Signaling Pathway |
| HP:0009802 | 0.0025531267598 | 0.4 | FGFR2 FGFR3 | Aplasia of the phalanges of the hand |
| HP:0009823 | 0.0025531267598 | 0.4 | FGFR2 FGFR3 | Aplasia involving bones of the upper limbs |
| HP:0410007 | 0.0025531267598 | 0.4 | FGFR2 FGFR3 | Abnormality of cartilage morphology |
| HP:0000303 | 0.00266433352331 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Mandibular prognathia |
| HP:0001363 | 0.00266433352331 | 0.6 | FGFR2 FGFR3 FGFR1 | Craniosynostosis |
| HP:0010460 | 0.00272124462781 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the female genitalia |
| HP:0002119 | 0.00272124462781 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Ventriculomegaly |
| HP:0001780 | 0.00278938291813 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of toe |
| HP:0005916 | 0.00279922194915 | 0.6 | FGFR1 FGFR3 RPS6KA3 | Abnormal metacarpal morphology |
| HP:0100755 | 0.00279922194915 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of salivation |
| HP:0200006 | 0.00295332132996 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Slanting of the palpebral fissure |
| HP:0011314 | 0.00300145409113 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of long bone morphology |
| HP:0009815 | 0.00305017006216 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia of the extremities |
| HP:0009944 | 0.0030633405246 | 0.4 | FGFR2 FGFR3 | Partial duplication of thumb phalanx |
| HP:0000680 | 0.0030633405246 | 0.4 | FGFR2 FGFR3 | Delayed eruption of primary teeth |
| HP:0000522 | 0.0030633405246 | 0.4 | FGFR2 FGFR3 | Alacrima |
| HP:0011386 | 0.0030633405246 | 0.4 | FGFR2 FGFR3 | Narrow internal auditory canal |
| HP:0009602 | 0.00308244473231 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of thumb phalanx |
| HP:0000429 | 0.00327673387131 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the nasal alae |
| HP:0006711 | 0.00330690735156 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia involving bones of the thorax |
| HP:0009774 | 0.00330690735156 | 0.6 | FGFR2 FGFR3 FGFR1 | Triangular shaped phalanges of the hand |
| HP:0005918 | 0.00335497414372 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal finger phalanx morphology |
| HP:0040069 | 0.00343460048625 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal lower limb bone morphology |
| HP:0002342 | 0.0034624184084 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Intellectual disability, moderate |
| HP:0000495 | 0.00361982515692 | 0.4 | FGFR2 FGFR3 | Recurrent corneal erosions |
| HP:0009999 | 0.00361982515692 | 0.4 | FGFR2 FGFR3 | Partial duplication of the phalanx of hand |
| HP:0000377 | 0.00368195710745 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the pinna |
| HP:0000668 | 0.00370466652798 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Hypodontia |
| HP:0000316 | 0.00373868304213 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Hypertelorism |
| KEGG:04151 | 0.00373902224905 | 0.6 | FGFR2 FGFR3 FGFR1 | PI3K-Akt signaling pathway |
| HP:0000684 | 0.00387225643734 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Delayed eruption of teeth |
| HP:0000189 | 0.00387225643734 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Narrow palate |
| HP:0007370 | 0.00403215607607 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the corpus callosum |
| HP:0009825 | 0.00422256197273 | 0.4 | FGFR2 FGFR3 | Aplasia involving bones of the extremities |
| HP:0010286 | 0.00422256197273 | 0.4 | FGFR2 FGFR3 | Abnormal salivary gland morphology |
| HP:0000452 | 0.00422256197273 | 0.4 | FGFR2 FGFR1 | Choanal stenosis |
| WP:WP474 | 0.00422982513182 | 0.4 | FGFR1 FGFR3 | Endochondral Ossification |
| HP:0002242 | 0.00431067736159 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal intestine morphology |
| HP:0010490 | 0.00431306699981 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of the palmar creases |
| HP:0001428 | 0.00431306699981 | 0.6 | FGFR2 FGFR3 FGFR1 | Somatic mutation |
| HP:0100240 | 0.00440504317323 | 0.6 | FGFR2 FGFR3 FGFR1 | Synostosis of joints |
| HP:0010936 | 0.00457008280214 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the lower urinary tract |
| HP:0001018 | 0.00468875889337 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormal palmar dermatoglyphics |
| HP:0002780 | 0.00487153229182 | 0.4 | FGFR2 FGFR1 | Bronchomalacia |
| HP:0000586 | 0.00487153229182 | 0.4 | FGFR2 FGFR1 | Shallow orbits |
| HP:3000030 | 0.00487153229182 | 0.4 | FGFR2 FGFR1 | Abnormality of bony orbit of skull |
| HP:0000410 | 0.00487153229182 | 0.4 | FGFR2 FGFR3 | Mixed hearing impairment |
| HP:0011384 | 0.00487153229182 | 0.4 | FGFR2 FGFR3 | Abnormality of the internal auditory canal |
| HP:0100761 | 0.00487153229182 | 0.4 | FGFR2 FGFR1 | Visceral angiomatosis |
| HP:0010647 | 0.00498434077123 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormal elasticity of skin |
| HP:0008050 | 0.00505184645775 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the palpebral fissures |
| HP:0000248 | 0.00529202687437 | 0.6 | FGFR2 FGFR3 FGFR1 | Brachycephaly |
| HP:0011328 | 0.00539731984092 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of fontanelles |
| HP:0003026 | 0.00539731984092 | 0.6 | FGFR2 FGFR3 FGFR1 | Short long bone |
| HP:0000633 | 0.00556671743772 | 0.4 | FGFR2 FGFR3 | Decreased lacrimation |
| HP:0100712 | 0.00556671743772 | 0.4 | RPS6KA3 FGFR3 | Abnormality of the lumbar spine |
| HP:0100702 | 0.00556671743772 | 0.4 | FGFR2 FGFR1 | Arachnoid cyst |
| HP:0100700 | 0.00556671743772 | 0.4 | FGFR2 FGFR1 | Abnormal arachnoid mater morphology |
| HP:0010059 | 0.00556671743772 | 0.4 | FGFR2 FGFR1 | Broad hallux phalanx |
| HP:0008386 | 0.00561205497082 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Aplasia/Hypoplasia of the nails |
| HP:0001273 | 0.00564773325088 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal corpus callosum morphology |
| HP:0002818 | 0.0061735066244 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the radius |
| HP:0001163 | 0.00629008671885 | 0.6 | FGFR1 FGFR3 RPS6KA3 | Abnormality of the metacarpal bones |
| HP:0002410 | 0.00630809873773 | 0.4 | FGFR2 FGFR1 | Aqueductal stenosis |
| HP:0007461 | 0.00630809873773 | 0.4 | FGFR2 FGFR1 | Hemangiomatosis |
| HP:0006101 | 0.00640811720481 | 0.6 | FGFR2 FGFR3 FGFR1 | Finger syndactyly |
| HP:0000130 | 0.0066485644099 | 0.6 | FGFR1 FGFR3 RPS6KA3 | Abnormality of the uterus |
| HP:0001770 | 0.00689491832004 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Toe syndactyly |
| HP:0002118 | 0.00708652002063 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the cerebral ventricles |
| HP:0002648 | 0.00708652002063 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of calvarial morphology |
| HP:0011065 | 0.00709565752293 | 0.4 | FGFR2 FGFR3 | Conical incisor |
| HP:0031013 | 0.00709565752293 | 0.4 | FGFR2 FGFR1 | Ankylosis |
| HP:0000587 | 0.00717888856225 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the optic nerve |
| HP:0000272 | 0.00740562628173 | 0.6 | FGFR2 FGFR3 FGFR1 | Malar flattening |
| HP:0040072 | 0.00753710429965 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of forearm bone |
| HP:0002973 | 0.00780468270807 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the forearm |
| HP:0000579 | 0.00792937512816 | 0.4 | FGFR2 FGFR3 | Nasolacrimal duct obstruction |
| WP:WP4657 | 0.00799132765459 | 0.4 | FGFR2 FGFR1 | 22q11.2 Deletion Syndrome |
| HP:0100807 | 0.00807848245275 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Long fingers |
| HP:0001317 | 0.0083587342088 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal cerebellum morphology |
| HP:0012369 | 0.00850099965 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of malar bones |
| HP:0011283 | 0.00856859850873 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the metencephalon |
| HP:0011282 | 0.00856859850873 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of hindbrain morphology |
| HP:0000407 | 0.00878236549578 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Sensorineural hearing impairment |
| HP:0000520 | 0.00879065778809 | 0.6 | FGFR2 FGFR3 FGFR1 | Proptosis |
| HP:0000882 | 0.00880923289202 | 0.4 | FGFR1 FGFR3 | Hypoplastic scapulae |
| HP:0007477 | 0.0089379069678 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormal dermatoglyphics |
| HP:0000765 | 0.00927785594799 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the thorax |
| HP:0000348 | 0.00938943928499 | 0.6 | FGFR2 FGFR3 FGFR1 | High forehead |
| HP:0001169 | 0.00973521215689 | 0.4 | FGFR1 RPS6KA3 | Broad palm |
| HP:0009811 | 0.00985583118217 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the elbow |
| HP:0002500 | 0.00997055798897 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the cerebral white matter |
| HP:0000164 | 0.00997055798897 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the dentition |
| HP:0009826 | 0.0101751301432 | 0.6 | FGFR2 FGFR3 FGFR1 | Limb undergrowth |
| HP:0006487 | 0.0105012068371 | 0.6 | FGFR2 FGFR3 FGFR1 | Bowing of the long bones |
| HP:0002823 | 0.0105012068371 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of femur morphology |
| HP:0031815 | 0.0105012068371 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormal oral physiology |
| HP:0000277 | 0.0106387322837 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the mandible |
| HP:0006713 | 0.0107072942689 | 0.4 | FGFR1 FGFR3 | Aplasia/Hypoplasia of the scapulae |
| HP:0001355 | 0.0107072942689 | 0.4 | FGFR2 FGFR3 | Megalencephaly |
| HP:0002032 | 0.0107072942689 | 0.4 | FGFR2 FGFR1 | Esophageal atresia |
| WP:WP2261 | 0.0109715753892 | 0.4 | FGFR2 FGFR1 | Signaling Pathways in Glioblastoma |
| HP:0010938 | 0.0110169532253 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the external nose |
| GO:0010518 | 0.0111628079368 | 0.6 | FGFR2 FGFR3 FGFR1 | positive regulation of phospholipase activity |
| HP:0010668 | 0.0111739705033 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the zygomatic bone |
| HP:0006504 | 0.0111739705033 | 0.6 | FGFR2 FGFR3 FGFR1 | Anomaly of the limb diaphyses |
| HP:0100886 | 0.0113397146668 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of globe location |
| HP:0006494 | 0.0113465056889 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/Hypoplasia involving bones of the feet |
| KEGG:01521 | 0.0114851584748 | 0.4 | FGFR2 FGFR3 | EGFR tyrosine kinase inhibitor resistance |
| HP:0040211 | 0.0116968496783 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormality of the skin of the palm |
| HP:0009738 | 0.011725460578 | 0.4 | FGFR2 FGFR3 | Abnormality of the antihelix |
| HP:0011354 | 0.0118033507746 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Generalized abnormality of skin |
| HP:0000486 | 0.0119383735197 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Strabismus |
| HP:0002104 | 0.0124188738287 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Apnea |
| GO:0001501 | 0.0125305574836 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | skeletal system development |
| HP:0000290 | 0.0126308245049 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the forehead |
| HP:0011389 | 0.0127728269628 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Functional abnormality of the inner ear |
| HP:0003974 | 0.0127896924378 | 0.4 | FGFR2 FGFR3 | Absent radius |
| HP:0002683 | 0.0128442724502 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the calvaria |
| HP:0030791 | 0.012988055981 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal jaw morphology |
| HP:0000422 | 0.0134266053844 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the nasal bridge |
| HP:0000359 | 0.0135752098131 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the inner ear |
| HP:0000549 | 0.0136499696929 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal conjugate eye movement |
| HP:0005105 | 0.0137250357747 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal nasal morphology |
| KEGG:05200 | 0.0137388951306 | 0.6 | FGFR2 FGFR3 FGFR1 | Pathways in cancer |
| HP:0001377 | 0.0138999712057 | 0.4 | FGFR2 FGFR3 | Limited elbow extension |
| HP:0003953 | 0.0138999712057 | 0.4 | FGFR2 FGFR3 | Absent forearm bone |
| HP:0009822 | 0.0138999712057 | 0.4 | FGFR2 FGFR3 | Aplasia involving forearm bones |
| HP:0010109 | 0.0138999712057 | 0.4 | FGFR2 FGFR1 | Short hallux |
| HP:0000306 | 0.0141499625944 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Abnormality of the chin |
| HP:0011481 | 0.0150562782431 | 0.4 | FGFR2 FGFR3 | Abnormal lacrimal duct morphology |
| HP:0004493 | 0.0150562782431 | 0.4 | FGFR1 RPS6KA3 | Craniofacial hyperostosis |
| HP:0009942 | 0.0150562782431 | 0.4 | FGFR2 FGFR3 | Duplication of thumb phalanx |
| HP:0010993 | 0.0154556290894 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the cerebral subcortex |
| HP:0000174 | 0.0162084757532 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal palate morphology |
| HP:0008678 | 0.0162526588224 | 0.6 | FGFR2 FGFR3 FGFR1 | Renal hypoplasia/aplasia |
| HP:0000243 | 0.0162585949147 | 0.4 | FGFR2 FGFR1 | Trigonocephaly |
| HP:0008362 | 0.0162585949147 | 0.4 | FGFR2 FGFR1 | Aplasia/Hypoplasia of the hallux |
| WP:WP4321 | 0.0163136918731 | 0.4 | FGFR1 RPS6KA3 | Thermogenesis |
| HP:0012385 | 0.0164736212267 | 0.6 | FGFR2 FGFR3 FGFR1 | Camptodactyly |
| REAC:R-HSA-5663202 | 0.016617401989 | 0.6 | FGFR2 FGFR3 FGFR1 | Diseases of signal transduction |
| KEGG:05215 | 0.0169933560846 | 0.4 | FGFR2 FGFR1 | Prostate cancer |
| HP:0002761 | 0.0175069025895 | 0.4 | FGFR1 FGFR3 | Generalized joint laxity |
| HP:0002650 | 0.0176138590684 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Scoliosis |
| HP:0000643 | 0.0188011826397 | 0.4 | FGFR2 FGFR3 | Blepharospasm |
| HP:0009658 | 0.0188011826397 | 0.4 | FGFR2 FGFR3 | Aplasia/Hypoplasia of the phalanges of the thumb |
| HP:0000698 | 0.0188011826397 | 0.4 | FGFR2 FGFR3 | Conical tooth |
| HP:0011063 | 0.0188011826397 | 0.4 | FGFR2 FGFR3 | Abnormality of incisor morphology |
| HP:0006288 | 0.0188011826397 | 0.4 | FGFR2 RPS6KA3 | Advanced eruption of teeth |
| GO:0060193 | 0.0188216371551 | 0.6 | FGFR2 FGFR3 FGFR1 | positive regulation of lipase activity |
| GO:0010517 | 0.0188216371551 | 0.6 | FGFR2 FGFR3 FGFR1 | regulation of phospholipase activity |
| HP:0007392 | 0.0201414164419 | 0.4 | FGFR2 FGFR3 | Excessive wrinkled skin |
| HP:0030044 | 0.0202838753763 | 0.6 | FGFR2 FGFR3 FGFR1 | Flexion contracture of digit |
| HP:0000047 | 0.0213196619429 | 0.6 | FGFR2 FGFR3 FGFR1 | Hypospadias |
| HP:0009702 | 0.0215275853758 | 0.4 | FGFR2 FGFR3 | Carpal synostosis |
| HP:0001167 | 0.0227034392536 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of finger |
| HP:0031879 | 0.0229596708254 | 0.4 | FGFR2 FGFR3 | Abnormal eyelid physiology |
| HP:0100728 | 0.0229596708254 | 0.4 | FGFR2 FGFR3 | Germ cell neoplasia |
| HP:0032040 | 0.0229596708254 | 0.4 | FGFR2 FGFR3 | Abnormal ocular adnexa physiology |
| HP:0100744 | 0.0229596708254 | 0.4 | FGFR2 FGFR1 | Abnormality of the humeroradial joint |
| HP:0010174 | 0.0229596708254 | 0.4 | FGFR2 FGFR1 | Broad phalanx of the toes |
| HP:0000677 | 0.0229596708254 | 0.4 | FGFR1 RPS6KA3 | Oligodontia |
| HP:0010674 | 0.0234789391763 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the curvature of the vertebral column |
| HP:0009115 | 0.0234789391763 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Aplasia/hypoplasia involving the skeleton |
| HP:0000356 | 0.0239308330272 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the outer ear |
| HP:0000336 | 0.0244376541782 | 0.4 | FGFR1 RPS6KA3 | Prominent supraorbital ridges |
| HP:0001702 | 0.0244376541782 | 0.4 | FGFR1 RPS6KA3 | Abnormal tricuspid valve morphology |
| HP:0010057 | 0.0244376541782 | 0.4 | FGFR2 FGFR1 | Abnormality of the phalanges of the hallux |
| HP:0100627 | 0.0249261794567 | 0.6 | FGFR2 FGFR3 FGFR1 | Displacement of the urethral meatus |
| HP:0032076 | 0.0249261794567 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal male urethral meatus morphology |
| CORUM:6834 | 0.0249780992026 | 0.2 | FGFR1 | FGF21-FGFR1c-KLB complex |
| CORUM:6828 | 0.0249780992026 | 0.2 | FGFR1 | FGF21-FGFR1c-KLB complex |
| CORUM:912 | 0.0249780992026 | 0.2 | FGFR1 | FGFR1-KAL11 complex |
| CORUM:6836 | 0.0249780992026 | 0.2 | FGFR1 | FGFR1c-KLB complex |
| GO:0004714 | 0.0250406933376 | 0.6 | FGFR2 FGFR3 FGFR1 | transmembrane receptor protein tyrosine kinase activity |
| HP:0006493 | 0.0252191757388 | 0.6 | FGFR2 FGFR3 FGFR1 | Aplasia/hypoplasia involving bones of the lower limbs |
| HP:0000343 | 0.0255144387308 | 0.6 | FGFR2 RPS6KA3 FGFR1 | Long philtrum |
| HP:0011821 | 0.0258033904131 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of facial skeleton |
| HP:0002438 | 0.0258119768497 | 0.6 | FGFR2 FGFR3 FGFR1 | Cerebellar malformation |
| HP:0000378 | 0.0259615168254 | 0.4 | FGFR2 FGFR3 | Cupped ear |
| HP:0000956 | 0.0259615168254 | 0.4 | FGFR2 FGFR3 | Acanthosis nigricans |
| HP:0002980 | 0.0259615168254 | 0.4 | FGFR2 FGFR3 | Femoral bowing |
| HP:0012718 | 0.0260448941493 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Morphological abnormality of the gastrointestinal tract |
| HP:0025033 | 0.0260448941493 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of digestive system morphology |
| HP:0001172 | 0.0264139121191 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal thumb morphology |
| HP:0001595 | 0.0267794985168 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal hair morphology |
| HP:0011729 | 0.0274033471259 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of joint mobility |
| HP:0002984 | 0.0291468055875 | 0.4 | FGFR2 FGFR3 | Hypoplasia of the radius |
| HP:0001631 | 0.0292374582023 | 0.6 | FGFR2 FGFR3 FGFR1 | Atrial septal defect |
| HP:0011994 | 0.0295629530581 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal atrial septum morphology |
| HP:0000492 | 0.0300073830984 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal eyelid morphology |
| HP:0010807 | 0.0308081945037 | 0.4 | FGFR2 FGFR3 | Open bite |
| HP:0001822 | 0.0308081945037 | 0.4 | FGFR2 FGFR3 | Hallux valgus |
| HP:0004278 | 0.0308081945037 | 0.4 | FGFR2 FGFR3 | Synostosis involving bones of the hand |
| HP:0002692 | 0.0308081945037 | 0.4 | FGFR2 FGFR1 | Hypoplastic facial bones |
| HP:0011356 | 0.0315662834758 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Regional abnormality of skin |
| HP:0200020 | 0.0325153883173 | 0.4 | FGFR2 FGFR3 | Corneal erosion |
| HP:0010743 | 0.0325153883173 | 0.4 | FGFR2 FGFR1 | Short metatarsal |
| HP:0005120 | 0.0326006997834 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormal cardiac atrium morphology |
| HP:0003319 | 0.0326006997834 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the cervical spine |
| HP:0001376 | 0.0333025936722 | 0.6 | FGFR2 FGFR3 FGFR1 | Limitation of joint mobility |
| HP:0011025 | 0.0335159803875 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal cardiovascular system physiology |
| HP:0002991 | 0.0342683684383 | 0.4 | FGFR2 FGFR3 | Abnormality of fibula morphology |
| HP:0000238 | 0.0351008048623 | 0.6 | FGFR2 FGFR3 FGFR1 | Hydrocephalus |
| HP:0005924 | 0.0360671162807 | 0.4 | RPS6KA3 FGFR3 | Abnormality of the epiphyses of the hand |
| HP:0004437 | 0.0360671162807 | 0.4 | FGFR1 RPS6KA3 | Cranial hyperostosis |
| HP:0003063 | 0.0360671162807 | 0.4 | FGFR2 FGFR1 | Abnormality of the humerus |
| HP:0009380 | 0.0360671162807 | 0.4 | FGFR2 FGFR3 | Aplasia of the fingers |
| HP:0004328 | 0.0371626603223 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal anterior eye segment morphology |
| HP:0001098 | 0.0377979531188 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal fundus morphology |
| HP:0100678 | 0.0379116132621 | 0.4 | FGFR2 FGFR3 | Premature skin wrinkling |
| HP:0004329 | 0.0382796920379 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal posterior eye segment morphology |
| HP:0002793 | 0.0384968933304 | 0.6 | FGFR2 FGFR3 RPS6KA3 | Abnormal pattern of respiration |
| HP:0002795 | 0.0390927093194 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Functional respiratory abnormality |
| HP:0000795 | 0.0396752856137 | 0.6 | FGFR2 FGFR3 FGFR1 | Abnormality of the urethra |
| HP:0001964 | 0.0398018408038 | 0.4 | FGFR2 FGFR1 | Aplasia/Hypoplasia of metatarsal bones |
| HP:0006481 | 0.0398018408038 | 0.4 | FGFR2 FGFR3 | Abnormality of primary teeth |
| HP:0003839 | 0.0417377803311 | 0.4 | RPS6KA3 FGFR3 | Abnormality of upper limb epiphysis morphology |
| HP:0011138 | 0.0437068046207 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of skin adnexa morphology |
| HP:0009891 | 0.0437194132729 | 0.4 | FGFR2 FGFR3 | Underdeveloped supraorbital ridges |
| HP:0000974 | 0.0437194132729 | 0.4 | FGFR2 FGFR3 | Hyperextensible skin |
| HP:0001199 | 0.0437194132729 | 0.4 | FGFR2 FGFR3 | Triphalangeal thumb |
| HP:0001513 | 0.0437746235645 | 0.6 | FGFR1 FGFR3 RPS6KA3 | Obesity |
| HP:0001760 | 0.0458823387011 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormality of the foot |
| HP:0004322 | 0.0462525985754 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Short stature |
| HP:0100774 | 0.0478196851342 | 0.4 | FGFR1 RPS6KA3 | Hyperostosis |
| HP:0001171 | 0.0478196851342 | 0.4 | FGFR1 FGFR3 | Split hand |
| HP:0001627 | 0.047946296424 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal heart morphology |
| HP:0011368 | 0.0490508933376 | 0.6 | FGFR2 FGFR3 FGFR1 | Epidermal thickening |
| GO:0060191 | 0.0493791608738 | 0.6 | FGFR2 FGFR3 FGFR1 | regulation of lipase activity |
| HP:0011297 | 0.0494900867638 | 0.8 | FGFR2 FGFR3 RPS6KA3 FGFR1 | Abnormal digit morphology |
| HP:0000995 | 0.0499382869304 | 0.4 | FGFR2 FGFR3 | Melanocytic nevus |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| FGFR2 | FGFR3 | 0.995 | 0.924 | bioplex (FGFR2) bioplex_WMM |
| FGFR2 | FGFR1 | 0.707 | 0.729 | bioplex (FGFR2) bioplex_WMM |
| RPS6KA3 | FGFR2 | 0.046 | 0.293 | bioplex (FGFR2) bioplex_WMM |
| FGFR2 | DNAJC30 | 0.043 | 0.269 | bioplex (FGFR2) bioplex_WMM |
| FGFR1 | FGFR3 | 0.008 | 0.068 | bioplex_WMM WMM_only |
| FGFR3 | DNAJC30 | 0.008 | 0.022 | bioplex_WMM WMM_only |
| RPS6KA3 | FGFR3 | 0.008 | 0.013 | bioplex_WMM WMM_only |
| RPS6KA3 | DNAJC30 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| FGFR1 | DNAJC30 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| RPS6KA3 | FGFR1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
Images
Click to enlarge
Complex HuMAP2_06605 has an average edge precision of 0.233 which is ranked 5645 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| FGFR1 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| FGFR2 | HuMAP2_02095 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| RPS6KA3 | HuMAP2_00566 HuMAP2_05297 HuMAP2_05462 HuMAP2_06014 HuMAP2_06605 |
| FGFR3 | HuMAP2_02095 HuMAP2_02142 HuMAP2_06014 HuMAP2_06274 HuMAP2_06605 |
| DNAJC30 | HuMAP2_06014 HuMAP2_06605 |