hu.MAP 2.0: Complex View

Human Protein Complex Map

Complex: HuMAP2_06664

Confidence: Medium

Genename	Protein Name	Links
FOXK2	Forkhead box protein K2 (G/T-mismatch specific binding protein) (nGTBP) (Interleukin enhancer-binding factor 1)	UniProt NCBI
DVL3	Segment polarity protein dishevelled homolog DVL-3 (Dishevelled-3) (DSH homolog 3)	UniProt NCBI
NXN	Nucleoredoxin (EC 1.8.1.8)	UniProt NCBI
FOXK1	Forkhead box protein K1 (Myocyte nuclear factor) (MNF)	UniProt NCBI
EPB41L4A	Band 4.1-like protein 4A (Protein NBL4)	UniProt NCBI
DVL1	Segment polarity protein dishevelled homolog DVL-1 (Dishevelled-1) (DSH homolog 1)	UniProt NCBI
DVL2	Segment polarity protein dishevelled homolog DVL-2 (Dishevelled-2) (DSH homolog 2)	UniProt NCBI

Enrichments

Term ID	Corrected Pval	Fraction Complex Coverage	Proteins	Term Name
REAC:R-HSA-5368598	4.25151809675e-08	0.428571428571	DVL1 DVL2 DVL3	Negative regulation of TCF-dependent signaling by DVL-interacting proteins
REAC:R-HSA-201688	5.94732974666e-07	0.428571428571	DVL1 DVL2 DVL3	WNT mediated activation of DVL
HP:0100798	6.38576154993e-06	0.428571428571	DVL1 DVL3 NXN	Fingernail dysplasia
GO:0042249	1.27120391093e-05	0.428571428571	DVL1 DVL2 DVL3	establishment of planar polarity of embryonic epithelium
GO:0090177	1.27120391093e-05	0.428571428571	DVL1 DVL2 DVL3	establishment of planar polarity involved in neural tube closure
GO:0090178	1.27120391093e-05	0.428571428571	DVL1 DVL2 DVL3	regulation of establishment of planar polarity involved in neural tube closure
GO:0090179	1.27120391093e-05	0.428571428571	DVL1 DVL2 DVL3	planar cell polarity pathway involved in neural tube closure
WP:WP4150	2.01090806007e-05	0.428571428571	DVL1 DVL2 DVL3	Wnt Signaling in Kidney Disease
WP:WP268	3.06804134301e-05	0.428571428571	DVL1 DVL2 DVL3	Notch Signaling
REAC:R-HSA-4641262	4.29273169575e-05	0.428571428571	DVL1 DVL2 DVL3	Disassembly of the destruction complex and recruitment of AXIN to the membrane
KEGG:04330	5.3549795788e-05	0.428571428571	DVL1 DVL2 DVL3	Notch signaling pathway
HP:0010297	5.9468424282e-05	0.428571428571	DVL1 DVL3 NXN	Bifid tongue
WP:WP363	6.1726263852e-05	0.428571428571	DVL1 DVL2 DVL3	Wnt Signaling Pathway
KEGG:05217	9.13787126912e-05	0.428571428571	DVL1 DVL2 DVL3	Basal cell carcinoma
GO:1905276	0.000111163123615	0.428571428571	DVL1 DVL2 DVL3	regulation of epithelial tube formation
GO:0150012	0.000111163123615	0.428571428571	DVL1 DVL2 DVL3	positive regulation of neuron projection arborization
HP:0003027	0.0001128375617	0.428571428571	DVL1 DVL3 NXN	Mesomelia
HP:0001052	0.000210221244229	0.428571428571	DVL1 DVL3 NXN	Nevus flammeus
HP:0011069	0.000230518728837	0.428571428571	DVL1 DVL3 NXN	Increased number of teeth
WP:WP2064	0.000234246533236	0.428571428571	DVL1 DVL2 DVL3	Neural Crest Differentiation
WP:WP4336	0.000253390302973	0.428571428571	DVL1 DVL2 DVL3	ncRNAs involved in Wnt signaling in hepatocellular carcinoma
HP:0025104	0.000274939800806	0.428571428571	DVL1 DVL3 NXN	Capillary malformation
HP:0010807	0.000299138836936	0.428571428571	DVL1 DVL3 NXN	Open bite
REAC:R-HSA-4641258	0.000307691590845	0.428571428571	DVL1 DVL2 DVL3	Degradation of DVL
WP:WP4258	0.000352401426229	0.428571428571	DVL1 DVL2 DVL3	LncRNA involvement in canonical Wnt signaling and colorectal cancer
KEGG:04916	0.000371874872479	0.428571428571	DVL1 DVL2 DVL3	Melanogenesis
GO:0150011	0.000380900357231	0.428571428571	DVL1 DVL2 DVL3	regulation of neuron projection arborization
WP:WP399	0.000489203368595	0.428571428571	DVL1 DVL2 DVL3	Wnt Signaling Pathway and Pluripotency
WP:WP3931	0.000504549841003	0.428571428571	DVL1 DVL2 DVL3	ESC Pluripotency Pathways
HP:0012815	0.000583357539395	0.428571428571	DVL1 DVL3 NXN	Hypoplastic female external genitalia
WP:WP710	0.000603363005383	0.428571428571	DVL1 DVL2 DVL3	DNA Damage Response (only ATM dependent)
WP:WP428	0.000657238949319	0.428571428571	DVL1 DVL2 DVL3	Wnt Signaling
HP:0001705	0.000692418575536	0.285714285714	DVL1 DVL3	Right ventricular outlet tract obstruction
HP:0040036	0.000692418575536	0.285714285714	DVL1 DVL3	Onychogryposis of fingernail
HP:0001853	0.000692418575536	0.285714285714	DVL1 DVL3	Bifid distal phalanx of toe
HP:0000960	0.000898974807669	0.428571428571	DVL1 DVL3 NXN	Sacral dimple
HP:0010767	0.00095166352735	0.428571428571	DVL1 DVL3 NXN	Sacrococcygeal pilonidal abnormality
KEGG:04550	0.000984164692148	0.428571428571	DVL1 DVL2 DVL3	Signaling pathways regulating pluripotency of stem cells
HP:0000637	0.00112194860564	0.428571428571	DVL1 DVL3 NXN	Long palpebral fissure
HP:0010781	0.00112194860564	0.428571428571	DVL1 DVL3 NXN	Skin dimple
HP:0010290	0.0011537726365	0.285714285714	DVL1 DVL3	Short hard palate
KEGG:05224	0.00116183627381	0.428571428571	DVL1 DVL2 DVL3	Breast cancer
KEGG:05226	0.00118882602816	0.428571428571	DVL1 DVL2 DVL3	Gastric cancer
HP:0011304	0.00124602529857	0.428571428571	DVL1 DVL3 NXN	Broad thumb
REAC:R-HSA-4086400	0.00126876263254	0.428571428571	DVL1 DVL2 DVL3	PCP/CE pathway
WP:WP4262	0.00144093759847	0.428571428571	DVL1 DVL2 DVL3	Breast cancer pathway
KEGG:04934	0.0014818224657	0.428571428571	DVL1 DVL2 DVL3	Cushing syndrome
KEGG:04390	0.00151349756768	0.428571428571	DVL1 DVL2 DVL3	Hippo signaling pathway
KEGG:04150	0.00157818210572	0.428571428571	DVL1 DVL2 DVL3	mTOR signaling pathway
KEGG:04310	0.00167858916845	0.428571428571	DVL1 DVL2 DVL3	Wnt signaling pathway
HP:0010733	0.00173027154874	0.285714285714	DVL1 DVL3	Naevus flammeus of the eyelid
HP:0000592	0.001833168498	0.428571428571	DVL1 DVL3 NXN	Blue sclerae
HP:0003042	0.0020041380536	0.428571428571	DVL1 DVL3 NXN	Elbow dislocation
HP:0009768	0.00209345261454	0.428571428571	DVL1 DVL3 NXN	Broad phalanges of the hand
KEGG:05225	0.00212228497248	0.428571428571	DVL1 DVL2 DVL3	Hepatocellular carcinoma
GO:0140058	0.00215539204286	0.428571428571	DVL1 DVL2 DVL3	neuron projection arborization
HP:0000527	0.0022799246445	0.428571428571	DVL1 DVL3 NXN	Long eyelashes
HP:0030310	0.00279356266298	0.428571428571	DVL1 DVL3 NXN	Upper extremity joint dislocation
HP:0008402	0.00322839434563	0.285714285714	DVL1 DVL3	Ridged fingernail
HP:0000591	0.00325569605486	0.428571428571	DVL1 DVL3 NXN	Abnormal sclera morphology
HP:0008873	0.00350463794031	0.428571428571	DVL1 DVL3 NXN	Disproportionate short-limb short stature
HP:0000212	0.00350463794031	0.428571428571	DVL1 DVL3 NXN	Gingival overgrowth
GO:1904886	0.00361126654538	0.428571428571	DVL1 DVL2 DVL3	beta-catenin destruction complex disassembly
HP:0002714	0.00390121143708	0.428571428571	DVL1 DVL3 NXN	Downturned corners of mouth
REAC:R-HSA-5663220	0.00396928319241	0.428571428571	DVL1 DVL2 DVL3	RHO GTPases Activate Formins
HP:0001500	0.00403972366653	0.428571428571	DVL1 DVL3 NXN	Broad finger
HP:0012905	0.00414986351758	0.285714285714	DVL1 DVL3	Euryblepharon
REAC:R-HSA-3858494	0.00433767078452	0.428571428571	DVL1 DVL2 DVL3	Beta-catenin independent WNT signaling
HP:0006009	0.00493969737088	0.428571428571	DVL1 DVL3 NXN	Broad phalanx
HP:0008501	0.0051861681154	0.285714285714	DVL1 DVL3	Median cleft lip and palate
HP:0005622	0.00614659531063	0.428571428571	DVL1 DVL3 NXN	Broad long bones
HP:0003764	0.00614659531063	0.428571428571	DVL1 DVL3 NXN	Nevus
HP:0000674	0.0063372308607	0.285714285714	DVL1 DVL3	Anodontia
HP:0003498	0.00652407882332	0.428571428571	DVL1 DVL3 NXN	Disproportionate short stature
HP:0005107	0.00652407882332	0.428571428571	DVL1 DVL3 NXN	Abnormal sacrum morphology
HP:0000207	0.00760297450628	0.285714285714	DVL1 DVL3	Triangular mouth
HP:0003422	0.00796556594493	0.428571428571	DVL1 DVL3 NXN	Vertebral segmentation defect
HP:0007665	0.00898332183607	0.285714285714	DVL1 DVL3	Curly eyelashes
HP:0009883	0.00898332183607	0.285714285714	DVL1 DVL3	Duplication of the distal phalanx of hand
HP:0009099	0.00898332183607	0.285714285714	DVL1 DVL3	Median cleft palate
HP:0000055	0.00911474446839	0.428571428571	DVL1 DVL3 NXN	Abnormality of female external genitalia
HP:0000768	0.0093569954776	0.428571428571	DVL1 DVL3 NXN	Pectus carinatum
HP:0004220	0.0104781956652	0.285714285714	DVL1 DVL3	Short middle phalanx of the 5th finger
HP:0009370	0.0104781956652	0.285714285714	DVL1 DVL3	Type A brachydactyly
HP:0002164	0.0106322692678	0.428571428571	DVL1 DVL3 NXN	Nail dysplasia
GO:0005109	0.0115540711621	0.428571428571	DVL1 DVL2 DVL3	frizzled binding
HP:0009161	0.0120875188399	0.285714285714	DVL1 DVL3	Aplasia/Hypoplasia of the middle phalanx of the 5th finger
HP:0009602	0.0126033076324	0.428571428571	DVL1 DVL3 NXN	Abnormality of thumb phalanx
HP:0009774	0.0135169732343	0.428571428571	DVL1 DVL3 NXN	Triangular shaped phalanges of the hand
HP:0004219	0.0138112142376	0.285714285714	DVL1 DVL3	Abnormality of the middle phalanx of the 5th finger
GO:0060606	0.0142076090165	0.428571428571	DVL1 DVL2 DVL3	tube closure
GO:0001843	0.0142076090165	0.428571428571	DVL1 DVL2 DVL3	neural tube closure
HP:0000668	0.015135153545	0.428571428571	DVL1 DVL3 NXN	Hypodontia
HP:0100541	0.0156492047667	0.285714285714	DVL1 DVL3	Femoral hernia
HP:0005743	0.0156492047667	0.285714285714	DVL1 DVL3	Avascular necrosis of the capital femoral epiphysis
KEGG:05165	0.0156896284271	0.428571428571	DVL1 DVL2 DVL3	Human papillomavirus infection
HP:0000322	0.017239739418	0.428571428571	DVL1 DVL3 NXN	Short philtrum
HP:0001231	0.0179819280801	0.428571428571	DVL1 DVL3 NXN	Abnormal fingernail morphology
REAC:R-HSA-201681	0.0182953414124	0.428571428571	DVL1 DVL2 DVL3	TCF dependent signaling in response to WNT
HP:0000126	0.0187449071166	0.428571428571	DVL1 DVL3 NXN	Hydronephrosis
HP:0010946	0.0187449071166	0.428571428571	DVL1 DVL3 NXN	Dilatation of the renal pelvis
GO:0014020	0.0189025357646	0.428571428571	DVL1 DVL2 DVL3	primary neural tube formation
HP:0009832	0.0195289520329	0.428571428571	DVL1 DVL3 NXN	Abnormal distal phalanx morphology of finger
HP:0010944	0.0195289520329	0.428571428571	DVL1 DVL3 NXN	Abnormal renal pelvis morphology
HP:0001805	0.0196677630092	0.285714285714	DVL1 DVL3	Onychogryposis
HP:0001596	0.022010230044	0.428571428571	DVL1 DVL3 NXN	Alopecia
GO:0030178	0.0224457600324	0.571428571429	DVL1 DVL2 NXN DVL3	negative regulation of Wnt signaling pathway
GO:0001841	0.0225450636661	0.428571428571	DVL1 DVL2 DVL3	neural tube formation
HP:0100490	0.0237747745163	0.428571428571	DVL1 DVL3 NXN	Camptodactyly of finger
HP:0000161	0.0241425774578	0.285714285714	DVL1 DVL3	Median cleft lip
HP:0000168	0.0246909739482	0.428571428571	DVL1 DVL3 NXN	Abnormality of the gingiva
HP:0001220	0.0246909739482	0.428571428571	DVL1 DVL3 NXN	Interphalangeal joint contracture of finger
WP:WP4656	0.0260504484155	0.285714285714	DVL1 DVL3	Joubert Syndrome
HP:0006101	0.0261084478552	0.428571428571	DVL1 DVL3 NXN	Finger syndactyly
HP:0000064	0.0265508883611	0.285714285714	DVL1 DVL3	Hypoplastic labia minora
HP:0000075	0.0265508883611	0.285714285714	DVL1 DVL3	Renal duplication
HP:0006261	0.0280804313779	0.428571428571	DVL1 DVL3 NXN	Abnormal phalangeal joint morphology of the hand
GO:0035947	0.0283955176165	0.285714285714	FOXK2 FOXK1	regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
HP:0009803	0.0285882991569	0.428571428571	DVL1 DVL3 NXN	Short phalanx of finger
HP:0000039	0.0290730325003	0.285714285714	DVL1 DVL3	Epispadias
HP:0040255	0.0290730325003	0.285714285714	DVL1 DVL3	Aplasia/Hypoplasia of the clitoris
HP:0000060	0.0290730325003	0.285714285714	DVL1 DVL3	Clitoral hypoplasia
HP:0011338	0.029102183295	0.428571428571	DVL1 DVL3 NXN	Abnormality of mouth shape
GO:0001838	0.0311716432999	0.428571428571	DVL1 DVL2 DVL3	embryonic epithelial tube formation
HP:0012785	0.0312185579762	0.428571428571	DVL1 DVL3 NXN	Flexion contracture of finger
HP:0100323	0.0317089330016	0.285714285714	DVL1 DVL3	Juvenile aseptic necrosis
HP:0000499	0.0340034356185	0.428571428571	DVL1 DVL3 NXN	Abnormal eyelash morphology
HP:0009376	0.0344585130221	0.285714285714	DVL1 DVL3	Aplasia/Hypoplasia of the phalanges of the 5th finger
HP:0000520	0.0357503243224	0.428571428571	DVL1 DVL3 NXN	Proptosis
HP:0004213	0.0373216957502	0.285714285714	DVL1 DVL3	Abnormal 5th finger phalanx morphology
HP:0000023	0.0400538015729	0.428571428571	DVL1 DVL3 NXN	Inguinal hernia
HP:0009811	0.0400538015729	0.428571428571	DVL1 DVL3 NXN	Abnormality of the elbow
HP:0009826	0.0413430401734	0.428571428571	DVL1 DVL3 NXN	Limb undergrowth
HP:0009767	0.0413430401734	0.428571428571	DVL1 DVL3 NXN	Aplasia/Hypoplasia of the phalanges of the hand
HP:0012880	0.0433885622377	0.285714285714	DVL1 DVL3	Abnormality of the labia minora
HP:0200007	0.0446848774817	0.428571428571	DVL1 DVL3 NXN	Abnormal size of the palpebral fissures
GO:0072175	0.0447246492298	0.428571428571	DVL1 DVL2 DVL3	epithelial tube formation
HP:0000582	0.0460698028121	0.428571428571	DVL1 DVL3 NXN	Upslanted palpebral fissure
HP:0009237	0.0465920925289	0.285714285714	DVL1 DVL3	Short 5th finger
GO:0016331	0.0478353182304	0.428571428571	DVL1 DVL2 DVL3	morphogenesis of embryonic epithelium
HP:0009473	0.0481996475112	0.428571428571	DVL1 DVL3 NXN	Joint contracture of the hand
REAC:R-HSA-195258	0.0486548926971	0.428571428571	DVL1 DVL2 DVL3	RHO GTPase Effectors
REAC:R-HSA-195721	0.0491203268289	0.428571428571	DVL1 DVL2 DVL3	Signaling by WNT
HP:0006262	0.0499089185913	0.285714285714	DVL1 DVL3	Aplasia/Hypoplasia of the 5th finger
HP:0005306	0.0499089185913	0.285714285714	DVL1 DVL3	Capillary hemangioma
CORUM:6693	0.0499886427319	0.142857142857	DVL1	DVL1-PI4K2A complex
CORUM:7158	0.0499886427319	0.142857142857	DVL1	TSC2-DVL complex

Edges

Protein 1	Protein 2	Score	Precision	Evidence
DVL2	DVL3	0.712	0.728	bioplex (DVL3) bioplex_WMM boldt youn_WMM gupta_WMM boldt_WMM
DVL3	EPB41L4A	0.236	0.469	bioplex (DVL3) bioplex_WMM
DVL1	DVL2	0.097	0.358	bioplex (DVL1) bioplex_WMM youn_WMM gupta_WMM
DVL3	FOXK2	0.048	0.295	bioplex (DVL3) bioplex_WMM youn_WMM
NXN	DVL3	0.047	0.293	bioplex (DVL3) bioplex_WMM youn_WMM gupta_WMM
FOXK1	FOXK2	0.044	0.279	hein_WMM bioplex_WMM boldt youn_WMM boldt_WMM
FOXK1	DVL3	0.02	0.185	bioplex (DVL3) bioplex_WMM youn_WMM
DVL2	EPB41L4A	0.008	0.06	bioplex_WMM WMM_only
FOXK2	EPB41L4A	0.008	0.037	bioplex_WMM WMM_only
NXN	EPB41L4A	0.008	0.032	bioplex_WMM WMM_only
FOXK1	EPB41L4A	0.008	0.013	bioplex_WMM WMM_only
DVL1	DVL3	0.008	0.009	youn_WMM gupta_WMM WMM_only
DVL1	NXN	0.007	0.002	youn_WMM gupta_WMM WMM_only
DVL2	FOXK2	0.007	0.005	bioplex_WMM youn_WMM WMM_only
DVL2	NXN	0.007	0.004	bioplex_WMM youn_WMM gupta_WMM WMM_only
DVL1	FOXK2	0.007	0.0	youn_WMM WMM_only
NXN	FOXK2	0.007	0.002	bioplex_WMM youn_WMM WMM_only
DVL1	FOXK1	0.007	0.0	youn_WMM WMM_only
DVL2	FOXK1	0.007	0.004	bioplex_WMM youn_WMM WMM_only
FOXK1	NXN	0.007	0.003	bioplex_WMM youn_WMM WMM_only

Images

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Complex HuMAP2_06664 has an average edge precision of 0.139 which is ranked 6782 out of all 6965 complexes.

Related Complexes

Genename	Complexes
FOXK2	HuMAP2_04648 HuMAP2_05887 HuMAP2_06664
DVL3	HuMAP2_03933 HuMAP2_04648 HuMAP2_05887 HuMAP2_06664
NXN	HuMAP2_01216 HuMAP2_05887 HuMAP2_06664
FOXK1	HuMAP2_00920 HuMAP2_05887 HuMAP2_06664
EPB41L4A	HuMAP2_04648 HuMAP2_05887 HuMAP2_06664
DVL1	HuMAP2_00482 HuMAP2_05124 HuMAP2_06664
DVL2	HuMAP2_00482 HuMAP2_03933 HuMAP2_05124 HuMAP2_05871 HuMAP2_06664

hu.MAP 2.0: Complex View

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Complex: HuMAP2_06664