hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06640
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| MTFR1 | Mitochondrial fission regulator 1 (Chondrocyte protein with a poly-proline region) | UniProt NCBI |
| CYLD | Ubiquitin carboxyl-terminal hydrolase CYLD (EC 3.4.19.12) (Deubiquitinating enzyme CYLD) (Ubiquitin thioesterase CYLD) (Ubiquitin-specific-processing protease CYLD) | UniProt NCBI |
| SPHK1 | Sphingosine kinase 1 (SK 1) (SPK 1) (EC 2.7.1.91) (Acetyltransferase SPHK1) (EC 2.3.1.-) | UniProt NCBI |
| SPATA2 | Spermatogenesis-associated protein 2 | UniProt NCBI |
| FGL2 | Fibroleukin (Fibrinogen-like protein 2) (pT49) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:6296 | 6.70868171695e-06 | 0.4 | SPATA2 CYLD | SPATA2-CYLD complex |
| GO:1990108 | 0.0135228859698 | 0.4 | SPATA2 CYLD | protein linear deubiquitination |
| GO:0010803 | 0.0146610377831 | 0.6 | SPATA2 SPHK1 CYLD | regulation of tumor necrosis factor-mediated signaling pathway |
| MIRNA:hsa-miR-362-5p | 0.0482780268961 | 0.4 | SPATA2 CYLD | hsa-miR-362-5p |
| KEGG:04217 | 0.0482876775804 | 0.4 | SPATA2 CYLD | Necroptosis |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| SPATA2 | FGL2 | 0.59 | 0.664 | bioplex (FGL2) bioplex_WMM |
| MTFR1 | FGL2 | 0.06 | 0.336 | bioplex (FGL2) bioplex_WMM |
| CYLD | FGL2 | 0.042 | 0.269 | bioplex (FGL2) bioplex_WMM |
| CYLD | SPHK1 | 0.04 | 0.268 | bioplex (SPHK1) bioplex_WMM |
| CYLD | SPATA2 | 0.013 | 0.151 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| SPATA2 | MTFR1 | 0.008 | 0.027 | bioplex_WMM WMM_only |
| CYLD | MTFR1 | 0.007 | 0.007 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06640 has an average edge precision of 0.246 which is ranked 5436 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| MTFR1 | HuMAP2_00373 HuMAP2_02980 HuMAP2_06270 HuMAP2_06640 |
| CYLD | HuMAP2_00317 HuMAP2_02980 HuMAP2_06270 HuMAP2_06640 |
| SPHK1 | HuMAP2_00317 HuMAP2_06270 HuMAP2_06640 |
| SPATA2 | HuMAP2_00373 HuMAP2_02980 HuMAP2_03175 HuMAP2_03640 HuMAP2_06270 HuMAP2_06640 |
| FGL2 | HuMAP2_00373 HuMAP2_02980 HuMAP2_03640 HuMAP2_06270 HuMAP2_06640 |