hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06632

Confidence: Medium

Genename	Protein Name	Links
NLRP3	NACHT, LRR and PYD domains-containing protein 3 (Angiotensin/vasopressin receptor AII/AVP-like) (Caterpiller protein 1.1) (CLR1.1) (Cold-induced autoinflammatory syndrome 1 protein) (Cryopyrin) (PYRIN-containing APAF1-like protein 1)	UniProt NCBI
SMAD4	Mothers against decapentaplegic homolog 4 (MAD homolog 4) (Mothers against DPP homolog 4) (Deletion target in pancreatic carcinoma 4) (SMAD family member 4) (SMAD 4) (Smad4) (hSMAD4)	UniProt NCBI
ALDOA	Fructose-bisphosphate aldolase A (EC 4.1.2.13) (Lung cancer antigen NY-LU-1) (Muscle-type aldolase)	UniProt NCBI
LHX4	LIM/homeobox protein Lhx4 (LIM homeobox protein 4)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
HP:0008373	0.000626948027784	1.0	NLRP3 LHX4 SMAD4 ALDOA	Puberty and gonadal disorders
HP:0000952	0.00157185823159	0.75	LHX4 SMAD4 ALDOA	Jaundice
HP:0000823	0.00191650845368	0.75	NLRP3 ALDOA LHX4	Delayed puberty
HP:0011354	0.00199865992944	1.0	NLRP3 LHX4 SMAD4 ALDOA	Generalized abnormality of skin
HP:0012438	0.00238393503741	0.5	SMAD4 ALDOA	Abnormal gallbladder physiology
HP:0001082	0.00238393503741	0.5	SMAD4 ALDOA	Cholecystitis
HP:0001392	0.00343790618967	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of the liver
HP:0001396	0.00345663399483	0.75	LHX4 SMAD4 ALDOA	Cholestasis
HP:0001005	0.00367883182322	0.75	LHX4 SMAD4 ALDOA	Dermatological manifestations of systemic disorders
HP:0002012	0.00662656539009	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of the abdominal organs
HP:0000818	0.00795942553801	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of the endocrine system
HP:0004322	0.00795942553801	1.0	NLRP3 LHX4 SMAD4 ALDOA	Short stature
HP:0004297	0.00934279216777	0.75	LHX4 SMAD4 ALDOA	Abnormality of the biliary system
HP:0000002	0.0104421214204	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of body height
HP:0003319	0.0107791805948	0.75	LHX4 SMAD4 ALDOA	Abnormality of the cervical spine
HP:0012378	0.0116099650177	0.75	NLRP3 SMAD4 LHX4	Fatigue
HP:0004299	0.0167125722923	0.75	NLRP3 SMAD4 LHX4	Hernia of the abdominal wall
HP:0010866	0.0173396229329	0.75	NLRP3 SMAD4 LHX4	Abdominal wall defect
HP:0004298	0.0229257986494	0.75	NLRP3 SMAD4 LHX4	Abnormality of the abdominal wall
HP:0001510	0.0229652026356	1.0	NLRP3 LHX4 SMAD4 ALDOA	Growth delay
HP:0100790	0.0284745095423	0.75	NLRP3 SMAD4 LHX4	Hernia
HP:0001081	0.0288545127028	0.5	SMAD4 ALDOA	Cholelithiasis
HP:0025408	0.0289176088458	0.75	NLRP3 SMAD4 ALDOA	Abnormal spleen morphology
HP:0011121	0.0320246870686	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of skin morphology
HP:0001743	0.0331125866707	0.75	NLRP3 SMAD4 ALDOA	Abnormality of the spleen
HP:0001249	0.0361704819456	1.0	NLRP3 LHX4 SMAD4 ALDOA	Intellectual disability
HP:0012437	0.0400245195282	0.5	SMAD4 ALDOA	Abnormal gallbladder morphology
HP:0001903	0.041529593035	0.75	NLRP3 SMAD4 ALDOA	Anemia
HP:0000951	0.042726547058	1.0	NLRP3 LHX4 SMAD4 ALDOA	Abnormality of the skin
CORUM:3200	0.0499140284799	0.25	SMAD4	SMAD4-SKI complex
CORUM:3038	0.0499140284799	0.25	SMAD4	SMAD2-SMAD4-FAST1 complex
CORUM:2704	0.0499140284799	0.25	SMAD4	Ectodermin-SMAD4 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
SMAD4	LHX4	0.548	0.642	bioplex (LHX4) bioplex_WMM
SMAD4	ALDOA	0.03	0.24	fraction
ALDOA	NLRP3	0.025	0.218	fraction
LHX4	ALDOA	0.007	0.003	bioplex (LHX4)

Images

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Complex HuMAP2_06632 has an average edge precision of 0.276 which is ranked 4942 out of all 6965 complexes.

Related Complexes

Genename	Complexes
NLRP3	HuMAP2_01956 HuMAP2_03394 HuMAP2_04215 HuMAP2_06496 HuMAP2_06632
SMAD4	HuMAP2_01167 HuMAP2_06632
ALDOA	HuMAP2_01418 HuMAP2_01883 HuMAP2_03109 HuMAP2_04680 HuMAP2_06632 HuMAP2_06652
LHX4	HuMAP2_01167 HuMAP2_04165 HuMAP2_06632

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06632