hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06633
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.03206737618e-12 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | oxoglutarate dehydrogenase complex |
| KEGG:00020 | 5.39736455749e-12 | 0.833333333333 | DLD OGDHL DLST OGDH DLAT | Citrate cycle (TCA cycle) |
| GO:0045240 | 2.27003984279e-11 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 6.3229743118e-11 | 0.833333333333 | DLD OGDHL DLST OGDH MRPS36 | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 5.49702738084e-10 | 0.666666666667 | DLD DLST OGDH DLAT | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:1990204 | 1.78902342295e-09 | 1.0 | OGDH MRPS36 OGDHL DLD DLAT DLST | oxidoreductase complex |
| KEGG:01200 | 6.64036171733e-09 | 0.833333333333 | DLD OGDHL DLST OGDH DLAT | Carbon metabolism |
| CORUM:7267 | 9.01288868683e-09 | 0.5 | DLD DLST OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| REAC:R-HSA-389661 | 3.27882210208e-08 | 0.666666666667 | DLD DLST OGDH DLAT | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 3.67598690243e-08 | 0.833333333333 | DLD OGDHL DLAT OGDH MRPS36 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| REAC:R-HSA-71406 | 3.23137788357e-07 | 0.666666666667 | DLD DLST OGDH DLAT | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP78 | 1.01861297007e-06 | 0.5 | DLD DLST OGDH | TCA Cycle (aka Krebs or citric acid cycle) |
| REAC:R-HSA-71064 | 1.30838871118e-06 | 0.5 | DLD DLST OGDH | Lysine catabolism |
| GO:0106077 | 7.26438828159e-06 | 0.5 | DLD DLST OGDH | histone succinylation |
| GO:0018335 | 7.26438828159e-06 | 0.5 | DLD DLST OGDH | protein succinylation |
| GO:0004591 | 7.26438828159e-06 | 0.5 | MRPS36 OGDHL OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71403 | 7.89904848188e-06 | 0.5 | DLD DLST OGDH | Citric acid cycle (TCA cycle) |
| GO:0006099 | 1.00004074113e-05 | 0.666666666667 | DLD DLST OGDHL OGDH | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | DLD DLST OGDH DLAT | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016624 | 0.000101639975642 | 0.5 | MRPS36 OGDHL OGDH | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| WP:WP3925 | 0.00016262225713 | 0.5 | DLD DLST OGDH | Amino Acid metabolism |
| GO:0009060 | 0.000373722975929 | 0.666666666667 | DLD DLST OGDHL OGDH | aerobic respiration |
| GO:0006554 | 0.00039905855691 | 0.5 | DLD DLST OGDH | lysine catabolic process |
| HP:0012401 | 0.00045066196833 | 0.333333333333 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| GO:0006553 | 0.000518697707158 | 0.5 | DLD DLST OGDH | lysine metabolic process |
| GO:0006103 | 0.000660060925697 | 0.5 | MRPS36 DLST OGDH | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71291 | 0.000702192273232 | 0.666666666667 | DLD DLST OGDH DLAT | Metabolism of amino acids and derivatives |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | DLD OGDHL DLST OGDH DLAT | Metabolic pathways |
| GO:0009068 | 0.00240920978697 | 0.5 | DLD DLST OGDH | aspartate family amino acid catabolic process |
| REAC:R-HSA-204174 | 0.00265393377546 | 0.333333333333 | DLD DLAT | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | DLD DLST | Tryptophan metabolism |
| GO:0005759 | 0.00447076835271 | 0.833333333333 | DLD DLST DLAT OGDH MRPS36 | mitochondrial matrix |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | DLD DLAT | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | DLD DLAT | Glycolysis and Gluconeogenesis |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | DLD DLST OGDHL OGDH | cellular respiration |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | DLD DLAT | Pyruvate metabolism |
| HP:0003128 | 0.010881087561 | 0.5 | DLD OGDH DLAT | Lactic acidosis |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | DLD DLST | Lysine degradation |
| GO:0005739 | 0.0118519643143 | 1.0 | OGDH MRPS36 OGDHL DLD DLAT DLST | mitochondrion |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | DLD DLAT | Glycolysis / Gluconeogenesis |
| GO:1902494 | 0.013185208462 | 1.0 | OGDH MRPS36 OGDHL DLD DLAT DLST | catalytic complex |
| HPA:008050_12 | 0.0142121920463 | 0.5 | MRPS36 DLST OGDH | cerebral cortex; neuropil[Supported,Medium] |
| REAC:R-HSA-5362517 | 0.0171765331493 | 0.333333333333 | DLD DLAT | Signaling by Retinoic Acid |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | DLD OGDHL DLAT OGDH MRPS36 | oxidoreductase activity |
| GO:0009066 | 0.0222806450818 | 0.5 | DLD DLST OGDH | aspartate family amino acid metabolic process |
| GO:0015980 | 0.023174580771 | 0.666666666667 | DLD DLST OGDHL OGDH | energy derivation by oxidation of organic compounds |
| HPA:040010_13 | 0.0384299204809 | 0.5 | MRPS36 DLST OGDH | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0391082704229 | 0.5 | MRPS36 DLST OGDH | cerebellum; Purkinje cells[Supported,High] |
| GO:0034603 | 0.0405595771497 | 0.333333333333 | DLD DLAT | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 0.0405595771497 | 0.333333333333 | DLD DLAT | pyruvate dehydrogenase (NAD+) activity |
| HPA:033010_13 | 0.0433434532907 | 0.5 | MRPS36 DLST OGDH | parathyroid gland; glandular cells[Supported,High] |
| HPA:031010_12 | 0.0451930166929 | 0.5 | MRPS36 DLST OGDH | ovary; follicle cells[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| OGDH | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| DLD | DLAT | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| OGDH | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLST | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLST | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| DLST | MRPS36 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | MRPS36 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MRPS36 | DLAT | 0.009 | 0.106 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | OGDHL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| DLST | OGDHL | 0.008 | 0.089 | bioplex_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| OGDHL | DLAT | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06633 has an average edge precision of 0.555 which is ranked 2171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |