hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06645
Confidence: Medium
Proteins| Genename | Protein Name | Links |
|---|---|---|
| RAB3GAP1 | Rab3 GTPase-activating protein catalytic subunit (RAB3 GTPase-activating protein 130 kDa subunit) (Rab3-GAP p130) (Rab3-GAP) | UniProt NCBI |
| GPAM | Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAT-1) (EC 2.3.1.15) | UniProt NCBI |
| SIRT2 | NAD-dependent protein deacetylase sirtuin-2 (EC 3.5.1.-) (Regulatory protein SIR2 homolog 2) (SIR2-like protein 2) | UniProt NCBI |
| MTDH | Protein LYRIC (3D3/LYRIC) (Astrocyte elevated gene-1 protein) (AEG-1) (Lysine-rich CEACAM1 co-isolated protein) (Metadherin) (Metastasis adhesion protein) | UniProt NCBI |
| RAB3GAP2 | Rab3 GTPase-activating protein non-catalytic subunit (RGAP-iso) (Rab3 GTPase-activating protein 150 kDa subunit) (Rab3-GAP p150) (Rab3-GAP150) (Rab3-GAP regulatory subunit) | UniProt NCBI |
| SNN | Stannin (AG8_1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0000064 | 0.0172946302375 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Hypoplastic labia minora |
| HP:0000480 | 0.0172946302375 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Retinal coloboma |
| HP:0000060 | 0.0189383441407 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Clitoral hypoplasia |
| HP:0009738 | 0.0189383441407 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Abnormality of the antihelix |
| HP:0040255 | 0.0189383441407 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Aplasia/Hypoplasia of the clitoris |
| GO:0097051 | 0.020283420769 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | establishment of protein localization to endoplasmic reticulum membrane |
| HP:0001264 | 0.0243148377528 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Spastic diplegia |
| REAC:R-HSA-6811436 | 0.0269276420577 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | COPI-independent Golgi-to-ER retrograde traffic |
| HP:0012880 | 0.0282698926051 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Abnormality of the labia minora |
| HP:0009465 | 0.032521154219 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Ulnar deviation of finger |
| HP:0000221 | 0.0394527338604 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Furrowed tongue |
| HP:0001845 | 0.0394527338604 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | Overlapping toe |
| GO:0050747 | 0.0405595771497 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | positive regulation of lipoprotein metabolic process |
| GO:1903061 | 0.0405595771497 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | positive regulation of protein lipidation |
| GO:1903373 | 0.0405595771497 | 0.333333333333 | RAB3GAP1 RAB3GAP2 | positive regulation of endoplasmic reticulum tubular network organization |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| RAB3GAP1 | SIRT2 | 0.826 | 0.774 | bioplex (SIRT2) bioplex_WMM youn_WMM |
| SIRT2 | RAB3GAP2 | 0.69 | 0.715 | bioplex (SIRT2) bioplex_WMM youn_WMM gupta_WMM |
| SIRT2 | GPAM | 0.125 | 0.399 | bioplex (SIRT2) bioplex_WMM |
| SIRT2 | MTDH | 0.041 | 0.27 | bioplex (SIRT2) bioplex_WMM youn_WMM gupta_WMM |
| SNN | MTDH | 0.024 | 0.214 | bioplex (SNN) bioplex_WMM |
| RAB3GAP2 | GPAM | 0.008 | 0.091 | bioplex_WMM WMM_only |
| RAB3GAP2 | MTDH | 0.008 | 0.084 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| MTDH | GPAM | 0.008 | 0.067 | bioplex_WMM WMM_only |
| RAB3GAP1 | GPAM | 0.008 | 0.067 | bioplex_WMM WMM_only |
| RAB3GAP1 | MTDH | 0.008 | 0.068 | bioplex_WMM youn_WMM gupta_WMM WMM_only |
| RAB3GAP1 | RAB3GAP2 | 0.0 | 0.003 | bioplex_WMM youn_WMM Malo gupta_WMM fraction |
Images
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Complex HuMAP2_06645 has an average edge precision of 0.25 which is ranked 5373 out of all 6965 complexes.
Related Complexes