hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06657
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CSNK2B | Casein kinase II subunit beta (CK II beta) (Phosvitin) (Protein G5a) | UniProt NCBI |
| CSNK2A1 | Casein kinase II subunit alpha (CK II alpha) (EC 2.7.11.1) | UniProt NCBI |
| NKAPD1 | Uncharacterized protein NKAPD1 (NKAP domain containing protein 1) | UniProt NCBI |
| CSNK2A2 | Casein kinase II subunit alpha' (CK II alpha') (EC 2.7.11.1) | UniProt NCBI |
| VSX1 | Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:2720 | 1.35146690511e-09 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:5224 | 1.35146690511e-09 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II (beta-dimer, alpha, alpha') |
| CORUM:2719 | 5.40532307664e-09 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Casein kinase II-HMG1 complex |
| CORUM:938 | 1.35119464053e-08 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | FACT complex, UV-activated |
| REAC:R-HSA-201688 | 1.52193981994e-07 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | WNT mediated activation of DVL |
| REAC:R-HSA-8934903 | 2.28267971382e-07 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Receptor Mediated Mitophagy |
| REAC:R-HSA-2514853 | 4.48293159034e-07 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Condensation of Prometaphase Chromosomes |
| REAC:R-HSA-445144 | 3.09448976434e-06 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Signal transduction by L1 |
| REAC:R-HSA-5205647 | 5.49186125546e-06 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Mitophagy |
| CORUM:5225 | 6.70868171695e-06 | 0.4 | CSNK2B CSNK2A1 | Casein kinase II (beta-dimer, alpha-dimer) |
| CORUM:5223 | 6.70868171695e-06 | 0.4 | CSNK2A2 CSNK2B | Casein kinase II (beta-dimer, alpha'-dimer) |
| REAC:R-HSA-1483191 | 7.0533398358e-06 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Synthesis of PC |
| REAC:R-HSA-8939243 | 1.93500285918e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-6814122 | 2.47599987196e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding |
| KEGG:04137 | 3.25178756029e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Mitophagy - animal |
| KEGG:04520 | 4.50168450517e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Adherens junction |
| WP:WP4336 | 5.07927414515e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | ncRNAs involved in Wnt signaling in hepatocellular carcinoma |
| KEGG:03008 | 6.2799572323e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Ribosome biogenesis in eukaryotes |
| KEGG:04064 | 6.78759182453e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | NF-kappa B signaling pathway |
| KEGG:05235 | 7.05133054154e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | PD-L1 expression and PD-1 checkpoint pathway in cancer |
| WP:WP4258 | 7.07040269841e-05 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | LncRNA involvement in canonical Wnt signaling and colorectal cancer |
| WP:WP428 | 0.000132131878655 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Wnt Signaling |
| REAC:R-HSA-8948751 | 0.000135380656388 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of PTEN stability and activity |
| REAC:R-HSA-1632852 | 0.000285779749786 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Macroautophagy |
| WP:WP4262 | 0.000290626512492 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Breast cancer pathway |
| KEGG:05162 | 0.000291563855438 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Measles |
| REAC:R-HSA-390466 | 0.000316649083447 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Chaperonin-mediated protein folding |
| REAC:R-HSA-6804756 | 0.000327410819085 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of TP53 Activity through Phosphorylation |
| REAC:R-HSA-391251 | 0.000384877154433 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Protein folding |
| KEGG:04310 | 0.000442131169771 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Wnt signaling pathway |
| REAC:R-HSA-9612973 | 0.000476047815537 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Autophagy |
| REAC:R-HSA-1483206 | 0.000534065976599 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Glycerophospholipid biosynthesis |
| REAC:R-HSA-373760 | 0.000596598643168 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | L1CAM interactions |
| REAC:R-HSA-6807070 | 0.00107590614735 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | PTEN Regulation |
| REAC:R-HSA-5633007 | 0.00169383519446 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Regulation of TP53 Activity |
| REAC:R-HSA-1483257 | 0.00272687308576 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Phospholipid metabolism |
| REAC:R-HSA-68877 | 0.00304975168622 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Mitotic Prometaphase |
| GO:0006656 | 0.00367721278555 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | phosphatidylcholine biosynthetic process |
| REAC:R-HSA-8878171 | 0.00459345384685 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-201681 | 0.00478425526644 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | TCF dependent signaling in response to WNT |
| REAC:R-HSA-1257604 | 0.00498022764952 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 0.00793834312405 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Intracellular signaling by second messengers |
| REAC:R-HSA-195721 | 0.0129604262881 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Signaling by WNT |
| GO:0005956 | 0.0135228859698 | 0.4 | CSNK2B CSNK2A1 | protein kinase CK2 complex |
| GO:0031519 | 0.0137266123698 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | PcG protein complex |
| REAC:R-HSA-3700989 | 0.0182828935298 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Transcriptional Regulation by TP53 |
| REAC:R-HSA-68886 | 0.0231915667986 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | M Phase |
| GO:0046470 | 0.0237016209836 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | phosphatidylcholine metabolic process |
| REAC:R-HSA-8953897 | 0.0498194225693 | 0.6 | CSNK2A2 CSNK2A1 CSNK2B | Cellular responses to external stimuli |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CSNK2A2 | CSNK2A1 | 1.0 | 0.949 | hein_WMM bioplex (CSNK2A2) bioplex_WMM boldt youn_WMM hein (CSNK2A2) Malo gupta_WMM fraction boldt_WMM |
| CSNK2A1 | CSNK2B | 1.0 | 0.949 | hein_WMM bioplex_WMM Guru boldt youn_WMM Malo gupta_WMM fraction boldt_WMM |
| CSNK2A2 | CSNK2B | 0.994 | 0.923 | hein_WMM bioplex_WMM boldt youn_WMM hein (CSNK2A2) gupta_WMM boldt_WMM |
| CSNK2A2 | NKAPD1 | 0.775 | 0.752 | bioplex (CSNK2A2,NKAPD1) bioplex_WMM |
| CSNK2A2 | VSX1 | 0.57 | 0.656 | bioplex (VSX1) bioplex_WMM |
| NKAPD1 | CSNK2A1 | 0.557 | 0.648 | bioplex (NKAPD1) bioplex_WMM |
| VSX1 | CSNK2A1 | 0.474 | 0.609 | bioplex (VSX1) bioplex_WMM |
| NKAPD1 | CSNK2B | 0.142 | 0.406 | bioplex (NKAPD1) bioplex_WMM |
| VSX1 | CSNK2B | 0.082 | 0.351 | bioplex (VSX1) bioplex_WMM |
Images
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Complex HuMAP2_06657 has an average edge precision of 0.694 which is ranked 1401 out of all 6965 complexes.
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