hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06627
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CHMP5 | Charged multivesicular body protein 5 (Chromatin-modifying protein 5) (SNF7 domain-containing protein 2) (Vacuolar protein sorting-associated protein 60) (Vps60) (hVps60) | UniProt NCBI |
| CHMP4A | Charged multivesicular body protein 4a (Chromatin-modifying protein 4a) (CHMP4a) (SNF7 homolog associated with Alix-2) (SNF7-1) (hSnf-1) (Vacuolar protein sorting-associated protein 32-1) (Vps32-1) (hVps32-1) | UniProt NCBI |
| VTA1 | Vacuolar protein sorting-associated protein VTA1 homolog (Dopamine-responsive gene 1 protein) (DRG-1) (LYST-interacting protein 5) (LIP5) (SKD1-binding protein 1) (SBP1) | UniProt NCBI |
| CHMP2A | Charged multivesicular body protein 2a (Chromatin-modifying protein 2a) (CHMP2a) (Putative breast adenocarcinoma marker BC-2) (Vacuolar protein sorting-associated protein 2-1) (Vps2-1) (hVps2-1) | UniProt NCBI |
| TRIM35 | Tripartite motif-containing protein 35 (Hemopoietic lineage switch protein 5) | UniProt NCBI |
| EHBP1L1 | EH domain-binding protein 1-like protein 1 | UniProt NCBI |
| ROCK1 | Rho-associated protein kinase 1 (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-35) (Rho-associated, coiled-coil-containing protein kinase 1) (Rho-associated, coiled-coil-containing protein kinase I) (ROCK-I) (p160 ROCK-1) (p160ROCK) | UniProt NCBI |
| STMN4 | Stathmin-4 (Stathmin-like protein B3) (RB3) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-162588 | 1.23350862584e-07 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Budding and maturation of HIV virion |
| REAC:R-HSA-917729 | 1.89437369763e-07 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Endosomal Sorting Complex Required For Transport (ESCRT) |
| CORUM:1186 | 5.64097851901e-07 | 0.375 | CHMP5 CHMP2A CHMP4A | ESCRT-III complex |
| GO:0046755 | 2.15049400405e-05 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | viral budding |
| GO:0036258 | 4.65382761126e-05 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | multivesicular body assembly |
| GO:0036257 | 5.34213382731e-05 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | multivesicular body organization |
| REAC:R-HSA-162599 | 7.33687312406e-05 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Late Phase of HIV Life Cycle |
| REAC:R-HSA-162587 | 0.000106676550723 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | HIV Life Cycle |
| GO:0019068 | 0.00013940565471 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | virion assembly |
| KEGG:04144 | 0.000180705822285 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Endocytosis |
| REAC:R-HSA-162906 | 0.000579260147565 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | HIV Infection |
| GO:1904896 | 0.000609225680053 | 0.375 | CHMP5 CHMP2A VTA1 | ESCRT complex disassembly |
| GO:1904903 | 0.000609225680053 | 0.375 | CHMP5 CHMP2A VTA1 | ESCRT III complex disassembly |
| GO:0000281 | 0.00129128001412 | 0.5 | CHMP5 CHMP4A CHMP2A ROCK1 | mitotic cytokinesis |
| GO:0007032 | 0.0015436837415 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | endosome organization |
| GO:0019058 | 0.00257918866807 | 0.625 | TRIM35 CHMP5 VTA1 CHMP2A CHMP4A | viral life cycle |
| KEGG:04217 | 0.00270238613907 | 0.375 | CHMP5 CHMP2A CHMP4A | Necroptosis |
| GO:0061952 | 0.00344619549436 | 0.375 | CHMP5 CHMP2A CHMP4A | midbody abscission |
| REAC:R-HSA-5663205 | 0.00377448547565 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Infectious disease |
| GO:0061640 | 0.0046819658936 | 0.5 | CHMP5 CHMP4A CHMP2A ROCK1 | cytoskeleton-dependent cytokinesis |
| GO:1902410 | 0.00779479116974 | 0.375 | CHMP5 CHMP2A CHMP4A | mitotic cytokinetic process |
| GO:0071985 | 0.0147863948461 | 0.375 | CHMP5 CHMP2A VTA1 | multivesicular body sorting pathway |
| REAC:R-HSA-9615710 | 0.0156064896573 | 0.25 | CHMP2A CHMP4A | Microautophagy |
| CORUM:7424 | 0.0248670854284 | 0.125 | ROCK1 | ISLR2-ROCK1 complex |
| REAC:R-HSA-199991 | 0.0250934257322 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Membrane Trafficking |
| REAC:R-HSA-5653656 | 0.0308930175437 | 0.5 | CHMP5 VTA1 CHMP2A CHMP4A | Vesicle-mediated transport |
| GO:0032506 | 0.0330194726961 | 0.375 | CHMP5 CHMP2A CHMP4A | cytokinetic process |
| GO:0000910 | 0.0335258158335 | 0.5 | CHMP5 CHMP4A CHMP2A ROCK1 | cytokinesis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CHMP5 | CHMP4A | 0.988 | 0.901 | hein_WMM bioplex_WMM Guru fraction |
| CHMP5 | VTA1 | 0.778 | 0.753 | hein_WMM bioplex (CHMP5) bioplex_WMM |
| CHMP5 | STMN4 | 0.153 | 0.411 | bioplex (CHMP5) bioplex_WMM |
| CHMP2A | VTA1 | 0.041 | 0.268 | hein_WMM bioplex (CHMP2A) bioplex_WMM |
| VTA1 | ROCK1 | 0.03 | 0.238 | fraction |
| TRIM35 | CHMP2A | 0.029 | 0.234 | bioplex (CHMP2A) bioplex_WMM |
| STMN4 | VTA1 | 0.024 | 0.21 | bioplex (STMN4) bioplex_WMM |
| CHMP5 | CHMP2A | 0.021 | 0.191 | hein_WMM bioplex (CHMP2A,CHMP5) bioplex_WMM |
| CHMP5 | EHBP1L1 | 0.02 | 0.187 | fraction |
| STMN4 | CHMP2A | 0.008 | 0.085 | bioplex_WMM WMM_only |
| TRIM35 | VTA1 | 0.008 | 0.06 | bioplex_WMM WMM_only |
| CHMP5 | TRIM35 | 0.008 | 0.024 | bioplex_WMM WMM_only |
| CHMP4A | CHMP2A | 0.007 | 0.005 | hein_WMM WMM_only |
| CHMP5 | ROCK1 | 0.007 | 0.003 | youn_WMM gupta_WMM WMM_only |
| CHMP4A | VTA1 | 0.007 | 0.001 | WMM_only bioplex_WMM |
| CHMP4A | EHBP1L1 | 0.0 | 0.006 | fraction |
Images
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Complex HuMAP2_06627 has an average edge precision of 0.224 which is ranked 5802 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CHMP5 | HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627 |
| CHMP4A | HuMAP2_00024 HuMAP2_01637 HuMAP2_04528 HuMAP2_06627 |
| VTA1 | HuMAP2_00578 HuMAP2_01637 HuMAP2_06208 HuMAP2_06627 HuMAP2_06668 |
| CHMP2A | HuMAP2_00578 HuMAP2_00867 HuMAP2_01274 HuMAP2_06208 HuMAP2_06457 HuMAP2_06627 |
| TRIM35 | HuMAP2_00258 HuMAP2_02019 HuMAP2_06457 HuMAP2_06627 |
| EHBP1L1 | HuMAP2_01825 HuMAP2_06627 |
| ROCK1 | HuMAP2_06587 HuMAP2_06627 |
| STMN4 | HuMAP2_00024 HuMAP2_04528 HuMAP2_06627 |