hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06633
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.03206737618e-12 | 0.833333333333 | DLST OGDH OGDHL DLD MRPS36 | oxoglutarate dehydrogenase complex |
| KEGG:00020 | 5.39736455749e-12 | 0.833333333333 | DLST DLAT OGDHL DLD OGDH | Citrate cycle (TCA cycle) |
| GO:0045240 | 2.27003984279e-11 | 0.833333333333 | DLST OGDH OGDHL DLD MRPS36 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 6.3229743118e-11 | 0.833333333333 | DLST OGDH OGDHL DLD MRPS36 | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 5.49702738084e-10 | 0.666666666667 | DLST DLAT DLD OGDH | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:1990204 | 1.78902342295e-09 | 1.0 | DLAT MRPS36 OGDH DLD DLST OGDHL | oxidoreductase complex |
| KEGG:01200 | 6.64036171733e-09 | 0.833333333333 | DLST DLAT OGDHL DLD OGDH | Carbon metabolism |
| CORUM:7267 | 9.01288868683e-09 | 0.5 | OGDH DLD DLST | KAT2A-Oxoglutarate dehydrogenase complex |
| REAC:R-HSA-389661 | 3.27882210208e-08 | 0.666666666667 | DLST DLAT DLD OGDH | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 3.67598690243e-08 | 0.833333333333 | OGDHL DLAT OGDH DLD MRPS36 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| REAC:R-HSA-71406 | 3.23137788357e-07 | 0.666666666667 | DLST DLAT DLD OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP78 | 1.01861297007e-06 | 0.5 | OGDH DLD DLST | TCA Cycle (aka Krebs or citric acid cycle) |
| REAC:R-HSA-71064 | 1.30838871118e-06 | 0.5 | OGDH DLD DLST | Lysine catabolism |
| GO:0106077 | 7.26438828159e-06 | 0.5 | OGDH DLD DLST | histone succinylation |
| GO:0018335 | 7.26438828159e-06 | 0.5 | OGDH DLD DLST | protein succinylation |
| GO:0004591 | 7.26438828159e-06 | 0.5 | OGDH MRPS36 OGDHL | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71403 | 7.89904848188e-06 | 0.5 | OGDH DLD DLST | Citric acid cycle (TCA cycle) |
| GO:0006099 | 1.00004074113e-05 | 0.666666666667 | DLST OGDH DLD OGDHL | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | DLST DLAT DLD OGDH | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016624 | 0.000101639975642 | 0.5 | OGDH MRPS36 OGDHL | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| WP:WP3925 | 0.00016262225713 | 0.5 | OGDH DLD DLST | Amino Acid metabolism |
| GO:0009060 | 0.000373722975929 | 0.666666666667 | DLST OGDH DLD OGDHL | aerobic respiration |
| GO:0006554 | 0.00039905855691 | 0.5 | OGDH DLD DLST | lysine catabolic process |
| HP:0012401 | 0.00045066196833 | 0.333333333333 | OGDH DLD | Abnormal urine alpha-ketoglutarate concentration |
| GO:0006553 | 0.000518697707158 | 0.5 | OGDH DLD DLST | lysine metabolic process |
| GO:0006103 | 0.000660060925697 | 0.5 | OGDH MRPS36 DLST | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71291 | 0.000702192273232 | 0.666666666667 | DLST DLAT DLD OGDH | Metabolism of amino acids and derivatives |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | DLST DLAT OGDHL DLD OGDH | Metabolic pathways |
| GO:0009068 | 0.00240920978697 | 0.5 | OGDH DLD DLST | aspartate family amino acid catabolic process |
| REAC:R-HSA-204174 | 0.00265393377546 | 0.333333333333 | DLAT DLD | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | DLST DLD | Tryptophan metabolism |
| GO:0005759 | 0.00447076835271 | 0.833333333333 | DLST DLAT OGDH DLD MRPS36 | mitochondrial matrix |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | DLAT DLD | Glycolysis and Gluconeogenesis |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | DLST OGDH DLD OGDHL | cellular respiration |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| HP:0003128 | 0.010881087561 | 0.5 | DLAT DLD OGDH | Lactic acidosis |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | DLST DLD | Lysine degradation |
| GO:0005739 | 0.0118519643143 | 1.0 | DLAT MRPS36 OGDH DLD DLST OGDHL | mitochondrion |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | DLAT DLD | Glycolysis / Gluconeogenesis |
| GO:1902494 | 0.013185208462 | 1.0 | DLAT MRPS36 OGDH DLD DLST OGDHL | catalytic complex |
| HPA:008050_12 | 0.0142121920463 | 0.5 | OGDH MRPS36 DLST | cerebral cortex; neuropil[Supported,Medium] |
| REAC:R-HSA-5362517 | 0.0171765331493 | 0.333333333333 | DLAT DLD | Signaling by Retinoic Acid |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | OGDHL DLAT OGDH DLD MRPS36 | oxidoreductase activity |
| GO:0009066 | 0.0222806450818 | 0.5 | OGDH DLD DLST | aspartate family amino acid metabolic process |
| GO:0015980 | 0.023174580771 | 0.666666666667 | DLST OGDH DLD OGDHL | energy derivation by oxidation of organic compounds |
| HPA:040010_13 | 0.0384299204809 | 0.5 | OGDH MRPS36 DLST | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0391082704229 | 0.5 | OGDH MRPS36 DLST | cerebellum; Purkinje cells[Supported,High] |
| GO:0034603 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase (NAD+) activity |
| HPA:033010_13 | 0.0433434532907 | 0.5 | OGDH MRPS36 DLST | parathyroid gland; glandular cells[Supported,High] |
| HPA:031010_12 | 0.0451930166929 | 0.5 | OGDH MRPS36 DLST | ovary; follicle cells[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| OGDH | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| DLD | DLAT | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| OGDH | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLST | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLST | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| DLST | MRPS36 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | MRPS36 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MRPS36 | DLAT | 0.009 | 0.106 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | OGDHL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| DLST | OGDHL | 0.008 | 0.089 | bioplex_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| OGDHL | DLAT | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06633 has an average edge precision of 0.555 which is ranked 2171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |