hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06629
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| NOB1 | RNA-binding protein NOB1 (Phosphorylation regulatory protein HP-10) (Protein ART-4) | UniProt NCBI |
| POLA1 | DNA polymerase alpha catalytic subunit (EC 2.7.7.7) (DNA polymerase alpha catalytic subunit p180) | UniProt NCBI |
| PRIM2 | DNA primase large subunit (EC 2.7.7.-) (DNA primase 58 kDa subunit) (p58) | UniProt NCBI |
| POLA2 | DNA polymerase alpha subunit B (DNA polymerase alpha 70 kDa subunit) | UniProt NCBI |
| PRIM1 | DNA primase small subunit (EC 2.7.7.-) (DNA primase 49 kDa subunit) (p49) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:1100 | 1.81514593393e-13 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA polymerase alpha-primase complex |
| REAC:R-HSA-68952 | 2.555871701e-11 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA replication initiation |
| REAC:R-HSA-174430 | 2.555871701e-11 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Telomere C-strand synthesis initiation |
| CORUM:1107 | 3.81057767206e-11 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA synthesome core complex |
| CORUM:1098 | 1.29720178257e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA synthesome complex (13 subunits) |
| CORUM:1108 | 2.4762098927e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA synthesome complex (15 subunits) |
| REAC:R-HSA-113501 | 2.60993891582e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Inhibition of replication initiation of damaged DNA by RB1/E2F1 |
| REAC:R-HSA-69109 | 3.65371807209e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Leading Strand Synthesis |
| REAC:R-HSA-69166 | 3.65371807209e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Removal of the Flap Intermediate |
| REAC:R-HSA-174411 | 3.65371807209e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Polymerase switching on the C-strand of the telomere |
| REAC:R-HSA-69091 | 3.65371807209e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Polymerase switching |
| CORUM:1099 | 4.31702996263e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA synthesome complex (17 subunits) |
| CORUM:1111 | 4.31702996263e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA synthesome complex (17 subunits) |
| REAC:R-HSA-69183 | 4.98207499369e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Processive synthesis on the lagging strand |
| GO:0005658 | 6.09856266088e-10 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | alpha DNA polymerase:primase complex |
| REAC:R-HSA-69186 | 1.76788755434e-09 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Lagging Strand Synthesis |
| REAC:R-HSA-113510 | 2.66887650159e-09 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | E2F mediated regulation of DNA replication |
| REAC:R-HSA-174417 | 3.87647729286e-09 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Telomere C-strand (Lagging Strand) Synthesis |
| KEGG:03030 | 6.83119004003e-09 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA replication |
| REAC:R-HSA-180786 | 9.99440778064e-09 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Extension of Telomeres |
| WP:WP466 | 1.00926677532e-08 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA Replication |
| REAC:R-HSA-69190 | 1.31129440131e-08 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA strand elongation |
| REAC:R-HSA-68962 | 1.49208230389e-08 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Activation of the pre-replicative complex |
| WP:WP4022 | 1.35209832475e-07 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Pyrimidine metabolism |
| REAC:R-HSA-157579 | 6.0508920703e-07 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Telomere Maintenance |
| REAC:R-HSA-69002 | 7.36239529367e-07 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA Replication Pre-Initiation |
| GO:0043601 | 1.54127830699e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | nuclear replisome |
| REAC:R-HSA-73886 | 1.94622174999e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Chromosome Maintenance |
| GO:0032201 | 2.13806517127e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | telomere maintenance via semi-conservative replication |
| GO:0030894 | 2.13806517127e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | replisome |
| REAC:R-HSA-69239 | 2.78534254864e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Synthesis of DNA |
| GO:0006270 | 3.33813219873e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA replication initiation |
| REAC:R-HSA-69306 | 3.63140268773e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA Replication |
| GO:0006269 | 3.6323771075e-06 | 0.6 | PRIM2 PRIM1 POLA1 | DNA replication, synthesis of RNA primer |
| REAC:R-HSA-69206 | 4.12021471894e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | G1/S Transition |
| REAC:R-HSA-453279 | 6.76665795869e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Mitotic G1-G1/S phases |
| REAC:R-HSA-69242 | 9.2847398572e-06 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | S Phase |
| GO:0043596 | 1.2328136433e-05 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | nuclear replication fork |
| WP:WP45 | 2.65535825723e-05 | 0.6 | POLA2 PRIM1 PRIM2 | G1 to S cell cycle control |
| GO:0033260 | 3.29372797631e-05 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | nuclear DNA replication |
| GO:0044786 | 4.46760620155e-05 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | cell cycle DNA replication |
| GO:0005657 | 7.72519331369e-05 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | replication fork |
| CORUM:1003 | 0.000241285563976 | 0.4 | POLA2 POLA1 | RC complex (Replication competent complex) |
| GO:0055029 | 0.000403202499238 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | nuclear DNA-directed RNA polymerase complex |
| GO:0000428 | 0.00042052183524 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA-directed RNA polymerase complex |
| GO:0030880 | 0.000475835425563 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | RNA polymerase complex |
| REAC:R-HSA-69278 | 0.00103692271301 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Cell Cycle, Mitotic |
| GO:0006261 | 0.00125226429768 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA-dependent DNA replication |
| GO:0032993 | 0.00170079952717 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | protein-DNA complex |
| REAC:R-HSA-1640170 | 0.0021256129161 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | Cell Cycle |
| GO:0000723 | 0.00245191852964 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | telomere maintenance |
| MIRNA:hsa-miR-3622b-5p | 0.00260542187685 | 0.6 | POLA2 PRIM1 NOB1 | hsa-miR-3622b-5p |
| GO:0032200 | 0.00342761547193 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | telomere organization |
| GO:0000082 | 0.00796512695553 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | G1/S transition of mitotic cell cycle |
| GO:0006260 | 0.00913982817851 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | DNA replication |
| GO:0044843 | 0.0100550100183 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | cell cycle G1/S phase transition |
| GO:0061695 | 0.0120893245383 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | transferase complex, transferring phosphorus-containing groups |
| WP:WP2446 | 0.0123508080289 | 0.4 | PRIM1 POLA1 | Retinoblastoma Gene in Cancer |
| GO:0003896 | 0.0135228859698 | 0.4 | PRIM1 PRIM2 | DNA primase activity |
| GO:0060249 | 0.0309921425814 | 0.8 | POLA2 PRIM2 PRIM1 POLA1 | anatomical structure homeostasis |
| MIRNA:hsa-miR-6862-5p | 0.0499078535759 | 0.4 | POLA2 NOB1 | hsa-miR-6862-5p |
| MIRNA:hsa-miR-888-3p | 0.0499078535759 | 0.4 | POLA2 PRIM1 | hsa-miR-888-3p |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| PRIM1 | POLA1 | 0.968 | 0.88 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM fraction |
| POLA2 | POLA1 | 0.902 | 0.826 | hein_WMM bioplex_WMM youn_WMM gupta_WMM fraction |
| PRIM1 | PRIM2 | 0.82 | 0.773 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM |
| PRIM1 | POLA2 | 0.644 | 0.687 | hein_WMM bioplex (PRIM1) bioplex_WMM youn_WMM fraction |
| PRIM1 | NOB1 | 0.039 | 0.264 | youn_WMM fraction |
| POLA1 | NOB1 | 0.01 | 0.114 | youn_WMM fraction bioplex_WMM |
| PRIM2 | POLA1 | 0.01 | 0.107 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| PRIM2 | POLA2 | 0.009 | 0.107 | hein_WMM bioplex_WMM youn_WMM gupta_WMM WMM_only |
| POLA2 | NOB1 | 0.007 | 0.005 | youn_WMM gupta_WMM WMM_only |
| PRIM2 | NOB1 | 0.007 | 0.004 | gupta_WMM WMM_only |
Images
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Complex HuMAP2_06629 has an average edge precision of 0.377 which is ranked 3563 out of all 6965 complexes.
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