hu.MAP 2.0: Complex View
Human Protein Complex Map
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Complex: HuMAP2_06665
Confidence: Medium High
Proteins| Genename | Protein Name | Links |
|---|---|---|
| CTSA | Lysosomal protective protein (EC 3.4.16.5) (Carboxypeptidase C) (Carboxypeptidase L) (Cathepsin A) (Protective protein cathepsin A) (PPCA) (Protective protein for beta-galactosidase) [Cleaved into: Lysosomal protective protein 32 kDa chain; Lysosomal protective protein 20 kDa chain] | UniProt NCBI |
| GLB1 | Beta-galactosidase (EC 3.2.1.23) (Acid beta-galactosidase) (Lactase) (Elastin receptor 1) | UniProt NCBI |
| SERPINB5 | Serpin B5 (Maspin) (Peptidase inhibitor 5) (PI-5) | UniProt NCBI |
Enrichments
| Term ID | Corrected Pval | Fraction Complex Coverage | Proteins | Term Name |
|---|---|---|---|---|
| HP:0004342 | 8.83967473292e-06 | 0.666666666667 | GLB1 CTSA | Abnormality of galactoside metabolism |
| HP:0008166 | 8.83967473292e-06 | 0.666666666667 | GLB1 CTSA | Decreased beta-galactosidase activity |
| HP:0003649 | 8.83967473292e-06 | 0.666666666667 | GLB1 CTSA | Abnormality of glycoside metabolism |
| REAC:R-HSA-4341670 | 2.00852924023e-05 | 0.666666666667 | GLB1 CTSA | Defective NEU1 causes sialidosis |
| CORUM:1379 | 2.01342304124e-05 | 0.666666666667 | GLB1 CTSA | GALNS-lysosomal hydrolase 1.27 MDa complex |
| HP:0010729 | 0.000318128568027 | 0.666666666667 | GLB1 CTSA | Cherry red spot of the macula |
| REAC:R-HSA-5609975 | 0.000802944115303 | 0.666666666667 | GLB1 CTSA | Diseases associated with glycosylation precursor biosynthesis |
| REAC:R-HSA-4085001 | 0.00290884705451 | 0.666666666667 | GLB1 CTSA | Sialic acid metabolism |
| KEGG:04142 | 0.00307537091529 | 0.666666666667 | GLB1 CTSA | Lysosome |
| REAC:R-HSA-1660662 | 0.00521352578002 | 0.666666666667 | GLB1 CTSA | Glycosphingolipid metabolism |
| HP:0000630 | 0.00834660940556 | 0.666666666667 | GLB1 CTSA | Abnormal retinal artery morphology |
| REAC:R-HSA-446219 | 0.0110397460449 | 0.666666666667 | GLB1 CTSA | Synthesis of substrates in N-glycan biosythesis |
| HP:3000036 | 0.0135801907106 | 0.666666666667 | GLB1 CTSA | Abnormality of head blood vessel |
| REAC:R-HSA-446193 | 0.0175395775792 | 0.666666666667 | GLB1 CTSA | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| REAC:R-HSA-428157 | 0.0180259784934 | 0.666666666667 | GLB1 CTSA | Sphingolipid metabolism |
| HP:0007759 | 0.0183346678183 | 0.666666666667 | GLB1 CTSA | Opacification of the corneal stroma |
| HP:0011492 | 0.0200772827833 | 0.666666666667 | GLB1 CTSA | Abnormality of corneal stroma |
| WP:WP4352 | 0.0212517549636 | 0.666666666667 | GLB1 CTSA | Ciliary landscape |
| HP:0003510 | 0.0257780467151 | 0.666666666667 | GLB1 CTSA | Severe short stature |
| HP:0003508 | 0.044442515366 | 0.666666666667 | GLB1 CTSA | Proportionate short stature |
| KEGG:00604 | 0.0466467988893 | 0.333333333333 | GLB1 | Glycosphingolipid biosynthesis - ganglio series |
| REAC:R-HSA-2206308 | 0.0498572752401 | 0.333333333333 | GLB1 | MPS IV - Morquio syndrome B |
| REAC:R-HSA-3781865 | 0.0499634502482 | 0.666666666667 | GLB1 CTSA | Diseases of glycosylation |
Edges
| Protein 1 | Protein 2 | Score | Precision | Evidence |
|---|---|---|---|---|
| GLB1 | CTSA | 0.845 | 0.788 | bioplex (GLB1) bioplex_WMM boldt boldt_WMM |
| CTSA | SERPINB5 | 0.058 | 0.325 | bioplex (SERPINB5) bioplex_WMM fraction |
Images
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Complex HuMAP2_06665 has an average edge precision of 0.556 which is ranked 2156 out of all 6965 complexes.
Related Complexes
| Genename | Complexes |
|---|---|
| CTSA | HuMAP2_00949 HuMAP2_01586 HuMAP2_06665 |
| GLB1 | HuMAP2_00918 HuMAP2_00949 HuMAP2_06665 |
| SERPINB5 | HuMAP2_03189 HuMAP2_06665 |