hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06633
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| DLD | Dihydrolipoyl dehydrogenase, mitochondrial (EC 1.8.1.4) (Dihydrolipoamide dehydrogenase) (Glycine cleavage system L protein) | UniProt NCBI |
| MRPS36 | 28S ribosomal protein S36, mitochondrial (MRP-S36) (S36mt) | UniProt NCBI |
| DLAT | Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial (EC 2.3.1.12) (70 kDa mitochondrial autoantigen of primary biliary cirrhosis) (PBC) (Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex) (M2 antigen complex 70 kDa subunit) (Pyruvate dehydrogenase complex component E2) (PDC-E2) (PDCE2) | UniProt NCBI |
| OGDHL | 2-oxoglutarate dehydrogenase-like, mitochondrial (EC 1.2.4.-) (2-oxoglutarate dehydrogenase complex component E1-like) (OGDC-E1-like) (Alpha-ketoglutarate dehydrogenase-like) | UniProt NCBI |
| DLST | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial (EC 2.3.1.61) (2-oxoglutarate dehydrogenase complex component E2) (OGDC-E2) (Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex) (E2K) | UniProt NCBI |
| OGDH | 2-oxoglutarate dehydrogenase, mitochondrial (EC 1.2.4.2) (2-oxoglutarate dehydrogenase complex component E1) (OGDC-E1) (Alpha-ketoglutarate dehydrogenase) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0045252 | 1.03206737618e-12 | 0.833333333333 | DLST OGDH DLD OGDHL MRPS36 | oxoglutarate dehydrogenase complex |
| KEGG:00020 | 5.39736455749e-12 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Citrate cycle (TCA cycle) |
| GO:0045240 | 2.27003984279e-11 | 0.833333333333 | DLST OGDH DLD OGDHL MRPS36 | dihydrolipoyl dehydrogenase complex |
| GO:0045239 | 6.3229743118e-11 | 0.833333333333 | DLST OGDH DLD OGDHL MRPS36 | tricarboxylic acid cycle enzyme complex |
| WP:WP2453 | 5.49702738084e-10 | 0.666666666667 | DLAT DLST DLD OGDH | TCA Cycle and Deficiency of Pyruvate Dehydrogenase complex (PDHc) |
| GO:1990204 | 1.78902342295e-09 | 1.0 | OGDHL DLST OGDH DLAT DLD MRPS36 | oxidoreductase complex |
| KEGG:01200 | 6.64036171733e-09 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Carbon metabolism |
| CORUM:7267 | 9.01288868683e-09 | 0.5 | DLST DLD OGDH | KAT2A-Oxoglutarate dehydrogenase complex |
| REAC:R-HSA-389661 | 3.27882210208e-08 | 0.666666666667 | DLAT DLST DLD OGDH | Glyoxylate metabolism and glycine degradation |
| GO:0016903 | 3.67598690243e-08 | 0.833333333333 | DLAT OGDH DLD OGDHL MRPS36 | oxidoreductase activity, acting on the aldehyde or oxo group of donors |
| REAC:R-HSA-71406 | 3.23137788357e-07 | 0.666666666667 | DLAT DLST DLD OGDH | Pyruvate metabolism and Citric Acid (TCA) cycle |
| WP:WP78 | 1.01861297007e-06 | 0.5 | DLST DLD OGDH | TCA Cycle (aka Krebs or citric acid cycle) |
| REAC:R-HSA-71064 | 1.30838871118e-06 | 0.5 | DLST DLD OGDH | Lysine catabolism |
| GO:0106077 | 7.26438828159e-06 | 0.5 | DLST DLD OGDH | histone succinylation |
| GO:0018335 | 7.26438828159e-06 | 0.5 | DLST DLD OGDH | protein succinylation |
| GO:0004591 | 7.26438828159e-06 | 0.5 | MRPS36 OGDHL OGDH | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| REAC:R-HSA-71403 | 7.89904848188e-06 | 0.5 | DLST DLD OGDH | Citric acid cycle (TCA cycle) |
| GO:0006099 | 1.00004074113e-05 | 0.666666666667 | DLST DLD OGDHL OGDH | tricarboxylic acid cycle |
| REAC:R-HSA-1428517 | 3.51056084595e-05 | 0.666666666667 | DLAT DLST DLD OGDH | The citric acid (TCA) cycle and respiratory electron transport |
| GO:0016624 | 0.000101639975642 | 0.5 | MRPS36 OGDHL OGDH | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| WP:WP3925 | 0.00016262225713 | 0.5 | DLST DLD OGDH | Amino Acid metabolism |
| GO:0009060 | 0.000373722975929 | 0.666666666667 | DLST DLD OGDHL OGDH | aerobic respiration |
| GO:0006554 | 0.00039905855691 | 0.5 | DLST DLD OGDH | lysine catabolic process |
| HP:0012401 | 0.00045066196833 | 0.333333333333 | DLD OGDH | Abnormal urine alpha-ketoglutarate concentration |
| GO:0006553 | 0.000518697707158 | 0.5 | DLST DLD OGDH | lysine metabolic process |
| GO:0006103 | 0.000660060925697 | 0.5 | DLST MRPS36 OGDH | 2-oxoglutarate metabolic process |
| REAC:R-HSA-71291 | 0.000702192273232 | 0.666666666667 | DLAT DLST DLD OGDH | Metabolism of amino acids and derivatives |
| KEGG:01100 | 0.0012193073463 | 0.833333333333 | DLAT DLST DLD OGDHL OGDH | Metabolic pathways |
| GO:0009068 | 0.00240920978697 | 0.5 | DLST DLD OGDH | aspartate family amino acid catabolic process |
| REAC:R-HSA-204174 | 0.00265393377546 | 0.333333333333 | DLAT DLD | Regulation of pyruvate dehydrogenase (PDH) complex |
| KEGG:00380 | 0.00414404804148 | 0.333333333333 | DLST DLD | Tryptophan metabolism |
| GO:0005759 | 0.00447076835271 | 0.833333333333 | DLAT DLST OGDH DLD MRPS36 | mitochondrial matrix |
| KEGG:00620 | 0.00460906737116 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| WP:WP534 | 0.00524729006009 | 0.333333333333 | DLAT DLD | Glycolysis and Gluconeogenesis |
| GO:0045333 | 0.0061921234234 | 0.666666666667 | DLST DLD OGDHL OGDH | cellular respiration |
| REAC:R-HSA-70268 | 0.00895825109095 | 0.333333333333 | DLAT DLD | Pyruvate metabolism |
| HP:0003128 | 0.010881087561 | 0.5 | DLAT DLD OGDH | Lactic acidosis |
| KEGG:00310 | 0.0113378999483 | 0.333333333333 | DLST DLD | Lysine degradation |
| GO:0005739 | 0.0118519643143 | 1.0 | OGDHL DLST OGDH DLAT DLD MRPS36 | mitochondrion |
| KEGG:00010 | 0.0120956152943 | 0.333333333333 | DLAT DLD | Glycolysis / Gluconeogenesis |
| GO:1902494 | 0.013185208462 | 1.0 | OGDHL DLST OGDH DLAT DLD MRPS36 | catalytic complex |
| HPA:008050_12 | 0.0142121920463 | 0.5 | DLST MRPS36 OGDH | cerebral cortex; neuropil[Supported,Medium] |
| REAC:R-HSA-5362517 | 0.0171765331493 | 0.333333333333 | DLAT DLD | Signaling by Retinoic Acid |
| GO:0016491 | 0.0222446676534 | 0.833333333333 | DLAT OGDH DLD OGDHL MRPS36 | oxidoreductase activity |
| GO:0009066 | 0.0222806450818 | 0.5 | DLST DLD OGDH | aspartate family amino acid metabolic process |
| GO:0015980 | 0.023174580771 | 0.666666666667 | DLST DLD OGDHL OGDH | energy derivation by oxidation of organic compounds |
| HPA:040010_13 | 0.0384299204809 | 0.5 | DLST MRPS36 OGDH | seminal vesicle; glandular cells[Supported,High] |
| HPA:007010_13 | 0.0391082704229 | 0.5 | DLST MRPS36 OGDH | cerebellum; Purkinje cells[Supported,High] |
| GO:0034603 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase [NAD(P)+] activity |
| GO:0034604 | 0.0405595771497 | 0.333333333333 | DLAT DLD | pyruvate dehydrogenase (NAD+) activity |
| HPA:033010_13 | 0.0433434532907 | 0.5 | DLST MRPS36 OGDH | parathyroid gland; glandular cells[Supported,High] |
| HPA:031010_12 | 0.0451930166929 | 0.5 | DLST MRPS36 OGDH | ovary; follicle cells[Supported,Medium] |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| OGDH | DLST | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM |
| OGDH | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| OGDHL | DLD | 1.0 | 0.949 | bioplex (DLD) bioplex_WMM |
| DLD | DLAT | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| OGDH | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLST | DLAT | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru youn_WMM Malo fraction treiber_WMM |
| DLD | MRPS36 | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM youn_WMM fraction |
| DLST | DLD | 1.0 | 0.949 | hein_WMM bioplex (DLD) bioplex_WMM Guru boldt youn_WMM Malo fraction boldt_WMM treiber_WMM |
| DLST | MRPS36 | 0.012 | 0.15 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | MRPS36 | 0.011 | 0.142 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| MRPS36 | DLAT | 0.009 | 0.106 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| OGDH | OGDHL | 0.008 | 0.091 | bioplex_WMM WMM_only |
| DLST | OGDHL | 0.008 | 0.089 | bioplex_WMM WMM_only |
| OGDHL | MRPS36 | 0.008 | 0.083 | bioplex_WMM WMM_only |
| OGDHL | DLAT | 0.008 | 0.07 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06633 has an average edge precision of 0.555 which is ranked 2171 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| DLD | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| MRPS36 | HuMAP2_02634 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLAT | HuMAP2_04548 HuMAP2_06086 HuMAP2_06633 |
| OGDHL | HuMAP2_01514 HuMAP2_02654 HuMAP2_03652 HuMAP2_04548 HuMAP2_04760 HuMAP2_06633 |
| DLST | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |
| OGDH | HuMAP2_00982 HuMAP2_04548 HuMAP2_06633 |