hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06626

Confidence: Very High

Genename	Protein Name	Links
AP2S1	AP-2 complex subunit sigma (Adaptor protein complex AP-2 subunit sigma) (Adaptor-related protein complex 2 subunit sigma) (Clathrin assembly protein 2 sigma small chain) (Clathrin coat assembly protein AP17) (Clathrin coat-associated protein AP17) (HA2 17 kDa subunit) (Plasma membrane adaptor AP-2 17 kDa protein) (Sigma2-adaptin)	UniProt NCBI
AP2A1	AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)	UniProt NCBI
AP2B1	AP-2 complex subunit beta (AP105B) (Adaptor protein complex AP-2 subunit beta) (Adaptor-related protein complex 2 subunit beta) (Beta-2-adaptin) (Beta-adaptin) (Clathrin assembly protein complex 2 beta large chain) (Plasma membrane adaptor HA2/AP2 adaptin beta subunit)	UniProt NCBI
CCDC32	Coiled-coil domain-containing protein 32	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-182218	2.70051608981e-08	0.75	AP2S1 AP2A1 AP2B1	Nef Mediated CD8 Down-regulation
REAC:R-HSA-167590	1.13404535396e-07	0.75	AP2S1 AP2A1 AP2B1	Nef Mediated CD4 Down-regulation
REAC:R-HSA-8866427	2.96966986958e-07	0.75	AP2S1 AP2A1 AP2B1	VLDLR internalisation and degradation
REAC:R-HSA-5140745	3.86037630079e-07	0.75	AP2S1 AP2A1 AP2B1	WNT5A-dependent internalization of FZD2, FZD5 and ROR2
REAC:R-HSA-177504	3.86037630079e-07	0.75	AP2S1 AP2A1 AP2B1	Retrograde neurotrophin signalling
REAC:R-HSA-5099900	4.9129586178e-07	0.75	AP2S1 AP2A1 AP2B1	WNT5A-dependent internalization of FZD4
WP:WP4159	6.59188144823e-07	0.75	AP2S1 AP2A1 AP2B1	GABA receptor Signaling
REAC:R-HSA-164938	1.10114453861e-06	0.75	AP2S1 AP2A1 AP2B1	Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
REAC:R-HSA-8964038	1.30754323077e-06	0.75	AP2S1 AP2A1 AP2B1	LDL clearance
REAC:R-HSA-164952	2.73044427427e-06	0.75	AP2S1 AP2A1 AP2B1	The role of Nef in HIV-1 replication and disease pathogenesis
WP:WP2267	3.41773973111e-06	0.75	AP2S1 AP2A1 AP2B1	Synaptic Vesicle Pathway
REAC:R-HSA-8964043	4.92812658075e-06	0.75	AP2S1 AP2A1 AP2B1	Plasma lipoprotein clearance
KEGG:04961	5.26171960509e-06	0.75	AP2S1 AP2A1 AP2B1	Endocrine and other factor-regulated calcium reabsorption
KEGG:04721	1.28493032652e-05	0.75	AP2S1 AP2A1 AP2B1	Synaptic vesicle cycle
REAC:R-HSA-437239	1.91225201676e-05	0.75	AP2S1 AP2A1 AP2B1	Recycling pathway of L1
GO:0030122	2.03382379613e-05	0.75	AP2S1 AP2A1 AP2B1	AP-2 adaptor complex
GO:0030128	2.03382379613e-05	0.75	AP2S1 AP2A1 AP2B1	clathrin coat of endocytic vesicle
REAC:R-HSA-3928665	2.0455616978e-05	0.75	AP2S1 AP2A1 AP2B1	EPH-ephrin mediated repulsion of cells
GO:0035615	3.05058200216e-05	0.75	AP2S1 AP2A1 AP2B1	clathrin adaptor activity
GO:0030132	3.05058200216e-05	0.75	AP2S1 AP2A1 AP2B1	clathrin coat of coated pit
REAC:R-HSA-174824	3.73348809378e-05	0.75	AP2S1 AP2A1 AP2B1	Plasma lipoprotein assembly, remodeling, and clearance
GO:0140312	4.35775472874e-05	0.75	AP2S1 AP2A1 AP2B1	cargo adaptor activity
WP:WP4549	5.53964457277e-05	0.75	AP2S1 AP2A1 AP2B1	Fragile X Syndrome
GO:0036020	5.99161085695e-05	0.75	AP2S1 AP2A1 AP2B1	endolysosome membrane
REAC:R-HSA-187037	8.36972120253e-05	0.75	AP2S1 AP2A1 AP2B1	Signaling by NTRK1 (TRKA)
GO:0030131	0.000103844122491	0.75	AP2S1 AP2A1 AP2B1	clathrin adaptor complex
REAC:R-HSA-2682334	0.00013762853655	0.75	AP2S1 AP2A1 AP2B1	EPH-Ephrin signaling
WP:WP437	0.000149962934646	0.75	AP2S1 AP2A1 AP2B1	EGF/EGFR Signaling Pathway
REAC:R-HSA-8856825	0.000152699585722	0.75	AP2S1 AP2A1 AP2B1	Cargo recognition for clathrin-mediated endocytosis
REAC:R-HSA-166520	0.000163333735977	0.75	AP2S1 AP2A1 AP2B1	Signaling by NTRKs
REAC:R-HSA-4086400	0.000163333735977	0.75	AP2S1 AP2A1 AP2B1	PCP/CE pathway
GO:0032802	0.000165189908538	0.75	AP2S1 AP2A1 AP2B1	low-density lipoprotein particle receptor catabolic process
GO:0036019	0.000203300410527	0.75	AP2S1 AP2A1 AP2B1	endolysosome
KEGG:05016	0.000238258771068	0.75	AP2S1 AP2A1 AP2B1	Huntington disease
GO:0030125	0.000296207880886	0.75	AP2S1 AP2A1 AP2B1	clathrin vesicle coat
REAC:R-HSA-373760	0.000297923324705	0.75	AP2S1 AP2A1 AP2B1	L1CAM interactions
REAC:R-HSA-2132295	0.000340340039133	0.75	AP2S1 AP2A1 AP2B1	MHC class II antigen presentation
REAC:R-HSA-162909	0.000396320737366	0.75	AP2S1 AP2A1 AP2B1	Host Interactions of HIV factors
REAC:R-HSA-8856828	0.000468996589794	0.75	AP2S1 AP2A1 AP2B1	Clathrin-mediated endocytosis
KEGG:04144	0.000539397470166	0.75	AP2S1 AP2A1 AP2B1	Endocytosis
GO:0032799	0.000558907067709	0.75	AP2S1 AP2A1 AP2B1	low-density lipoprotein receptor particle metabolic process
REAC:R-HSA-3858494	0.000562319812212	0.75	AP2S1 AP2A1 AP2B1	Beta-catenin independent WNT signaling
GO:0030118	0.000834605087859	0.75	AP2S1 AP2A1 AP2B1	clathrin coat
GO:0050690	0.000943419049714	0.75	AP2S1 AP2A1 AP2B1	regulation of defense response to virus by virus
GO:0030119	0.00132566605022	0.75	AP2S1 AP2A1 AP2B1	AP-type membrane coat adaptor complex
GO:0030669	0.00132566605022	0.75	AP2S1 AP2A1 AP2B1	clathrin-coated endocytic vesicle membrane
GO:0032801	0.00163061517788	0.75	AP2S1 AP2A1 AP2B1	receptor catabolic process
GO:0072583	0.00163061517788	0.75	AP2S1 AP2A1 AP2B1	clathrin-dependent endocytosis
GO:0034383	0.00163061517788	0.75	AP2S1 AP2A1 AP2B1	low-density lipoprotein particle clearance
GO:0005905	0.00197902980402	0.75	AP2S1 AP2A1 AP2B1	clathrin-coated pit
REAC:R-HSA-162906	0.00243524237836	0.75	AP2S1 AP2A1 AP2B1	HIV Infection
GO:0030276	0.00386509246613	0.75	AP2S1 AP2A1 AP2B1	clathrin binding
GO:0045334	0.00416219722544	0.75	AP2S1 AP2A1 AP2B1	clathrin-coated endocytic vesicle
GO:0034381	0.00514395792508	0.75	AP2S1 AP2A1 AP2B1	plasma lipoprotein particle clearance
GO:0030120	0.00587743889796	0.75	AP2S1 AP2A1 AP2B1	vesicle coat
REAC:R-HSA-195721	0.00653784113487	0.75	AP2S1 AP2A1 AP2B1	Signaling by WNT
REAC:R-HSA-5663205	0.0100576606226	0.75	AP2S1 AP2A1 AP2B1	Infectious disease
REAC:R-HSA-9006934	0.0147563350021	0.75	AP2S1 AP2A1 AP2B1	Signaling by Receptor Tyrosine Kinases
GO:0097006	0.0158182712902	0.75	AP2S1 AP2A1 AP2B1	regulation of plasma lipoprotein particle levels
GO:0030117	0.0225145500348	0.75	AP2S1 AP2A1 AP2B1	membrane coat
GO:0048475	0.0225145500348	0.75	AP2S1 AP2A1 AP2B1	coated membrane
GO:0030665	0.0254442868917	0.75	AP2S1 AP2A1 AP2B1	clathrin-coated vesicle membrane
GO:0048013	0.0264744736345	0.75	AP2S1 AP2A1 AP2B1	ephrin receptor signaling pathway
REAC:R-HSA-422475	0.0294332368862	0.75	AP2S1 AP2A1 AP2B1	Axon guidance
GO:0019886	0.0410761885593	0.75	AP2S1 AP2A1 AP2B1	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0002495	0.0424904593616	0.75	AP2S1 AP2A1 AP2B1	antigen processing and presentation of peptide antigen via MHC class II
GO:0060071	0.0424904593616	0.75	AP2S1 AP2A1 AP2B1	Wnt signaling pathway, planar cell polarity pathway
REAC:R-HSA-199991	0.0426366599823	0.75	AP2S1 AP2A1 AP2B1	Membrane Trafficking
GO:0090175	0.0439367749778	0.75	AP2S1 AP2A1 AP2B1	regulation of establishment of planar polarity
GO:0002504	0.0439367749778	0.75	AP2S1 AP2A1 AP2B1	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
REAC:R-HSA-382551	0.047385920536	0.75	AP2S1 AP2A1 AP2B1	Transport of small molecules

Edges

Protein 1	Protein 2	Score	Precision	Evidence
AP2A1	AP2B1	1.0	0.949	hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM treiber_WMM
CCDC32	AP2S1	0.987	0.901	bioplex (AP2S1) bioplex_WMM
AP2S1	AP2A1	0.98	0.896	hein_WMM bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
AP2S1	AP2B1	0.889	0.818	hein_WMM bioplex (AP2S1) bioplex_WMM Guru boldt youn_WMM gupta_WMM fraction boldt_WMM
CCDC32	AP2A1	0.008	0.083	bioplex_WMM WMM_only
CCDC32	AP2B1	0.007	0.002	bioplex_WMM WMM_only

Images

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Complex HuMAP2_06626 has an average edge precision of 0.608 which is ranked 1905 out of all 6965 complexes.

Related Complexes

Genename	Complexes
AP2S1	HuMAP2_02111 HuMAP2_02595 HuMAP2_03002 HuMAP2_04081 HuMAP2_06613 HuMAP2_06626 HuMAP2_06848
AP2A1	HuMAP2_02595 HuMAP2_03676 HuMAP2_06613 HuMAP2_06626 HuMAP2_06848
AP2B1	HuMAP2_05170 HuMAP2_06626 HuMAP2_06848
CCDC32	HuMAP2_00989 HuMAP2_02111 HuMAP2_02595 HuMAP2_03002 HuMAP2_04081 HuMAP2_06613 HuMAP2_06626

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06626