hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06662
Confidence: High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| PCGF2 | Polycomb group RING finger protein 2 (DNA-binding protein Mel-18) (RING finger protein 110) (Zinc finger protein 144) | UniProt NCBI |
| CBX8 | Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1) | UniProt NCBI |
| PHC1 | Polyhomeotic-like protein 1 (hPH1) (Early development regulatory protein 1) | UniProt NCBI |
| PHC2 | Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2) | UniProt NCBI |
| PHC3 | Polyhomeotic-like protein 3 (Early development regulatory protein 3) (Homolog of polyhomeotic 3) (hPH3) | UniProt NCBI |
| SCMH1 | Polycomb protein SCMH1 (Sex comb on midleg homolog 1) | UniProt NCBI |
| CBX2 | Chromobox protein homolog 2 | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| CORUM:115 | 1.13542635141e-17 | 0.857142857143 | CBX2 CBX8 PHC3 PHC1 PHC2 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| CORUM:116 | 2.27072192598e-17 | 0.857142857143 | CBX2 CBX8 PHC3 PHC1 PHC2 SCMH1 | Polycomb repressive complex 1 (PRC1, hPRC-H) |
| REAC:R-HSA-4655427 | 3.86614097777e-16 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation of DNA methylation proteins |
| GO:0035102 | 1.15597615235e-13 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | PRC1 complex |
| REAC:R-HSA-3899300 | 2.96070890203e-13 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation of transcription cofactors |
| REAC:R-HSA-4570464 | 4.04583533895e-13 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation of RNA binding proteins |
| REAC:R-HSA-4551638 | 6.36202152662e-12 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation of chromatin organization proteins |
| REAC:R-HSA-3108214 | 1.10273472623e-11 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation of DNA damage response and repair proteins |
| GO:0000152 | 1.20970476635e-10 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | nuclear ubiquitin ligase complex |
| GO:0031519 | 2.15953733604e-10 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | PcG protein complex |
| REAC:R-HSA-8939243 | 2.16151370172e-10 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known |
| REAC:R-HSA-3108232 | 2.03100723442e-09 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMO E3 ligases SUMOylate target proteins |
| REAC:R-HSA-8943724 | 2.39506093598e-09 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Regulation of PTEN gene transcription |
| REAC:R-HSA-2990846 | 2.52047032694e-09 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | SUMOylation |
| REAC:R-HSA-2559580 | 1.17706961511e-07 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Oxidative Stress Induced Senescence |
| REAC:R-HSA-6807070 | 1.96582967691e-07 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | PTEN Regulation |
| REAC:R-HSA-2559583 | 1.04547497522e-06 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Cellular Senescence |
| REAC:R-HSA-8878171 | 2.25185647673e-06 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Transcriptional regulation by RUNX1 |
| REAC:R-HSA-1257604 | 2.57913231767e-06 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | PIP3 activates AKT signaling |
| REAC:R-HSA-9006925 | 5.64016631059e-06 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Intracellular signaling by second messengers |
| GO:0000151 | 8.59377073213e-06 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | ubiquitin ligase complex |
| CORUM:5518 | 3.02079974644e-05 | 0.285714285714 | PHC1 PHC2 | BMI1-HPH1-HPH2 complex |
| REAC:R-HSA-2262752 | 4.99176972433e-05 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Cellular responses to stress |
| REAC:R-HSA-8953750 | 6.32191831593e-05 | 0.428571428571 | PCGF2 PHC1 PHC3 | Transcriptional Regulation by E2F6 |
| REAC:R-HSA-212436 | 0.00012164166601 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | Generic Transcription Pathway |
| REAC:R-HSA-8953897 | 0.000123063682134 | 0.714285714286 | CBX2 PHC2 CBX8 PHC3 PHC1 | Cellular responses to external stimuli |
| REAC:R-HSA-73857 | 0.00023249479605 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | RNA Polymerase II Transcription |
| REAC:R-HSA-597592 | 0.00039194203242 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | Post-translational protein modification |
| REAC:R-HSA-74160 | 0.000444522787502 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | Gene expression (Transcription) |
| REAC:R-HSA-392499 | 0.00334345902737 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | Metabolism of proteins |
| GO:1990234 | 0.00351782066073 | 0.857142857143 | CBX2 PHC3 CBX8 PCGF2 PHC1 PHC2 | transferase complex |
| GO:0070317 | 0.0245293846287 | 0.428571428571 | PCGF2 PHC1 PHC3 | negative regulation of G0 to G1 transition |
| GO:0070316 | 0.026626530587 | 0.428571428571 | PCGF2 PHC1 PHC3 | regulation of G0 to G1 transition |
| GO:0045023 | 0.0311716432999 | 0.428571428571 | PCGF2 PHC1 PHC3 | G0 to G1 transition |
| CORUM:0000000 | 0.0437772681198 | 0.857142857143 | CBX2 CBX8 PHC3 PHC1 PHC2 SCMH1 | CORUM root |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| CBX8 | PHC1 | 0.986 | 0.901 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM hein (CBX8) |
| SCMH1 | PHC1 | 0.965 | 0.874 | bioplex (PHC1) bioplex_WMM |
| CBX8 | PCGF2 | 0.955 | 0.862 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | SCMH1 | 0.926 | 0.844 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC3 | 0.871 | 0.804 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | CBX2 | 0.765 | 0.749 | bioplex (PCGF2) bioplex_WMM |
| PCGF2 | PHC1 | 0.706 | 0.727 | bioplex (PCGF2,PHC1) bioplex_WMM |
| PCGF2 | PHC2 | 0.68 | 0.708 | bioplex (PCGF2) bioplex_WMM |
| PHC1 | CBX2 | 0.6 | 0.67 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| PHC1 | PHC3 | 0.364 | 0.543 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| PHC1 | PHC2 | 0.21 | 0.457 | hein_WMM bioplex (PHC1) bioplex_WMM youn_WMM |
| CBX8 | PHC3 | 0.123 | 0.395 | hein_WMM bioplex_WMM youn_WMM hein (CBX8) |
| CBX8 | PHC2 | 0.067 | 0.352 | hein_WMM bioplex_WMM youn_WMM hein (CBX8) |
| PHC2 | PHC3 | 0.017 | 0.175 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX2 | PHC2 | 0.01 | 0.126 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX8 | CBX2 | 0.01 | 0.126 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| CBX8 | SCMH1 | 0.01 | 0.1 | bioplex_WMM WMM_only |
| CBX2 | PHC3 | 0.01 | 0.1 | hein_WMM bioplex_WMM youn_WMM WMM_only |
| SCMH1 | CBX2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| SCMH1 | PHC2 | 0.009 | 0.109 | bioplex_WMM WMM_only |
| SCMH1 | PHC3 | 0.009 | 0.107 | bioplex_WMM WMM_only |
Images
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Complex HuMAP2_06662 has an average edge precision of 0.468 which is ranked 2714 out of all 6965 complexes.
Related Complexes