hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06655
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| VPS29 | Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29) | UniProt NCBI |
| VPS35 | Vacuolar protein sorting-associated protein 35 (hVPS35) (Maternal-embryonic 3) (Vesicle protein sorting 35) | UniProt NCBI |
| SNX2 | Sorting nexin-2 (Transformation-related gene 9 protein) (TRG-9) | UniProt NCBI |
| VPS26A | Vacuolar protein sorting-associated protein 26A (Vesicle protein sorting 26A) (hVPS26) | UniProt NCBI |
| TBC1D5 | TBC1 domain family member 5 | UniProt NCBI |
| VPS26B | Vacuolar protein sorting-associated protein 26B (Vesicle protein sorting 26B) | UniProt NCBI |
| SNX6 | Sorting nexin-6 (TRAF4-associated factor 2) [Cleaved into: Sorting nexin-6, N-terminally processed] | UniProt NCBI |
| SNX1 | Sorting nexin-1 | UniProt NCBI |
| SNX5 | Sorting nexin-5 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| GO:0030904 | 2.45186057677e-23 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | retromer complex |
| GO:0042147 | 1.31563265323e-16 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | retrograde transport, endosome to Golgi |
| CORUM:657 | 8.53043734036e-16 | 0.555555555556 | SNX2 SNX1 VPS26A VPS29 VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1059 | 8.53043734036e-16 | 0.555555555556 | SNX2 SNX1 VPS26A VPS29 VPS35 | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26A) |
| CORUM:1060 | 8.53043734036e-16 | 0.555555555556 | SNX2 SNX1 VPS35 VPS29 VPS26B | Retromer complex (SNX1, SNX2, VPS35, VPS29, VPS26B) |
| GO:0016482 | 2.68767309729e-14 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | cytosolic transport |
| GO:0016197 | 5.9276591382e-13 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | endosomal transport |
| KEGG:04144 | 1.34864237169e-12 | 0.888888888889 | SNX2 VPS35 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | Endocytosis |
| GO:0030905 | 3.07384073035e-09 | 0.444444444444 | SNX2 SNX5 SNX6 SNX1 | retromer, tubulation complex |
| GO:0030906 | 3.07384073035e-09 | 0.444444444444 | VPS26A VPS35 VPS29 VPS26B | retromer, cargo-selective complex |
| CORUM:656 | 6.30476064954e-09 | 0.333333333333 | VPS26A VPS29 VPS35 | VPS35-VPS29-VPS26A complex |
| GO:0005768 | 1.5089698386e-08 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | endosome |
| GO:0097422 | 1.53650749201e-08 | 0.444444444444 | VPS26A SNX5 SNX6 VPS35 | tubular endosome |
| GO:0098796 | 3.65145237997e-07 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | membrane protein complex |
| GO:0010008 | 1.18281293387e-06 | 0.777777777778 | SNX2 VPS35 TBC1D5 SNX1 SNX6 VPS26A SNX5 | endosome membrane |
| GO:0044440 | 3.00781428963e-06 | 0.777777777778 | SNX2 VPS35 TBC1D5 SNX1 SNX6 VPS26A SNX5 | endosomal part |
| CORUM:1058 | 1.34129279418e-05 | 0.222222222222 | SNX6 SNX1 | SNX complex (SNX1, SNX6) |
| GO:0046907 | 3.3037540428e-05 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | intracellular transport |
| GO:0005769 | 3.32431831541e-05 | 0.666666666667 | VPS35 SNX1 VPS26B SNX6 VPS26A SNX5 | early endosome |
| CORUM:1070 | 4.02261743042e-05 | 0.222222222222 | SNX2 SNX1 | SNX complex (SNX1, SNX1a, SNX2, SNX4) |
| REAC:R-HSA-3238698 | 5.35023353638e-05 | 0.333333333333 | VPS26A VPS29 VPS35 | WNT ligand biogenesis and trafficking |
| GO:0016192 | 6.88978461682e-05 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | vesicle-mediated transport |
| GO:0031410 | 7.21802775348e-05 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | cytoplasmic vesicle |
| GO:0097708 | 7.26002015799e-05 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | intracellular vesicle |
| CORUM:1091 | 8.0427137187e-05 | 0.222222222222 | SNX2 SNX1 | SNX complex (SNX1, SNX1a, SNX2, SNX4, LEPR) |
| CORUM:1095 | 8.0427137187e-05 | 0.222222222222 | SNX2 SNX1 | SNX complex (SNX1, SNX1a, SNX2, SNX4, EGFR) |
| CORUM:1096 | 8.0427137187e-05 | 0.222222222222 | SNX2 SNX1 | SNX complex (SNX1, SNX1a, SNX2, SNX4, PDGFRA) |
| CORUM:1093 | 8.0427137187e-05 | 0.222222222222 | SNX2 SNX1 | SNX complex (SNX1, SNX1a, SNX2, SNX4, INSR) |
| GO:0016236 | 9.78459946749e-05 | 0.666666666667 | VPS35 TBC1D5 VPS26B SNX6 VPS26A SNX5 | macroautophagy |
| GO:0051649 | 0.00021282459198 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | establishment of localization in cell |
| GO:0016241 | 0.000481221610391 | 0.555555555556 | VPS26A SNX5 VPS35 VPS26B SNX6 | regulation of macroautophagy |
| GO:0061919 | 0.00131562959967 | 0.666666666667 | VPS35 TBC1D5 VPS26B SNX6 VPS26A SNX5 | process utilizing autophagic mechanism |
| GO:0006914 | 0.00131562959967 | 0.666666666667 | VPS35 TBC1D5 VPS26B SNX6 VPS26A SNX5 | autophagy |
| GO:0051641 | 0.00248350783981 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | cellular localization |
| GO:0006886 | 0.00537320209692 | 0.777777777778 | VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A VPS29 | intracellular protein transport |
| GO:0010506 | 0.0098286041725 | 0.555555555556 | VPS26A SNX5 VPS35 VPS26B SNX6 | regulation of autophagy |
| GO:0005773 | 0.010944340885 | 0.666666666667 | SNX2 VPS35 TBC1D5 SNX1 SNX6 VPS26A | vacuole |
| GO:0044433 | 0.0127826629372 | 0.777777777778 | SNX2 VPS35 TBC1D5 SNX1 SNX6 VPS26A SNX5 | cytoplasmic vesicle part |
| GO:1990126 | 0.0174298251805 | 0.333333333333 | VPS26A VPS29 VPS35 | retrograde transport, endosome to plasma membrane |
| GO:0098805 | 0.0184453266777 | 0.777777777778 | SNX2 VPS35 TBC1D5 SNX1 SNX6 VPS26A SNX5 | whole membrane |
| CORUM:1072 | 0.0249698419797 | 0.111111111111 | SNX2 | SNX complex (SNX2), oligomeric |
| GO:0031982 | 0.0258329558349 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | vesicle |
| GO:0044425 | 0.0305435489729 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | membrane part |
| CORUM:0000000 | 0.0319384059855 | 0.777777777778 | SNX2 VPS35 SNX1 VPS26B SNX6 VPS26A VPS29 | CORUM root |
| GO:0012505 | 0.0445398812368 | 1.0 | SNX2 VPS35 TBC1D5 SNX1 VPS26B SNX6 VPS26A SNX5 VPS29 | endomembrane system |
| GO:1990460 | 0.0486736709081 | 0.222222222222 | SNX2 SNX1 | leptin receptor binding |
| CORUM:1104 | 0.0499262710315 | 0.111111111111 | SNX1 | SNX complex (SNX1, SNX1a, TFRC) |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| VPS35 | VPS26A | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A,VPS29) bioplex_WMM Guru hein (VPS26A) gupta_WMM fraction |
| VPS26A | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26A) bioplex_WMM hein (VPS26A) gupta_WMM |
| VPS26B | TBC1D5 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM hein (VPS26B) |
| VPS26B | VPS29 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B,VPS29) bioplex_WMM Guru hein (VPS26B) fraction boldt_WMM |
| VPS26B | VPS35 | 1.0 | 0.949 | hein_WMM bioplex (VPS26B) bioplex_WMM Guru boldt hein (VPS26B) fraction boldt_WMM |
| SNX2 | VPS26A | 1.0 | 0.949 | bioplex_WMM youn_WMM gupta_WMM fraction |
| VPS35 | VPS29 | 0.999 | 0.949 | hein_WMM bioplex (VPS29) bioplex_WMM Guru gupta_WMM fraction boldt_WMM |
| SNX2 | SNX6 | 0.993 | 0.918 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX2 | SNX5 | 0.99 | 0.909 | bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| SNX1 | VPS26B | 0.988 | 0.901 | fraction |
| VPS26B | SNX2 | 0.988 | 0.901 | fraction |
| SNX1 | VPS35 | 0.988 | 0.901 | youn_WMM gupta_WMM fraction |
| SNX2 | VPS35 | 0.988 | 0.902 | bioplex_WMM youn_WMM gupta_WMM fraction |
| SNX1 | VPS26A | 0.952 | 0.858 | youn_WMM gupta_WMM fraction |
| SNX1 | SNX6 | 0.951 | 0.858 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| VPS26B | VPS26A | 0.888 | 0.818 | bioplex (VPS26A,VPS26B) bioplex_WMM fraction |
| TBC1D5 | VPS29 | 0.884 | 0.816 | hein_WMM bioplex (VPS29) bioplex_WMM gupta_WMM |
| SNX1 | SNX5 | 0.567 | 0.654 | bioplex (SNX1) bioplex_WMM Guru youn_WMM gupta_WMM fraction |
| VPS26A | SNX5 | 0.288 | 0.489 | bioplex_WMM fraction |
| SNX1 | SNX2 | 0.273 | 0.485 | bioplex (SNX1) bioplex_WMM youn_WMM gupta_WMM |
| SNX6 | VPS26A | 0.056 | 0.313 | bioplex_WMM gupta_WMM fraction treiber_WMM |
| SNX1 | VPS29 | 0.047 | 0.292 | gupta_WMM fraction |
| VPS26B | SNX6 | 0.025 | 0.218 | fraction |
| SNX2 | VPS29 | 0.024 | 0.214 | bioplex_WMM fraction |
| VPS35 | TBC1D5 | 0.019 | 0.182 | hein_WMM bioplex_WMM gupta_WMM WMM_only |
| VPS35 | SNX6 | 0.017 | 0.176 | bioplex_WMM gupta_WMM fraction |
| SNX6 | SNX5 | 0.007 | 0.004 | bioplex_WMM youn_WMM WMM_only |
| SNX6 | TBC1D5 | 0.007 | 0.001 | youn_WMM gupta_WMM WMM_only |
| VPS35 | SNX5 | 0.006 | 0.008 | bioplex_WMM gupta_WMM fraction |
| SNX6 | VPS29 | 0.004 | 0.008 | bioplex_WMM fraction |
| SNX5 | VPS29 | 0.004 | 0.014 | bioplex_WMM fraction |
| SNX1 | TBC1D5 | 0.0 | 0.018 | youn_WMM gupta_WMM fraction |
| VPS26B | SNX5 | 0.0 | 0.013 | fraction |
| SNX2 | TBC1D5 | 0.0 | 0.012 | youn_WMM gupta_WMM fraction |
Images
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Complex HuMAP2_06655 has an average edge precision of 0.556 which is ranked 2157 out of all 6965 complexes.
Related Complexes