hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06633
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.03206737618e-12 | 0.833333333333 | OGDH DLST DLD OGDHL MRPS36 | oxoglutarate dehydrogenase complex |
| KEGG:00020 | 5.39736455749e-12 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Citrate cycle (TCA cycle) |
| GO:0045240 | 2.27003984279e-11 | 0.833333333333 | OGDH DLST DLD OGDHL MRPS36 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 6.3229743118e-11 | 0.833333333333 | OGDH DLST DLD OGDHL MRPS36 | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 5.49702738084e-10 | 0.666666666667 | DLAT DLD DLST OGDH | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:1990204 | 1.78902342295e-09 | 1.0 | OGDHL MRPS36 DLD DLAT OGDH DLST | oxidoreductase complex |
| KEGG:01200 | 6.64036171733e-09 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Carbon metabolism |
| CORUM:7267 | 9.01288868683e-09 | 0.5 | DLD DLST OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| REAC:R-HSA-389661 | 3.27882210208e-08 | 0.666666666667 | DLAT DLD DLST OGDH | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 3.67598690243e-08 | 0.833333333333 | DLAT OGDHL DLD OGDH MRPS36 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| REAC:R-HSA-71406 | 3.23137788357e-07 | 0.666666666667 | DLAT DLD DLST OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP78 | 1.01861297007e-06 | 0.5 | DLD DLST OGDH | TCA Cycle (aka Krebs or citric acid cycle) |
| REAC:R-HSA-71064 | 1.30838871118e-06 | 0.5 | DLD DLST OGDH | Lysine catabolism |
| GO:0106077 | 7.26438828159e-06 | 0.5 | DLD DLST OGDH | histone succinylation |
| GO:0018335 | 7.26438828159e-06 | 0.5 | DLD DLST OGDH | protein succinylation |
| GO:0004591 | 7.26438828159e-06 | 0.5 | OGDHL MRPS36 OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71403 | 7.89904848188e-06 | 0.5 | DLD DLST OGDH | Citric acid cycle (TCA cycle) |
| GO:0006099 | 1.00004074113e-05 | 0.666666666667 | OGDHL DLD DLST OGDH | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | DLAT DLD DLST OGDH | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016624 | 0.000101639975642 | 0.5 | OGDHL MRPS36 OGDH | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| WP:WP3925 | 0.00016262225713 | 0.5 | DLD DLST OGDH | Amino Acid metabolism |
| GO:0009060 | 0.000373722975929 | 0.666666666667 | OGDHL DLD DLST OGDH | aerobic respiration |
| GO:0006554 | 0.00039905855691 | 0.5 | DLD DLST OGDH | lysine catabolic process |
| HP:0012401 | 0.00045066196833 | 0.333333333333 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| GO:0006553 | 0.000518697707158 | 0.5 | DLD DLST OGDH | lysine metabolic process |
| GO:0006103 | 0.000660060925697 | 0.5 | MRPS36 DLST OGDH | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71291 | 0.000702192273232 | 0.666666666667 | DLAT DLD DLST OGDH | Metabolism of amino acids and derivatives |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Metabolic pathways |
| GO:0009068 | 0.00240920978697 | 0.5 | DLD DLST OGDH | aspartate family amino acid catabolic process |
| REAC:R-HSA-204174 | 0.00265393377546 | 0.333333333333 | DLAT DLD | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | DLD DLST | Tryptophan metabolism |
| GO:0005759 | 0.00447076835271 | 0.833333333333 | DLAT DLST DLD OGDH MRPS36 | mitochondrial matrix |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | DLAT DLD | Glycolysis and Gluconeogenesis |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | OGDHL DLD DLST OGDH | cellular respiration |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| HP:0003128 | 0.010881087561 | 0.5 | DLAT DLD OGDH | Lactic acidosis |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | DLD DLST | Lysine degradation |
| GO:0005739 | 0.0118519643143 | 1.0 | OGDHL MRPS36 DLD DLAT OGDH DLST | mitochondrion |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | DLAT DLD | Glycolysis / Gluconeogenesis |
| GO:1902494 | 0.013185208462 | 1.0 | OGDHL MRPS36 DLD DLAT OGDH DLST | catalytic complex |
| HPA:008050_12 | 0.0142121920463 | 0.5 | MRPS36 DLST OGDH | cerebral cortex; neuropil[Supported,Medium] |
| REAC:R-HSA-5362517 | 0.0171765331493 | 0.333333333333 | DLAT DLD | Signaling by Retinoic Acid |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | DLAT OGDHL DLD OGDH MRPS36 | oxidoreductase activity |
| GO:0009066 | 0.0222806450818 | 0.5 | DLD DLST OGDH | aspartate family amino acid metabolic process |
| GO:0015980 | 0.023174580771 | 0.666666666667 | OGDHL DLD DLST OGDH | energy derivation by oxidation of organic compounds |
| HPA:040010_13 | 0.0384299204809 | 0.5 | MRPS36 DLST OGDH | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0391082704229 | 0.5 | MRPS36 DLST OGDH | cerebellum; Purkinje cells[Supported,High] |
| GO:0034603 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase (NAD+) activity |
| HPA:033010_13 | 0.0433434532907 | 0.5 | MRPS36 DLST OGDH | parathyroid gland; glandular cells[Supported,High] |
| HPA:031010_12 | 0.0451930166929 | 0.5 | MRPS36 DLST OGDH | ovary; follicle cells[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| OGDH | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| DLD | DLAT | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| OGDH | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLST | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLST | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| DLST | MRPS36 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | MRPS36 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MRPS36 | DLAT | 0.009 | 0.106 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | OGDHL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| DLST | OGDHL | 0.008 | 0.089 | bioplex_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| OGDHL | DLAT | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06633 has an average edge precision of 0.555 which is ranked 2171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |