hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06633
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.03206737618e-12 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | oxoglutarate dehydrogenase complex |
| KEGG:00020 | 5.39736455749e-12 | 0.833333333333 | DLD OGDHL DLST DLAT OGDH | Citrate cycle (TCA cycle) |
| GO:0045240 | 2.27003984279e-11 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 6.3229743118e-11 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 5.49702738084e-10 | 0.666666666667 | DLD DLST DLAT OGDH | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:1990204 | 1.78902342295e-09 | 1.0 | DLST OGDH MRPS36 OGDHL DLD DLAT | oxidoreductase complex |
| KEGG:01200 | 6.64036171733e-09 | 0.833333333333 | DLD OGDHL DLST DLAT OGDH | Carbon metabolism |
| CORUM:7267 | 9.01288868683e-09 | 0.5 | DLD OGDH DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| REAC:R-HSA-389661 | 3.27882210208e-08 | 0.666666666667 | DLD DLST DLAT OGDH | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 3.67598690243e-08 | 0.833333333333 | DLD OGDHL OGDH DLAT MRPS36 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| REAC:R-HSA-71406 | 3.23137788357e-07 | 0.666666666667 | DLD DLST DLAT OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP78 | 1.01861297007e-06 | 0.5 | DLD OGDH DLST | TCA Cycle (aka Krebs or citric acid cycle) |
| REAC:R-HSA-71064 | 1.30838871118e-06 | 0.5 | DLD OGDH DLST | Lysine catabolism |
| GO:0106077 | 7.26438828159e-06 | 0.5 | DLD OGDH DLST | histone succinylation |
| GO:0018335 | 7.26438828159e-06 | 0.5 | DLD OGDH DLST | protein succinylation |
| GO:0004591 | 7.26438828159e-06 | 0.5 | MRPS36 OGDH OGDHL | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71403 | 7.89904848188e-06 | 0.5 | DLD OGDH DLST | Citric acid cycle (TCA cycle) |
| GO:0006099 | 1.00004074113e-05 | 0.666666666667 | DLD DLST OGDH OGDHL | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | DLD DLST DLAT OGDH | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016624 | 0.000101639975642 | 0.5 | MRPS36 OGDH OGDHL | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| WP:WP3925 | 0.00016262225713 | 0.5 | DLD OGDH DLST | Amino Acid metabolism |
| GO:0009060 | 0.000373722975929 | 0.666666666667 | DLD DLST OGDH OGDHL | aerobic respiration |
| GO:0006554 | 0.00039905855691 | 0.5 | DLD OGDH DLST | lysine catabolic process |
| HP:0012401 | 0.00045066196833 | 0.333333333333 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| GO:0006553 | 0.000518697707158 | 0.5 | DLD OGDH DLST | lysine metabolic process |
| GO:0006103 | 0.000660060925697 | 0.5 | MRPS36 OGDH DLST | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71291 | 0.000702192273232 | 0.666666666667 | DLD DLST DLAT OGDH | Metabolism of amino acids and derivatives |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | DLD OGDHL DLST DLAT OGDH | Metabolic pathways |
| GO:0009068 | 0.00240920978697 | 0.5 | DLD OGDH DLST | aspartate family amino acid catabolic process |
| REAC:R-HSA-204174 | 0.00265393377546 | 0.333333333333 | DLD DLAT | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | DLD DLST | Tryptophan metabolism |
| GO:0005759 | 0.00447076835271 | 0.833333333333 | DLD DLST OGDH DLAT MRPS36 | mitochondrial matrix |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | DLD DLAT | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | DLD DLAT | Glycolysis and Gluconeogenesis |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | DLD DLST OGDH OGDHL | cellular respiration |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | DLD DLAT | Pyruvate metabolism |
| HP:0003128 | 0.010881087561 | 0.5 | DLD DLAT OGDH | Lactic acidosis |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | DLD DLST | Lysine degradation |
| GO:0005739 | 0.0118519643143 | 1.0 | DLST OGDH MRPS36 OGDHL DLD DLAT | mitochondrion |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | DLD DLAT | Glycolysis / Gluconeogenesis |
| GO:1902494 | 0.013185208462 | 1.0 | DLST OGDH MRPS36 OGDHL DLD DLAT | catalytic complex |
| HPA:008050_12 | 0.0142121920463 | 0.5 | MRPS36 OGDH DLST | cerebral cortex; neuropil[Supported,Medium] |
| REAC:R-HSA-5362517 | 0.0171765331493 | 0.333333333333 | DLD DLAT | Signaling by Retinoic Acid |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | DLD OGDHL OGDH DLAT MRPS36 | oxidoreductase activity |
| GO:0009066 | 0.0222806450818 | 0.5 | DLD OGDH DLST | aspartate family amino acid metabolic process |
| GO:0015980 | 0.023174580771 | 0.666666666667 | DLD DLST OGDH OGDHL | energy derivation by oxidation of organic compounds |
| HPA:040010_13 | 0.0384299204809 | 0.5 | MRPS36 OGDH DLST | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0391082704229 | 0.5 | MRPS36 OGDH DLST | cerebellum; Purkinje cells[Supported,High] |
| GO:0034603 | 0.0405595771497 | 0.333333333333 | DLD DLAT | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 0.0405595771497 | 0.333333333333 | DLD DLAT | pyruvate dehydrogenase (NAD+) activity |
| HPA:033010_13 | 0.0433434532907 | 0.5 | MRPS36 OGDH DLST | parathyroid gland; glandular cells[Supported,High] |
| HPA:031010_12 | 0.0451930166929 | 0.5 | MRPS36 OGDH DLST | ovary; follicle cells[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| OGDH | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| DLD | DLAT | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| OGDH | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLST | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLST | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| DLST | MRPS36 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | MRPS36 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MRPS36 | DLAT | 0.009 | 0.106 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | OGDHL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| DLST | OGDHL | 0.008 | 0.089 | bioplex_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| OGDHL | DLAT | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06633 has an average edge precision of 0.555 which is ranked 2171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |