hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06621
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PRKDC | DNA-dependent protein kinase catalytic subunit (DNA-PK catalytic subunit) (DNA-PKcs) (EC 2.7.11.1) (DNPK1) (p460) | UniProt NCBI |
| MINPP1 | Multiple inositol polyphosphate phosphatase 1 (EC 3.1.3.62) (2,3-bisphosphoglycerate 3-phosphatase) (2,3-BPG phosphatase) (EC 3.1.3.80) (Inositol (1,3,4,5)-tetrakisphosphate 3-phosphatase) (Ins(1,3,4,5)P(4) 3-phosphatase) | UniProt NCBI |
| SFPQ | Splicing factor, proline- and glutamine-rich (100 kDa DNA-pairing protein) (hPOMp100) (DNA-binding p52/p100 complex, 100 kDa subunit) (Polypyrimidine tract-binding protein-associated-splicing factor) (PSF) (PTB-associated-splicing factor) | UniProt NCBI |
| TMOD2 | Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod) | UniProt NCBI |
| CWF19L1 | CWF19-like protein 1 (C19L1) | UniProt NCBI |
| MSH2 | DNA mismatch repair protein Msh2 (hMSH2) (MutS protein homolog 2) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:7285 | 0.000301662071994 | 0.333333333333 | PRKDC SFPQ | HEXIM1-DNA-PK-paraspeckle components-ribonucleoprotein complex |
| CORUM:1335 | 0.00113798027977 | 0.333333333333 | SFPQ MSH2 | SNW1 complex |
| CORUM:1183 | 0.00338990891159 | 0.333333333333 | PRKDC SFPQ | CDC5L complex |
| WP:WP4016 | 0.0165558163549 | 0.333333333333 | PRKDC MSH2 | DNA IR-damage and cellular response via ATR |
| HP:0003003 | 0.0497285764978 | 0.333333333333 | MINPP1 MSH2 | Colon cancer |
| CORUM:330 | 0.0499726005494 | 0.166666666667 | SFPQ | PSF-p54(nrb) complex |
| CORUM:360 | 0.0499726005494 | 0.166666666667 | PRKDC | Artemis-DNA-PK complex |
| CORUM:361 | 0.0499726005494 | 0.166666666667 | PRKDC | Artemis-DNA-PK complex |
| CORUM:374 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH6 complex |
| CORUM:375 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH3 complex |
| CORUM:378 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH3 complex |
| CORUM:1078 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH6 complex |
| CORUM:2740 | 0.0499726005494 | 0.166666666667 | MSH2 | MSH2-MSH6 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SFPQ | PRKDC | 0.119 | 0.392 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| SFPQ | CWF19L1 | 0.039 | 0.264 | bioplex_WMM fraction |
| SFPQ | MINPP1 | 0.031 | 0.24 | bioplex (MINPP1) fraction |
| SFPQ | TMOD2 | 0.027 | 0.225 | fraction |
| SFPQ | MSH2 | 0.024 | 0.214 | bioplex_WMM boldt fraction boldt_WMM treiber_WMM |
| MSH2 | CWF19L1 | 0.007 | 0.006 | bioplex_WMM youn_WMM WMM_only |
| PRKDC | CWF19L1 | 0.007 | 0.004 | bioplex_WMM WMM_only |
| PRKDC | TMOD2 | 0.007 | 0.002 | gupta_WMM WMM_only |
| TMOD2 | CWF19L1 | 0.007 | 0.001 | bioplex_WMM WMM_only |
| MINPP1 | MSH2 | 0.007 | 0.002 | bioplex_WMM WMM_only |
| MINPP1 | PRKDC | 0.006 | 0.005 | bioplex (MINPP1) bioplex_WMM |
| PRKDC | MSH2 | 0.003 | 0.015 | bioplex_WMM boldt gupta_WMM boldt_WMM treiber_WMM |
Images
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Complex HuMAP2_06621 has an average edge precision of 0.114 which is ranked 6893 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| PRKDC | HuMAP2_01370 HuMAP2_02284 HuMAP2_05624 HuMAP2_06176 HuMAP2_06621 |
| MINPP1 | HuMAP2_01369 HuMAP2_02092 HuMAP2_06621 |
| SFPQ | HuMAP2_00259 HuMAP2_06616 HuMAP2_06621 HuMAP2_06971 |
| TMOD2 | HuMAP2_06038 HuMAP2_06621 HuMAP2_06706 |
| CWF19L1 | HuMAP2_06621 |
| MSH2 | HuMAP2_03273 HuMAP2_05036 HuMAP2_05731 HuMAP2_06621 |