hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06651
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| UPF3A | Regulator of nonsense transcripts 3A (Nonsense mRNA reducing factor 3A) (Up-frameshift suppressor 3 homolog A) (hUpf3) | UniProt NCBI |
| CASC3 | Protein CASC3 (Cancer susceptibility candidate gene 3 protein) (Metastatic lymph node gene 51 protein) (MLN 51) (Protein barentsz) (Btz) | UniProt NCBI |
| CA1 | Carbonic anhydrase 1 (EC 4.2.1.1) (Carbonate dehydratase I) (Carbonic anhydrase B) (CAB) (Carbonic anhydrase I) (CA-I) | UniProt NCBI |
| HBD | Hemoglobin subunit delta (Delta-globin) (Hemoglobin delta chain) | UniProt NCBI |
| HBB | Hemoglobin subunit beta (Beta-globin) (Hemoglobin beta chain) [Cleaved into: LVV-hemorphin-7; Spinorphin] | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| REAC:R-HSA-1247673 | 0.000377631329325 | 0.4 | HBB CA1 | Erythrocytes take up oxygen and release carbon dioxide |
| REAC:R-HSA-1237044 | 0.000606744453221 | 0.4 | HBB CA1 | Erythrocytes take up carbon dioxide and release oxygen |
| REAC:R-HSA-1480926 | 0.000606744453221 | 0.4 | HBB CA1 | O2/CO2 exchange in erythrocytes |
| HP:0001935 | 0.0150562782431 | 0.4 | HBB HBD | Microcytic anemia |
| KEGG:03015 | 0.0162467151192 | 0.4 | UPF3A CASC3 | mRNA surveillance pathway |
| HP:0011902 | 0.0162585949147 | 0.4 | HBB HBD | Abnormal hemoglobin |
| GO:0031721 | 0.0270421395626 | 0.4 | HBB HBD | hemoglobin alpha binding |
| KEGG:03013 | 0.0489206453689 | 0.4 | UPF3A CASC3 | RNA transport |
| CORUM:772 | 0.0499494897235 | 0.2 | CASC3 | EIF4A3-MLN51 complex |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| HBB | UPF3A | 0.165 | 0.42 | bioplex (UPF3A) bioplex_WMM |
| UPF3A | HBD | 0.091 | 0.354 | bioplex (UPF3A) bioplex_WMM |
| UPF3A | CA1 | 0.066 | 0.349 | bioplex (UPF3A) bioplex_WMM |
| CASC3 | UPF3A | 0.052 | 0.302 | bioplex (UPF3A) bioplex_WMM |
| CASC3 | CA1 | 0.007 | 0.011 | bioplex_WMM WMM_only |
| HBB | CA1 | 0.007 | 0.005 | bioplex_WMM WMM_only |
| HBD | CA1 | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CASC3 | HBB | 0.007 | 0.003 | bioplex_WMM WMM_only |
| CASC3 | HBD | 0.006 | 0.001 | bioplex_WMM WMM_only |
| HBB | HBD | 0.006 | 0.007 | bioplex_WMM WMM_only boldt_WMM |
Images
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Complex HuMAP2_06651 has an average edge precision of 0.145 which is ranked 6735 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| UPF3A | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| CASC3 | HuMAP2_00752 HuMAP2_02221 HuMAP2_03053 HuMAP2_06651 |
| CA1 | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| HBD | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |
| HBB | HuMAP2_04634 HuMAP2_06091 HuMAP2_06651 |