hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06641

Confidence: Medium

Genename	Protein Name	Links
BCL2L1	Bcl-2-like protein 1 (Bcl2-L-1) (Apoptosis regulator Bcl-X)	UniProt NCBI
BAD	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	UniProt NCBI
TRMO	tRNA (adenine(37)-N6)-methyltransferase (EC 2.1.1.-) (tRNA methyltransferase O)	UniProt NCBI
BCL2L11	Bcl-2-like protein 11 (Bcl2-L-11) (Bcl2-interacting mediator of cell death)	UniProt NCBI
BCL2L15	Bcl-2-like protein 15 (Bcl2-L-15)	UniProt NCBI
BCL2	Apoptosis regulator Bcl-2	UniProt NCBI
RHPN2	Rhophilin-2 (76 kDa RhoB effector protein) (GTP-Rho-binding protein 2) (p76RBE)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-111453	3.59524219422e-10	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
REAC:R-HSA-109606	6.52796408062e-07	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Intrinsic Pathway for Apoptosis
WP:WP254	9.77716590408e-07	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Apoptosis
KEGG:01521	1.01825346936e-06	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	EGFR tyrosine kinase inhibitor resistance
WP:WP1772	1.49257404165e-06	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Apoptosis Modulation and Signaling
WP:WP3872	3.84177292062e-06	0.428571428571	BCL2 BCL2L1 BCL2L15	Regulation of Apoptosis by Parathyroid Hormone-related Protein
KEGG:04210	8.50589518326e-06	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Apoptosis
KEGG:04215	1.34541590884e-05	0.428571428571	BCL2 BCL2L1 BCL2L11	Apoptosis - multiple species
WP:WP2447	2.83260963691e-05	0.428571428571	BCL2 BCL2L1 BAD	Amyotrophic lateral sclerosis (ALS)
WP:WP286	3.85160299844e-05	0.428571428571	BCL2 BCL2L1 BAD	IL-3 Signaling Pathway
REAC:R-HSA-114452	4.29273169575e-05	0.428571428571	BCL2 BAD BCL2L11	Activation of BH3-only proteins
WP:WP3611	5.43473459381e-05	0.428571428571	BCL2 BCL2L1 BCL2L11	Photodynamic therapy-induced AP-1 survival signaling.
KEGG:05014	6.87187450392e-05	0.428571428571	BCL2 BCL2L1 BAD	Amyotrophic lateral sclerosis (ALS)
GO:2001244	6.98341385223e-05	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	positive regulation of intrinsic apoptotic signaling pathway
REAC:R-HSA-109581	9.11840957805e-05	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Apoptosis
REAC:R-HSA-844455	9.49682863429e-05	0.285714285714	BCL2 BCL2L1	The NLRP1 inflammasome
REAC:R-HSA-5357801	9.7846880833e-05	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Programmed Cell Death
GO:0001836	0.00010471199091	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	release of cytochrome c from mitochondria
WP:WP4216	0.000190638595503	0.428571428571	BCL2 BAD BCL2L11	Chromosomal and microsatellite instability in colorectal cancer
KEGG:01524	0.00019596836567	0.428571428571	BCL2 BCL2L1 BAD	Platinum drug resistance
WP:WP4172	0.000240159876739	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	PI3K-Akt Signaling Pathway
KEGG:04151	0.000282169949161	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	PI3K-Akt signaling pathway
KEGG:05210	0.000290407824229	0.428571428571	BCL2 BAD BCL2L11	Colorectal cancer
GO:0046902	0.000359116957816	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	regulation of mitochondrial membrane permeability
KEGG:05145	0.000438494812888	0.428571428571	BCL2 BCL2L1 BAD	Toxoplasmosis
GO:0090559	0.00057242223549	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	regulation of membrane permeability
WP:WP710	0.000603363005383	0.428571428571	BCL2 BAD BCL2L11	DNA Damage Response (only ATM dependent)
KEGG:05162	0.00110907784383	0.428571428571	BCL2 BCL2L1 BAD	Measles
KEGG:04140	0.00124404158756	0.428571428571	BCL2 BCL2L1 BAD	Autophagy - animal
WP:WP3657	0.00153544244266	0.285714285714	BCL2 BCL2L1	Hematopoietic Stem Cell Gene Regulation by GABP alpha/beta Complex
KEGG:05200	0.00159650327269	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	Pathways in cancer
MIRNA:hsa-miR-16-1-3p	0.00223152957134	0.428571428571	BCL2 TRMO BCL2L11	hsa-miR-16-1-3p
GO:0008637	0.00225019801643	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	apoptotic mitochondrial changes
WP:WP205	0.00231614132512	0.285714285714	BCL2L1 BAD	IL-7 Signaling Pathway
REAC:R-HSA-111447	0.00331497172198	0.285714285714	BCL2 BAD	Activation of BAD and translocation to mitochondria
KEGG:05170	0.00414294664142	0.428571428571	BCL2 BCL2L1 BAD	Human immunodeficiency virus 1 infection
MIRNA:hsa-miR-3120-3p	0.004168862574	0.428571428571	BCL2L11 BCL2L1 RHPN2	hsa-miR-3120-3p
GO:2001235	0.00449957152016	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	positive regulation of apoptotic signaling pathway
GO:0007006	0.00467022701645	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	mitochondrial membrane organization
GO:2001242	0.00484567677782	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	regulation of intrinsic apoptotic signaling pathway
WP:WP3981	0.00528100979744	0.285714285714	BCL2 BAD	miRNA regulation of prostate cancer signaling pathways
REAC:R-HSA-622312	0.00539383467143	0.285714285714	BCL2 BCL2L1	Inflammasomes
WP:WP3941	0.00665530732433	0.285714285714	BCL2 BAD	Oxidative Damage
GO:0005741	0.00735794310123	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	mitochondrial outer membrane
WP:WP364	0.00859430044807	0.285714285714	BCL2L1 BAD	IL-6 signaling pathway
WP:WP1971	0.00901151528078	0.285714285714	BCL2 BAD	Integrated Cancer Pathway
WP:WP4008	0.00901151528078	0.285714285714	BCL2 BAD	NO/cGMP/PKG mediated Neuroprotection
GO:0031968	0.0101054812095	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	organelle outer membrane
GO:0019867	0.010417139491	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	outer membrane
GO:0001844	0.0115540711621	0.428571428571	BCL2 BAD BCL2L11	protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:0010821	0.0117361179993	0.571428571429	BCL2 BAD BCL2L1 BCL2L11	regulation of mitochondrion organization
WP:WP304	0.0153237691065	0.285714285714	BCL2 BAD	Kit receptor signaling pathway
GO:0090199	0.0189025357646	0.428571428571	BCL2L11 BCL2L1 BAD	regulation of release of cytochrome c from mitochondria
KEGG:04115	0.019730410569	0.285714285714	BCL2 BCL2L1	p53 signaling pathway
KEGG:05212	0.0242823355935	0.285714285714	BCL2L1 BAD	Pancreatic cancer
WP:WP1438	0.0249993571594	0.142857142857	BCL2	Influenza A virus infection
KEGG:05220	0.0263752467347	0.285714285714	BCL2L1 BAD	Chronic myeloid leukemia
WP:WP2034	0.0267680695584	0.285714285714	BCL2L1 BAD	Leptin signaling pathway
WP:WP4298	0.0274952756989	0.285714285714	BCL2 BCL2L1	Viral Acute Myocarditis
KEGG:05168	0.0277884425258	0.428571428571	BCL2 BCL2L1 BAD	Herpes simplex virus 1 infection
KEGG:04064	0.030052232514	0.285714285714	BCL2 BCL2L1	NF-kappa B signaling pathway
WP:WP4263	0.033657197369	0.285714285714	BCL2L1 BAD	Pancreatic adenocarcinoma pathway
WP:WP673	0.0352930687583	0.285714285714	BCL2L11 BAD	ErbB Signaling Pathway
GO:0051881	0.0362050681854	0.428571428571	BCL2 BCL2L1 BAD	regulation of mitochondrial membrane potential
WP:WP231	0.0378182063894	0.285714285714	BCL2L1 BAD	TNF alpha Signaling Pathway
GO:0070059	0.0389125948999	0.428571428571	BCL2 BCL2L1 BCL2L11	intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
KEGG:05215	0.0389687236976	0.285714285714	BCL2 BAD	Prostate cancer
KEGG:01522	0.0389687236976	0.285714285714	BCL2 BAD	Endocrine resistance
KEGG:05222	0.0407115897186	0.285714285714	BCL2 BCL2L1	Small cell lung cancer
GO:0051204	0.0417514312642	0.428571428571	BCL2 BAD BCL2L11	protein insertion into mitochondrial membrane
REAC:R-HSA-168643	0.0431362871916	0.285714285714	BCL2 BCL2L1	Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REAC:R-HSA-193648	0.0431362871916	0.285714285714	BCL2L11 BAD	NRAGE signals death through JNK
WP:WP4658	0.0440421557794	0.285714285714	BCL2 BCL2L1	Small cell lung cancer
CORUM:7275	0.0499886427319	0.142857142857	BCL2	BCL2-CISD2 complex
CORUM:5812	0.0499886427319	0.142857142857	BCL2L1	p53-BCL2 complex
CORUM:5811	0.0499886427319	0.142857142857	BCL2	p53-BCL2 complex
CORUM:5526	0.0499886427319	0.142857142857	BCL2	CALM1-FKBP38-BCL2 complex
CORUM:1062	0.0499886427319	0.142857142857	BCL2	BAR-BCL2-CASP8 complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
BAD	BCL2L1	0.976	0.892	bioplex (BCL2L1) bioplex_WMM
BCL2	BCL2L1	0.831	0.778	bioplex (BCL2L1) bioplex_WMM
BCL2L11	BCL2L1	0.773	0.752	bioplex (BCL2L1,BCL2L11) bioplex_WMM
BCL2L11	RHPN2	0.731	0.736	bioplex (BCL2L11) bioplex_WMM
RHPN2	TRMO	0.149	0.41	bioplex (TRMO) bioplex_WMM
BCL2	BCL2L11	0.066	0.35	bioplex (BCL2L11) bioplex_WMM
BCL2L1	BCL2L15	0.024	0.213	bioplex (BCL2L15) bioplex_WMM
BAD	BCL2	0.009	0.101	bioplex_WMM WMM_only
BCL2	RHPN2	0.009	0.096	bioplex_WMM WMM_only
BCL2L1	RHPN2	0.009	0.098	bioplex_WMM WMM_only
BAD	BCL2L11	0.008	0.068	bioplex_WMM WMM_only

Images

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Complex HuMAP2_06641 has an average edge precision of 0.409 which is ranked 3214 out of all 6965 complexes.

Related Complexes

Genename	Complexes
BCL2L1	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
BAD	HuMAP2_00315 HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_04311 HuMAP2_04651 HuMAP2_05206 HuMAP2_06018 HuMAP2_06641
TRMO	HuMAP2_01477 HuMAP2_02295 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2L11	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641
BCL2L15	HuMAP2_01477 HuMAP2_02045 HuMAP2_06589 HuMAP2_06641
BCL2	HuMAP2_01477 HuMAP2_01697 HuMAP2_02045 HuMAP2_02295 HuMAP2_06589 HuMAP2_06641
RHPN2	HuMAP2_01477 HuMAP2_02295 HuMAP2_03520 HuMAP2_05402 HuMAP2_06589 HuMAP2_06641

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06641