hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06609
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CCN2 | CCN family member 2 (Cellular communication network factor 2) (Connective tissue growth factor) (Hypertrophic chondrocyte-specific protein 24) (Insulin-like growth factor-binding protein 8) (IBP-8) (IGF-binding protein 8) (IGFBP-8) | UniProt NCBI |
| EP300 | Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-) | UniProt NCBI |
| CITED2 | Cbp/p300-interacting transactivator 2 (MSG-related protein 1) (MRG-1) (P35srj) | UniProt NCBI |
| C3orf62 | Uncharacterized protein C3orf62 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-8866907 | 0.000361772624521 | 0.5 | EP300 CITED2 | Activation of the TFAP2 (AP-2) family of transcription factors |
| REAC:R-HSA-1234158 | 0.000452175281072 | 0.5 | EP300 CITED2 | Regulation of gene expression by Hypoxia-inducible Factor |
| REAC:R-HSA-9614657 | 0.00105460323216 | 0.5 | EP300 CITED2 | FOXO-mediated transcription of cell death genes |
| REAC:R-HSA-8864260 | 0.00407268683926 | 0.5 | EP300 CITED2 | Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors |
| REAC:R-HSA-9614085 | 0.0165385846138 | 0.5 | EP300 CITED2 | FOXO-mediated transcription |
| REAC:R-HSA-1234174 | 0.0269852439715 | 0.5 | EP300 CITED2 | Cellular response to hypoxia |
| REAC:R-HSA-8878159 | 0.041754071825 | 0.5 | CCN2 EP300 | Transcriptional regulation by RUNX3 |
| CORUM:1158 | 0.0499140284799 | 0.25 | EP300 | p33ING1b-p300 complex |
| CORUM:2642 | 0.0499140284799 | 0.25 | EP300 | SMAD1-P300 complex |
| CORUM:5375 | 0.0499140284799 | 0.25 | EP300 | EGR-EP300 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| EP300 | C3orf62 | 0.275 | 0.487 | bioplex (C3orf62) bioplex_WMM |
| CCN2 | EP300 | 0.267 | 0.483 | bioplex (CCN2) bioplex_WMM |
| EP300 | CITED2 | 0.059 | 0.332 | hein_WMM hein (EP300) |
Images
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Complex HuMAP2_06609 has an average edge precision of 0.434 which is ranked 2981 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CCN2 | HuMAP2_02545 HuMAP2_06609 |
| EP300 | HuMAP2_02545 HuMAP2_06609 |
| CITED2 | HuMAP2_02545 HuMAP2_06609 |
| C3orf62 | HuMAP2_02545 HuMAP2_06609 |