hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06618
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| SYNRG | Synergin gamma (AP1 subunit gamma-binding protein 1) (Gamma-synergin) | UniProt NCBI |
| AP1AR | AP-1 complex-associated regulatory protein (2c18) (Adaptor-related protein complex 1-associated regulatory protein) (Gamma-1-adaptin brefeldin A resistance protein) (GBAR) (Gamma-BAR) (Gamma-A1-adaptin and kinesin interactor) (Gadkin) | UniProt NCBI |
| HEATR5B | HEAT repeat-containing protein 5B | UniProt NCBI |
| AP1S2 | AP-1 complex subunit sigma-2 (Adaptor protein complex AP-1 subunit sigma-1B) (Adaptor-related protein complex 1 subunit sigma-1B) (Clathrin assembly protein complex 1 sigma-1B small chain) (Golgi adaptor HA1/AP1 adaptin sigma-1B subunit) (Sigma 1B subunit of AP-1 clathrin) (Sigma-adaptin 1B) (Sigma1B-adaptin) | UniProt NCBI |
| AP1M2 | AP-1 complex subunit mu-2 (AP-mu chain family member mu1B) (Adaptor protein complex AP-1 subunit mu-2) (Adaptor-related protein complex 1 subunit mu-2) (Clathrin assembly protein complex 1 mu-2 medium chain 2) (Golgi adaptor HA1/AP1 adaptin mu-2 subunit) (Mu-adaptin 2) (Mu1B-adaptin) | UniProt NCBI |
| AP1G2 | AP-1 complex subunit gamma-like 2 (Gamma2-adaptin) (G2ad) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:144 | 5.71747411144e-11 | 0.666666666667 | AP1M2 AP1AR AP1G2 AP1S2 | Gamma-BAR-AP1 complex |
| CORUM:36 | 1.26104188141e-07 | 0.5 | AP1M2 AP1S2 AP1G2 | AP1 adaptor complex |
| REAC:R-HSA-432720 | 3.878939824e-05 | 0.5 | AP1M2 AP1S2 AP1G2 | Lysosome Vesicle Biogenesis |
| REAC:R-HSA-199992 | 0.000351485615181 | 0.5 | AP1M2 AP1S2 AP1G2 | trans-Golgi Network Vesicle Budding |
| KEGG:04142 | 0.000441153492847 | 0.5 | AP1M2 AP1S2 AP1G2 | Lysosome |
| REAC:R-HSA-164940 | 0.000797179114843 | 0.333333333333 | AP1M2 AP1S2 | Nef mediated downregulation of MHC class I complex cell surface expression |
| KEGG:05170 | 0.00211201253822 | 0.5 | AP1M2 AP1S2 AP1G2 | Human immunodeficiency virus 1 infection |
| REAC:R-HSA-164938 | 0.00338255333894 | 0.333333333333 | AP1M2 AP1S2 | Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters |
| REAC:R-HSA-164952 | 0.0060953046166 | 0.333333333333 | AP1M2 AP1S2 | The role of Nef in HIV-1 replication and disease pathogenesis |
| GO:0030119 | 0.00661098268806 | 0.5 | AP1G2 SYNRG AP1S2 | AP-type membrane coat adaptor complex |
| REAC:R-HSA-432722 | 0.0314333263146 | 0.333333333333 | AP1M2 AP1S2 | Golgi Associated Vesicle Biogenesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SYNRG | AP1S2 | 1.0 | 0.949 | hein_WMM bioplex (AP1S2) bioplex_WMM youn_WMM hein (AP1S2) |
| AP1S2 | AP1AR | 0.999 | 0.949 | hein_WMM bioplex (AP1S2) bioplex_WMM hein (AP1S2) |
| HEATR5B | AP1S2 | 0.999 | 0.948 | hein_WMM bioplex (AP1S2) bioplex_WMM hein (AP1S2) |
| AP1S2 | AP1G2 | 0.998 | 0.941 | hein_WMM bioplex (AP1S2) bioplex_WMM hein (AP1S2) |
| AP1M2 | AP1S2 | 0.994 | 0.92 | bioplex (AP1M2) bioplex_WMM |
| AP1M2 | AP1G2 | 0.827 | 0.774 | bioplex (AP1M2) bioplex_WMM |
| SYNRG | AP1G2 | 0.042 | 0.27 | hein_WMM bioplex (AP1G2) bioplex_WMM |
| SYNRG | HEATR5B | 0.012 | 0.146 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| HEATR5B | AP1AR | 0.01 | 0.116 | hein_WMM bioplex_WMM WMM_only |
| AP1AR | AP1G2 | 0.01 | 0.098 | hein_WMM bioplex_WMM WMM_only |
| HEATR5B | AP1G2 | 0.01 | 0.103 | hein_WMM bioplex_WMM WMM_only |
| SYNRG | AP1AR | 0.009 | 0.107 | hein_WMM bioplex_WMM WMM_only |
| HEATR5B | AP1M2 | 0.0 | 0.001 | bioplex (AP1M2) bioplex_WMM |
Images
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Complex HuMAP2_06618 has an average edge precision of 0.486 which is ranked 2582 out of all 6965 complexes.
Related Complexes