hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06643
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CDKN2A | Tumor suppressor ARF (Alternative reading frame) (ARF) (Cyclin-dependent kinase inhibitor 2A) (p14ARF) | UniProt NCBI |
| CDK6 | Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE) | UniProt NCBI |
| CDKN2B | Cyclin-dependent kinase 4 inhibitor B (Multiple tumor suppressor 2) (MTS-2) (p14-INK4b) (p15-INK4b) (p15INK4B) | UniProt NCBI |
| CDKN2C | Cyclin-dependent kinase 4 inhibitor C (Cyclin-dependent kinase 6 inhibitor) (p18-INK4c) (p18-INK6) | UniProt NCBI |
| OGFRL1 | Opioid growth factor receptor-like protein 1 | UniProt NCBI |
| CDK4 | Cyclin-dependent kinase 4 (EC 2.7.11.22) (Cell division protein kinase 4) (PSK-J3) | UniProt NCBI |
| CDKN2D | Cyclin-dependent kinase 4 inhibitor D (p19-INK4d) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-2559585 | 6.99307747711e-14 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Oncogene Induced Senescence |
| REAC:R-HSA-69236 | 4.04583533895e-13 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | G1 Phase |
| REAC:R-HSA-69231 | 4.04583533895e-13 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cyclin D associated events in G1 |
| WP:WP45 | 1.66485079619e-12 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | G1 to S cell cycle control |
| WP:WP179 | 7.2482059599e-11 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cell Cycle |
| KEGG:04110 | 8.78984306893e-11 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cell cycle |
| REAC:R-HSA-2559582 | 1.31082855861e-10 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Senescence-Associated Secretory Phenotype (SASP) |
| WP:WP3998 | 1.97884850665e-10 | 0.714285714286 | CDK6 CDKN2B CDKN2C CDKN2A CDK4 | Prader-Willi and Angelman Syndrome |
| REAC:R-HSA-2559580 | 3.10311120023e-10 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-453279 | 9.68838483071e-10 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Mitotic G1-G1/S phases |
| REAC:R-HSA-2559583 | 4.32657851567e-09 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cellular Senescence |
| WP:WP2261 | 4.95057419087e-09 | 0.714285714286 | CDK6 CDKN2B CDKN2C CDKN2A CDK4 | Signaling Pathways in Glioblastoma |
| REAC:R-HSA-9630750 | 1.06309369927e-08 | 0.428571428571 | CDK6 CDKN2A CDK4 | Evasion of Oncogene Induced Senescence Due to p16INK4A Defects |
| REAC:R-HSA-9632693 | 1.06309369927e-08 | 0.428571428571 | CDK6 CDKN2A CDK4 | Evasion of Oxidative Stress Induced Senescence Due to p16INK4A Defects |
| REAC:R-HSA-9630794 | 1.06309369927e-08 | 0.428571428571 | CDK6 CDKN2A CDK4 | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| REAC:R-HSA-9630747 | 1.06309369927e-08 | 0.428571428571 | CDK6 CDKN2A CDK4 | Diseases of Cellular Senescence |
| REAC:R-HSA-9632700 | 1.06309369927e-08 | 0.428571428571 | CDK6 CDKN2A CDK4 | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6 |
| GO:2000134 | 1.16148933036e-08 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of G1/S transition of mitotic cell cycle |
| GO:1902807 | 1.24640425525e-08 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of cell cycle G1/S phase transition |
| GO:0016538 | 7.47192024193e-08 | 0.714285714286 | CDK4 CDKN2B CDKN2C CDKN2A CDKN2D | cyclin-dependent protein serine/threonine kinase regulator activity |
| KEGG:04934 | 7.67716805159e-08 | 0.714285714286 | CDK6 CDKN2B CDKN2C CDKN2A CDK4 | Cushing syndrome |
| GO:2000045 | 7.96669644135e-08 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of G1/S transition of mitotic cell cycle |
| GO:0004861 | 1.07497741607e-07 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| GO:1902806 | 1.36821120036e-07 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of cell cycle G1/S phase transition |
| REAC:R-HSA-2262752 | 4.59314510627e-07 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cellular responses to stress |
| GO:0007050 | 1.33598389589e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | cell cycle arrest |
| REAC:R-HSA-8953897 | 1.36666920225e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cellular responses to external stimuli |
| GO:1901991 | 1.77170380636e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of mitotic cell cycle phase transition |
| REAC:R-HSA-69278 | 1.91008072332e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cell Cycle, Mitotic |
| GO:0000082 | 1.94088919272e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | G1/S transition of mitotic cell cycle |
| GO:1901988 | 2.60513428009e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of cell cycle phase transition |
| GO:0044843 | 2.75840102142e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | cell cycle G1/S phase transition |
| REAC:R-HSA-1640170 | 5.63049101506e-06 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | Cell Cycle |
| WP:WP2877 | 9.20256761883e-06 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | Vitamin D Receptor Pathway |
| HP:0002894 | 1.05955488393e-05 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Neoplasm of the pancreas |
| HP:0012334 | 1.10641924054e-05 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Extrahepatic cholestasis |
| GO:0045930 | 1.10705652415e-05 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of mitotic cell cycle |
| GO:0030291 | 1.27197659979e-05 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | protein serine/threonine kinase inhibitor activity |
| WP:WP4204 | 1.36545401812e-05 | 0.428571428571 | CDK6 CDKN2A CDK4 | Tumor suppressor activity of SMARCB1 |
| KEGG:04218 | 1.54550028729e-05 | 0.571428571429 | CDK6 CDKN2B CDKN2A CDK4 | Cellular senescence |
| GO:0010948 | 1.63926986258e-05 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of cell cycle process |
| CORUM:1642 | 3.02079974644e-05 | 0.285714285714 | CDK4 CDKN2A | p16-cyclin D2-CDK4 complex |
| CORUM:1633 | 3.02079974644e-05 | 0.285714285714 | CDK6 CDK4 | CyclinD1-CDK4-CDK6 complex |
| CORUM:5100 | 3.02079974644e-05 | 0.285714285714 | CDK6 CDK4 | CyclinD3-CDK4-CDK6 complex |
| HP:0100641 | 3.15359643514e-05 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Neoplasm of the adrenal cortex |
| REAC:R-HSA-9632697 | 3.1663182739e-05 | 0.285714285714 | CDK4 CDKN2A | Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| REAC:R-HSA-9630791 | 3.1663182739e-05 | 0.285714285714 | CDK4 CDKN2A | Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 |
| KEGG:05203 | 4.37888853972e-05 | 0.571428571429 | CDK6 CDKN2B CDKN2A CDK4 | Viral carcinogenesis |
| KEGG:05166 | 5.27961755709e-05 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Human T-cell leukemia virus 1 infection |
| GO:1901990 | 5.35127598823e-05 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of mitotic cell cycle phase transition |
| CORUM:5101 | 6.04024714829e-05 | 0.285714285714 | CDK6 CDK4 | CyclinD3-CDK4-CDK6-p21 complex |
| GO:0019887 | 6.1014874829e-05 | 0.714285714286 | CDK4 CDKN2B CDKN2C CDKN2A CDKN2D | protein kinase regulator activity |
| GO:1901987 | 8.12576677855e-05 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of cell cycle phase transition |
| KEGG:05218 | 0.000124522301094 | 0.428571428571 | CDK6 CDKN2A CDK4 | Melanoma |
| GO:0019207 | 0.000130163302766 | 0.714285714286 | CDK4 CDKN2B CDKN2C CDKN2A CDKN2D | kinase regulator activity |
| KEGG:04115 | 0.000137123265923 | 0.428571428571 | CDK6 CDKN2A CDK4 | p53 signaling pathway |
| KEGG:05223 | 0.000137123265923 | 0.428571428571 | CDK6 CDKN2A CDK4 | Non-small cell lung cancer |
| HP:0100631 | 0.000140903306855 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Neoplasm of the adrenal gland |
| KEGG:05214 | 0.000164807013602 | 0.428571428571 | CDK6 CDKN2A CDK4 | Glioma |
| WP:WP4255 | 0.00018262033446 | 0.428571428571 | CDK6 CDKN2A CDK4 | Non-small cell lung cancer |
| KEGG:05212 | 0.000187840964122 | 0.428571428571 | CDK6 CDKN2A CDK4 | Pancreatic cancer |
| KEGG:05220 | 0.000212916179135 | 0.428571428571 | CDK6 CDKN2A CDK4 | Chronic myeloid leukemia |
| HP:0008069 | 0.000217296764045 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Neoplasm of the skin |
| GO:0004860 | 0.000229373391109 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | protein kinase inhibitor activity |
| WP:WP4263 | 0.000305723735218 | 0.428571428571 | CDK6 CDKN2A CDK4 | Pancreatic adenocarcinoma pathway |
| GO:0019210 | 0.000310987597034 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | kinase inhibitor activity |
| GO:0044772 | 0.000321955679491 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | mitotic cell cycle phase transition |
| KEGG:01522 | 0.000384620372076 | 0.428571428571 | CDK4 CDKN2A CDKN2C | Endocrine resistance |
| HP:0001480 | 0.000410070446942 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Freckling |
| KEGG:05222 | 0.000410972913564 | 0.428571428571 | CDK6 CDKN2B CDK4 | Small cell lung cancer |
| GO:0045786 | 0.000434415170379 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | negative regulation of cell cycle |
| WP:WP4658 | 0.000459444370287 | 0.428571428571 | CDK6 CDKN2B CDK4 | Small cell lung cancer |
| GO:0044770 | 0.000472769829579 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | cell cycle phase transition |
| HP:0007378 | 0.000509446300841 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Neoplasm of the gastrointestinal tract |
| GO:0007346 | 0.000571114136273 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of mitotic cell cycle |
| GO:0000079 | 0.000820699113124 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | regulation of cyclin-dependent protein serine/threonine kinase activity |
| HP:0001732 | 0.000937641310515 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Abnormality of the pancreas |
| GO:1904029 | 0.000971413809773 | 0.571428571429 | CDKN2D CDKN2C CDKN2A CDKN2B | regulation of cyclin-dependent protein kinase activity |
| HP:0006753 | 0.00112194860564 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Neoplasm of the stomach |
| HP:0100522 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Thymoma |
| HP:0030688 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Increased glucagon level |
| HP:0030687 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Abnormal glucagon level |
| HP:0030404 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Glucagonoma |
| HP:0011761 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Pituitary null cell adenoma |
| HP:0012197 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Insulinoma |
| HP:0008291 | 0.0011537726365 | 0.285714285714 | CDKN2B CDKN2C | Pituitary corticotropic cell adenoma |
| HP:0002861 | 0.00118290692185 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Melanoma |
| HP:0011792 | 0.00126348759091 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Neoplasm by histology |
| GO:0010564 | 0.00148227154193 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of cell cycle process |
| KEGG:05200 | 0.00159650327269 | 0.571428571429 | CDK6 CDKN2B CDKN2A CDK4 | Pathways in cancer |
| HP:0030405 | 0.00173027154874 | 0.285714285714 | CDKN2B CDKN2C | Pancreatic endocrine tumor |
| HP:0008208 | 0.00173027154874 | 0.285714285714 | CDKN2B CDKN2C | Parathyroid hyperplasia |
| HP:0008261 | 0.00173027154874 | 0.285714285714 | CDKN2B CDKN2C | Pancreatic islet cell adenoma |
| HP:0011732 | 0.0020041380536 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Abnormality of adrenal morphology |
| KEGG:05225 | 0.00212228497248 | 0.428571428571 | CDK6 CDKN2A CDK4 | Hepatocellular carcinoma |
| HP:0100013 | 0.0023771553591 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Neoplasm of the breast |
| HP:0006767 | 0.0024218379091 | 0.285714285714 | CDKN2B CDKN2C | Pituitary prolactin cell adenoma |
| HP:0100521 | 0.0024218379091 | 0.285714285714 | CDKN2B CDKN2C | Neoplasm of the thymus |
| HP:0007449 | 0.0024218379091 | 0.285714285714 | CDKN2B CDKN2C | Confetti-like hypopigmented macules |
| HP:0011760 | 0.0024218379091 | 0.285714285714 | CDKN2B CDKN2C | Pituitary growth hormone cell adenoma |
| HP:0012029 | 0.00322839434563 | 0.285714285714 | CDKN2B CDKN2C | Abnormal urine hormone level |
| HP:0012030 | 0.00322839434563 | 0.285714285714 | CDKN2B CDKN2C | Increased urinary cortisol level |
| HP:0002044 | 0.00322839434563 | 0.285714285714 | CDKN2B CDKN2C | Zollinger-Ellison syndrome |
| HP:0008256 | 0.00322839434563 | 0.285714285714 | CDKN2B CDKN2C | Adrenocortical adenoma |
| GO:1903047 | 0.00399398022056 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | mitotic cell cycle process |
| HP:0100570 | 0.00414986351758 | 0.285714285714 | CDKN2B CDKN2C | Carcinoid tumor |
| KEGG:05163 | 0.00433149349207 | 0.428571428571 | CDK6 CDKN2A CDK4 | Human cytomegalovirus infection |
| HP:0100568 | 0.00510151282311 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Neoplasm of the endocrine system |
| HP:0008283 | 0.0051861681154 | 0.285714285714 | CDKN2B CDKN2C | Fasting hyperinsulinemia |
| HP:0006744 | 0.0051861681154 | 0.285714285714 | CDKN2B CDKN2C | Adrenocortical carcinoma |
| HP:0001031 | 0.0051861681154 | 0.285714285714 | CDKN2B CDKN2C | Subcutaneous lipoma |
| HP:0000488 | 0.00578386403101 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Retinopathy |
| HP:0003764 | 0.00614659531063 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Nevus |
| WP:WP2828 | 0.00629697152788 | 0.285714285714 | CDK4 CDKN2A | Bladder Cancer |
| HP:0020073 | 0.0063372308607 | 0.285714285714 | CDKN2B CDKN2C | Hypopigmented macule |
| KEGG:05219 | 0.00655764034054 | 0.285714285714 | CDK4 CDKN2A | Bladder cancer |
| HP:0100242 | 0.0073244450141 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Sarcoma |
| HP:0012056 | 0.00760297450628 | 0.285714285714 | CDK4 CDKN2A | Cutaneous melanoma |
| HP:0012091 | 0.00864276387293 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Abnormality of pancreas physiology |
| HP:0003118 | 0.00898332183607 | 0.285714285714 | CDKN2B CDKN2C | Increased circulating cortisol level |
| WP:WP1971 | 0.00901151528078 | 0.285714285714 | CDK4 CDKN2B | Integrated Cancer Pathway |
| GO:0008285 | 0.00979493405468 | 0.714285714286 | CDK6 CDKN2B CDKN2C CDKN2A CDKN2D | negative regulation of cell population proliferation |
| GO:0000278 | 0.00995795310122 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | mitotic cell cycle |
| HP:0000958 | 0.0103685612154 | 0.428571428571 | CDK4 CDKN2A CDKN2B | Dry skin |
| HP:0100733 | 0.0120875188399 | 0.285714285714 | CDKN2B CDKN2C | Neoplasm of the parathyroid gland |
| HP:0002897 | 0.0120875188399 | 0.285714285714 | CDKN2B CDKN2C | Parathyroid adenoma |
| HP:0003165 | 0.0138112142376 | 0.285714285714 | CDKN2B CDKN2C | Elevated circulating parathyroid hormone level |
| HP:0000854 | 0.0138112142376 | 0.285714285714 | CDKN2B CDKN2C | Thyroid adenoma |
| GO:0042127 | 0.0144907808623 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of cell population proliferation |
| GO:0051726 | 0.0159107434364 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | regulation of cell cycle |
| HP:0004375 | 0.017239739418 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Neoplasm of the nervous system |
| HP:0000845 | 0.017601413367 | 0.285714285714 | CDKN2B CDKN2C | Growth hormone excess |
| HP:0011766 | 0.017601413367 | 0.285714285714 | CDKN2B CDKN2C | Abnormality of the parathyroid morphology |
| HP:0000843 | 0.0196677630092 | 0.285714285714 | CDKN2B CDKN2C | Hyperparathyroidism |
| HP:0000834 | 0.0203343378628 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Abnormality of the adrenal glands |
| HP:0004398 | 0.0218481766952 | 0.285714285714 | CDKN2B CDKN2C | Peptic ulcer |
| WP:WP707 | 0.0219463745449 | 0.285714285714 | CDK6 CDK4 | DNA Damage Response |
| WP:WP1530 | 0.0239551606733 | 0.285714285714 | CDK6 CDK4 | miRNA Regulation of DNA Damage Response |
| HP:0100763 | 0.0250997734473 | 0.571428571429 | CDK4 CDKN2C CDKN2A CDKN2B | Abnormality of the lymphatic system |
| HP:0010615 | 0.0265508883611 | 0.285714285714 | CDKN2B CDKN2C | Angiofibromas |
| HP:0100633 | 0.0265508883611 | 0.285714285714 | CDKN2B CDKN2C | Esophagitis |
| HP:0006476 | 0.0265508883611 | 0.285714285714 | CDKN2B CDKN2C | Abnormality of the pancreatic islet cells |
| HP:0000825 | 0.0265508883611 | 0.285714285714 | CDKN2B CDKN2C | Hyperinsulinemic hypoglycemia |
| HP:0012093 | 0.0290730325003 | 0.285714285714 | CDKN2B CDKN2C | Abnormality of endocrine pancreas physiology |
| WP:WP2446 | 0.0369669918209 | 0.285714285714 | CDK6 CDK4 | Retinoblastoma Gene in Cancer |
| HP:0002717 | 0.0373216957502 | 0.285714285714 | CDKN2B CDKN2C | Adrenal overactivity |
| HP:0002893 | 0.0402984044053 | 0.285714285714 | CDKN2B CDKN2C | Pituitary adenoma |
| HP:0100634 | 0.0402984044053 | 0.285714285714 | CDKN2B CDKN2C | Neuroendocrine neoplasm |
| MIRNA:hsa-miR-34a-5p | 0.0410817809572 | 0.571428571429 | CDK6 CDKN2C CDKN2A CDK4 | hsa-miR-34a-5p |
| HP:0001396 | 0.0426592871787 | 0.428571428571 | CDKN2B CDKN2A CDKN2C | Cholestasis |
| HP:0002574 | 0.0433885622377 | 0.285714285714 | CDKN2B CDKN2C | Episodic abdominal pain |
| HP:0032148 | 0.0433885622377 | 0.285714285714 | CDKN2B CDKN2C | Episodic pain |
| GO:0008283 | 0.0445849091293 | 0.857142857143 | CDKN2D CDKN2C CDK6 CDKN2A CDKN2B CDK4 | cell population proliferation |
| HP:0011731 | 0.0499089185913 | 0.285714285714 | CDKN2B CDKN2C | Abnormality of circulating cortisol level |
| HP:0100530 | 0.0499089185913 | 0.285714285714 | CDKN2B CDKN2C | Abnormal calcium-phosphate regulating hormone level |
| CORUM:3084 | 0.0499886427319 | 0.142857142857 | CDK4 | CCND1-CDK4 complex |
| CORUM:5287 | 0.0499886427319 | 0.142857142857 | CDK4 | CCND1-CDK4 complex |
| CORUM:5107 | 0.0499886427319 | 0.142857142857 | CDK4 | p34(SEI-1)-CDK4-CyclinD2 complex |
| CORUM:3089 | 0.0499886427319 | 0.142857142857 | CDK6 | CCND3-CDK6 complex |
| CORUM:3088 | 0.0499886427319 | 0.142857142857 | CDK6 | CCND2-CDK6 complex |
| CORUM:3087 | 0.0499886427319 | 0.142857142857 | CDK6 | CCND1-CDK6 complex |
| CORUM:3086 | 0.0499886427319 | 0.142857142857 | CDK4 | CCND3-CDK4 complex |
| CORUM:3085 | 0.0499886427319 | 0.142857142857 | CDK4 | CCND2-CDK4 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CDKN2B | CDK4 | 1.0 | 0.949 | hein_WMM bioplex (CDK4) bioplex_WMM hein (CDK4) |
| CDKN2A | CDK4 | 0.974 | 0.886 | hein_WMM bioplex (CDK4) bioplex_WMM youn_WMM hein (CDK4) gupta_WMM |
| CDKN2B | CDK6 | 0.877 | 0.811 | bioplex (CDK6) bioplex_WMM |
| CDKN2C | CDK4 | 0.654 | 0.692 | bioplex (CDK4,CDKN2C) bioplex_WMM |
| CDK4 | OGFRL1 | 0.65 | 0.689 | bioplex (CDK4) bioplex_WMM |
| CDKN2D | CDK6 | 0.161 | 0.417 | bioplex (CDK6) bioplex_WMM |
| CDKN2B | CDKN2D | 0.013 | 0.149 | bioplex_WMM WMM_only |
| CDKN2A | CDK6 | 0.012 | 0.145 | bioplex (CDK6) bioplex_WMM |
| CDKN2C | CDKN2A | 0.011 | 0.139 | bioplex_WMM WMM_only |
| CDKN2B | CDKN2A | 0.01 | 0.137 | hein_WMM bioplex_WMM WMM_only |
| CDKN2A | CDKN2D | 0.01 | 0.109 | bioplex_WMM WMM_only |
| CDKN2B | CDKN2C | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CDKN2C | CDKN2D | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CDKN2B | OGFRL1 | 0.009 | 0.108 | bioplex_WMM WMM_only |
| OGFRL1 | CDKN2D | 0.009 | 0.108 | bioplex_WMM WMM_only |
| CDKN2A | OGFRL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CDKN2C | OGFRL1 | 0.008 | 0.085 | bioplex_WMM WMM_only |
| CDK4 | CDK6 | 0.007 | 0.006 | bioplex (CDK4,CDK6) bioplex_WMM |
| CDKN2C | CDK6 | 0.004 | 0.01 | bioplex (CDK6,CDKN2C) bioplex_WMM |
| CDK4 | CDKN2D | 0.0 | 0.0 | bioplex (CDK4) bioplex_WMM |
Images
Click to enlarge
Complex HuMAP2_06643 has an average edge precision of 0.286 which is ranked 4794 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CDKN2A | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |
| CDK6 | HuMAP2_01198 HuMAP2_03365 HuMAP2_04118 HuMAP2_06643 |
| CDKN2B | HuMAP2_01131 HuMAP2_01198 HuMAP2_03365 HuMAP2_06643 |
| CDKN2C | HuMAP2_01131 HuMAP2_01816 HuMAP2_02228 HuMAP2_02676 HuMAP2_03854 HuMAP2_05212 HuMAP2_06056 HuMAP2_06643 |
| OGFRL1 | HuMAP2_01131 HuMAP2_02676 HuMAP2_06643 |
| CDK4 | HuMAP2_01131 HuMAP2_02676 HuMAP2_03636 HuMAP2_06643 |
| CDKN2D | HuMAP2_01198 HuMAP2_04118 HuMAP2_06643 |